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Abnormality of urine calcium concentration

MedGen UID:
869017
•Concept ID:
C4023434
•
Finding
Synonyms: Abnormality of urine Ca concentration; Abnormality of urine Ca2+ concentration
 
HPO: HP:0011280

Definition

An abnormality of calcium concentration in the urine. [from HPO]

Conditions with this feature

Primary hyperoxaluria, type II
MedGen UID:
120616
•Concept ID:
C0268165
•
Disease or Syndrome
Primary hyperoxaluria type 2 (PH2), caused by deficiency of the enzyme glyoxylate reductase/hydroxypyruvate reductase (GR/HPR), is characterized by recurrent nephrolithiasis (deposition of calcium oxalate in the renal pelvis/urinary tract), nephrocalcinosis (deposition of calcium oxalate in the renal parenchyma), and end-stage renal disease (ESRD). After ESRD, oxalosis (widespread tissue deposition of calcium oxalate) usually develops. Symptom onset is typically in childhood.
See: Condition Record
Primary hyperoxaluria, type II

Professional guidelines

PubMed

Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Renal stone disease: Causes, evaluation and medical treatment.
Heilberg IP, Schor N
Arq Bras Endocrinol Metabol 2006 Aug;50(4):823-31. doi: 10.1590/s0004-27302006000400027. PMID: 17117307
Lopinavir/ritonavir: a review of its use in the management of HIV infection.
Cvetkovic RS, Goa KL
Drugs 2003;63(8):769-802. doi: 10.2165/00003495-200363080-00004. PMID: 12662125

Recent clinical studies

Etiology

Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
Medical therapy and new approaches to management of urolithiasis.
Pak CY, Resnick MI
Urol Clin North Am 2000 May;27(2):243-53. doi: 10.1016/s0094-0143(05)70254-8. PMID: 10778467
Magnesium hydrogen carbonate natural mineral water enriched with K(+)-citrate and vitamin B6 improves urinary abnormalities in patients with calcium oxalate nephrolithiasis.
Bren A, Kmetec A, Kveder R, Kaplan-Pavlovcic S
Urol Int 1998;60(2):105-7. doi: 10.1159/000030221. PMID: 9563149
Asymptomatic primary hyperparathyroidism.
Mitlak BH, Daly M, Potts JT Jr, Schoenfeld D, Neer RM
J Bone Miner Res 1991 Oct;6 Suppl 2:S103-10; discussion S121-4. doi: 10.1002/jbmr.5650061422. PMID: 1763660
Idiopathic calcium oxalate urolithiasis.
Smith LH
Endocrinol Metab Clin North Am 1990 Dec;19(4):937-47. PMID: 2081520

Diagnosis

Fahr's syndrome: literature review of current evidence.
Saleem S, Aslam HM, Anwar M, Anwar S, Saleem M, Saleem A, Rehmani MA
Orphanet J Rare Dis 2013 Oct 8;8:156. doi: 10.1186/1750-1172-8-156. PMID: 24098952Free PMC Article
Rhabdomyolysis.
Zimmerman JL, Shen MC
Chest 2013 Sep;144(3):1058-1065. doi: 10.1378/chest.12-2016. PMID: 24008958
Medullary sponge kidney associated with congenital hemihypertrophy.
Indridason OS, Thomas L, Berkoben M
J Am Soc Nephrol 1996 Aug;7(8):1123-30. doi: 10.1681/ASN.V781123. PMID: 8866402
Idiopathic calcium oxalate urolithiasis.
Smith LH
Endocrinol Metab Clin North Am 1990 Dec;19(4):937-47. PMID: 2081520
Vitamin D metabolite-mediated hypercalcemia.
Adams JS
Endocrinol Metab Clin North Am 1989 Sep;18(3):765-78. PMID: 2673772

Therapy

Incomplete Distal Renal Tubular Acidosis and Kidney Stones.
Fuster DG, Moe OW
Adv Chronic Kidney Dis 2018 Jul;25(4):366-374. doi: 10.1053/j.ackd.2018.05.007. PMID: 30139463Free PMC Article
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
Magnesium hydrogen carbonate natural mineral water enriched with K(+)-citrate and vitamin B6 improves urinary abnormalities in patients with calcium oxalate nephrolithiasis.
Bren A, Kmetec A, Kveder R, Kaplan-Pavlovcic S
Urol Int 1998;60(2):105-7. doi: 10.1159/000030221. PMID: 9563149
Vitamin D metabolite-mediated hypercalcemia.
Adams JS
Endocrinol Metab Clin North Am 1989 Sep;18(3):765-78. PMID: 2673772
Clinical toxicologic and pharmacologic studies of gallium nitrate.
Krakoff IH, Newman RA, Goldberg RS
Cancer 1979 Nov;44(5):1722-7. doi: 10.1002/1097-0142(197911)44:5<1722::aid-cncr2820440528>3.0.co;2-c. PMID: 387208

Prognosis

Urinary minerals excretion among primary schoolchildren in Dubai-United Arab Emirates.
Al Ghali R, El-Mallah C, Obeid O, El-Saleh O, Smail L, Haroun D
PLoS One 2021;16(8):e0255195. Epub 2021 Aug 5 doi: 10.1371/journal.pone.0255195. PMID: 34351961Free PMC Article
Rhabdomyolysis.
Zimmerman JL, Shen MC
Chest 2013 Sep;144(3):1058-1065. doi: 10.1378/chest.12-2016. PMID: 24008958
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
Magnesium hydrogen carbonate natural mineral water enriched with K(+)-citrate and vitamin B6 improves urinary abnormalities in patients with calcium oxalate nephrolithiasis.
Bren A, Kmetec A, Kveder R, Kaplan-Pavlovcic S
Urol Int 1998;60(2):105-7. doi: 10.1159/000030221. PMID: 9563149

Clinical prediction guides

Rhabdomyolysis.
Zimmerman JL, Shen MC
Chest 2013 Sep;144(3):1058-1065. doi: 10.1378/chest.12-2016. PMID: 24008958
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Clinical and metabolic evaluation of Korean patients with urolithiasis.
Park KJ, Jeon SS, Han DH, Lee SY
Scand J Clin Lab Invest 2011 Oct;71(6):481-5. Epub 2011 Jun 30 doi: 10.3109/00365513.2011.587528. PMID: 21714706
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
The role of Tamm-Horsfall glycoprotein and Nephrocalcin in calcium oxalate monohydrate crystallization processes.
Hess B
Scanning Microsc 1991 Sep;5(3):689-95; discussion 696. PMID: 1808706

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