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Abnormality of prothrombin

MedGen UID:
868606
•Concept ID:
C4023005
•
Anatomical Abnormality
HPO: HP:0012200

Definition

An anomaly of clotting factor II, which is known as prothrombin, a vitamin K-dependent proenzyme that functions in the blood coagulation cascade. [from HPO]

Professional guidelines

PubMed

Haemostatic alterations and management of haemostasis in patients with cirrhosis.
Lisman T, Caldwell SH, Intagliata NM
J Hepatol 2022 Jun;76(6):1291-1305. doi: 10.1016/j.jhep.2021.11.004. PMID: 35589251
Cirrhosis: Diagnosis and Management.
Smith A, Baumgartner K, Bositis C
Am Fam Physician 2019 Dec 15;100(12):759-770. PMID: 31845776
AGA Clinical Practice Update: Coagulation in Cirrhosis.
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390

Recent clinical studies

Clinical prediction guides

Prothrombin Segovia: a new congenital abnormality of prothrombin.
Rocha E, Paramo JA, Bascones C, Fisac PR, Cuesta B, Fernandez J
Scand J Haematol 1986 May;36(5):444-9. doi: 10.1111/j.1600-0609.1986.tb02279.x. PMID: 3090681

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