U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Placental Lesion

MedGen UID:
857489
•Concept ID:
C3897895
•
Finding

Definition

Macroscopically identifiable placental parenchymal abnormality. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlacental Lesion

Professional guidelines

PubMed

Massive perivillous fibrin deposition: Diagnosis, obstetrical features, and treatment.
Cheloufi M, Coulomb A, Abisror N, Kayem G, Fain O, Alijotas-Reig J, Mekinian A
Eur J Obstet Gynecol Reprod Biol 2024 Jan;292:125-132. Epub 2023 Nov 19 doi: 10.1016/j.ejogrb.2023.11.024. PMID: 37995528
Placental mesenchymal dysplasia - morphology and differential diagnosis.
Daumová M, Hadravská Š, Peteříková AS, Hasch M, Martínek P
Cesk Patol 2021 Winter;57(4):203-207. PMID: 35042352

Recent clinical studies

Etiology

Massive perivillous fibrin deposition: Diagnosis, obstetrical features, and treatment.
Cheloufi M, Coulomb A, Abisror N, Kayem G, Fain O, Alijotas-Reig J, Mekinian A
Eur J Obstet Gynecol Reprod Biol 2024 Jan;292:125-132. Epub 2023 Nov 19 doi: 10.1016/j.ejogrb.2023.11.024. PMID: 37995528
Shallow Placentation: A Distinct Category of Placental Lesions.
Stanek J
Am J Perinatol 2023 Sep;40(12):1328-1335. Epub 2021 Sep 29 doi: 10.1055/s-0041-1735554. PMID: 34587634
Impact of multiple placental pathologies on neonatal death, bronchopulmonary dysplasia, and neurodevelopmental impairment in preterm infants.
Mir IN, Chalak LF, Brown LS, Johnson-Welch S, Heyne R, Rosenfeld CR, Kapadia VS
Pediatr Res 2020 Apr;87(5):885-891. Epub 2019 Dec 7 doi: 10.1038/s41390-019-0715-y. PMID: 31812153Free PMC Article
Placental maternal vascular malperfusion and adverse pregnancy outcomes in gestational diabetes mellitus.
Scifres CM, Parks WT, Feghali M, Caritis SN, Catov JM
Placenta 2017 Jan;49:10-15. Epub 2016 Nov 10 doi: 10.1016/j.placenta.2016.11.004. PMID: 28012449
Placental pathology, first-trimester biomarkers and adverse pregnancy outcomes.
Odibo AO, Patel KR, Spitalnik A, Odibo L, Huettner P
J Perinatol 2014 Mar;34(3):186-91. Epub 2014 Jan 16 doi: 10.1038/jp.2013.176. PMID: 24434779

Diagnosis

Massive perivillous fibrin deposition: Diagnosis, obstetrical features, and treatment.
Cheloufi M, Coulomb A, Abisror N, Kayem G, Fain O, Alijotas-Reig J, Mekinian A
Eur J Obstet Gynecol Reprod Biol 2024 Jan;292:125-132. Epub 2023 Nov 19 doi: 10.1016/j.ejogrb.2023.11.024. PMID: 37995528
Shallow Placentation: A Distinct Category of Placental Lesions.
Stanek J
Am J Perinatol 2023 Sep;40(12):1328-1335. Epub 2021 Sep 29 doi: 10.1055/s-0041-1735554. PMID: 34587634
Placental mesenchymal dysplasia - morphology and differential diagnosis.
Daumová M, Hadravská Š, Peteříková AS, Hasch M, Martínek P
Cesk Patol 2021 Winter;57(4):203-207. PMID: 35042352
Placental mesenchymal dysplasia.
Pawoo N, Heller DS
Arch Pathol Lab Med 2014 Sep;138(9):1247-9. doi: 10.5858/arpa.2013-0399-RS. PMID: 25171710
The immunological basis of villitis of unknown etiology - review.
Tamblyn JA, Lissauer DM, Powell R, Cox P, Kilby MD
Placenta 2013 Oct;34(10):846-55. Epub 2013 Jul 26 doi: 10.1016/j.placenta.2013.07.002. PMID: 23891153

