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Sclerosis of hand bone

MedGen UID:
867321
•Concept ID:
C4021684
•
Disease or Syndrome
Synonyms: Generalised sclerosis of hand bones; Generalized sclerosis of hand bones; Hand bone sclerosis; Increased bone density in hand bone; Increased bone density in hand bones
 
HPO: HP:0004054

Definition

Osteosclerosis affecting one or more bones of the hand. [from HPO]

Conditions with this feature

Dysosteosclerosis
MedGen UID:
98150
•Concept ID:
C0432262
•
Disease or Syndrome
A rare genetic primary bone dysplasia disease characterized by progressive osteosclerosis and platyspondyly.
See: Condition Record
Dysosteosclerosis

Professional guidelines

PubMed

Combining systemic and locally applied cellular therapies for the treatment of systemic sclerosis.
Velier M, Daumas A, Simoncini S, Arcani R, Magalon J, Benyamine A, Granel B, Dignat George F, Chabannon C, Sabatier F
Bone Marrow Transplant 2022 Jan;57(1):17-22. Epub 2021 Oct 18 doi: 10.1038/s41409-021-01492-7. PMID: 34663928
Midkine: an emerging target of drug development for treatment of multiple diseases.
Muramatsu T, Kadomatsu K
Br J Pharmacol 2014 Feb;171(4):811-3. doi: 10.1111/bph.12571. PMID: 24460672Free PMC Article
Treatment of systemic sclerosis.
Allanore Y, Kahan A
Joint Bone Spine 2006 Jul;73(4):363-8. Epub 2006 Jan 6 doi: 10.1016/j.jbspin.2005.12.003. PMID: 16495105

Recent clinical studies

Etiology

Avascular Necrosis of the Carpal Bones Other Than Kienböck Disease.
Afshar A, Tabrizi A
J Hand Surg Am 2020 Feb;45(2):148-152. Epub 2019 Oct 1 doi: 10.1016/j.jhsa.2019.05.022. PMID: 31585747
Overview of osteo-articular involvement in systemic sclerosis: Specific risk factors, clinico-sonographic evaluation, and comparison with healthy women from the French OFELY cohort.
Thietart S, Louati K, Gatfosse M, Sornay-Rendu E, Gaigneux E, Lemeunier L, Delmaire P, Riviere S, Mahevas T, Sellam J, Berenbaum F, Fain O, Roland C, Mekinian A
Best Pract Res Clin Rheumatol 2018 Aug;32(4):591-604. Epub 2019 Feb 20 doi: 10.1016/j.berh.2019.01.008. PMID: 31174827
Acro-osteolysis.
Botou A, Bangeas A, Alexiou I, Sakkas LI
Clin Rheumatol 2017 Jan;36(1):9-14. Epub 2016 Oct 29 doi: 10.1007/s10067-016-3459-7. PMID: 27796661
The emerging role of endothelin-1 in the pathogenesis of subchondral bone disturbance and osteoarthritis.
Sin A, Tang W, Wen CY, Chung SK, Chiu KY
Osteoarthritis Cartilage 2015 Apr;23(4):516-24. Epub 2014 Nov 20 doi: 10.1016/j.joca.2014.11.002. PMID: 25463446
Preiser's disease.
Vidal MA, Linscheid RL, Amadio PC, Dobyns JH
Ann Chir Main Memb Super 1991;10(3):227-35. doi: 10.1016/s0753-9053(05)80287-x. PMID: 1718357

Diagnosis

Osteoid osteomas of the hands and feet: a series of 71 cases.
Alruwaii F, Molligan JF, Ilaslan H, John I, Herradura AS, Alkashash A, Chen S, Nystrom L, Kilpatrick SE, Reith JD, Wenger DE, Powell GM, Fritchie KJ
Virchows Arch 2023 Jul;483(1):41-46. Epub 2023 Jun 9 doi: 10.1007/s00428-023-03576-9. PMID: 37294448
Classification and Radiographic Characterization of Kienböck Disease.
Lockwood WC, Lauder A
Hand Clin 2022 Nov;38(4):405-415. doi: 10.1016/j.hcl.2022.03.004. PMID: 36244708
The emerging role of endothelin-1 in the pathogenesis of subchondral bone disturbance and osteoarthritis.
Sin A, Tang W, Wen CY, Chung SK, Chiu KY
Osteoarthritis Cartilage 2015 Apr;23(4):516-24. Epub 2014 Nov 20 doi: 10.1016/j.joca.2014.11.002. PMID: 25463446
Chondrocalcinosis of the wrist.
Saffar P
J Hand Surg Br 2004 Oct;29(5):486-93. doi: 10.1016/j.jhsb.2004.02.013. PMID: 15336755
Imaging and staging of avascular osteonecroses at the wrist and hand.
Schmitt R, Heinze A, Fellner F, Obletter N, Strühn R, Bautz W
Eur J Radiol 1997 Sep;25(2):92-103. doi: 10.1016/s0720-048x(97)00065-x. PMID: 9283837

