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Anterior wedging of L2

MedGen UID:
868711
•Concept ID:
C4023114
•
Finding
HPO: HP:0011941

Definition

An abnormality of the shape of the lumbar vertebra L2 such that it is wedge-shaped (narrow towards the front). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnterior wedging of L2

Conditions with this feature

Mucopolysaccharidosis type 6
MedGen UID:
44514
•Concept ID:
C0026709
•
Disease or Syndrome
Mucopolysaccharidosis type VI (MPS6) is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Clinical features and severity are variable, but usually include short stature, hepatosplenomegaly, dysostosis multiplex, stiff joints, corneal clouding, cardiac abnormalities, and facial dysmorphism. Intelligence is usually normal (Azevedo et al., 2004).
See: Condition Record
Mucopolysaccharidosis type 6

Professional guidelines

PubMed

Preventive effects of conservative treatment with short-term teriparatide on the progression of vertebral body collapse after osteoporotic vertebral compression fracture.
Park JH, Kang KC, Shin DE, Koh YG, Son JS, Kim BH
Osteoporos Int 2014 Feb;25(2):613-8. Epub 2013 Aug 14 doi: 10.1007/s00198-013-2458-7. PMID: 23943161

Recent clinical studies

Etiology

Efficacy of Non-Fusion Surgeries in the Management of AO Type C Injuries of the Thoracic and Thoracolumbar Spine: A Retrospective Study.
Murugan C, Shetty AP, Kavishwar R, Krishnan V, Kanna RM, Rajasekaran S
Neurol India 2022 Sep-Oct;70(Supplement):S189-S194. doi: 10.4103/0028-3886.360910. PMID: 36412367
Closing-opening wedge osteotomy for the treatment of congenital kyphosis in children.
Xu HF, Li C, Ma ZS, Wu ZX, Sha J, Diwu WL, Yan YB, Liu ZC, Fan ZZ, Huang LY
J Orthop Surg (Hong Kong) 2022 Sep-Dec;30(3):10225536221118600. doi: 10.1177/10225536221118600. PMID: 36120861
Wedging of vertebral bodies at the thoracolumbar spine in healthy individuals on whole body MRI screening: correlation with disc degeneration and disc herniation.
Kim J, Park HJ, Kim MS, Kim JN, Choi YJ, Rho MH, Park JY
Acta Radiol 2022 Jul;63(7):958-963. Epub 2021 Jun 9 doi: 10.1177/02841851211024005. PMID: 34107750
"Outcome of thoracolumbar compression fractures following non-operative treatment".
Soultanis K, Thano A, Soucacos PN
Injury 2021 Dec;52(12):3685-3690. Epub 2021 May 16 doi: 10.1016/j.injury.2021.05.019. PMID: 34049701
Vertebral osteotomy for correction of kyphosis in ankylosing spondylitis.
Thomasen E
Clin Orthop Relat Res 1985 Apr;(194):142-52. PMID: 3978906

Diagnosis

Equivalent values between anterior vertebral height, wedge ratio, and wedge angle for evaluating vertebral mobility and deformity in osteoporotic vertebral fractures: a conventional observational study.
Sato K, Kogawa M, Yamada Y, Yamashiro M, Kasama F, Matsuda M
J Orthop Surg Res 2023 Apr 8;18(1):284. doi: 10.1186/s13018-023-03758-w. PMID: 37031169Free PMC Article
Equivalent values between anterior vertebral height, wedge ratio, and wedge angle in osteoporotic vertebral fractures.
Sato K, Kogawa M, Yamada Y, Yamashiro M, Kasama F, Matsuda M
J Bone Miner Metab 2022 Jan;40(1):132-140. Epub 2021 Aug 22 doi: 10.1007/s00774-021-01264-9. PMID: 34420088
Nonoperative management of pediatric aortic injury with seat belt syndrome.
Parrish DW, Barnhorst A, Trebska-McGowan K, Amendola M, Haynes JH
Ann Vasc Surg 2015 Aug;29(6):1316.e1-6. Epub 2015 May 28 doi: 10.1016/j.avsg.2015.02.019. PMID: 26028461
Wedging of vertebral bodies at the thoracolumbar junction in asymptomatic healthy subjects on magnetic resonance imaging.
Matsumoto M, Okada E, Kaneko Y, Ichihara D, Watanabe K, Chiba K, Toyama Y, Fujiwara H, Momoshima S, Nishiwaki Y, Hashimoto T, Takahata T
Surg Radiol Anat 2011 Apr;33(3):223-8. Epub 2010 Nov 23 doi: 10.1007/s00276-010-0746-x. PMID: 21104252
Butterfly vertebra anomaly: A case report.
Ekim A
J Back Musculoskelet Rehabil 2010;23(3):161-4. doi: 10.3233/BMR-2010-0262. PMID: 20858946

