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Neuroendocrine cell hyperplasia of infancy

MedGen UID:
837309
•Concept ID:
C3161105
•
Disease or Syndrome
Synonyms: chronic tachypnoe of infancy; CTI; NCHI; NEHI; Neuroendocrine Cell Hyperplasia of Infancy; neuroendocrine cell hyperplasia of infancy
SNOMED CT: Neuroendocrine cell hyperplasia of infancy (707435002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016322
Orphanet: ORPHA217560

Definition

Neuroendocrine cell hyperplasia of infancy (NCHI) is a non-lethal pediatric form of interstitial lung disease (ILD, see this term) characterized by tachypnea without respiratory failure. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroendocrine cell hyperplasia of infancy

Professional guidelines

PubMed

French national cohort of neuroendocrine cell hyperplasia of infancy (FRENCHI) study: diagnosis and initial management.
Fabre C, Thumerelle C, Dervaux M, Abou-Taam R, Bihouee T, Brouard J, Clement A, Delacourt C, Delestrain C, Epaud R, Ghdifan S, Hadchouel A, Houdouin V, Labouret G, Perisson C, Reix P, Renoux MC, Troussier F, Weiss L, Mazenq J, Nathan N, Dubus JC
Eur J Pediatr 2022 Aug;181(8):3067-3073. Epub 2022 Jun 9 doi: 10.1007/s00431-022-04510-y. PMID: 35678871
Diagnostic criteria and follow-up in neuroendocrine cell hyperplasia of infancy: a case series.
Gomes VC, Silva MC, Maia Filho JH, Daltro P, Ramos SG, Brody AS, Marchiori E
J Bras Pneumol 2013 Sep-Oct;39(5):569-78. doi: 10.1590/S1806-37132013000500007. PMID: 24310630Free PMC Article

Recent clinical studies

Etiology

Neuroendocrine Cell Hyperplasia of Infancy. Clinical Score and Comorbidities.
Liptzin DR, Pickett K, Brinton JT, Agarwal A, Fishman MP, Casey A, Towe CT, Taylor JB, Kurland G, Hagood JS, Wambach J, Srivastava R, Al-Saleh H, Dell SD, Young LR, Deterding RR
Ann Am Thorac Soc 2020 Jun;17(6):724-728. doi: 10.1513/AnnalsATS.201908-617OC. PMID: 32109152Free PMC Article
Lung and airway shape in neuroendocrine cell hyperplasia of infancy.
Mastej EJ, DeBoer EM, Humphries SM, Cook MC, Hunter KS, Liptzin DR, Weinman JP, Deterding RR
Pediatr Radiol 2018 Nov;48(12):1745-1754. Epub 2018 Jun 28 doi: 10.1007/s00247-018-4189-6. PMID: 29955904
Interstitial lung disease in newborns.
Nogee LM
Semin Fetal Neonatal Med 2017 Aug;22(4):227-233. Epub 2017 Mar 28 doi: 10.1016/j.siny.2017.03.003. PMID: 28363760Free PMC Article
Paediatric interstitial lung disease: classification and definitions.
Dishop MK
Paediatr Respir Rev 2011 Dec;12(4):230-7. Epub 2011 Mar 5 doi: 10.1016/j.prrv.2011.01.002. PMID: 22018036
Familial neuroendocrine cell hyperplasia of infancy.
Popler J, Gower WA, Mogayzel PJ Jr, Nogee LM, Langston C, Wilson AC, Hay TC, Deterding RR
Pediatr Pulmonol 2010 Aug;45(8):749-55. doi: 10.1002/ppul.21219. PMID: 20623780

Diagnosis

Long-term evolution of neuroendocrine cell hyperplasia of infancy: the FRENCHI findings.
Dervaux M, Thumerelle C, Fabre C, Abou-Taam R, Bihouee T, Brouard J, Clement A, Delacourt C, Delestrain C, Epaud R, Ghdifan S, Hadchouel A, Houdouin V, Labouret G, Perisson C, Reix P, Renoux MC, Troussier F, Weiss L, Mazenq J, Nathan N, Dubus JC
Eur J Pediatr 2023 Feb;182(2):949-956. Epub 2022 Nov 30 doi: 10.1007/s00431-022-04734-y. PMID: 36449078
French national cohort of neuroendocrine cell hyperplasia of infancy (FRENCHI) study: diagnosis and initial management.
Fabre C, Thumerelle C, Dervaux M, Abou-Taam R, Bihouee T, Brouard J, Clement A, Delacourt C, Delestrain C, Epaud R, Ghdifan S, Hadchouel A, Houdouin V, Labouret G, Perisson C, Reix P, Renoux MC, Troussier F, Weiss L, Mazenq J, Nathan N, Dubus JC
Eur J Pediatr 2022 Aug;181(8):3067-3073. Epub 2022 Jun 9 doi: 10.1007/s00431-022-04510-y. PMID: 35678871
Interstitial lung disease in infancy.
Bush A, Gilbert C, Gregory J, Nicholson AG, Semple T, Pabary R
Early Hum Dev 2020 Nov;150:105186. Epub 2020 Sep 15 doi: 10.1016/j.earlhumdev.2020.105186. PMID: 32958330
Neuroendocrine Cell Hyperplasia of Infancy. Clinical Score and Comorbidities.
Liptzin DR, Pickett K, Brinton JT, Agarwal A, Fishman MP, Casey A, Towe CT, Taylor JB, Kurland G, Hagood JS, Wambach J, Srivastava R, Al-Saleh H, Dell SD, Young LR, Deterding RR
Ann Am Thorac Soc 2020 Jun;17(6):724-728. doi: 10.1513/AnnalsATS.201908-617OC. PMID: 32109152Free PMC Article
Interstitial lung disease in newborns.
Nogee LM
Semin Fetal Neonatal Med 2017 Aug;22(4):227-233. Epub 2017 Mar 28 doi: 10.1016/j.siny.2017.03.003. PMID: 28363760Free PMC Article

