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Elevated coagulation factor V activity

MedGen UID:
866756
•Concept ID:
C4021106
•
Finding
Synonyms: Elevated factor V activity; Plasma factor V elevated
 
HPO: HP:0011996

Definition

Increased activity of coagulation factor V, Factor V, which is activated to factor Va by means of minute amounts of thrombin (and inactivated by larger amounts of thrombin). Activated factor V (fVa) is a cofactor in the formation of the prothrombinase complex. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated coagulation factor V activity

Conditions with this feature

Factor 5 excess with spontaneous thrombosis
MedGen UID:
341996
•Concept ID:
C1851378
•
Disease or Syndrome
See: Condition Record
Factor 5 excess with spontaneous thrombosis

Professional guidelines

PubMed

Comprehensive evaluation of genetic and acquired thrombophilia markers for an individualized prediction of clinical thrombosis in patients with lymphoma and multiple myeloma.
Sánchez Prieto I, Gutiérrez Jomarrón I, Martínez Vázquez C, Rodríguez Barquero P, Gili Herreros P, García-Suárez J
J Thromb Thrombolysis 2024 Aug;57(6):984-995. Epub 2024 Apr 27 doi: 10.1007/s11239-024-02977-0. PMID: 38676874Free PMC Article
Maximising the diagnostic potential of APTT-based screening assays for activated protein C resistance.
Moore GW, Chege E, Culhane AP, Hunt BJ
Int J Lab Hematol 2015 Dec;37(6):844-52. Epub 2015 Aug 25 doi: 10.1111/ijlh.12419. PMID: 26303324
Assessment of hemostatic risk factors in predicting arterial thrombotic events.
Feinbloom D, Bauer KA
Arterioscler Thromb Vasc Biol 2005 Oct;25(10):2043-53. Epub 2005 Aug 11 doi: 10.1161/01.ATV.0000181762.31694.da. PMID: 16100033

Recent clinical studies

Etiology

Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM, Thibord F, Kral-Pointner JB, Hong MG, Suchon P, Germain M, Schrottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin DM, Smith NL, Smadja DM, Holmström M, Magnusson M, Silveira A, Uhlén M, Renné T, Martinez-Perez A, Emmerich J, Deleuze JF, Antovic J, Soria Fernandez JM, Assinger A, Schwenk JM, Souto Andres JC, Morange PE, Butler LM, Trégouët DA, Odeberg J
Nat Commun 2023 Jun 7;14(1):3280. doi: 10.1038/s41467-023-38383-y. PMID: 37286573Free PMC Article
Markers of Hereditary Thrombophilia with Unclear Significance.
Sachs UJ, Kirsch-Altena A, Müller J
Hamostaseologie 2022 Dec;42(6):370-380. Epub 2022 Dec 22 doi: 10.1055/s-0042-1757562. PMID: 36549289
Hypercoagulability and Migraine.
Tietjen GE, Collins SA
Headache 2018 Jan;58(1):173-183. Epub 2017 Feb 9 doi: 10.1111/head.13044. PMID: 28181217
Evolution of Factor V Leiden.
van Mens TE, Levi M, Middeldorp S
Thromb Haemost 2013 Jul;110(1):23-30. Epub 2013 Apr 25 doi: 10.1160/TH13-02-0115. PMID: 23615810
Hemostasis factors and aging.
Mari D, Coppola R, Provenzano R
Exp Gerontol 2008 Feb;43(2):66-73. Epub 2007 Jul 4 doi: 10.1016/j.exger.2007.06.014. PMID: 17869046

Diagnosis

Endothelial dysfunction, thrombophilia, and nailfold capillaroscopic features in livedoid vasculopathy.
Apti Sengun O, Ergun T, Guctekin T, Alibaz Oner F
Microvasc Res 2023 Nov;150:104591. Epub 2023 Aug 4 doi: 10.1016/j.mvr.2023.104591. PMID: 37543163
Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM, Thibord F, Kral-Pointner JB, Hong MG, Suchon P, Germain M, Schrottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin DM, Smith NL, Smadja DM, Holmström M, Magnusson M, Silveira A, Uhlén M, Renné T, Martinez-Perez A, Emmerich J, Deleuze JF, Antovic J, Soria Fernandez JM, Assinger A, Schwenk JM, Souto Andres JC, Morange PE, Butler LM, Trégouët DA, Odeberg J
Nat Commun 2023 Jun 7;14(1):3280. doi: 10.1038/s41467-023-38383-y. PMID: 37286573Free PMC Article
Laboratory Testing for the Evaluation of Phenotypic Activated Protein C Resistance.
Morimont L, Donis N, Bouvy C, Mullier F, Dogné JM, Douxfils J
Semin Thromb Hemost 2022 Sep;48(6):680-689. Epub 2022 Oct 12 doi: 10.1055/s-0042-1758162. PMID: 36223771
Hypercoagulability and Migraine.
Tietjen GE, Collins SA
Headache 2018 Jan;58(1):173-183. Epub 2017 Feb 9 doi: 10.1111/head.13044. PMID: 28181217
Advances in laboratory testing for thrombophilia.
Johnson NV, Khor B, Van Cott EM
Am J Hematol 2012 May;87 Suppl 1:S108-12. Epub 2012 Apr 4 doi: 10.1002/ajh.23186. PMID: 22473489