Therapy

Finite element analysis of wedge and biconcave deformity in four different height restoration after augmentation of osteoporotic vertebral compression fractures.
Zuo XH, Chen YB, Xie P, Zhang WD, Xue XY, Zhang QX, Shan B, Zhang XB, Bao HG, Si YN
J Orthop Surg Res 2021 Feb 15;16(1):138. doi: 10.1186/s13018-021-02225-8. PMID: 33588890Free PMC Article
Treatment of unstable thoracolumbar junction fractures: short-segment pedicle fixation with inclusion of the fracture level versus long-segment instrumentation.
Dobran M, Nasi D, Brunozzi D, di Somma L, Gladi M, Iacoangeli M, Scerrati M
Acta Neurochir (Wien) 2016 Oct;158(10):1883-9. Epub 2016 Aug 19 doi: 10.1007/s00701-016-2907-0. PMID: 27541493
A morphometric analysis of all lumbar intervertebral discs and vertebral bodies in degenerative spondylolisthesis.
Abu-Leil S, Floman Y, Bronstein Y, Masharawi Y
Eur Spine J 2016 Aug;25(8):2535-45. Epub 2016 Jun 27 doi: 10.1007/s00586-016-4673-3. PMID: 27349752
Nonoperative management of pediatric aortic injury with seat belt syndrome.
Parrish DW, Barnhorst A, Trebska-McGowan K, Amendola M, Haynes JH
Ann Vasc Surg 2015 Aug;29(6):1316.e1-6. Epub 2015 May 28 doi: 10.1016/j.avsg.2015.02.019. PMID: 26028461
Kyphosis recurrence after posterior short-segment fixation in thoracolumbar burst fractures.
Wang XY, Dai LY, Xu HZ, Chi YL
J Neurosurg Spine 2008 Mar;8(3):246-54. doi: 10.3171/SPI/2008/8/3/246. PMID: 18312076

Prognosis

Radiographic Factors for Progression of Thoracolumbar Kyphosis in Achondroplasia Patients after Walking Age: A Generalized Estimating Equation Analysis.
Mok S, Chang SY, Park SC, Chae I, Kim H, Chang BS, Cho TJ, Ko JM
Clin Orthop Surg 2022 Sep;14(3):410-416. Epub 2022 Jul 21 doi: 10.4055/cios22046. PMID: 36061843Free PMC Article
Equivalent values between anterior vertebral height, wedge ratio, and wedge angle in osteoporotic vertebral fractures.
Sato K, Kogawa M, Yamada Y, Yamashiro M, Kasama F, Matsuda M
J Bone Miner Metab 2022 Jan;40(1):132-140. Epub 2021 Aug 22 doi: 10.1007/s00774-021-01264-9. PMID: 34420088
Infantile developmental thoracolumbar kyphosis with segmental subluxation of the spine.
Tsirikos AI, McMaster MJ
J Bone Joint Surg Br 2010 Mar;92(3):430-5. doi: 10.1302/0301-620X.92B3.23075. PMID: 20190317
Kyphosis recurrence after posterior short-segment fixation in thoracolumbar burst fractures.
Wang XY, Dai LY, Xu HZ, Chi YL
J Neurosurg Spine 2008 Mar;8(3):246-54. doi: 10.3171/SPI/2008/8/3/246. PMID: 18312076
Vertebral osteotomy for correction of kyphosis in ankylosing spondylitis.
Thomasen E
Clin Orthop Relat Res 1985 Apr;(194):142-52. PMID: 3978906

Clinical prediction guides

Efficacy of Non-Fusion Surgeries in the Management of AO Type C Injuries of the Thoracic and Thoracolumbar Spine: A Retrospective Study.
Murugan C, Shetty AP, Kavishwar R, Krishnan V, Kanna RM, Rajasekaran S
Neurol India 2022 Sep-Oct;70(Supplement):S189-S194. doi: 10.4103/0028-3886.360910. PMID: 36412367
Closing-opening wedge osteotomy for the treatment of congenital kyphosis in children.
Xu HF, Li C, Ma ZS, Wu ZX, Sha J, Diwu WL, Yan YB, Liu ZC, Fan ZZ, Huang LY
J Orthop Surg (Hong Kong) 2022 Sep-Dec;30(3):10225536221118600. doi: 10.1177/10225536221118600. PMID: 36120861
"Outcome of thoracolumbar compression fractures following non-operative treatment".
Soultanis K, Thano A, Soucacos PN
Injury 2021 Dec;52(12):3685-3690. Epub 2021 May 16 doi: 10.1016/j.injury.2021.05.019. PMID: 34049701
Clinical and radiological outcomes of modified posterior closing wedge osteotomy for the treatment of posttraumatic thoracolumbar kyphosis.
Jo DJ, Kim YS, Kim SM, Kim KT, Seo EM
J Neurosurg Spine 2015 Oct;23(4):510-7. Epub 2015 Jul 3 doi: 10.3171/2015.1.SPINE131011. PMID: 26140402
Wedging of vertebral bodies at the thoracolumbar junction in asymptomatic healthy subjects on magnetic resonance imaging.
Matsumoto M, Okada E, Kaneko Y, Ichihara D, Watanabe K, Chiba K, Toyama Y, Fujiwara H, Momoshima S, Nishiwaki Y, Hashimoto T, Takahata T
Surg Radiol Anat 2011 Apr;33(3):223-8. Epub 2010 Nov 23 doi: 10.1007/s00276-010-0746-x. PMID: 21104252

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