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Abnormal number of erythroid precursors

MedGen UID:
868633
•Concept ID:
C4023033
•
Anatomical Abnormality
HPO: HP:0012131

Definition

A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. [from HPO]

Professional guidelines

PubMed

Effect of 5-aminolevulinic acid on erythropoiesis: a preclinical in vitro characterization for the treatment of congenital sideroblastic anemia.
Fujiwara T, Okamoto K, Niikuni R, Takahashi K, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Ichinohasama R, Nakamura Y, Nakajima M, Tanaka T, Harigae H
Biochem Biophys Res Commun 2014 Nov 7;454(1):102-8. Epub 2014 Oct 18 doi: 10.1016/j.bbrc.2014.10.050. PMID: 25450364
Clinical potential for noninvasive prenatal diagnosis through detection of fetal cells in maternal blood.
Purwosunu Y, Sekizawa A, Koide K, Okazaki S, Farina A, Okai T
Taiwan J Obstet Gynecol 2006 Mar;45(1):10-20. doi: 10.1016/S1028-4559(09)60184-4. PMID: 17272202
Culture of fetal cells from maternal blood for prenatal diagnosis.
Elicha Gussin HA, Elias S
Hum Reprod Update 2002 Nov-Dec;8(6):523-7. doi: 10.1093/humupd/8.6.523. PMID: 12498422

Recent clinical studies

Etiology

Perturbation of autocrine/paracrine loops of burst-forming units of erythroid-derived cells in rHuEPO-hyporesponsive hemodialysis patients.
Nakao K, Wada J, Ota K, Ichikawa H, Akagi S, Okamoto A, Hida K, Nagake Y, Makino H
Am J Kidney Dis 2003 Mar;41(3):624-36. doi: 10.1053/ajkd.2003.50124. PMID: 12612986
Cell cycling stress in the monocyte line as a risk factor for progression of the aplastic anaemia/paroxysmal nocturnal haemoglobinuria syndrome to myelodysplastic syndrome.
Nissen C, Genitsch A, Sendelov S, Dalle Carbonare V, Wodnar-Filipowicz A
Acta Haematol 2000;103(1):33-40. doi: 10.1159/000041002. PMID: 10705157
High incidence of transiently appearing complement-sensitive bone marrow precursor cells in patients with severe aplastic anemia--A possible role of high endogenous IL-2 in their suppression.
Nissen C, Tichelli A, Gratwohl A, Warthmann C, Moser Y, dalle Carbonare V, Sendelov S, Chklovskaia E, Jansen W, Wodnar-Filipowicz A, Sadallah S, Speck B
Acta Haematol 1999;101(4):165-72. doi: 10.1159/000040948. PMID: 10436296
Cryopreservation of the bone marrow from patients with acute myeloid leukaemia leads to functional abnormalities.
Novitzky N, Kruger W, Mohamed R
Eur J Haematol 1999 Feb;62(2):83-9. doi: 10.1111/j.1600-0609.1999.tb01726.x. PMID: 10052710
Human erythrocyte glycophorins: protein and gene structure analyses.
Cartron JP, Rahuel C
Transfus Med Rev 1992 Apr;6(2):63-92. doi: 10.1016/s0887-7963(92)70158-8. PMID: 1591491

Diagnosis

Update on anemia and neutropenia in copper deficiency.
Lazarchick J
Curr Opin Hematol 2012 Jan;19(1):58-60. doi: 10.1097/MOH.0b013e32834da9d2. PMID: 22080848
Endogenous erythroid colony assay in patients with polycythemia vera and its clinical significance.
Bai J, Shao ZH, Liu H, Shi J, He GS, Cao YR, Cui ZZ, Wu YH, Sun J, Tian Z, Jia HR, Qian LS, Yang TY, Yang CL
Chin Med J (Engl) 2004 May;117(5):668-72. PMID: 15161531
High incidence of transiently appearing complement-sensitive bone marrow precursor cells in patients with severe aplastic anemia--A possible role of high endogenous IL-2 in their suppression.
Nissen C, Tichelli A, Gratwohl A, Warthmann C, Moser Y, dalle Carbonare V, Sendelov S, Chklovskaia E, Jansen W, Wodnar-Filipowicz A, Sadallah S, Speck B
Acta Haematol 1999;101(4):165-72. doi: 10.1159/000040948. PMID: 10436296
Polycythaemia vera. IV. Specific binding of stem cell factor to normal and polycythaemia vera highly purified erythroid progenitor cells.
Dai CH, Krantz SB, Koury ST, Kollar K
Br J Haematol 1994 Nov;88(3):497-505. doi: 10.1111/j.1365-2141.1994.tb05065.x. PMID: 7529530
Copper deficiency in humans.
Williams DM
Semin Hematol 1983 Apr;20(2):118-28. PMID: 6410510

