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Hypertension, pregnancy-induced

MedGen UID:
852894
•Concept ID:
C0852036
•
Disease or Syndrome
Synonyms: Gestational Hypertension; Hypertension, Gestational; Hypertension, Pregnancy Induced; Hypertension, Pregnancy-Induced; Hypertensions, Pregnancy Induced; Induced Hypertension, Pregnancy; Induced Hypertensions, Pregnancy; Pregnancy Induced Hypertension; Pregnancy-Induced Hypertension
SNOMED CT: GH - Gestational hypertension (48194001); Gestational hypertension (48194001); Hypertension induced by pregnancy (48194001); PIH - Pregnancy-induced hypertension (48194001); Pregnancy-induced hypertension (48194001)
 
Monarch Initiative: MONDO:0024664
OMIM®: 189800

Definition

A blood pressure elevation after 20 weeks of gestation in the absence of either proteinuria or systemic findings like thrombocytopenia, impaired liver function, progressive renal insufficiency, pulmonary edema or the new-onset of cerebral or visual disturbances. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypertension, pregnancy-induced

Professional guidelines

PubMed

Phenotype-Directed Management of Hypertension in Pregnancy.
McLaughlin K, Snelgrove JW, Sienas LE, Easterling TR, Kingdom JC, Albright CM
J Am Heart Assoc 2022 Apr 5;11(7):e023694. Epub 2022 Mar 14 doi: 10.1161/JAHA.121.023694. PMID: 35285667Free PMC Article
Hypertension and Pregnancy: Management and Future Risks.
Reddy S, Jim B
Adv Chronic Kidney Dis 2019 Mar;26(2):137-145. doi: 10.1053/j.ackd.2019.03.017. PMID: 31023448
Pharmacogenetics in the treatment of pre-eclampsia: current findings, challenges and perspectives.
Luizon MR, Palei AC, Cavalli RC, Sandrim VC
Pharmacogenomics 2017 Apr;18(6):571-583. Epub 2017 Mar 30 doi: 10.2217/pgs-2016-0198. PMID: 28358601

Curated

UK NICE guideline (NG133), Hypertension in pregnancy: diagnosis and management, 2023

Recent clinical studies

Etiology

Hypertensive disorders of pregnancy.
Wu P, Green M, Myers JE
BMJ 2023 Jun 30;381:e071653. doi: 10.1136/bmj-2022-071653. PMID: 37391211
Hypertension in Pregnancy: A Diagnostic and Therapeutic Overview.
Cífková R
High Blood Press Cardiovasc Prev 2023 Jul;30(4):289-303. Epub 2023 Jun 13 doi: 10.1007/s40292-023-00582-5. PMID: 37308715Free PMC Article
Hypertensive Disorders of Pregnancy.
Khedagi AM, Bello NA
Cardiol Clin 2021 Feb;39(1):77-90. Epub 2020 Nov 2 doi: 10.1016/j.ccl.2020.09.005. PMID: 33222817Free PMC Article
Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222.
Obstet Gynecol 2020 Jun;135(6):e237-e260. doi: 10.1097/AOG.0000000000003891. PMID: 32443079
ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia.
Obstet Gynecol 2019 Jan;133(1):1. doi: 10.1097/AOG.0000000000003018. PMID: 30575675

Diagnosis

Hypertensive disorders of pregnancy.
Wu P, Green M, Myers JE
BMJ 2023 Jun 30;381:e071653. doi: 10.1136/bmj-2022-071653. PMID: 37391211
Hypertension in Pregnancy: A Diagnostic and Therapeutic Overview.
Cífková R
High Blood Press Cardiovasc Prev 2023 Jul;30(4):289-303. Epub 2023 Jun 13 doi: 10.1007/s40292-023-00582-5. PMID: 37308715Free PMC Article
Hypertensive Disorders of Pregnancy.
Khedagi AM, Bello NA
Cardiol Clin 2021 Feb;39(1):77-90. Epub 2020 Nov 2 doi: 10.1016/j.ccl.2020.09.005. PMID: 33222817Free PMC Article
Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222.
Obstet Gynecol 2020 Jun;135(6):e237-e260. doi: 10.1097/AOG.0000000000003891. PMID: 32443079
ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia.
Obstet Gynecol 2019 Jan;133(1):1. doi: 10.1097/AOG.0000000000003018. PMID: 30575675

