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Abnormal small intestinal villus morphology

MedGen UID:
868929
•Concept ID:
C4023341
•
Anatomical Abnormality
Synonyms: Abnormal shape of small intestinal villus; Abnormality of small intestinal villus morphology
 
HPO: HP:0011472

Professional guidelines

PubMed

Small bowel enterocyte abnormalities caused by methotrexate treatment in acute lymphoblastic leukaemia of childhood.
Gwavava NJ, Pinkerton CR, Glasgow JF, Sloan JM, Bridges JM
J Clin Pathol 1981 Jul;34(7):790-5. doi: 10.1136/jcp.34.7.790. PMID: 6943149Free PMC Article
Radiation enteritis in children. A retrospective review, clinicopathologic correlation, and dietary management.
Donaldson SS, Jundt S, Ricour C, Sarrazin D, Lemerle J, Schweisguth O
Cancer 1975 Apr;35(4):1167-78. doi: 10.1002/1097-0142(197504)35:4<1167::aid-cncr2820350423>3.0.co;2-y. PMID: 163677

Recent clinical studies

Etiology

Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.
Israelyan N, Del Colle A, Li Z, Park Y, Xing A, Jacobsen JPR, Luna RA, Jensen DD, Madra M, Saurman V, Rahim R, Latorre R, Law K, Carson W, Bunnett NW, Caron MG, Margolis KG
Gastroenterology 2019 Aug;157(2):507-521.e4. Epub 2019 May 7 doi: 10.1053/j.gastro.2019.04.022. PMID: 31071306Free PMC Article
Short bowel mucosal morphology, proliferation and inflammation at first and repeat STEP procedures.
Mutanen A, Barrett M, Feng Y, Lohi J, Rabah R, Teitelbaum DH, Pakarinen MP
J Pediatr Surg 2019 Mar;54(3):511-516. Epub 2018 Apr 17 doi: 10.1016/j.jpedsurg.2018.04.016. PMID: 29753524
Discriminant value of IEL counts and distribution pattern through the spectrum of gluten sensitivity: a simple diagnostic approach.
Kirmizi A, Kalkan C, Yuksel S, Gencturk Z, Savas B, Soykan İ, Cetinkaya H, Ensari A
Virchows Arch 2018 Nov;473(5):551-558. Epub 2018 Aug 9 doi: 10.1007/s00428-018-2430-1. PMID: 30094491
Pediatric duodenal biopsies: mucosal morphology and glycohydrolase expression do not change along the duodenum.
Van Beers EH, Einerhand AW, Taminiau JA, Heymans HS, Dekker J, Büller HA
J Pediatr Gastroenterol Nutr 1998 Feb;26(2):186-93. doi: 10.1097/00005176-199802000-00013. PMID: 9481636
Intestinal immune cells in Strongyloides stercoralis infection.
Trajman A, MacDonald TT, Elia CC
J Clin Pathol 1997 Dec;50(12):991-5. doi: 10.1136/jcp.50.12.991. PMID: 9516879Free PMC Article

Diagnosis

Discriminant value of IEL counts and distribution pattern through the spectrum of gluten sensitivity: a simple diagnostic approach.
Kirmizi A, Kalkan C, Yuksel S, Gencturk Z, Savas B, Soykan İ, Cetinkaya H, Ensari A
Virchows Arch 2018 Nov;473(5):551-558. Epub 2018 Aug 9 doi: 10.1007/s00428-018-2430-1. PMID: 30094491
Measuring Change In Small Intestinal Histology In Patients With Celiac Disease.
Adelman DC, Murray J, Wu TT, Mäki M, Green PH, Kelly CP
Am J Gastroenterol 2018 Mar;113(3):339-347. Epub 2018 Feb 20 doi: 10.1038/ajg.2017.480. PMID: 29460921
Histological abnormalities of the small bowel mucosa in cirrhosis and portal hypertension.
Wakim-Fleming J, Zein NN, Bennett A, Lopez R, Santisi J, Carey WD
World J Gastroenterol 2008 Nov 7;14(41):6370-5. doi: 10.3748/wjg.14.6370. PMID: 19009654Free PMC Article
Food-induced malabsorption syndromes.
Savilahti E
J Pediatr Gastroenterol Nutr 2000;30 Suppl:S61-6. doi: 10.1097/00005176-200001001-00010. PMID: 10634301
Pediatric duodenal biopsies: mucosal morphology and glycohydrolase expression do not change along the duodenum.
Van Beers EH, Einerhand AW, Taminiau JA, Heymans HS, Dekker J, Büller HA
J Pediatr Gastroenterol Nutr 1998 Feb;26(2):186-93. doi: 10.1097/00005176-199802000-00013. PMID: 9481636

