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Previously Treated Childhood Rhabdomyosarcoma

MedGen UID:
852755
•Concept ID:
C0796528
•
Finding

Definition

A childhood rhabdomyosarcoma for which a patient has received treatment in the past. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPreviously Treated Childhood Rhabdomyosarcoma

Professional guidelines

PubMed

Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines.
Dávila Fajardo R, Scarzello G, Gaze MN, Boterberg T, Cameron A, Fuchs J, Guérin F, Hoskin P, Krasin MJ, Kroon P, Magelssen H, Mercke C, Merks JHM, Paulsen F, Pommier P, Ramos M, Rees H, Rogers T, Schmid M, Seitz G, Slater O, Smeulders N, Stenman J, Terwisscha S, Chargari C, Mandeville HC
Radiother Oncol 2024 Jun;195:110273. Epub 2024 Apr 7 doi: 10.1016/j.radonc.2024.110273. PMID: 38588921
Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2014 Sep 4;2014(9):CD006647. doi: 10.1002/14651858.CD006647.pub4. PMID: 25188452Free PMC Article
Surgical management of gynecologic rhabdomyosarcoma.
Harting MT, Blakely ML, Andrassy RJ
Curr Treat Options Oncol 2004 Apr;5(2):109-18. doi: 10.1007/s11864-004-0043-1. PMID: 14990205

Recent clinical studies

Etiology

Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines.
Dávila Fajardo R, Scarzello G, Gaze MN, Boterberg T, Cameron A, Fuchs J, Guérin F, Hoskin P, Krasin MJ, Kroon P, Magelssen H, Mercke C, Merks JHM, Paulsen F, Pommier P, Ramos M, Rees H, Rogers T, Schmid M, Seitz G, Slater O, Smeulders N, Stenman J, Terwisscha S, Chargari C, Mandeville HC
Radiother Oncol 2024 Jun;195:110273. Epub 2024 Apr 7 doi: 10.1016/j.radonc.2024.110273. PMID: 38588921
Circulating Tumor DNA Is Prognostic in Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group.
Abbou S, Klega K, Tsuji J, Tanhaemami M, Hall D, Barkauskas DA, Krailo MD, Cibulskis C, Nag A, Thorner AR, Pollock S, Imamovic-Tuco A, Shern JF, DuBois SG, Venkatramani R, Hawkins DS, Crompton BD
J Clin Oncol 2023 May 1;41(13):2382-2393. Epub 2023 Feb 1 doi: 10.1200/JCO.22.00409. PMID: 36724417Free PMC Article
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Rhabdomyosarcoma: current challenges and their implications for developing therapies.
Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C
Cold Spring Harb Perspect Med 2014 Nov 3;4(11):a025650. doi: 10.1101/cshperspect.a025650. PMID: 25368019Free PMC Article
Rhabdomyosarcoma in children.
Hayes-Jordan A, Andrassy R
Curr Opin Pediatr 2009 Jun;21(3):373-8. doi: 10.1097/MOP.0b013e32832b4171. PMID: 19448544

Diagnosis

Entinostat as a combinatorial therapeutic for rhabdomyosarcoma.
Chauhan S, Lian E, Habib I, Liu Q, Anders NM, Bugg MM, Federman NC, Reid JM, Stewart CF, Cates T, Michalek JE, Keller C
Sci Rep 2024 Aug 15;14(1):18936. doi: 10.1038/s41598-024-66545-5. PMID: 39147820Free PMC Article
Circulating Tumor DNA Is Prognostic in Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group.
Abbou S, Klega K, Tsuji J, Tanhaemami M, Hall D, Barkauskas DA, Krailo MD, Cibulskis C, Nag A, Thorner AR, Pollock S, Imamovic-Tuco A, Shern JF, DuBois SG, Venkatramani R, Hawkins DS, Crompton BD
J Clin Oncol 2023 May 1;41(13):2382-2393. Epub 2023 Feb 1 doi: 10.1200/JCO.22.00409. PMID: 36724417Free PMC Article
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Rhabdomyosarcoma: current challenges and their implications for developing therapies.
Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C
Cold Spring Harb Perspect Med 2014 Nov 3;4(11):a025650. doi: 10.1101/cshperspect.a025650. PMID: 25368019Free PMC Article
Rhabdomyosarcoma in children.
Hayes-Jordan A, Andrassy R
Curr Opin Pediatr 2009 Jun;21(3):373-8. doi: 10.1097/MOP.0b013e32832b4171. PMID: 19448544