Therapy

Hypertension in Pregnancy: A Diagnostic and Therapeutic Overview.
Cífková R
High Blood Press Cardiovasc Prev 2023 Jul;30(4):289-303. Epub 2023 Jun 13 doi: 10.1007/s40292-023-00582-5. PMID: 37308715Free PMC Article
Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association.
Garovic VD, Dechend R, Easterling T, Karumanchi SA, McMurtry Baird S, Magee LA, Rana S, Vermunt JV, August P; American Heart Association Council on Hypertension; Council on the Kidney in Cardiovascular Disease, Kidney in Heart Disease Science Committee; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Peripheral Vascular Disease; and Stroke Council
Hypertension 2022 Feb;79(2):e21-e41. Epub 2021 Dec 15 doi: 10.1161/HYP.0000000000000208. PMID: 34905954Free PMC Article
Prevention, Diagnosis, and Management of Hypertensive Disorders of Pregnancy: a Comparison of International Guidelines.
Sinkey RG, Battarbee AN, Bello NA, Ives CW, Oparil S, Tita ATN
Curr Hypertens Rep 2020 Aug 27;22(9):66. doi: 10.1007/s11906-020-01082-w. PMID: 32852691Free PMC Article
Hypertensive Disorders of Pregnancy.
Wilkerson RG, Ogunbodede AC
Emerg Med Clin North Am 2019 May;37(2):301-316. doi: 10.1016/j.emc.2019.01.008. PMID: 30940374
Pregnancy-Induced hypertension.
Kintiraki E, Papakatsika S, Kotronis G, Goulis DG, Kotsis V
Hormones (Athens) 2015 Apr-Jun;14(2):211-23. doi: 10.14310/horm.2002.1582. PMID: 26158653

Prognosis

Incidence and Long-Term Outcomes of Hypertensive Disorders of Pregnancy.
Garovic VD, White WM, Vaughan L, Saiki M, Parashuram S, Garcia-Valencia O, Weissgerber TL, Milic N, Weaver A, Mielke MM
J Am Coll Cardiol 2020 May 12;75(18):2323-2334. doi: 10.1016/j.jacc.2020.03.028. PMID: 32381164Free PMC Article
Hypertension in Pregnancy.
Malik R, Kumar V
Adv Exp Med Biol 2017;956:375-393. doi: 10.1007/5584_2016_150. PMID: 27957708
Epidemiology of hypertensive disorders in pregnancy: prevalence, risk factors, predictors and prognosis.
Umesawa M, Kobashi G
Hypertens Res 2017 Mar;40(3):213-220. Epub 2016 Sep 29 doi: 10.1038/hr.2016.126. PMID: 27682655
Hypertension in pregnancy.
Vest AR, Cho LS
Curr Atheroscler Rep 2014 Mar;16(3):395. doi: 10.1007/s11883-013-0395-8. PMID: 24477794
Etiology and management of postpartum hypertension-preeclampsia.
Sibai BM
Am J Obstet Gynecol 2012 Jun;206(6):470-5. Epub 2011 Sep 16 doi: 10.1016/j.ajog.2011.09.002. PMID: 21963308