Therapy

Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.
Israelyan N, Del Colle A, Li Z, Park Y, Xing A, Jacobsen JPR, Luna RA, Jensen DD, Madra M, Saurman V, Rahim R, Latorre R, Law K, Carson W, Bunnett NW, Caron MG, Margolis KG
Gastroenterology 2019 Aug;157(2):507-521.e4. Epub 2019 May 7 doi: 10.1053/j.gastro.2019.04.022. PMID: 31071306Free PMC Article
Short bowel mucosal morphology, proliferation and inflammation at first and repeat STEP procedures.
Mutanen A, Barrett M, Feng Y, Lohi J, Rabah R, Teitelbaum DH, Pakarinen MP
J Pediatr Surg 2019 Mar;54(3):511-516. Epub 2018 Apr 17 doi: 10.1016/j.jpedsurg.2018.04.016. PMID: 29753524
Discriminant value of IEL counts and distribution pattern through the spectrum of gluten sensitivity: a simple diagnostic approach.
Kirmizi A, Kalkan C, Yuksel S, Gencturk Z, Savas B, Soykan İ, Cetinkaya H, Ensari A
Virchows Arch 2018 Nov;473(5):551-558. Epub 2018 Aug 9 doi: 10.1007/s00428-018-2430-1. PMID: 30094491
Glutamine: commercially essential or conditionally essential? A critical appraisal of the human data.
Buchman AL
Am J Clin Nutr 2001 Jul;74(1):25-32. doi: 10.1093/ajcn/74.1.25. PMID: 11451714
Gastrointestinal complications of immunodeficiency syndromes.
Katz AJ, Rosen FS
Ciba Found Symp 1977 Apr 26-28;(46):243-61. doi: 10.1002/9780470720288.ch12. PMID: 346324

Prognosis

Measuring Change In Small Intestinal Histology In Patients With Celiac Disease.
Adelman DC, Murray J, Wu TT, Mäki M, Green PH, Kelly CP
Am J Gastroenterol 2018 Mar;113(3):339-347. Epub 2018 Feb 20 doi: 10.1038/ajg.2017.480. PMID: 29460921
Application of novel magnified single balloon enteroscopy for a patient with Cronkhite-Canada syndrome.
Murata M, Bamba S, Takahashi K, Imaeda H, Nishida A, Inatomi O, Tsujikawa T, Kushima R, Sugimoto M, Andoh A
World J Gastroenterol 2017 Jun 14;23(22):4121-4126. doi: 10.3748/wjg.v23.i22.4121. PMID: 28652665Free PMC Article
Histological abnormalities of the small bowel mucosa in cirrhosis and portal hypertension.
Wakim-Fleming J, Zein NN, Bennett A, Lopez R, Santisi J, Carey WD
World J Gastroenterol 2008 Nov 7;14(41):6370-5. doi: 10.3748/wjg.14.6370. PMID: 19009654Free PMC Article
Duodenal histology, ulceration, and Helicobacter pylori in the presence or absence of non-steroidal anti-inflammatory drugs.
Taha AS, Dahill S, Nakshabendi I, Lee FD, Sturrock RD, Russell RI
Gut 1993 Sep;34(9):1162-6. doi: 10.1136/gut.34.9.1162. PMID: 8406146Free PMC Article
Radiation enteritis in children. A retrospective review, clinicopathologic correlation, and dietary management.
Donaldson SS, Jundt S, Ricour C, Sarrazin D, Lemerle J, Schweisguth O
Cancer 1975 Apr;35(4):1167-78. doi: 10.1002/1097-0142(197504)35:4<1167::aid-cncr2820350423>3.0.co;2-y. PMID: 163677

Clinical prediction guides

Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine.
Hendrickson SM, Thomas A, Prongay K, Haertel AJ, Garzel LM, Gill L, Barr T, Rhoades NS, Reader R, Galan M, Carroll JM, Roberts CT, Gao L, Amanna IJ, Messaoudi I, Slifka MK
Nat Commun 2022 Jan 11;13(1):234. doi: 10.1038/s41467-021-27925-x. PMID: 35017515Free PMC Article
Short bowel mucosal morphology, proliferation and inflammation at first and repeat STEP procedures.
Mutanen A, Barrett M, Feng Y, Lohi J, Rabah R, Teitelbaum DH, Pakarinen MP
J Pediatr Surg 2019 Mar;54(3):511-516. Epub 2018 Apr 17 doi: 10.1016/j.jpedsurg.2018.04.016. PMID: 29753524
Measuring Change In Small Intestinal Histology In Patients With Celiac Disease.
Adelman DC, Murray J, Wu TT, Mäki M, Green PH, Kelly CP
Am J Gastroenterol 2018 Mar;113(3):339-347. Epub 2018 Feb 20 doi: 10.1038/ajg.2017.480. PMID: 29460921
Histological abnormalities of the small bowel mucosa in cirrhosis and portal hypertension.
Wakim-Fleming J, Zein NN, Bennett A, Lopez R, Santisi J, Carey WD
World J Gastroenterol 2008 Nov 7;14(41):6370-5. doi: 10.3748/wjg.14.6370. PMID: 19009654Free PMC Article
Ultrastructural changes in the upper small intestinal mucosa in patients with cholera.
Mathan MM, Chandy G, Mathan VI
Gastroenterology 1995 Aug;109(2):422-30. doi: 10.1016/0016-5085(95)90329-1. PMID: 7615191

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