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Medial calcification of small arteries

MedGen UID:
868500
•Concept ID:
C4022894
•
Pathologic Function
HPO: HP:0012458

Definition

Calcification, that is, pathological deposition of calcium salts in the tunica media of small arteries. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMedial calcification of small arteries

Professional guidelines

PubMed

Ruptured carotid artery aneurysms of the ophthalmic (C6) segment: clinical and angiographic long term follow-up of a multidisciplinary management strategy.
Sherif C, Gruber A, Dorfer C, Bavinzski G, Standhardt H, Knosp E
J Neurol Neurosurg Psychiatry 2009 Nov;80(11):1261-7. Epub 2009 Jun 21 doi: 10.1136/jnnp.2008.170860. PMID: 19546107

Recent clinical studies

Etiology

Neuropathologic Findings in Chronic Kidney Disease (CKD).
Vinters HV, Magaki SD, Williams CK
J Stroke Cerebrovasc Dis 2021 Sep;30(9):105657. Epub 2021 Feb 10 doi: 10.1016/j.jstrokecerebrovasdis.2021.105657. PMID: 33579545
An Update on Calciphylaxis.
García-Lozano JA, Ocampo-Candiani J, Martínez-Cabriales SA, Garza-Rodríguez V
Am J Clin Dermatol 2018 Aug;19(4):599-608. doi: 10.1007/s40257-018-0361-x. PMID: 29808451
The Cerebrovascular-Chronic Kidney Disease Connection: Perspectives and Mechanisms.
Lau WL, Huisa BN, Fisher M
Transl Stroke Res 2017 Feb;8(1):67-76. Epub 2016 Sep 14 doi: 10.1007/s12975-016-0499-x. PMID: 27628245Free PMC Article
Calcific uraemic arteriolopathy.
Disbrow MB, Qaqish I, Kransdorf M, Chakkera HA
BMJ Case Rep 2015 Aug 27;2015 doi: 10.1136/bcr-2014-207935. PMID: 26315356Free PMC Article
Pre-uremic calciphylaxis.
Nayer A, Virmani S, Gonzalez-Suarez M, Goez-Gutierrez E, Rosenberg AE, Salman LH, Asif A
Iran J Kidney Dis 2014 May;8(3):252-6. PMID: 24878953

Diagnosis

Neuropathologic Findings in Chronic Kidney Disease (CKD).
Vinters HV, Magaki SD, Williams CK
J Stroke Cerebrovasc Dis 2021 Sep;30(9):105657. Epub 2021 Feb 10 doi: 10.1016/j.jstrokecerebrovasdis.2021.105657. PMID: 33579545
An Update on Calciphylaxis.
García-Lozano JA, Ocampo-Candiani J, Martínez-Cabriales SA, Garza-Rodríguez V
Am J Clin Dermatol 2018 Aug;19(4):599-608. doi: 10.1007/s40257-018-0361-x. PMID: 29808451
Calcific uraemic arteriolopathy.
Disbrow MB, Qaqish I, Kransdorf M, Chakkera HA
BMJ Case Rep 2015 Aug 27;2015 doi: 10.1136/bcr-2014-207935. PMID: 26315356Free PMC Article
Pre-uremic calciphylaxis.
Nayer A, Virmani S, Gonzalez-Suarez M, Goez-Gutierrez E, Rosenberg AE, Salman LH, Asif A
Iran J Kidney Dis 2014 May;8(3):252-6. PMID: 24878953
Peripheral arterial calcification: prevalence, mechanism, detection, and clinical implications.
Rocha-Singh KJ, Zeller T, Jaff MR
Catheter Cardiovasc Interv 2014 May 1;83(6):E212-20. Epub 2014 Feb 10 doi: 10.1002/ccd.25387. PMID: 24402839Free PMC Article

Therapy

Transplant Vasculopathy Versus Native Atherosclerosis: Similarities and Differences.
Weis M, Weis M
Transplantation 2024 Jun 1;108(6):1342-1349. Epub 2023 Oct 30 doi: 10.1097/TP.0000000000004853. PMID: 37899386
Aortic calcification: A postmortem CT validation study in a middle-aged population.
Vos A, Houben IB, Celeng C, Takx RAP, Isgum I, Mali WPTM, Vink A, de Jong PA
Eur J Radiol 2023 Feb;159:110687. Epub 2023 Jan 4 doi: 10.1016/j.ejrad.2023.110687. PMID: 36610325
Calciphylaxis and Martorell Hypertensive Ischemic Leg Ulcer: Same Pattern - One Pathophysiology.
Hafner J
Dermatology 2016;232(5):523-533. Epub 2016 Sep 14 doi: 10.1159/000448245. PMID: 27622522
New Insights into the Pros and Cons of the Clinical Use of Vitamin K Antagonists (VKAs) Versus Direct Oral Anticoagulants (DOACs).
van Gorp RH, Schurgers LJ
Nutrients 2015 Nov 17;7(11):9538-57. doi: 10.3390/nu7115479. PMID: 26593943Free PMC Article
Calcific uraemic arteriolopathy.
Disbrow MB, Qaqish I, Kransdorf M, Chakkera HA
BMJ Case Rep 2015 Aug 27;2015 doi: 10.1136/bcr-2014-207935. PMID: 26315356Free PMC Article

