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Abnormality of somatosensory evoked potentials

MedGen UID:
867219
Concept ID:
C4021577
Anatomical Abnormality
Synonym: Abnormality of SSEPs
 
HPO: HP:0007377

Definition

An abnormality of somatosensory evoked potentials (SSEP), i.e., of the electrical signals of sensation going from the body to the brain in response to a defined stimulus. Recording electrodes are placed over the scalp, spine, and peripheral nerves proximal to the stimulation site. Clinical studies generally use electrical stimulation of peripheral nerves to elicit potentials. SSEP testing determines whether peripheral sensory nerves are able to transmit sensory information like pain, temperature, and touch to the brain. Abnormal SSEPs can result from dysfunction at the level of the peripheral nerve, plexus, spinal root, spinal cord, brain stem, thalamocortical projections, or primary somatosensory cortex. [from HPO]

Conditions with this feature

Hereditary spastic paraplegia 7
MedGen UID:
339552
Concept ID:
C1846564
Disease or Syndrome
Spastic paraplegia 7 (SPG7) is characterized by insidiously progressive bilateral leg weakness and spasticity. Most affected individuals have decreased vibration sense and cerebellar signs. Onset is mostly in adulthood, although symptoms may start as early as age 11 years and as late as age 72 years. Additional features including ataxia (gait and limbs), spastic dysarthria, dysphagia, pale optic disks, ataxia, nystagmus, strabismus, ptosis, hearing loss, motor and sensory neuropathy, amyotrophy, scoliosis, pes cavus, and urinary sphincter disturbances may be observed.

Professional guidelines

PubMed

Garcia-Larrea L, Hagiwara K
Rev Neurol (Paris) 2019 Jan-Feb;175(1-2):26-37. Epub 2018 Oct 26 doi: 10.1016/j.neurol.2018.09.015. PMID: 30482566
Sène D
Joint Bone Spine 2018 Oct;85(5):553-559. Epub 2017 Nov 16 doi: 10.1016/j.jbspin.2017.11.002. PMID: 29154979
Strupp M, Kim JS, Murofushi T, Straumann D, Jen JC, Rosengren SM, Della Santina CC, Kingma H
J Vestib Res 2017;27(4):177-189. doi: 10.3233/VES-170619. PMID: 29081426Free PMC Article

Recent clinical studies

Etiology

Eftimov F, Lucke IM, Querol LA, Rajabally YA, Verhamme C
Brain 2020 Dec 5;143(11):3214-3224. doi: 10.1093/brain/awaa265. PMID: 33155018Free PMC Article
Zhu B, Coppola G, Shoaran M
Cephalalgia 2019 Aug;39(9):1143-1155. Epub 2019 Mar 26 doi: 10.1177/0333102419839975. PMID: 30913908
Garcia-Larrea L, Hagiwara K
Rev Neurol (Paris) 2019 Jan-Feb;175(1-2):26-37. Epub 2018 Oct 26 doi: 10.1016/j.neurol.2018.09.015. PMID: 30482566
Kuwabara S, Sekiguchi Y, Misawa S
Clin Neurophysiol 2017 Jan;128(1):215-219. Epub 2016 Nov 20 doi: 10.1016/j.clinph.2016.11.009. PMID: 27923188
Sala F, Tramontano V, Squintani G, Arcaro C, Tot E, Pinna G, Meglio M
J Clin Neurophysiol 2014 Aug;31(4):326-36. doi: 10.1097/WNP.0000000000000115. PMID: 25083844

Diagnosis

Eftimov F, Lucke IM, Querol LA, Rajabally YA, Verhamme C
Brain 2020 Dec 5;143(11):3214-3224. doi: 10.1093/brain/awaa265. PMID: 33155018Free PMC Article
Macerollo A, Brown MJN, Kilner JM, Chen R
Trends Neurosci 2018 May;41(5):294-310. Epub 2018 Mar 14 doi: 10.1016/j.tins.2018.02.007. PMID: 29549962
Kuwabara S, Sekiguchi Y, Misawa S
Clin Neurophysiol 2017 Jan;128(1):215-219. Epub 2016 Nov 20 doi: 10.1016/j.clinph.2016.11.009. PMID: 27923188
Fisher MA
Clin Neurophysiol 2002 Mar;113(3):317-35. doi: 10.1016/s1388-2457(02)00018-4. PMID: 11897532
Eisen A
Neurol Clin 1985 Aug;3(3):495-510. PMID: 2995782

