U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adult Acute Myeloid Leukemia without Maturation

MedGen UID:
83533
Concept ID:
C0279623
Neoplastic Process
Synonyms: Adult Acute Myeloblastic Leukemia; Adult Acute Myeloblastic Leukemia without Maturation; Adult Acute Myeloblastic Leukemia without Maturation (M1); Adult Acute Myelogenous Leukemia without Maturation; M1 Adult Acute Myeloblastic Leukemia; M1 Adult Acute Myelogenous Leukemia; M1 Adult Acute Myelogenous Leukemia without Maturation; M1 Adult Acute Myeloid Leukemia; M1 Adult Acute Myeloid Leukemia without Maturation

Definition

An acute myeloid leukemia without maturation occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Acute Myeloid Leukemia without Maturation

Professional guidelines

PubMed

Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, Röllig C, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A, Löwenberg B
Blood 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867. PMID: 35797463
Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, Dombret H, Ebert BL, Fenaux P, Larson RA, Levine RL, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz M, Sierra J, Tallman MS, Tien HF, Wei AH, Löwenberg B, Bloomfield CD
Blood 2017 Jan 26;129(4):424-447. Epub 2016 Nov 28 doi: 10.1182/blood-2016-08-733196. PMID: 27895058Free PMC Article

Recent clinical studies

Etiology

Bhansali RS, Pratz KW, Lai C
J Hematol Oncol 2023 Mar 25;16(1):29. doi: 10.1186/s13045-023-01424-6. PMID: 36966300Free PMC Article
Stubbins RJ, Francis A, Kuchenbauer F, Sanford D
Curr Oncol 2022 Aug 30;29(9):6245-6259. doi: 10.3390/curroncol29090491. PMID: 36135060Free PMC Article
Pollyea DA, Bixby D, Perl A, Bhatt VR, Altman JK, Appelbaum FR, de Lima M, Fathi AT, Foran JM, Gojo I, Hall AC, Jacoby M, Lancet J, Mannis G, Marcucci G, Martin MG, Mims A, Neff J, Nejati R, Olin R, Percival ME, Prebet T, Przespolewski A, Rao D, Ravandi-Kashani F, Shami PJ, Stone RM, Strickland SA, Sweet K, Vachhani P, Wieduwilt M, Gregory KM, Ogba N, Tallman MS
J Natl Compr Canc Netw 2021 Jan 6;19(1):16-27. doi: 10.6004/jnccn.2021.0002. PMID: 33406488
Narayanan D, Weinberg OK
Int J Lab Hematol 2020 Feb;42(1):3-15. Epub 2019 Dec 10 doi: 10.1111/ijlh.13135. PMID: 31820579
Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, Dombret H, Ebert BL, Fenaux P, Larson RA, Levine RL, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz M, Sierra J, Tallman MS, Tien HF, Wei AH, Löwenberg B, Bloomfield CD
Blood 2017 Jan 26;129(4):424-447. Epub 2016 Nov 28 doi: 10.1182/blood-2016-08-733196. PMID: 27895058Free PMC Article

Diagnosis

Pollyea DA, Altman JK, Assi R, Bixby D, Fathi AT, Foran JM, Gojo I, Hall AC, Jonas BA, Kishtagari A, Lancet J, Maness L, Mangan J, Mannis G, Marcucci G, Mims A, Moriarty K, Mustafa Ali M, Neff J, Nejati R, Olin R, Percival ME, Perl A, Przespolewski A, Rao D, Ravandi F, Shallis R, Shami PJ, Stein E, Stone RM, Sweet K, Thota S, Uy G, Vachhani P, Cassara CJ, Freedman-Cass DA, Stehman K
J Natl Compr Canc Netw 2023 May;21(5):503-513. doi: 10.6004/jnccn.2023.0025. PMID: 37156478
Pollyea DA, Bixby D, Perl A, Bhatt VR, Altman JK, Appelbaum FR, de Lima M, Fathi AT, Foran JM, Gojo I, Hall AC, Jacoby M, Lancet J, Mannis G, Marcucci G, Martin MG, Mims A, Neff J, Nejati R, Olin R, Percival ME, Prebet T, Przespolewski A, Rao D, Ravandi-Kashani F, Shami PJ, Stone RM, Strickland SA, Sweet K, Vachhani P, Wieduwilt M, Gregory KM, Ogba N, Tallman MS
J Natl Compr Canc Netw 2021 Jan 6;19(1):16-27. doi: 10.6004/jnccn.2021.0002. PMID: 33406488
Narayanan D, Weinberg OK
Int J Lab Hematol 2020 Feb;42(1):3-15. Epub 2019 Dec 10 doi: 10.1111/ijlh.13135. PMID: 31820579
Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, Dombret H, Ebert BL, Fenaux P, Larson RA, Levine RL, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz M, Sierra J, Tallman MS, Tien HF, Wei AH, Löwenberg B, Bloomfield CD
Blood 2017 Jan 26;129(4):424-447. Epub 2016 Nov 28 doi: 10.1182/blood-2016-08-733196. PMID: 27895058Free PMC Article
Döhner H, Estey EH, Amadori S, Appelbaum FR, Büchner T, Burnett AK, Dombret H, Fenaux P, Grimwade D, Larson RA, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz MA, Sierra J, Tallman MS, Löwenberg B, Bloomfield CD; European LeukemiaNet
Blood 2010 Jan 21;115(3):453-74. Epub 2009 Oct 30 doi: 10.1182/blood-2009-07-235358. PMID: 19880497

