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Abnormal labia minora morphology

MedGen UID:
868302
•Concept ID:
C4022696
•
Anatomical Abnormality
Synonyms: Abnormality of the inner vaginal lips; Abnormality of the labia minora
 
HPO: HP:0012880

Definition

An anomaly of the labia minora, the folds of skin between the outer labia. [from HPO]

Professional guidelines

PubMed

Clinicopathologic Diagnostic Criteria for Vulvar Lichen Planus.
Day T, Wilkinson E, Rowan D, Scurry J; ISSVD Difficult Pathologic Diagnoses Committee*
J Low Genit Tract Dis 2020 Jul;24(3):317-329. doi: 10.1097/LGT.0000000000000532. PMID: 32205763
Relationship between phenotype and genotype of 102 Chinese newborns with Prader-Willi syndrome.
Ge MM, Gao YY, Wu BB, Yan K, Qin Q, Wang H, Zhou W, Yang L
Mol Biol Rep 2019 Oct;46(5):4717-4724. Epub 2019 Jul 3 doi: 10.1007/s11033-019-04916-2. PMID: 31270759
Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis.
de Munnik SA, Bicknell LS, Aftimos S, Al-Aama JY, van Bever Y, Bober MB, Clayton-Smith J, Edrees AY, Feingold M, Fryer A, van Hagen JM, Hennekam RC, Jansweijer MC, Johnson D, Kant SG, Opitz JM, Ramadevi AR, Reardon W, Ross A, Sarda P, Schrander-Stumpel CT, Schoots J, Temple IK, Terhal PA, Toutain A, Wise CA, Wright M, Skidmore DL, Samuels ME, Hoefsloot LH, Knoers NV, Brunner HG, Jackson AP, Bongers EM
Eur J Hum Genet 2012 Jun;20(6):598-606. Epub 2012 Feb 15 doi: 10.1038/ejhg.2011.269. PMID: 22333897Free PMC Article

Recent clinical studies

Etiology

Molecular subtype and growth hormone effects on dysmorphology in Prader-Willi syndrome.
Oldzej J, Manazir J, Gold JA, Mahmoud R, Osann K, Flodman P, Cassidy SB, Kimonis VE
Am J Med Genet A 2020 Jan;182(1):169-175. Epub 2019 Nov 29 doi: 10.1002/ajmg.a.61408. PMID: 31782896
Anatomy and Aesthetics of the Labia Minora: The Ideal Vulva?
Clerico C, Lari A, Mojallal A, Boucher F
Aesthetic Plast Surg 2017 Jun;41(3):714-719. Epub 2017 Mar 10 doi: 10.1007/s00266-017-0831-1. PMID: 28314908
Meier-Gorlin syndrome.
de Munnik SA, Hoefsloot EH, Roukema J, Schoots J, Knoers NV, Brunner HG, Jackson AP, Bongers EM
Orphanet J Rare Dis 2015 Sep 17;10:114. doi: 10.1186/s13023-015-0322-x. PMID: 26381604Free PMC Article
Normal anatomic relationships in prepubescent female external genitalia.
Chalmers DJ, O'Donnell CI, Casperson KJ, Berngard SC, Hou AH, Nuss GR, Cost NG, Wilcox DT
J Pediatr Urol 2014 Dec;10(6):1117-21. Epub 2014 Jun 2 doi: 10.1016/j.jpurol.2014.04.011. PMID: 24953545
Female epispadias.
Shetty MV, Bhaskaran A, Sen TK
Afr J Paediatr Surg 2011 May-Aug;8(2):215-7. doi: 10.4103/0189-6725.86066. PMID: 22005369

Diagnosis

Laparoscopy Assisted Peritoneal Pull-Through Vaginoplasty in Transgender Women.
Castanon CDG, Matic S, Bizic M, Stojanovic B, Bencic M, Grubor N, Pusica S, Korac G, Djordjevic ML
Urology 2022 Aug;166:301-302. Epub 2022 May 10 doi: 10.1016/j.urology.2022.05.001. PMID: 35550383
Clinicopathologic Diagnostic Criteria for Vulvar Lichen Planus.
Day T, Wilkinson E, Rowan D, Scurry J; ISSVD Difficult Pathologic Diagnoses Committee*
J Low Genit Tract Dis 2020 Jul;24(3):317-329. doi: 10.1097/LGT.0000000000000532. PMID: 32205763
Anatomy and Aesthetics of the Labia Minora: The Ideal Vulva?
Clerico C, Lari A, Mojallal A, Boucher F
Aesthetic Plast Surg 2017 Jun;41(3):714-719. Epub 2017 Mar 10 doi: 10.1007/s00266-017-0831-1. PMID: 28314908
Meier-Gorlin syndrome.
de Munnik SA, Hoefsloot EH, Roukema J, Schoots J, Knoers NV, Brunner HG, Jackson AP, Bongers EM
Orphanet J Rare Dis 2015 Sep 17;10:114. doi: 10.1186/s13023-015-0322-x. PMID: 26381604Free PMC Article
Female epispadias.
Shetty MV, Bhaskaran A, Sen TK
Afr J Paediatr Surg 2011 May-Aug;8(2):215-7. doi: 10.4103/0189-6725.86066. PMID: 22005369