Prognosis

Transplant Vasculopathy Versus Native Atherosclerosis: Similarities and Differences.
Weis M, Weis M
Transplantation 2024 Jun 1;108(6):1342-1349. Epub 2023 Oct 30 doi: 10.1097/TP.0000000000004853. PMID: 37899386
Aortic calcification: A postmortem CT validation study in a middle-aged population.
Vos A, Houben IB, Celeng C, Takx RAP, Isgum I, Mali WPTM, Vink A, de Jong PA
Eur J Radiol 2023 Feb;159:110687. Epub 2023 Jan 4 doi: 10.1016/j.ejrad.2023.110687. PMID: 36610325
Calcified facial and maxillary arteries: Incidental radiographic findings indicative of Mönckeberg arteriosclerosis.
Fitzgerald J, Ziegler ME, Green PT, Neville BW
J Am Dent Assoc 2021 Nov;152(11):943-946. Epub 2021 Aug 7 doi: 10.1016/j.adaj.2021.04.018. PMID: 34373081
Histopathological evidence of aortopathy in newborns and infants with Tetralogy of Fallot at the time of the surgical repair.
Fabian O, Gebauer R, Koblizek M, Hornofova L, Janousek J
Cardiovasc Pathol 2019 May-Jun;40:59-64. Epub 2019 Feb 28 doi: 10.1016/j.carpath.2019.02.004. PMID: 30904751
Peripheral arterial calcification: prevalence, mechanism, detection, and clinical implications.
Rocha-Singh KJ, Zeller T, Jaff MR
Catheter Cardiovasc Interv 2014 May 1;83(6):E212-20. Epub 2014 Feb 10 doi: 10.1002/ccd.25387. PMID: 24402839Free PMC Article

Clinical prediction guides

Aortic calcification: A postmortem CT validation study in a middle-aged population.
Vos A, Houben IB, Celeng C, Takx RAP, Isgum I, Mali WPTM, Vink A, de Jong PA
Eur J Radiol 2023 Feb;159:110687. Epub 2023 Jan 4 doi: 10.1016/j.ejrad.2023.110687. PMID: 36610325
Histopathological characterization of intimal lesions and arterial wall calcification in the arteries of the leg of elderly cadavers.
Vos A, de Jong PA, Verdoorn D, Mali WPTM, Bleys RLAW, Vink A
Clin Anat 2021 Sep;34(6):835-841. Epub 2020 Nov 20 doi: 10.1002/ca.23701. PMID: 33174629Free PMC Article
A Novel Scoring System for Small Artery Disease and Medial Arterial Calcification Is Strongly Associated With Major Adverse Limb Events in Patients With Chronic Limb-Threatening Ischemia.
Ferraresi R, Ucci A, Pizzuto A, Losurdo F, Caminiti M, Minnella D, Casini A, Clerici G, Montero-Baker M, Mills J
J Endovasc Ther 2021 Apr;28(2):194-207. Epub 2020 Oct 15 doi: 10.1177/1526602820966309. PMID: 33054496
Prevalence of Calcification in Human Femoropopliteal Arteries and its Association with Demographics, Risk Factors, and Arterial Stiffness.
Kamenskiy A, Poulson W, Sim S, Reilly A, Luo J, MacTaggart J
Arterioscler Thromb Vasc Biol 2018 Apr;38(4):e48-e57. Epub 2018 Jan 25 doi: 10.1161/ATVBAHA.117.310490. PMID: 29371245Free PMC Article
Peripheral arterial calcification: prevalence, mechanism, detection, and clinical implications.
Rocha-Singh KJ, Zeller T, Jaff MR
Catheter Cardiovasc Interv 2014 May 1;83(6):E212-20. Epub 2014 Feb 10 doi: 10.1002/ccd.25387. PMID: 24402839Free PMC Article

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