Therapy

Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Bhansali RS, Pratz KW, Lai C
J Hematol Oncol 2023 Mar 25;16(1):29. doi: 10.1186/s13045-023-01424-6. PMID: 36966300Free PMC Article
Alfayez M, Kantarjian H, Kadia T, Ravandi-Kashani F, Daver N
Leuk Lymphoma 2020 Feb;61(2):288-297. Epub 2019 Sep 24 doi: 10.1080/10428194.2019.1660970. PMID: 31547736
Guerra VA, DiNardo C, Konopleva M
Best Pract Res Clin Haematol 2019 Jun;32(2):145-153. Epub 2019 May 24 doi: 10.1016/j.beha.2019.05.008. PMID: 31203996Free PMC Article
Stein EM, DiNardo CD, Pollyea DA, Fathi AT, Roboz GJ, Altman JK, Stone RM, DeAngelo DJ, Levine RL, Flinn IW, Kantarjian HM, Collins R, Patel MR, Frankel AE, Stein A, Sekeres MA, Swords RT, Medeiros BC, Willekens C, Vyas P, Tosolini A, Xu Q, Knight RD, Yen KE, Agresta S, de Botton S, Tallman MS
Blood 2017 Aug 10;130(6):722-731. Epub 2017 Jun 6 doi: 10.1182/blood-2017-04-779405. PMID: 28588020Free PMC Article

Prognosis

Rautenberg C, Stölzel F, Röllig C, Stelljes M, Gaidzik V, Lauseker M, Kriege O, Verbeek M, Unglaub JM, Thol F, Krause SW, Hänel M, Neuerburg C, Vucinic V, Jehn CF, Severmann J, Wass M, Fransecky L, Chemnitz J, Holtick U, Schäfer-Eckart K, Schröder J, Kraus S, Krüger W, Kaiser U, Scholl S, Koch K, Henning L, Kobbe G, Haas R, Alakel N, Röhnert MA, Sockel K, Hanoun M, Platzbecker U, Holderried TAW, Morgner A, Heuser M, Sauer T, Götze KS, Wagner-Drouet E, Döhner K, Döhner H, Schliemann C, Schetelig J, Bornhäuser M, Germing U, Schroeder T, Middeke JM
Blood Cancer J 2021 Oct 4;11(10):164. doi: 10.1038/s41408-021-00558-5. PMID: 34608129Free PMC Article
Sasaki K, Ravandi F, Kadia TM, DiNardo CD, Short NJ, Borthakur G, Jabbour E, Kantarjian HM
Cancer 2021 Jun 15;127(12):2049-2061. Epub 2021 Apr 5 doi: 10.1002/cncr.33458. PMID: 33818756
Uy GL, Aldoss I, Foster MC, Sayre PH, Wieduwilt MJ, Advani AS, Godwin JE, Arellano ML, Sweet KL, Emadi A, Ravandi F, Erba HP, Byrne M, Michaelis L, Topp MS, Vey N, Ciceri F, Carrabba MG, Paolini S, Huls GA, Jongen-Lavrencic M, Wermke M, Chevallier P, Gyan E, Récher C, Stiff PJ, Pettit KM, Löwenberg B, Church SE, Anderson E, Vadakekolathu J, Santaguida M, Rettig MP, Muth J, Curtis T, Fehr E, Guo K, Zhao J, Bakkacha O, Jacobs K, Tran K, Kaminker P, Kostova M, Bonvini E, Walter RB, Davidson-Moncada JK, Rutella S, DiPersio JF
Blood 2021 Feb 11;137(6):751-762. doi: 10.1182/blood.2020007732. PMID: 32929488Free PMC Article
Heuser M, Ofran Y, Boissel N, Brunet Mauri S, Craddock C, Janssen J, Wierzbowska A, Buske C; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2020 Jun;31(6):697-712. Epub 2020 Mar 17 doi: 10.1016/j.annonc.2020.02.018. PMID: 32171751
Huang L, Wang SA, DiNardo C, Li S, Hu S, Xu J, Zhou W, Goswami M, Medeiros LJ, Tang G
Leuk Res 2017 Feb;53:20-27. Epub 2016 Dec 2 doi: 10.1016/j.leukres.2016.11.016. PMID: 27951415