Therapy

Molecular subtype and growth hormone effects on dysmorphology in Prader-Willi syndrome.
Oldzej J, Manazir J, Gold JA, Mahmoud R, Osann K, Flodman P, Cassidy SB, Kimonis VE
Am J Med Genet A 2020 Jan;182(1):169-175. Epub 2019 Nov 29 doi: 10.1002/ajmg.a.61408. PMID: 31782896
Vaginoplasty and creating labia minora in children with disorders of sex development.
Acimi S, Bessahraoui M, Acimi MA, Abderrahmane N, Debbous L
Int Urol Nephrol 2019 Mar;51(3):395-399. Epub 2018 Dec 13 doi: 10.1007/s11255-018-2058-8. PMID: 30547360
Unilateral hypertrophy of the labia minora: A case series.
Boulos S, Rubin AI, Yan AC, McMahon PJ, Perman MJ
Pediatr Dermatol 2018 May;35(3):e198-e199. Epub 2018 Mar 24 doi: 10.1111/pde.13467. PMID: 29573456
Self-attempted labioplasty with elastic bands resulting in severe necrosis.
Farahani F, Gentry A, Lara-Torre E, McCuin E
J Low Genit Tract Dis 2015 Apr;19(2):e35-7. doi: 10.1097/LGT.0000000000000067. PMID: 25062401
Perineal hemangioma, anorectal malformation, and genital anomaly: a new association?
Bouchard S, Yazbeck S, Lallier M
J Pediatr Surg 1999 Jul;34(7):1133-5. doi: 10.1016/s0022-3468(99)90584-5. PMID: 10442608

Prognosis

Labia majora labioplasty in HIV-related vaginal lipodystrophy: technique description and literature review.
Lapalorcia LM, Podda S, Campiglio G, Cordellini M
Aesthetic Plast Surg 2013 Aug;37(4):711-4. Epub 2013 Jun 15 doi: 10.1007/s00266-013-0159-4. PMID: 23771244
Female epispadias.
Shetty MV, Bhaskaran A, Sen TK
Afr J Paediatr Surg 2011 May-Aug;8(2):215-7. doi: 10.4103/0189-6725.86066. PMID: 22005369
Humoral immunodeficiency with facial dysmorphology and limb anomalies: a new syndrome.
Hoffman HM, Bastian JF, Bird LM
Clin Dysmorphol 2001 Jan;10(1):1-8. doi: 10.1097/00019605-200101000-00001. PMID: 11152140
Perineal hemangioma, anorectal malformation, and genital anomaly: a new association?
Bouchard S, Yazbeck S, Lallier M
J Pediatr Surg 1999 Jul;34(7):1133-5. doi: 10.1016/s0022-3468(99)90584-5. PMID: 10442608
Surgical correction of virilised female external genitalia.
Engert J
Prog Pediatr Surg 1989;23:151-64. doi: 10.1007/978-3-642-74241-5_16. PMID: 2498995

Clinical prediction guides

Labia minora reduction techniques: a comprehensive literature review.
Oranges CM, Sisti A, Sisti G
Aesthet Surg J 2015 May;35(4):419-31. doi: 10.1093/asj/sjv023. PMID: 25908699
Sexual function in adult life following Passerini-Glazel feminizing genitoplasty in patients with congenital adrenal hyperplasia.
Lesma A, Bocciardi A, Corti S, Chiumello G, Rigatti P, Montorsi F
J Urol 2014 Jan;191(1):206-11. Epub 2013 Aug 6 doi: 10.1016/j.juro.2013.07.097. PMID: 23933397
Labia majora labioplasty in HIV-related vaginal lipodystrophy: technique description and literature review.
Lapalorcia LM, Podda S, Campiglio G, Cordellini M
Aesthetic Plast Surg 2013 Aug;37(4):711-4. Epub 2013 Jun 15 doi: 10.1007/s00266-013-0159-4. PMID: 23771244
Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis.
de Munnik SA, Bicknell LS, Aftimos S, Al-Aama JY, van Bever Y, Bober MB, Clayton-Smith J, Edrees AY, Feingold M, Fryer A, van Hagen JM, Hennekam RC, Jansweijer MC, Johnson D, Kant SG, Opitz JM, Ramadevi AR, Reardon W, Ross A, Sarda P, Schrander-Stumpel CT, Schoots J, Temple IK, Terhal PA, Toutain A, Wise CA, Wright M, Skidmore DL, Samuels ME, Hoefsloot LH, Knoers NV, Brunner HG, Jackson AP, Bongers EM
Eur J Hum Genet 2012 Jun;20(6):598-606. Epub 2012 Feb 15 doi: 10.1038/ejhg.2011.269. PMID: 22333897Free PMC Article
Reduction clitoro-labioplasty versus clitoro-labiectomy in managing adult onset clitoro-labiomegaly.
Ali AH, Thabet SM
Gynecol Obstet Invest 2009;68(4):224-9. Epub 2009 Sep 2 doi: 10.1159/000235872. PMID: 19729942

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