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Black pigment gallstones

MedGen UID:
868695
•Concept ID:
C4023098
•
Finding
HPO: HP:0011982

Definition

A type of pigment gallstone that is hard and black, containing calcium carbonate and calcium phosphates. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBlack pigment gallstones

Professional guidelines

PubMed

Evaluation of gallstone classification and their diagnosis through serum parameters as emerging tools in treatment: a narrative review.
Sharma B, Sharma SR
Postgrad Med 2022 Sep;134(7):644-653. Epub 2022 Jul 27 doi: 10.1080/00325481.2022.2103350. PMID: 35841159
Gallstone dissolution in vitro using methyl tert-butyl ether: radiologic selection criteria.
Nelson PE, Moyer TP, Thistle JL
Gastroenterology 1990 May;98(5 Pt 1):1280-3. doi: 10.1016/s0016-5085(12)90345-5. PMID: 2323520
Pathogenesis of gallstones: implications for management.
Duane WC
Hosp Pract (Off Ed) 1990 Mar 15;25(3):65-76, 79-80. doi: 10.1080/21548331.1990.11703924. PMID: 2107192

Recent clinical studies

Etiology

Limits and perspective of oral therapy with statins and aspirin for the prevention of symptomatic cholesterol gallstone disease.
Cariati A, Piromalli E
Expert Opin Pharmacother 2012 Jun;13(9):1223-7. doi: 10.1517/14656566.2012.685161. PMID: 22607008
An animal model of black pigment gallstones caused by nanobacteria.
Wang L, Shen W, Wen J, An X, Cao L, Wang B
Dig Dis Sci 2006 Jun;51(6):1126-32. doi: 10.1007/s10620-006-8019-6. PMID: 16865581
Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life.
Vítek L, Carey MC
Eur J Clin Invest 2003 Sep;33(9):799-810. doi: 10.1046/j.1365-2362.2003.01214.x. PMID: 12925040
Gallstones and gall bladder carcinoma.
Vitetta L, Sali A, Little P, Mrazek L
Aust N Z J Surg 2000 Sep;70(9):667-73. doi: 10.1046/j.1440-1622.2000.01926.x. PMID: 10976897
Physical and metabolic factors in gallstone pathogenesis.
Donovan JM
Gastroenterol Clin North Am 1999 Mar;28(1):75-97. doi: 10.1016/s0889-8553(05)70044-3. PMID: 10198779

Diagnosis

Gastrointestinal and hepatic complications of sickle cell disease.
Ebert EC, Nagar M, Hagspiel KD
Clin Gastroenterol Hepatol 2010 Jun;8(6):483-9; quiz e70. Epub 2010 Mar 6 doi: 10.1016/j.cgh.2010.02.016. PMID: 20215064
Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life.
Vítek L, Carey MC
Eur J Clin Invest 2003 Sep;33(9):799-810. doi: 10.1046/j.1365-2362.2003.01214.x. PMID: 12925040

Therapy

Black Pigment Gallstone Inspired Platinum-Chelated Bilirubin Nanoparticles for Combined Photoacoustic Imaging and Photothermal Therapy of Cancers.
Lee DY, Kim JY, Lee Y, Lee S, Miao W, Kim HS, Min JJ, Jon S
Angew Chem Int Ed Engl 2017 Oct 23;56(44):13684-13688. Epub 2017 Sep 22 doi: 10.1002/anie.201707137. PMID: 28869355
Limits and perspective of oral therapy with statins and aspirin for the prevention of symptomatic cholesterol gallstone disease.
Cariati A, Piromalli E
Expert Opin Pharmacother 2012 Jun;13(9):1223-7. doi: 10.1517/14656566.2012.685161. PMID: 22607008
Gastrointestinal and hepatic complications of sickle cell disease.
Ebert EC, Nagar M, Hagspiel KD
Clin Gastroenterol Hepatol 2010 Jun;8(6):483-9; quiz e70. Epub 2010 Mar 6 doi: 10.1016/j.cgh.2010.02.016. PMID: 20215064
Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life.
Vítek L, Carey MC
Eur J Clin Invest 2003 Sep;33(9):799-810. doi: 10.1046/j.1365-2362.2003.01214.x. PMID: 12925040

Prognosis

Black pigment gallstones with cholesterol gallstones in the same gallbladder. 13 cases in a surgical series of 1226 patients with gallbladder stones.
Cetta F, Lombardo F, Malet PF
Dig Dis Sci 1995 Mar;40(3):534-8. doi: 10.1007/BF02064363. PMID: 7895539

Clinical prediction guides

Gallstones and gall bladder carcinoma.
Vitetta L, Sali A, Little P, Mrazek L
Aust N Z J Surg 2000 Sep;70(9):667-73. doi: 10.1046/j.1440-1622.2000.01926.x. PMID: 10976897
Human gallstones contain pronucleating nonmucin glycoproteins that are immunoglobulins.
Lipsett PA, Hildreth J, Kaufman HS, Lillemoe KD, Pitt HA
Ann Surg 1994 Jan;219(1):25-33. doi: 10.1097/00000658-199401000-00005. PMID: 8297172Free PMC Article
Calcium in human gallbladder bile.
Shiffman ML, Sugerman HJ, Kellum JM, Moore EW
J Lab Clin Med 1992 Dec;120(6):875-84. PMID: 1453109

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