Therapy

Entinostat as a combinatorial therapeutic for rhabdomyosarcoma.
Chauhan S, Lian E, Habib I, Liu Q, Anders NM, Bugg MM, Federman NC, Reid JM, Stewart CF, Cates T, Michalek JE, Keller C
Sci Rep 2024 Aug 15;14(1):18936. doi: 10.1038/s41598-024-66545-5. PMID: 39147820Free PMC Article
Rhabdomyosarcoma: current challenges and their implications for developing therapies.
Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C
Cold Spring Harb Perspect Med 2014 Nov 3;4(11):a025650. doi: 10.1101/cshperspect.a025650. PMID: 25368019Free PMC Article
Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2014 Sep 4;2014(9):CD006647. doi: 10.1002/14651858.CD006647.pub4. PMID: 25188452Free PMC Article
Treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence: third study of the International Society of Paediatric Oncology--SIOP Malignant Mesenchymal Tumor 89.
Stevens MC, Rey A, Bouvet N, Ellershaw C, Flamant F, Habrand JL, Marsden HB, Martelli H, Sanchez de Toledo J, Spicer RD, Spooner D, Terrier-Lacombe MJ, van Unnik A, Oberlin O
J Clin Oncol 2005 Apr 20;23(12):2618-28. Epub 2005 Feb 22 doi: 10.1200/JCO.2005.08.130. PMID: 15728225
Vinorelbine in previously treated advanced childhood sarcomas: evidence of activity in rhabdomyosarcoma.
Casanova M, Ferrari A, Spreafico F, Terenziani M, Massimino M, Luksch R, Cefalo G, Polastri D, Marcon I, Bellani FF
Cancer 2002 Jun 15;94(12):3263-8. doi: 10.1002/cncr.10600. PMID: 12115359

Prognosis

Entinostat as a combinatorial therapeutic for rhabdomyosarcoma.
Chauhan S, Lian E, Habib I, Liu Q, Anders NM, Bugg MM, Federman NC, Reid JM, Stewart CF, Cates T, Michalek JE, Keller C
Sci Rep 2024 Aug 15;14(1):18936. doi: 10.1038/s41598-024-66545-5. PMID: 39147820Free PMC Article
Circulating Tumor DNA Is Prognostic in Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group.
Abbou S, Klega K, Tsuji J, Tanhaemami M, Hall D, Barkauskas DA, Krailo MD, Cibulskis C, Nag A, Thorner AR, Pollock S, Imamovic-Tuco A, Shern JF, DuBois SG, Venkatramani R, Hawkins DS, Crompton BD
J Clin Oncol 2023 May 1;41(13):2382-2393. Epub 2023 Feb 1 doi: 10.1200/JCO.22.00409. PMID: 36724417Free PMC Article
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Rhabdomyosarcoma: current challenges and their implications for developing therapies.
Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C
Cold Spring Harb Perspect Med 2014 Nov 3;4(11):a025650. doi: 10.1101/cshperspect.a025650. PMID: 25368019Free PMC Article
Rhabdomyosarcoma in children.
Hayes-Jordan A, Andrassy R
Curr Opin Pediatr 2009 Jun;21(3):373-8. doi: 10.1097/MOP.0b013e32832b4171. PMID: 19448544

Clinical prediction guides

Entinostat as a combinatorial therapeutic for rhabdomyosarcoma.
Chauhan S, Lian E, Habib I, Liu Q, Anders NM, Bugg MM, Federman NC, Reid JM, Stewart CF, Cates T, Michalek JE, Keller C
Sci Rep 2024 Aug 15;14(1):18936. doi: 10.1038/s41598-024-66545-5. PMID: 39147820Free PMC Article
SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation.
Wang L, Hensch NR, Bondra K, Sreenivas P, Zhao XR, Chen J, Moreno Campos R, Baxi K, Vaseva AV, Sunkel BD, Gryder BE, Pomella S, Stanton BZ, Zheng S, Chen EY, Rota R, Khan J, Houghton PJ, Ignatius MS
Cancer Res 2021 Nov 1;81(21):5451-5463. Epub 2021 Aug 30 doi: 10.1158/0008-5472.CAN-20-4191. PMID: 34462275Free PMC Article
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Refinement of risk stratification for childhood rhabdomyosarcoma using FOXO1 fusion status in addition to established clinical outcome predictors: A report from the Children's Oncology Group.
Hibbitts E, Chi YY, Hawkins DS, Barr FG, Bradley JA, Dasgupta R, Meyer WH, Rodeberg DA, Rudzinski ER, Spunt SL, Skapek SX, Wolden SL, Arndt CAS
Cancer Med 2019 Oct;8(14):6437-6448. Epub 2019 Aug 27 doi: 10.1002/cam4.2504. PMID: 31456361Free PMC Article
Vinorelbine in previously treated advanced childhood sarcomas: evidence of activity in rhabdomyosarcoma.
Casanova M, Ferrari A, Spreafico F, Terenziani M, Massimino M, Luksch R, Cefalo G, Polastri D, Marcon I, Bellani FF
Cancer 2002 Jun 15;94(12):3263-8. doi: 10.1002/cncr.10600. PMID: 12115359

Recent systematic reviews

Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2014 Sep 4;2014(9):CD006647. doi: 10.1002/14651858.CD006647.pub4. PMID: 25188452Free PMC Article

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