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Hypocalcification of dental enamel

MedGen UID:
869123
•Concept ID:
C4023541
•
Disease or Syndrome
Synonyms: Decreased enamel calcification; Poorly calcified tooth enamel
 
HPO: HP:0011084

Definition

A form of hypomineralization of enamel characterized by reduced calcification. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypocalcification of dental enamel

Conditions with this feature

Amelogenesis imperfecta, type 3C
MedGen UID:
1676410
•Concept ID:
C5193069
•
Disease or Syndrome
Amelogenesis imperfecta type IIIC is characterized by hypocalcified enamel in both the primary and secondary dentition. The enamel is rough and yellow-brown; under normal use, the enamel disintegrates from occlusal surfaces of the molars, leaving a ring of intact enamel remaining on the sides. Some affected individuals have anterior open bite (Kim et al., 2019).
See: Condition Record
Amelogenesis imperfecta, type 3C

Professional guidelines

PubMed

Orthodontic findings and treatment need in patients with amelogenesis imperfecta: a descriptive analysis.
Möhlhenrich SC, Chhatwani S, Schmidt P, Kniha K, Postberg J, Schulte AG, Jackowski J, Zimmer S, Danesh G
Head Face Med 2024 Jun 14;20(1):36. doi: 10.1186/s13005-024-00436-y. PMID: 38877506Free PMC Article
Esthetic management of white spot lesions by using minimal intervention techniques of bleaching and resin infiltration: A clinical report.
Alverson BW, Capehart KL, Babb CS, Romero MF
J Prosthet Dent 2021 Oct;126(4):455-458. Epub 2020 Sep 30 doi: 10.1016/j.prosdent.2020.08.010. PMID: 33008631

Recent clinical studies

Etiology

Oral health-related quality of life and oral manifestations of Syrian children with congenital heart disease: a case-control study.
Bsesa SS, Srour S, Dashash M
BMC Oral Health 2023 May 23;23(1):316. doi: 10.1186/s12903-023-03017-8. PMID: 37221589Free PMC Article
Assessment of oral health-related quality of life (OHRQoL) in children with molar incisor hypomineralization (MIH) - A systematic review and meta-analysis of observational studies.
Jawdekar AM, Kamath S, Kale S, Mistry L
J Indian Soc Pedod Prev Dent 2022 Oct-Dec;40(4):368-376. doi: 10.4103/jisppd.jisppd_27_23. PMID: 36861552
Mandibular metastases in neuroblastoma: Outcomes and dental sequelae.
Singh A, Modak S, Solano AK, Kushner BH, Wolden S, Huryn J, Estilo CL
Pediatr Blood Cancer 2021 Apr;68(4):e28918. Epub 2021 Jan 28 doi: 10.1002/pbc.28918. PMID: 33507629Free PMC Article
Clinical and radiographic analysis of traumatized primary teeth and permanent successors: Longitudinal study.
Carvalho Pugliesi DM, C Araujo LD, S Junior VE, Cunha RF
J Indian Soc Pedod Prev Dent 2020 Jul-Sep;38(3):232-237. doi: 10.4103/JISPPD.JISPPD_324_20. PMID: 33004720
Hypocalcification and hypoplasia in permanent teeth of children from different ethnic groups in South Africa assessed with a new index.
Hargreaves JA, Cleaton-Jones PE, Williams SD
Adv Dent Res 1989 Sep;3(2):126-31. doi: 10.1177/08959374890030021001. PMID: 2640424

Diagnosis

Management of oral manifestations of a child with Heimler Syndrome-2.
Yap LC, Williams L, Stinton N, Malik G
BMJ Case Rep 2024 Apr 24;17(4) doi: 10.1136/bcr-2023-257354. PMID: 38663901Free PMC Article
Assessment of oral health-related quality of life (OHRQoL) in children with molar incisor hypomineralization (MIH) - A systematic review and meta-analysis of observational studies.
Jawdekar AM, Kamath S, Kale S, Mistry L
J Indian Soc Pedod Prev Dent 2022 Oct-Dec;40(4):368-376. doi: 10.4103/jisppd.jisppd_27_23. PMID: 36861552
Mandibular metastases in neuroblastoma: Outcomes and dental sequelae.
Singh A, Modak S, Solano AK, Kushner BH, Wolden S, Huryn J, Estilo CL
Pediatr Blood Cancer 2021 Apr;68(4):e28918. Epub 2021 Jan 28 doi: 10.1002/pbc.28918. PMID: 33507629Free PMC Article
Apgar index as a probable risk indicator for enamel defects in primary dentition: a cross sectional study.
Nirmala SV, Quadar MA, Veluru S, Tharay N, Kolli NK, Minor Babu MS
J Indian Soc Pedod Prev Dent 2015 Jul-Sep;33(3):229-33. doi: 10.4103/0970-4388.160396. PMID: 26156278
Amelogenesis imperfecta: diagnosis and resolution of a case with hypoplasia and hypocalcification of enamel, dental agenesis, and skeletal open bite.
Pulgar Encinas R, García-Espona I, Navajas Rodriguez de Mondelo JM
Quintessence Int 2001 Mar;32(3):183-9. PMID: 12066657

