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Abnormal T3/T4 ratio

MedGen UID:
868453
•Concept ID:
C4022847
•
Anatomical Abnormality
HPO: HP:0012558

Definition

A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that deviates from normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal T3/T4 ratio

Professional guidelines

PubMed

Iodized oil treatment for endemic goiter does not induce the surge of positive serum concentrations of anti-thyroglobulin or anti-microsomal autoantibodies.
Knobel M, Medeiros-Neto G
J Endocrinol Invest 1986 Aug;9(4):321-4. doi: 10.1007/BF03346935. PMID: 3023472

Recent clinical studies

Etiology

Stability of nasal symmetry following primary cleft lip and nasal repair: five years of follow-up.
Alkebsi K, Sakran KA, Abdo Y, Shi B, Li C
Int J Oral Maxillofac Surg 2023 Apr;52(4):451-459. Epub 2022 Aug 13 doi: 10.1016/j.ijom.2022.07.011. PMID: 35973881
Quantification of serum thyroid hormones using tandem mass spectrometry in patients with Down syndrome.
Iwano R, Toki M, Hanakawa J, Asakura Y, Adachi M, Tanaka Y, Muroya K
Biomed Chromatogr 2022 Jan;36(1):e5249. Epub 2021 Oct 19 doi: 10.1002/bmc.5249. PMID: 34569083
Relative Morphokinetics Assessed by Time-Lapse Imaging Are Altered in Embryos From Patients With Endometriosis.
Freis A, Dietrich JE, Binder M, Holschbach V, Strowitzki T, Germeyer A
Reprod Sci 2018 Aug;25(8):1279-1285. Epub 2017 Nov 15 doi: 10.1177/1933719117741373. PMID: 29141509
Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients.
Gullo D, Latina A, Frasca F, Le Moli R, Pellegriti G, Vigneri R
PLoS One 2011;6(8):e22552. Epub 2011 Aug 1 doi: 10.1371/journal.pone.0022552. PMID: 21829633Free PMC Article
Selenium, zinc, and thyroid hormones in healthy subjects: low T3/T4 ratio in the elderly is related to impaired selenium status.
Olivieri O, Girelli D, Stanzial AM, Rossi L, Bassi A, Corrocher R
Biol Trace Elem Res 1996 Jan;51(1):31-41. doi: 10.1007/BF02790145. PMID: 8834378

Diagnosis

Quantification of serum thyroid hormones using tandem mass spectrometry in patients with Down syndrome.
Iwano R, Toki M, Hanakawa J, Asakura Y, Adachi M, Tanaka Y, Muroya K
Biomed Chromatogr 2022 Jan;36(1):e5249. Epub 2021 Oct 19 doi: 10.1002/bmc.5249. PMID: 34569083
Relative Morphokinetics Assessed by Time-Lapse Imaging Are Altered in Embryos From Patients With Endometriosis.
Freis A, Dietrich JE, Binder M, Holschbach V, Strowitzki T, Germeyer A
Reprod Sci 2018 Aug;25(8):1279-1285. Epub 2017 Nov 15 doi: 10.1177/1933719117741373. PMID: 29141509
MECHANISMS IN ENDOCRINOLOGY: Novel genetic causes of short stature.
Wit JM, Oostdijk W, Losekoot M, van Duyvenvoorde HA, Ruivenkamp CA, Kant SG
Eur J Endocrinol 2016 Apr;174(4):R145-73. Epub 2015 Nov 17 doi: 10.1530/EJE-15-0937. PMID: 26578640
Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients.
Gullo D, Latina A, Frasca F, Le Moli R, Pellegriti G, Vigneri R
PLoS One 2011;6(8):e22552. Epub 2011 Aug 1 doi: 10.1371/journal.pone.0022552. PMID: 21829633Free PMC Article
Thyroid function in molar pregnancy.
Nagataki S, Mizuno M, Sakamoto S, Irie M, Shizume K
J Clin Endocrinol Metab 1977 Feb;44(2):254-63. doi: 10.1210/jcem-44-2-254. PMID: 402378