Clinical prediction guides

Shiba N
Int J Hematol 2023 Feb;117(2):173-181. Epub 2023 Jan 18 doi: 10.1007/s12185-023-03533-x. PMID: 36653696
Chiche E, Rahmé R, Bertoli S, Dumas PY, Micol JB, Hicheri Y, Pasquier F, Peterlin P, Chevallier P, Thomas X, Loschi M, Genthon A, Legrand O, Mohty M, Raffoux E, Auberger P, Caulier A, Joris M, Bonmati C, Roth-Guepin G, Lejeune C, Pigneux A, Vey N, Recher C, Ades L, Cluzeau T
Blood Adv 2021 Jan 12;5(1):176-184. doi: 10.1182/bloodadvances.2020003159. PMID: 33570629Free PMC Article
Khanal N, Upadhyay Banskota S, Bhatt VR
Clin Pharmacol Ther 2020 Sep;108(3):506-514. Epub 2020 Aug 11 doi: 10.1002/cpt.1962. PMID: 32572947Free PMC Article
Benetatos L, Vartholomatos G
Cell Mol Life Sci 2018 Jun;75(11):1999-2009. Epub 2018 Feb 26 doi: 10.1007/s00018-018-2783-2. PMID: 29484447Free PMC Article
Grimwade D, Ivey A, Huntly BJ
Blood 2016 Jan 7;127(1):29-41. Epub 2015 Dec 10 doi: 10.1182/blood-2015-07-604496. PMID: 26660431Free PMC Article

Recent systematic reviews

Ali Hailan YM, Al-Dubai HN, Yassin MA
Oncology 2023;101(6):362-368. Epub 2023 May 9 doi: 10.1159/000530463. PMID: 37231874
de Baat EC, Mulder RL, Armenian S, Feijen EA, Grotenhuis H, Hudson MM, Mavinkurve-Groothuis AM, Kremer LC, van Dalen EC
Cochrane Database Syst Rev 2022 Sep 27;9(9):CD014638. doi: 10.1002/14651858.CD014638.pub2. PMID: 36162822Free PMC Article
Stemler J, de Jonge N, Skoetz N, Sinkó J, Brüggemann RJ, Busca A, Ben-Ami R, Ráčil Z, Piechotta V, Lewis R, Cornely OA
Lancet Haematol 2022 May;9(5):e361-e373. doi: 10.1016/S2352-3026(22)00073-4. PMID: 35483397
Wang J, Zhou M, Xu JY, Zhou RF, Chen B, Wan Y
JAMA Netw Open 2020 Oct 1;3(10):e2017652. doi: 10.1001/jamanetworkopen.2020.17652. PMID: 33030550Free PMC Article
Smith TJ, Bohlke K, Lyman GH, Carson KR, Crawford J, Cross SJ, Goldberg JM, Khatcheressian JL, Leighl NB, Perkins CL, Somlo G, Wade JL, Wozniak AJ, Armitage JO; American Society of Clinical Oncology
J Clin Oncol 2015 Oct 1;33(28):3199-212. Epub 2015 Jul 13 doi: 10.1200/JCO.2015.62.3488. PMID: 26169616

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...