Therapy

The improved clinical course of persistent tachypnea of infancy with inhaled bronchodilators and corticosteroids.
Marczak H, Peradzyńska J, Seidl E, Griese M, Urbankowski T, Lange J, Bogusławski S, Krenke K
Pediatr Pulmonol 2021 Dec;56(12):3952-3959. Epub 2021 Sep 21 doi: 10.1002/ppul.25674. PMID: 34520130
Growth trajectories and oxygen use in neuroendocrine cell hyperplasia of infancy.
Nevel RJ, Garnett ET, Schaudies DA, Young LR
Pediatr Pulmonol 2018 May;53(5):656-663. Epub 2018 Feb 2 doi: 10.1002/ppul.23958. PMID: 29393588Free PMC Article

Prognosis

Interstitial lung disease in infancy.
Bush A, Gilbert C, Gregory J, Nicholson AG, Semple T, Pabary R
Early Hum Dev 2020 Nov;150:105186. Epub 2020 Sep 15 doi: 10.1016/j.earlhumdev.2020.105186. PMID: 32958330
Neuroendocrine Cell Hyperplasia of Infancy. Clinical Score and Comorbidities.
Liptzin DR, Pickett K, Brinton JT, Agarwal A, Fishman MP, Casey A, Towe CT, Taylor JB, Kurland G, Hagood JS, Wambach J, Srivastava R, Al-Saleh H, Dell SD, Young LR, Deterding RR
Ann Am Thorac Soc 2020 Jun;17(6):724-728. doi: 10.1513/AnnalsATS.201908-617OC. PMID: 32109152Free PMC Article
Interstitial lung disease in newborns.
Nogee LM
Semin Fetal Neonatal Med 2017 Aug;22(4):227-233. Epub 2017 Mar 28 doi: 10.1016/j.siny.2017.03.003. PMID: 28363760Free PMC Article
Paediatric interstitial lung disease: classification and definitions.
Dishop MK
Paediatr Respir Rev 2011 Dec;12(4):230-7. Epub 2011 Mar 5 doi: 10.1016/j.prrv.2011.01.002. PMID: 22018036
Interstitial lung disease in children.
Das S, Langston C, Fan LL
Curr Opin Pediatr 2011 Jun;23(3):325-31. doi: 10.1097/MOP.0b013e3283464a37. PMID: 21572385

Clinical prediction guides

French national cohort of neuroendocrine cell hyperplasia of infancy (FRENCHI) study: diagnosis and initial management.
Fabre C, Thumerelle C, Dervaux M, Abou-Taam R, Bihouee T, Brouard J, Clement A, Delacourt C, Delestrain C, Epaud R, Ghdifan S, Hadchouel A, Houdouin V, Labouret G, Perisson C, Reix P, Renoux MC, Troussier F, Weiss L, Mazenq J, Nathan N, Dubus JC
Eur J Pediatr 2022 Aug;181(8):3067-3073. Epub 2022 Jun 9 doi: 10.1007/s00431-022-04510-y. PMID: 35678871
The improved clinical course of persistent tachypnea of infancy with inhaled bronchodilators and corticosteroids.
Marczak H, Peradzyńska J, Seidl E, Griese M, Urbankowski T, Lange J, Bogusławski S, Krenke K
Pediatr Pulmonol 2021 Dec;56(12):3952-3959. Epub 2021 Sep 21 doi: 10.1002/ppul.25674. PMID: 34520130
Neuroendocrine Cell Hyperplasia of Infancy. Clinical Score and Comorbidities.
Liptzin DR, Pickett K, Brinton JT, Agarwal A, Fishman MP, Casey A, Towe CT, Taylor JB, Kurland G, Hagood JS, Wambach J, Srivastava R, Al-Saleh H, Dell SD, Young LR, Deterding RR
Ann Am Thorac Soc 2020 Jun;17(6):724-728. doi: 10.1513/AnnalsATS.201908-617OC. PMID: 32109152Free PMC Article
Growth trajectories and oxygen use in neuroendocrine cell hyperplasia of infancy.
Nevel RJ, Garnett ET, Schaudies DA, Young LR
Pediatr Pulmonol 2018 May;53(5):656-663. Epub 2018 Feb 2 doi: 10.1002/ppul.23958. PMID: 29393588Free PMC Article
Exacerbations in neuroendocrine cell hyperplasia of infancy are characterized by increased air trapping.
Houin PR, Deterding RR, Young LR
Pediatr Pulmonol 2016 Mar;51(3):E9-12. Epub 2015 Dec 7 doi: 10.1002/ppul.23347. PMID: 26642007

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