Therapy

Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone?
Ettleson MD, Bianco AC
J Clin Endocrinol Metab 2020 Sep 1;105(9):e3090-104. doi: 10.1210/clinem/dgaa430. PMID: 32614450Free PMC Article
Decreased sensitivity of thyrotropin-thyroid hormone feedback control in hypothyroid and athyreotic patients treated with levothyroxine. Is serum triiodothyronine involved?
Solter D, Solter M
Ann Endocrinol (Paris) 2018 Apr;79(2):62-66. Epub 2018 Mar 9 doi: 10.1016/j.ando.2017.11.003. PMID: 29530271
Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients.
Gullo D, Latina A, Frasca F, Le Moli R, Pellegriti G, Vigneri R
PLoS One 2011;6(8):e22552. Epub 2011 Aug 1 doi: 10.1371/journal.pone.0022552. PMID: 21829633Free PMC Article
Thyroid functions in lithium-treated psychiatric patients: a cross-sectional study.
Deodhar SD, Singh B, Pathak CM, Sharan P, Kulhara P
Biol Trace Elem Res 1999 Feb;67(2):151-63. doi: 10.1007/BF02784070. PMID: 10073421
Selenium, zinc, and thyroid hormones in healthy subjects: low T3/T4 ratio in the elderly is related to impaired selenium status.
Olivieri O, Girelli D, Stanzial AM, Rossi L, Bassi A, Corrocher R
Biol Trace Elem Res 1996 Jan;51(1):31-41. doi: 10.1007/BF02790145. PMID: 8834378

Prognosis

Artificial Intelligence-Based Prediction of Recurrence after Curative Resection for Colorectal Cancer from Digital Pathological Images.
Nakanishi R, Morooka K, Omori K, Toyota S, Tanaka Y, Hasuda H, Koga N, Nonaka K, Hu Q, Nakaji Y, Nakanoko T, Ando K, Ota M, Kimura Y, Oki E, Oda Y, Yoshizumi T
Ann Surg Oncol 2023 Jun;30(6):3506-3514. Epub 2022 Dec 13 doi: 10.1245/s10434-022-12926-x. PMID: 36512260
Stability of nasal symmetry following primary cleft lip and nasal repair: five years of follow-up.
Alkebsi K, Sakran KA, Abdo Y, Shi B, Li C
Int J Oral Maxillofac Surg 2023 Apr;52(4):451-459. Epub 2022 Aug 13 doi: 10.1016/j.ijom.2022.07.011. PMID: 35973881
Clinical Prognostic Significance of HOXC9 Expression in Patients with Colorectal Cancer.
Hu M, Ou-Yang W, Jing D, Chen R
Clin Lab 2019 Aug 1;65(8) doi: 10.7754/Clin.Lab.2019.190122. PMID: 31414766
Relative Morphokinetics Assessed by Time-Lapse Imaging Are Altered in Embryos From Patients With Endometriosis.
Freis A, Dietrich JE, Binder M, Holschbach V, Strowitzki T, Germeyer A
Reprod Sci 2018 Aug;25(8):1279-1285. Epub 2017 Nov 15 doi: 10.1177/1933719117741373. PMID: 29141509
Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice.
Bassett JH, Boyde A, Zikmund T, Evans H, Croucher PI, Zhu X, Park JW, Cheng SY, Williams GR
Endocrinology 2014 Sep;155(9):3699-712. Epub 2014 Jun 10 doi: 10.1210/en.2013-2156. PMID: 24914936Free PMC Article

Clinical prediction guides

Clinical Prognostic Significance of HOXC9 Expression in Patients with Colorectal Cancer.
Hu M, Ou-Yang W, Jing D, Chen R
Clin Lab 2019 Aug 1;65(8) doi: 10.7754/Clin.Lab.2019.190122. PMID: 31414766
Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice.
Bassett JH, Boyde A, Zikmund T, Evans H, Croucher PI, Zhu X, Park JW, Cheng SY, Williams GR
Endocrinology 2014 Sep;155(9):3699-712. Epub 2014 Jun 10 doi: 10.1210/en.2013-2156. PMID: 24914936Free PMC Article
Thyroid disease in patients with McCune-Albright syndrome.
Congedo V, Celi FS
Pediatr Endocrinol Rev 2007 Aug;4 Suppl 4:429-33. PMID: 17982391
Selenium, zinc, and thyroid hormones in healthy subjects: low T3/T4 ratio in the elderly is related to impaired selenium status.
Olivieri O, Girelli D, Stanzial AM, Rossi L, Bassi A, Corrocher R
Biol Trace Elem Res 1996 Jan;51(1):31-41. doi: 10.1007/BF02790145. PMID: 8834378
Thyroid function in molar pregnancy.
Nagataki S, Mizuno M, Sakamoto S, Irie M, Shizume K
J Clin Endocrinol Metab 1977 Feb;44(2):254-63. doi: 10.1210/jcem-44-2-254. PMID: 402378

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