Therapy

Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM, Thibord F, Kral-Pointner JB, Hong MG, Suchon P, Germain M, Schrottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin DM, Smith NL, Smadja DM, Holmström M, Magnusson M, Silveira A, Uhlén M, Renné T, Martinez-Perez A, Emmerich J, Deleuze JF, Antovic J, Soria Fernandez JM, Assinger A, Schwenk JM, Souto Andres JC, Morange PE, Butler LM, Trégouët DA, Odeberg J
Nat Commun 2023 Jun 7;14(1):3280. doi: 10.1038/s41467-023-38383-y. PMID: 37286573Free PMC Article
Hypercoagulability and Migraine.
Tietjen GE, Collins SA
Headache 2018 Jan;58(1):173-183. Epub 2017 Feb 9 doi: 10.1111/head.13044. PMID: 28181217
Inherited prothrombotic risk factors in children with first ischemic stroke.
Zadro R, Herak DC
Biochem Med (Zagreb) 2012;22(3):298-310. doi: 10.11613/bm.2012.033. PMID: 23092062Free PMC Article
Advances in laboratory testing for thrombophilia.
Johnson NV, Khor B, Van Cott EM
Am J Hematol 2012 May;87 Suppl 1:S108-12. Epub 2012 Apr 4 doi: 10.1002/ajh.23186. PMID: 22473489
Heritable coagulopathies in pregnancy.
Lockwood CJ
Obstet Gynecol Surv 1999 Dec;54(12):754-65. doi: 10.1097/00006254-199912000-00004. PMID: 10596396

Prognosis

Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM, Thibord F, Kral-Pointner JB, Hong MG, Suchon P, Germain M, Schrottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin DM, Smith NL, Smadja DM, Holmström M, Magnusson M, Silveira A, Uhlén M, Renné T, Martinez-Perez A, Emmerich J, Deleuze JF, Antovic J, Soria Fernandez JM, Assinger A, Schwenk JM, Souto Andres JC, Morange PE, Butler LM, Trégouët DA, Odeberg J
Nat Commun 2023 Jun 7;14(1):3280. doi: 10.1038/s41467-023-38383-y. PMID: 37286573Free PMC Article
Coagulation factor abnormalities related to discordance between anti-factor Xa and activated partial thromboplastin time in patients supported with continuous-flow left ventricular assist devices.
Adatya S, Sunny R, Fitzpatrick MJ, Colvin M, Thennapan T, John R, Dodge Zantek N, Pritzker M, Eckman P, Uriel N
J Heart Lung Transplant 2016 Nov;35(11):1311-1320. Epub 2016 Oct 1 doi: 10.1016/j.healun.2016.09.010. PMID: 27836023
High coagulation factor VIII and von Willebrand factor in patients with lymphoma and leukemia.
Mohren M, Jentsch-Ullrich K, Koenigsmann M, Kropf S, Schalk E, Lutze G
Int J Hematol 2016 Feb;103(2):189-95. Epub 2015 Nov 26 doi: 10.1007/s12185-015-1913-y. PMID: 26612425
Hemostasis factors and aging.
Mari D, Coppola R, Provenzano R
Exp Gerontol 2008 Feb;43(2):66-73. Epub 2007 Jul 4 doi: 10.1016/j.exger.2007.06.014. PMID: 17869046
Assessment of hemostatic risk factors in predicting arterial thrombotic events.
Feinbloom D, Bauer KA
Arterioscler Thromb Vasc Biol 2005 Oct;25(10):2043-53. Epub 2005 Aug 11 doi: 10.1161/01.ATV.0000181762.31694.da. PMID: 16100033

Clinical prediction guides

Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM, Thibord F, Kral-Pointner JB, Hong MG, Suchon P, Germain M, Schrottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin DM, Smith NL, Smadja DM, Holmström M, Magnusson M, Silveira A, Uhlén M, Renné T, Martinez-Perez A, Emmerich J, Deleuze JF, Antovic J, Soria Fernandez JM, Assinger A, Schwenk JM, Souto Andres JC, Morange PE, Butler LM, Trégouët DA, Odeberg J
Nat Commun 2023 Jun 7;14(1):3280. doi: 10.1038/s41467-023-38383-y. PMID: 37286573Free PMC Article
Marked factor V activity elevation in severe COVID-19 is associated with venous thromboembolism.
Stefely JA, Christensen BB, Gogakos T, Cone Sullivan JK, Montgomery GG, Barranco JP, Van Cott EM
Am J Hematol 2020 Dec;95(12):1522-1530. Epub 2020 Sep 18 doi: 10.1002/ajh.25979. PMID: 32833259Free PMC Article
Hemostasis factors and aging.
Mari D, Coppola R, Provenzano R
Exp Gerontol 2008 Feb;43(2):66-73. Epub 2007 Jul 4 doi: 10.1016/j.exger.2007.06.014. PMID: 17869046
Assessment of hemostatic risk factors in predicting arterial thrombotic events.
Feinbloom D, Bauer KA
Arterioscler Thromb Vasc Biol 2005 Oct;25(10):2043-53. Epub 2005 Aug 11 doi: 10.1161/01.ATV.0000181762.31694.da. PMID: 16100033
Diagnosis and clinical characteristics of inherited activated protein C resistance.
Samama MM, Simon D, Horellou MH, Trossaërt M, Elalamy I, Conard J
Haemostasis 1996 Oct;26 Suppl 4:315-30. doi: 10.1159/000217312. PMID: 8979137

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