Therapy

Assessment of oral health-related quality of life (OHRQoL) in children with molar incisor hypomineralization (MIH) - A systematic review and meta-analysis of observational studies.
Jawdekar AM, Kamath S, Kale S, Mistry L
J Indian Soc Pedod Prev Dent 2022 Oct-Dec;40(4):368-376. doi: 10.4103/jisppd.jisppd_27_23. PMID: 36861552
Apgar index as a probable risk indicator for enamel defects in primary dentition: a cross sectional study.
Nirmala SV, Quadar MA, Veluru S, Tharay N, Kolli NK, Minor Babu MS
J Indian Soc Pedod Prev Dent 2015 Jul-Sep;33(3):229-33. doi: 10.4103/0970-4388.160396. PMID: 26156278
Clinical tips for porcelain veneer cases with enamel hypocalcification.
Small BW
Gen Dent 2011 Nov-Dec;59(6):414-6. PMID: 22313911
Apgar index as a correlate of enamel defects of primary dentition.
Aminabadi NA, Farahani RM, Gajan EB
Oral Health Prev Dent 2008;6(4):331-5. PMID: 19178099
Effect of carbonated beverages, coffee, sports and high energy drinks, and bottled water on the in vitro erosion characteristics of dental enamel.
Kitchens M, Owens BM
J Clin Pediatr Dent 2007 Spring;31(3):153-9. doi: 10.17796/jcpd.31.3.1157l653t8206100. PMID: 17550037

Prognosis

Mandibular metastases in neuroblastoma: Outcomes and dental sequelae.
Singh A, Modak S, Solano AK, Kushner BH, Wolden S, Huryn J, Estilo CL
Pediatr Blood Cancer 2021 Apr;68(4):e28918. Epub 2021 Jan 28 doi: 10.1002/pbc.28918. PMID: 33507629Free PMC Article
Amelogenesis imperfecta: a clinician's challenge.
Chamarthi V, Varma BR, Jayanthi M
J Indian Soc Pedod Prev Dent 2012 Jan-Mar;30(1):70-3. doi: 10.4103/0970-4388.95587. PMID: 22565521
Apgar index as a correlate of enamel defects of primary dentition.
Aminabadi NA, Farahani RM, Gajan EB
Oral Health Prev Dent 2008;6(4):331-5. PMID: 19178099
Enamel incremental lines as recorders for disease in infancy and their relation to the diagnosis of SIDS.
Teivens A, Mörnstad H, Norén JG, Gidlund E
Forensic Sci Int 1996 Aug 15;81(2-3):175-83. doi: 10.1016/s0379-0738(96)01982-2. PMID: 8837493
Hypocalcification and hypoplasia in primary teeth of pre-school children from different ethnic groups in South Africa.
Hargreaves JA, Cleaton-Jones PE, Roberts GJ, Williams SD
Adv Dent Res 1989 Sep;3(2):110-3. doi: 10.1177/08959374890030020701. PMID: 2640421

Clinical prediction guides

Assessment of oral health-related quality of life (OHRQoL) in children with molar incisor hypomineralization (MIH) - A systematic review and meta-analysis of observational studies.
Jawdekar AM, Kamath S, Kale S, Mistry L
J Indian Soc Pedod Prev Dent 2022 Oct-Dec;40(4):368-376. doi: 10.4103/jisppd.jisppd_27_23. PMID: 36861552
Does primary trauma lead to developmental defects in permanent teeth?
Gibbison R, Crozier R
Evid Based Dent 2022 Sep;23(3):112-113. Epub 2022 Sep 23 doi: 10.1038/s41432-022-0808-z. PMID: 36151286
FAM83H and Autosomal Dominant Hypocalcified Amelogenesis Imperfecta.
Wang SK, Zhang H, Hu CY, Liu JF, Chadha S, Kim JW, Simmer JP, Hu JCC
J Dent Res 2021 Mar;100(3):293-301. Epub 2020 Oct 9 doi: 10.1177/0022034520962731. PMID: 33034243Free PMC Article
Clinical and radiographic analysis of traumatized primary teeth and permanent successors: Longitudinal study.
Carvalho Pugliesi DM, C Araujo LD, S Junior VE, Cunha RF
J Indian Soc Pedod Prev Dent 2020 Jul-Sep;38(3):232-237. doi: 10.4103/JISPPD.JISPPD_324_20. PMID: 33004720
Structural and calcification patterns of the neonatal line in the enamel of human deciduous teeth.
Kodaka T, Sano T, Higashi S
Scanning Microsc 1996;10(3):737-43; discussion 743-4. PMID: 9813636

Recent systematic reviews

Assessment of oral health-related quality of life (OHRQoL) in children with molar incisor hypomineralization (MIH) - A systematic review and meta-analysis of observational studies.
Jawdekar AM, Kamath S, Kale S, Mistry L
J Indian Soc Pedod Prev Dent 2022 Oct-Dec;40(4):368-376. doi: 10.4103/jisppd.jisppd_27_23. PMID: 36861552
Does primary trauma lead to developmental defects in permanent teeth?
Gibbison R, Crozier R
Evid Based Dent 2022 Sep;23(3):112-113. Epub 2022 Sep 23 doi: 10.1038/s41432-022-0808-z. PMID: 36151286

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