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Impaired ristocetin cofactor assay activity

MedGen UID:
868227
•Concept ID:
C4022619
•
Finding
HPO: HP:0030129

Definition

Abnormal response to ristocetin as manifested by reduced or lacking aggregation of platelets upon addition of ristocetin to platelet-poor plasma. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired ristocetin cofactor assay activity

Professional guidelines

PubMed

AGA Clinical Practice Update: Coagulation in Cirrhosis.
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390
The influence of clinical characteristics, laboratory and inflammatory markers on 'high on-treatment platelet reactivity' as measured with different platelet function tests.
Elsenberg EH, van Werkum JW, van de Wal RM, Zomer AC, Bouman HJ, Verheugt FW, Berg JM, Hackeng CM
Thromb Haemost 2009 Oct;102(4):719-27. doi: 10.1160/TH09-05-0285. PMID: 19806258
Impaired bradykinin response to ischaemia and exercise in patients with mild congestive heart failure during angiotensin-converting enzyme treatment. Relationships with endothelial function, coagulation and inflammation.
Cugno M, Agostoni P, Mari D, Meroni PL, Gregorini L, Bussotti M, Anguissola GB, Donatelli F, Nussberger J
Br J Haematol 2005 Jul;130(1):113-20. doi: 10.1111/j.1365-2141.2005.05569.x. PMID: 15982353

Recent clinical studies

Etiology

Refining the standard of care in immune thrombotic thrombocytopenic purpura.
Laurence J
Clin Adv Hematol Oncol 2024 Oct;22(8):381-391. PMID: 39356816
Human ABO Blood Groups and Their Associations with Different Diseases.
Abegaz SB
Biomed Res Int 2021;2021:6629060. Epub 2021 Jan 23 doi: 10.1155/2021/6629060. PMID: 33564677Free PMC Article
Interplay between platelets and coagulation.
Sang Y, Roest M, de Laat B, de Groot PG, Huskens D
Blood Rev 2021 Mar;46:100733. Epub 2020 Jul 12 doi: 10.1016/j.blre.2020.100733. PMID: 32682574Free PMC Article
AGA Clinical Practice Update: Coagulation in Cirrhosis.
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390
Coagulopathy in Cushing's syndrome.
Trementino L, Arnaldi G, Appolloni G, Daidone V, Scaroni C, Casonato A, Boscaro M
Neuroendocrinology 2010;92 Suppl 1:55-9. Epub 2010 Sep 10 doi: 10.1159/000314349. PMID: 20829619

Diagnosis

Refining the standard of care in immune thrombotic thrombocytopenic purpura.
Laurence J
Clin Adv Hematol Oncol 2024 Oct;22(8):381-391. PMID: 39356816
Interplay between platelets and coagulation.
Sang Y, Roest M, de Laat B, de Groot PG, Huskens D
Blood Rev 2021 Mar;46:100733. Epub 2020 Jul 12 doi: 10.1016/j.blre.2020.100733. PMID: 32682574Free PMC Article
Hemostasis in the Very Young.
Kenet G, Barg AA, Nowak-Göttl U
Semin Thromb Hemost 2018 Oct;44(7):617-623. Epub 2018 Jun 18 doi: 10.1055/s-0038-1660852. PMID: 29913536
Acquired von Willebrand Syndrome.
Mital A
Adv Clin Exp Med 2016 Nov-Dec;25(6):1337-1344. doi: 10.17219/acem/64942. PMID: 28028990
Coagulopathy in Cushing's syndrome.
Trementino L, Arnaldi G, Appolloni G, Daidone V, Scaroni C, Casonato A, Boscaro M
Neuroendocrinology 2010;92 Suppl 1:55-9. Epub 2010 Sep 10 doi: 10.1159/000314349. PMID: 20829619