Therapy

Deficient RPS19 protein production induces cell cycle arrest in erythroid progenitor cells.
Kuramitsu M, Hamaguchi I, Takuo M, Masumi A, Momose H, Takizawa K, Mochizuki M, Naito S, Yamaguchi K
Br J Haematol 2008 Feb;140(3):348-59. doi: 10.1111/j.1365-2141.2007.06930.x. PMID: 18217898
Cell cycling stress in the monocyte line as a risk factor for progression of the aplastic anaemia/paroxysmal nocturnal haemoglobinuria syndrome to myelodysplastic syndrome.
Nissen C, Genitsch A, Sendelov S, Dalle Carbonare V, Wodnar-Filipowicz A
Acta Haematol 2000;103(1):33-40. doi: 10.1159/000041002. PMID: 10705157
High incidence of transiently appearing complement-sensitive bone marrow precursor cells in patients with severe aplastic anemia--A possible role of high endogenous IL-2 in their suppression.
Nissen C, Tichelli A, Gratwohl A, Warthmann C, Moser Y, dalle Carbonare V, Sendelov S, Chklovskaia E, Jansen W, Wodnar-Filipowicz A, Sadallah S, Speck B
Acta Haematol 1999;101(4):165-72. doi: 10.1159/000040948. PMID: 10436296
Large domains of apparent delayed replication timing associated with triplet repeat expansion at FRAXA and FRAXE.
Subramanian PS, Nelson DL, Chinault AC
Am J Hum Genet 1996 Aug;59(2):407-16. PMID: 8755928Free PMC Article
Copper deficiency in humans.
Williams DM
Semin Hematol 1983 Apr;20(2):118-28. PMID: 6410510

Prognosis

PROGNOSIS OF THE COURSE OF CHORNOBYL-ORIGINATED ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN IN UKRAINE DEPENDING ON THE REASON OF STANDARD CHEMOTHERAPY INTERRUPTION.
Bebeshko VG, Bruslova KM, Tsvetkova NM, Lyashenko LO, Pushkariova TI, Gonchar LO, Tryhlib IV, Yatsemirskyi SM, Samson YM, Boyarskyi VG, Grischenko KV, Polyanska VM, Dmytrenko IV
Probl Radiac Med Radiobiol 2019 Dec;24:335-349. doi: 10.33145/2304-8336-2019-24-335-349. PMID: 31841478
The immunophenotype of different immature, myeloid and B-cell lineage-committed CD34+ hematopoietic cells allows discrimination between normal/reactive and myelodysplastic syndrome precursors.
Matarraz S, López A, Barrena S, Fernandez C, Jensen E, Flores J, Bárcena P, Rasillo A, Sayagues JM, Sánchez ML, Hernandez-Campo P, Hernandez Rivas JM, Salvador C, Fernandez-Mosteirín N, Giralt M, Perdiguer L, Orfao A
Leukemia 2008 Jun;22(6):1175-83. Epub 2008 Mar 13 doi: 10.1038/leu.2008.49. PMID: 18337765
Circulating megakaryocytes and their progenitors in early thrombocytopenia in preterm neonates.
Murray NA, Roberts IA
Pediatr Res 1996 Jul;40(1):112-9. doi: 10.1203/00006450-199607000-00020. PMID: 8798256
Abnormal kinetics of colony formation by erythroid burst-forming units (BFU-E) in chronic myeloid leukaemia.
Marley SB, Lewis JL, Goldman JM, Gordon MY
Br J Haematol 1996 Jun;93(4):878-83. doi: 10.1046/j.1365-2141.1996.d01-1738.x. PMID: 8703820
Hematological causes of venous thrombosis in young people: high incidence of myeloproliferative disorder as underlying disease in patients with splanchnic venous thrombosis.
Teofili L, De Stefano V, Leone G, Micalizzi P, Iovino MS, Alfano G, Bizzi B
Thromb Haemost 1992 Mar 2;67(3):297-301. PMID: 1641818

Clinical prediction guides

Loss of Forkhead box M1 promotes erythropoiesis through increased proliferation of erythroid progenitors.
Youn M, Wang N, LaVasseur C, Bibikova E, Kam S, Glader B, Sakamoto KM, Narla A
Haematologica 2017 May;102(5):826-834. Epub 2017 Feb 2 doi: 10.3324/haematol.2016.156257. PMID: 28154085Free PMC Article
Autosomal dominant thrombocytopenia: incomplete megakaryocyte differentiation and linkage to human chromosome 10.
Drachman JG, Jarvik GP, Mehaffey MG
Blood 2000 Jul 1;96(1):118-25. PMID: 10891439
Large domains of apparent delayed replication timing associated with triplet repeat expansion at FRAXA and FRAXE.
Subramanian PS, Nelson DL, Chinault AC
Am J Hum Genet 1996 Aug;59(2):407-16. PMID: 8755928Free PMC Article
Copper deficiency in humans.
Williams DM
Semin Hematol 1983 Apr;20(2):118-28. PMID: 6410510
Congenital dyserythropoietic anaemia type I: absence of clonal expression in the nuclear abnormalities of cultured erythroblasts.
Vainchenker W, Guichard J, Bouguet J, Breton-Gorius J
Br J Haematol 1980 Sep;46(1):33-7. doi: 10.1111/j.1365-2141.1980.tb05932.x. PMID: 7426450

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