Therapy

Avoidance of Pitfalls and Complications During Surgery for Temporal Lobe Epilepsy.
Arivazhagan A, Sinha S, Rao MB
Acta Neurochir Suppl 2023;130:109-119. doi: 10.1007/978-3-030-12887-6_14. PMID: 37548730
Radiographic signs of hook of hamate fracture: evaluation of diagnostic utility.
Spencer J, Hunt SL, Zhang C, Walter C, Everist B
Skeletal Radiol 2019 Dec;48(12):1891-1898. Epub 2019 May 27 doi: 10.1007/s00256-019-03221-0. PMID: 31134315
Therapeutic abortion and ectopic pregnancy: alternative sources for fetal stem cell research and therapy in Iran as an Islamic country.
Goodarzi P, Falahzadeh K, Aghayan H, Payab M, Larijani B, Alavi-Moghadam S, Tayanloo-Beik A, Adibi H, Gilany K, Arjmand B
Cell Tissue Bank 2019 Mar;20(1):11-24. Epub 2018 Dec 7 doi: 10.1007/s10561-018-9741-y. PMID: 30535614
Azathioprine for multiple sclerosis.
Casetta I, Iuliano G, Filippini G
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD003982. doi: 10.1002/14651858.CD003982.pub2. PMID: 17943809Free PMC Article
Treatment of systemic sclerosis.
Allanore Y, Kahan A
Joint Bone Spine 2006 Jul;73(4):363-8. Epub 2006 Jan 6 doi: 10.1016/j.jbspin.2005.12.003. PMID: 16495105

Prognosis

Associations between radiographic features, clinical features and ultrasound of thumb-base osteoarthritis: A secondary analysis of the COMBO study.
Shi Y, Fu K, Oo WM, Deveza LA, Wang X, Duong V, Robbins SR, Hunter DJ
Int J Rheum Dis 2022 Jan;25(1):38-46. Epub 2021 Nov 24 doi: 10.1111/1756-185X.14248. PMID: 34821056Free PMC Article
Distal radius and tibia bone microarchitecture impairment in female patients with diffuse systemic sclerosis.
Sampaio-Barros MM, Alvarenga JC, Takayama L, Assad APL, Sampaio-Barros PD, Pereira RMR
Osteoporos Int 2019 Aug;30(8):1679-1691. Epub 2019 Apr 27 doi: 10.1007/s00198-019-04965-0. PMID: 31030240
Late Nailfold Videocapillaroscopy Pattern Associated With Hand Calcinosis and Acro-Osteolysis in Systemic Sclerosis.
Morardet L, Avouac J, Sammour M, Baron M, Kahan A, Feydy A, Allanore Y
Arthritis Care Res (Hoboken) 2016 Mar;68(3):366-73. doi: 10.1002/acr.22672. PMID: 26223810
Cellular players in angiogenesis during the course of systemic sclerosis.
Cipriani P, Marrelli A, Liakouli V, Di Benedetto P, Giacomelli R
Autoimmun Rev 2011 Aug;10(10):641-6. Epub 2011 Apr 22 doi: 10.1016/j.autrev.2011.04.016. PMID: 21549220
Treatment of systemic sclerosis.
Allanore Y, Kahan A
Joint Bone Spine 2006 Jul;73(4):363-8. Epub 2006 Jan 6 doi: 10.1016/j.jbspin.2005.12.003. PMID: 16495105

Clinical prediction guides

A Quantitative Analysis of Subchondral Bone Density Around Osteochondritis Dissecans Lesions of the Capitellum.
Miyamura S, Lans J, Shimada K, Murase T, Chen NC
J Hand Surg Am 2022 Aug;47(8):790.e1-790.e11. Epub 2021 Aug 25 doi: 10.1016/j.jhsa.2021.06.020. PMID: 34452800
CBCT characteristics and interpretation challenges of temporomandibular joint osteoarthritis in a hand osteoarthritis cohort.
Ottersen MK, Abrahamsson AK, Larheim TA, Arvidsson LZ
Dentomaxillofac Radiol 2019 May;48(4):20180245. Epub 2019 Jan 28 doi: 10.1259/dmfr.20180245. PMID: 30633546Free PMC Article
Radiographic changes of the distal phalangeal tuft of the hands in subjects with systemic sclerosis. Systematic review.
Izquierdo YE, Calvo Páramo E, Castañeda LM, Gómez SV, Zambrano FS
Reumatol Clin (Engl Ed) 2018 Jan-Feb;14(1):20-26. Epub 2016 Oct 13 doi: 10.1016/j.reuma.2016.08.009. PMID: 27746086
Arthritis in scleroderma.
Misra R, Darton K, Jewkes RF, Black CM, Maini RN
Br J Rheumatol 1995 Sep;34(9):831-7. doi: 10.1093/rheumatology/34.9.831. PMID: 7582722
Preiser's disease.
Vidal MA, Linscheid RL, Amadio PC, Dobyns JH
Ann Chir Main Memb Super 1991;10(3):227-35. doi: 10.1016/s0753-9053(05)80287-x. PMID: 1718357

Recent systematic reviews

Radiographic changes of the distal phalangeal tuft of the hands in subjects with systemic sclerosis. Systematic review.
Izquierdo YE, Calvo Páramo E, Castañeda LM, Gómez SV, Zambrano FS
Reumatol Clin (Engl Ed) 2018 Jan-Feb;14(1):20-26. Epub 2016 Oct 13 doi: 10.1016/j.reuma.2016.08.009. PMID: 27746086
Azathioprine for multiple sclerosis.
Casetta I, Iuliano G, Filippini G
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD003982. doi: 10.1002/14651858.CD003982.pub2. PMID: 17943809Free PMC Article

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