Therapy

Refining the standard of care in immune thrombotic thrombocytopenic purpura.
Laurence J
Clin Adv Hematol Oncol 2024 Oct;22(8):381-391. PMID: 39356816
High-volume hemofiltration does not protect human kidney endothelial and tubular epithelial cells from septic plasma-induced injury.
Medica D, Quercia AD, Marengo M, Fanelli V, Castellano G, Fabbrini P, Migliori M, Merlotti G, Camussi G, Joannes-Boyau O, Honorè PM, Cantaluppi V
Sci Rep 2024 Aug 7;14(1):18323. doi: 10.1038/s41598-024-69202-z. PMID: 39112634Free PMC Article
AGA Clinical Practice Update: Coagulation in Cirrhosis.
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390
Liver Disease and Hemostatic (Dys)function.
Tripodi A
Semin Thromb Hemost 2015 Jul;41(5):462-7. Epub 2015 Jun 16 doi: 10.1055/s-0035-1550440. PMID: 26080306
Coagulopathy in Cushing's syndrome.
Trementino L, Arnaldi G, Appolloni G, Daidone V, Scaroni C, Casonato A, Boscaro M
Neuroendocrinology 2010;92 Suppl 1:55-9. Epub 2010 Sep 10 doi: 10.1159/000314349. PMID: 20829619

Prognosis

Atrial fibrillation and the prothrombotic state: revisiting Virchow's triad in 2020.
Ding WY, Gupta D, Lip GYH
Heart 2020 Oct;106(19):1463-1468. Epub 2020 Jul 16 doi: 10.1136/heartjnl-2020-316977. PMID: 32675218
Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.
Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A
Am J Respir Crit Care Med 2019 Jan 15;199(2):181-189. doi: 10.1164/rccm.201804-0678OC. PMID: 30114376Free PMC Article
Acquired von Willebrand Syndrome.
Mital A
Adv Clin Exp Med 2016 Nov-Dec;25(6):1337-1344. doi: 10.17219/acem/64942. PMID: 28028990
Liver Disease and Hemostatic (Dys)function.
Tripodi A
Semin Thromb Hemost 2015 Jul;41(5):462-7. Epub 2015 Jun 16 doi: 10.1055/s-0035-1550440. PMID: 26080306
Dyslipidemias and fibrinolysis.
Puccetti L, Bruni F, Pasqui AL, Pastorelli M, Bova G, Cercignani M, Palazzuoli A, Auteri A
Ital Heart J 2002 Oct;3(10):579-86. PMID: 12478815

Clinical prediction guides

Refining the standard of care in immune thrombotic thrombocytopenic purpura.
Laurence J
Clin Adv Hematol Oncol 2024 Oct;22(8):381-391. PMID: 39356816
Comprehensive investigation of platelet function in patients with cirrhosis.
Lecchi A, Tosetti G, Ghali C, La Marca S, Clerici M, Padovan L, Femia EA, Primignani M, La Mura V, Lampertico P, Peyvandi F, Tripodi A
Thromb Res 2024 May;237:64-70. Epub 2024 Mar 16 doi: 10.1016/j.thromres.2024.03.017. PMID: 38552496
AGA Clinical Practice Update: Coagulation in Cirrhosis.
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390
Liver Disease and Hemostatic (Dys)function.
Tripodi A
Semin Thromb Hemost 2015 Jul;41(5):462-7. Epub 2015 Jun 16 doi: 10.1055/s-0035-1550440. PMID: 26080306
Coagulopathy in Cushing's syndrome.
Trementino L, Arnaldi G, Appolloni G, Daidone V, Scaroni C, Casonato A, Boscaro M
Neuroendocrinology 2010;92 Suppl 1:55-9. Epub 2010 Sep 10 doi: 10.1159/000314349. PMID: 20829619

Recent systematic reviews

Hemostatic Abnormalities in Dementia: A Systematic Review and Meta-Analysis.
Loures CMG, Duarte RCF, Silva MVF, Cicarini WB, de Souza LC, Caramelli P, Borges KBG, Carvalho MDG
Semin Thromb Hemost 2019 Jul;45(5):514-522. Epub 2019 May 16 doi: 10.1055/s-0039-1688444. PMID: 31096308
Association between circulating hemostatic measures and dementia or cognitive impairment: systematic review and meta-analyzes.
Quinn TJ, Gallacher J, Deary IJ, Lowe GD, Fenton C, Stott DJ
J Thromb Haemost 2011 Aug;9(8):1475-82. doi: 10.1111/j.1538-7836.2011.04403.x. PMID: 21676170
Endothelial dysfunction in lacunar stroke: a systematic review.
Knottnerus IL, Ten Cate H, Lodder J, Kessels F, van Oostenbrugge RJ
Cerebrovasc Dis 2009;27(5):519-26. Epub 2009 Apr 16 doi: 10.1159/000212672. PMID: 19372654

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