Clinical prediction guides

Guideline No. 426: Hypertensive Disorders of Pregnancy: Diagnosis, Prediction, Prevention, and Management.
Magee LA, Smith GN, Bloch C, Côté AM, Jain V, Nerenberg K, von Dadelszen P, Helewa M, Rey E
J Obstet Gynaecol Can 2022 May;44(5):547-571.e1. doi: 10.1016/j.jogc.2022.03.002. PMID: 35577426
Systematic review of prediction models for gestational hypertension and preeclampsia.
Antwi E, Amoakoh-Coleman M, Vieira DL, Madhavaram S, Koram KA, Grobbee DE, Agyepong IA, Klipstein-Grobusch K
PLoS One 2020;15(4):e0230955. Epub 2020 Apr 21 doi: 10.1371/journal.pone.0230955. PMID: 32315307Free PMC Article
Chronic Hypertension and Pregnancy.
Guedes-Martins L
Adv Exp Med Biol 2017;956:395-407. doi: 10.1007/5584_2016_81. PMID: 27722962
Epidemiology of hypertensive disorders in pregnancy: prevalence, risk factors, predictors and prognosis.
Umesawa M, Kobashi G
Hypertens Res 2017 Mar;40(3):213-220. Epub 2016 Sep 29 doi: 10.1038/hr.2016.126. PMID: 27682655
Pregnancy-Induced hypertension.
Kintiraki E, Papakatsika S, Kotronis G, Goulis DG, Kotsis V
Hormones (Athens) 2015 Apr-Jun;14(2):211-23. doi: 10.14310/horm.2002.1582. PMID: 26158653

Recent systematic reviews

Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis.
Toloza FJK, Derakhshan A, Männistö T, Bliddal S, Popova PV, Carty DM, Chen L, Taylor P, Mosso L, Oken E, Suvanto E, Itoh S, Kishi R, Bassols J, Auvinen J, López-Bermejo A, Brown SJ, Boucai L, Hisada A, Yoshinaga J, Shilova E, Grineva EN, Vrijkotte TGM, Sunyer J, Jiménez-Zabala A, Riaño-Galan I, Lopez-Espinosa MJ, Prokop LJ, Singh Ospina N, Brito JP, Rodriguez-Gutierrez R, Alexander EK, Chaker L, Pearce EN, Peeters RP, Feldt-Rasmussen U, Guxens M, Chatzi L, Delles C, Roeters van Lennep JE, Pop VJM, Lu X, Walsh JP, Nelson SM, Korevaar TIM, Maraka S
Lancet Diabetes Endocrinol 2022 Apr;10(4):243-252. Epub 2022 Mar 4 doi: 10.1016/S2213-8587(22)00007-9. PMID: 35255260Free PMC Article
Oral Antihypertensives for Nonsevere Pregnancy Hypertension: Systematic Review, Network Meta- and Trial Sequential Analyses.
Bone JN, Sandhu A, Abalos ED, Khalil A, Singer J, Prasad S, Omar S, Vidler M, von Dadelszen P, Magee LA
Hypertension 2022 Mar;79(3):614-628. Epub 2022 Jan 4 doi: 10.1161/HYPERTENSIONAHA.121.18415. PMID: 35138877Free PMC Article
Prenatal exercise for the prevention of gestational diabetes mellitus and hypertensive disorders of pregnancy: a systematic review and meta-analysis.
Davenport MH, Ruchat SM, Poitras VJ, Jaramillo Garcia A, Gray CE, Barrowman N, Skow RJ, Meah VL, Riske L, Sobierajski F, James M, Kathol AJ, Nuspl M, Marchand AA, Nagpal TS, Slater LG, Weeks A, Adamo KB, Davies GA, Barakat R, Mottola MF
Br J Sports Med 2018 Nov;52(21):1367-1375. doi: 10.1136/bjsports-2018-099355. PMID: 30337463
Exercise during pregnancy and risk of gestational hypertensive disorders: a systematic review and meta-analysis.
Magro-Malosso ER, Saccone G, Di Tommaso M, Roman A, Berghella V
Acta Obstet Gynecol Scand 2017 Aug;96(8):921-931. Epub 2017 May 19 doi: 10.1111/aogs.13151. PMID: 28401531
Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies.
Bartsch E, Medcalf KE, Park AL, Ray JG; High Risk of Pre-eclampsia Identification Group
BMJ 2016 Apr 19;353:i1753. doi: 10.1136/bmj.i1753. PMID: 27094586Free PMC Article

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    Clinical resources

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE guideline (NG133), Hypertension in pregnancy: diagnosis and management, 2023

    Consumer resources

    Reviews

    Related information

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    • OMIM
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    • PMC Articles
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