Therapy

Zhu B, Coppola G, Shoaran M
Cephalalgia 2019 Aug;39(9):1143-1155. Epub 2019 Mar 26 doi: 10.1177/0333102419839975. PMID: 30913908
Sène D
Joint Bone Spine 2018 Oct;85(5):553-559. Epub 2017 Nov 16 doi: 10.1016/j.jbspin.2017.11.002. PMID: 29154979
Paiva ES, da Costa ED, Scheinberg M
Curr Pain Headache Rep 2008 Oct;12(5):321-6. doi: 10.1007/s11916-008-0054-x. PMID: 18765135
Soria ED, Fine EJ
Electromyogr Clin Neurophysiol 1992 Jan-Feb;32(1-2):63-71. PMID: 1541249
Hacke W
Cent Nerv Syst Trauma 1985 Summer;2(2):123-36. doi: 10.1089/cns.1985.2.123. PMID: 2937558

Prognosis

Sène D
Joint Bone Spine 2018 Oct;85(5):553-559. Epub 2017 Nov 16 doi: 10.1016/j.jbspin.2017.11.002. PMID: 29154979
Horn J, Tjepkema-Cloostermans MC
Semin Neurol 2017 Feb;37(1):60-65. Epub 2017 Feb 1 doi: 10.1055/s-0036-1594252. PMID: 28147419
Kuwabara S, Sekiguchi Y, Misawa S
Clin Neurophysiol 2017 Jan;128(1):215-219. Epub 2016 Nov 20 doi: 10.1016/j.clinph.2016.11.009. PMID: 27923188
Robinson LR, Micklesen PJ, Tirschwell DL, Lew HL
Crit Care Med 2003 Mar;31(3):960-7. doi: 10.1097/01.CCM.0000053643.21751.3B. PMID: 12627012
Peñarrocha M, Alfaro A, Bagán JV, López-Trigo J
J Oral Maxillofac Surg 1992 May;50(5):472-6. doi: 10.1016/s0278-2391(10)80318-0. PMID: 1315385

Clinical prediction guides

Macerollo A, Brown MJN, Kilner JM, Chen R
Trends Neurosci 2018 May;41(5):294-310. Epub 2018 Mar 14 doi: 10.1016/j.tins.2018.02.007. PMID: 29549962
Horn J, Tjepkema-Cloostermans MC
Semin Neurol 2017 Feb;37(1):60-65. Epub 2017 Feb 1 doi: 10.1055/s-0036-1594252. PMID: 28147419
Tsao WC, Lyu RK, Ro LS, Lao MF, Chen CM, Wu YR, Huang CC, Chang HS, Kuo HC, Chu CC, Chang KH
PLoS One 2014;9(11):e113631. Epub 2014 Nov 25 doi: 10.1371/journal.pone.0113631. PMID: 25422930Free PMC Article
Comi G
Clin Neurosci 1997;4(6):374-9. PMID: 9358983
Peñarrocha M, Alfaro A, Bagán JV, López-Trigo J
J Oral Maxillofac Surg 1992 May;50(5):472-6. doi: 10.1016/s0278-2391(10)80318-0. PMID: 1315385

Recent systematic reviews

Paramento M, Passarotto E, Maccarone MC, Agostini M, Contessa P, Rubega M, Formaggio E, Masiero S
PLoS One 2024;19(5):e0303086. Epub 2024 May 22 doi: 10.1371/journal.pone.0303086. PMID: 38776317Free PMC Article
Sysoeva OV, Smirnov K, Stroganova TA
Clin Neurophysiol 2020 Jan;131(1):213-224. Epub 2019 Nov 21 doi: 10.1016/j.clinph.2019.11.003. PMID: 31812082
Tedesco Triccas L, Meyer S, Mantini D, Camilleri K, Falzon O, Camilleri T, Verheyden G
J Neurosci Methods 2019 Jan 1;311:318-330. Epub 2018 Aug 14 doi: 10.1016/j.jneumeth.2018.08.009. PMID: 30118725
Alcantara J, Alcantara JD, Alcantara J
Explore (NY) 2011 Nov-Dec;7(6):384-90. doi: 10.1016/j.explore.2011.08.001. PMID: 22051563
Robinson LR, Micklesen PJ, Tirschwell DL, Lew HL
Crit Care Med 2003 Mar;31(3):960-7. doi: 10.1097/01.CCM.0000053643.21751.3B. PMID: 12627012

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