Therapy

Shallow Placentation: A Distinct Category of Placental Lesions.
Stanek J
Am J Perinatol 2023 Sep;40(12):1328-1335. Epub 2021 Sep 29 doi: 10.1055/s-0041-1735554. PMID: 34587634
Chronic histiocytic intervillositis (CHI): current treatments and perinatal outcomes, a systematic review and a meta-analysis.
Moar L, Simela C, Nanda S, Marnerides A, Al-Adnani M, Nelson-Piercy C, Nicolaides KH, Shangaris P
Front Endocrinol (Lausanne) 2022;13:945543. Epub 2022 Jul 22 doi: 10.3389/fendo.2022.945543. PMID: 35937841Free PMC Article
Impact of multiple placental pathologies on neonatal death, bronchopulmonary dysplasia, and neurodevelopmental impairment in preterm infants.
Mir IN, Chalak LF, Brown LS, Johnson-Welch S, Heyne R, Rosenfeld CR, Kapadia VS
Pediatr Res 2020 Apr;87(5):885-891. Epub 2019 Dec 7 doi: 10.1038/s41390-019-0715-y. PMID: 31812153Free PMC Article
Antagonists of TNFα for recurrent miscarriages: 2 Illustrative cases.
Mekinian A, Houfflin-Debarge V, Kolanska K, Cohen J, Abisror N, Bornes M, Kayem G, Fain O
Eur J Obstet Gynecol Reprod Biol 2019 May;236:263-264. Epub 2019 Mar 6 doi: 10.1016/j.ejogrb.2019.02.036. PMID: 30872045
Congenital systemic juvenile xanthogranuloma with placental lesion.
Takeuchi M, Nakayama M, Nakano A, Kitajima H, Sawada A
Pediatr Int 2009 Dec;51(6):833-6. doi: 10.1111/j.1442-200X.2009.02932.x. PMID: 20158626

Prognosis

Massive perivillous fibrin deposition: Diagnosis, obstetrical features, and treatment.
Cheloufi M, Coulomb A, Abisror N, Kayem G, Fain O, Alijotas-Reig J, Mekinian A
Eur J Obstet Gynecol Reprod Biol 2024 Jan;292:125-132. Epub 2023 Nov 19 doi: 10.1016/j.ejogrb.2023.11.024. PMID: 37995528
The impact of placental massive perivillous fibrin deposition on neonatal outcome in pregnancies complicated by fetal growth restriction.
Spinillo A, Gardella B, Muscettola G, Cesari S, Fiandrino G, Tzialla C
Placenta 2019 Nov;87:46-52. Epub 2019 Sep 17 doi: 10.1016/j.placenta.2019.09.007. PMID: 31546153
Placental Pathology in Placental Mesenchymal Dysplasia with 13q12.11 Deletion and a 25-Week Gestation Female Infant.
Johnson SL, Walters-Sen LC, Stanek JW
Am J Case Rep 2018 Mar 29;19:369-373. doi: 10.12659/AJCR.907329. PMID: 29593209Free PMC Article
Placental lesion multiplicity: risk factor for IUGR and neonatal cranial ultrasound abnormalities.
Viscardi RM, Sun CC
Early Hum Dev 2001 Apr;62(1):1-10. doi: 10.1016/s0378-3782(01)00114-1. PMID: 11245990
Chronic villitis of unknown etiology in twin gestations.
Jacques SM, Qureshi F
Pediatr Pathol 1994 Jul-Aug;14(4):575-84. doi: 10.3109/15513819409023332. PMID: 7971577

Clinical prediction guides

Massive perivillous fibrin deposition of the placenta and pregnancy outcome: A retrospective observational study.
Lampi K, Papadogiannakis N, Sirotkina M, Pettersson K, Ajne G
Placenta 2022 Jan;117:213-218. Epub 2021 Dec 16 doi: 10.1016/j.placenta.2021.12.013. PMID: 34959167
Villitis of unknown etiology (VUE): effect on placental size and association with clinical parameters.
Sebastian T, Ravikumar G, Crasta J
J Matern Fetal Neonatal Med 2022 May;35(9):1695-1702. Epub 2020 May 20 doi: 10.1080/14767058.2020.1767577. PMID: 32434412
Platelet alloimmunization is associated with low grade chronic histiocytic intervillositis - A new link to a rare placental lesion?
Nedberg NH, Turowski G, Guz K, Przytuła E, Uhrynowska M, Roald B, Husebekk A, Sitras V, Nystad M, Dębska M, Brojer E, Tiller H
Placenta 2021 Sep 1;112:89-96. Epub 2021 Jul 23 doi: 10.1016/j.placenta.2021.07.291. PMID: 34329972
A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis.
Gomez-Lopez N, Romero R, Xu Y, Plazyo O, Unkel R, Than NG, Chaemsaithong P, Chaiworapongsa T, Dong Z, Tarca AL, Abrahams VM, Yeo L, Hassan SS
Reprod Sci 2017 Jun;24(6):934-953. Epub 2016 Nov 16 doi: 10.1177/1933719116675058. PMID: 27852921Free PMC Article
Follow-up study of lympho-histiocytic villitis and incidental retroplacental hematoma.
Bendon R, Coventry S, Bendon J, Nordmann A, Schikler K
Pediatr Dev Pathol 2014 Mar-Apr;17(2):94-101. Epub 2014 Jan 22 doi: 10.2350/13-10-1395-OA.1. PMID: 24450427

Recent systematic reviews

Chronic histiocytic intervillositis (CHI): current treatments and perinatal outcomes, a systematic review and a meta-analysis.
Moar L, Simela C, Nanda S, Marnerides A, Al-Adnani M, Nelson-Piercy C, Nicolaides KH, Shangaris P
Front Endocrinol (Lausanne) 2022;13:945543. Epub 2022 Jul 22 doi: 10.3389/fendo.2022.945543. PMID: 35937841Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...