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Abnormality of the intrinsic pathway

MedGen UID:
869188
•Concept ID:
C4023610
•
Anatomical Abnormality
HPO: HP:0010989

Definition

An abnormality of the intrinsic pathway (also known as the contact activation pathway) of the coagulation cascade. [from HPO]

Professional guidelines

PubMed

Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.
Vucic S, Stanley Chen KH, Kiernan MC, Hallett M, Benninger DH, Di Lazzaro V, Rossini PM, Benussi A, Berardelli A, Currà A, Krieg SM, Lefaucheur JP, Long Lo Y, Macdonell RA, Massimini M, Rosanova M, Picht T, Stinear CM, Paulus W, Ugawa Y, Ziemann U, Chen R
Clin Neurophysiol 2023 Jun;150:131-175. Epub 2023 Mar 29 doi: 10.1016/j.clinph.2023.03.010. PMID: 37068329Free PMC Article
Clinical Evaluation of Bleeding and Bruising in Primary Care.
Neutze D, Roque J
Am Fam Physician 2016 Feb 15;93(4):279-86. PMID: 26926815
Diagnosis, pathophysiology, and treatment of photophobia.
Katz BJ, Digre KB
Surv Ophthalmol 2016 Jul-Aug;61(4):466-77. Epub 2016 Feb 12 doi: 10.1016/j.survophthal.2016.02.001. PMID: 26875996

Recent clinical studies

Etiology

COVID-19 and pediatric fatty liver disease: Is there interplay?
Di Sessa A, Lanzaro F, Zarrilli S, Picone V, Guarino S, Miraglia Del Giudice E, Marzuillo P
World J Gastroenterol 2021 Jun 14;27(22):3064-3072. doi: 10.3748/wjg.v27.i22.3064. PMID: 34168408Free PMC Article
Lamin A involvement in ageing processes.
Cenni V, Capanni C, Mattioli E, Schena E, Squarzoni S, Bacalini MG, Garagnani P, Salvioli S, Franceschi C, Lattanzi G
Ageing Res Rev 2020 Sep;62:101073. Epub 2020 May 21 doi: 10.1016/j.arr.2020.101073. PMID: 32446955
Systemic lupus erythematosus and immunodeficiency.
Sawada T, Fujimori D, Yamamoto Y
Immunol Med 2019 Mar;42(1):1-9. Epub 2019 Jun 17 doi: 10.1080/25785826.2019.1628466. PMID: 31204893
Coagulation Testing in the Core Laboratory.
Winter WE, Flax SD, Harris NS
Lab Med 2017 Nov 8;48(4):295-313. doi: 10.1093/labmed/lmx050. PMID: 29126301
Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.
EFSA GMO Panel Working Group on Animal Feeding Trials
Food Chem Toxicol 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13 doi: 10.1016/j.fct.2008.02.008. PMID: 18328408

Diagnosis

Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.
Vucic S, Stanley Chen KH, Kiernan MC, Hallett M, Benninger DH, Di Lazzaro V, Rossini PM, Benussi A, Berardelli A, Currà A, Krieg SM, Lefaucheur JP, Long Lo Y, Macdonell RA, Massimini M, Rosanova M, Picht T, Stinear CM, Paulus W, Ugawa Y, Ziemann U, Chen R
Clin Neurophysiol 2023 Jun;150:131-175. Epub 2023 Mar 29 doi: 10.1016/j.clinph.2023.03.010. PMID: 37068329Free PMC Article
Coagulation Testing in the Core Laboratory.
Winter WE, Flax SD, Harris NS
Lab Med 2017 Nov 8;48(4):295-313. doi: 10.1093/labmed/lmx050. PMID: 29126301
Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine.
Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL
Chest 2017 Jan;151(1):181-192. Epub 2016 Sep 16 doi: 10.1016/j.chest.2016.09.001. PMID: 27645688Free PMC Article
Diagnosis, pathophysiology, and treatment of photophobia.
Katz BJ, Digre KB
Surv Ophthalmol 2016 Jul-Aug;61(4):466-77. Epub 2016 Feb 12 doi: 10.1016/j.survophthal.2016.02.001. PMID: 26875996
Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.
EFSA GMO Panel Working Group on Animal Feeding Trials
Food Chem Toxicol 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13 doi: 10.1016/j.fct.2008.02.008. PMID: 18328408

Therapy

Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation.
Marquardt V, Theruvath J, Pauck D, Picard D, Qin N, Blümel L, Maue M, Bartl J, Ahmadov U, Langini M, Meyer FD, Cole A, Cruz-Cruz J, Graef CM, Wölfl M, Milde T, Witt O, Erdreich-Epstein A, Leprivier G, Kahlert U, Stefanski A, Stühler K, Keir ST, Bigner DD, Hauer J, Beez T, Knobbe-Thomsen CB, Fischer U, Felsberg J, Hansen FK, Vibhakar R, Venkatraman S, Cheshier SH, Reifenberger G, Borkhardt A, Kurz T, Remke M, Mitra S
J Immunother Cancer 2023 Jan;11(1) doi: 10.1136/jitc-2022-005871. PMID: 36639156Free PMC Article
The IL-4, IL-13 and IL-31 pathways in atopic dermatitis.
Dubin C, Del Duca E, Guttman-Yassky E
Expert Rev Clin Immunol 2021 Aug;17(8):835-852. Epub 2021 Jul 21 doi: 10.1080/1744666X.2021.1940962. PMID: 34106037
Systemic lupus erythematosus and immunodeficiency.
Sawada T, Fujimori D, Yamamoto Y
Immunol Med 2019 Mar;42(1):1-9. Epub 2019 Jun 17 doi: 10.1080/25785826.2019.1628466. PMID: 31204893
Is β-Catenin a Druggable Target for Cancer Therapy?
Cui C, Zhou X, Zhang W, Qu Y, Ke X
Trends Biochem Sci 2018 Aug;43(8):623-634. Epub 2018 Jul 2 doi: 10.1016/j.tibs.2018.06.003. PMID: 30056837
Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.
EFSA GMO Panel Working Group on Animal Feeding Trials
Food Chem Toxicol 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13 doi: 10.1016/j.fct.2008.02.008. PMID: 18328408

Prognosis

Toward More Granular Guidelines in AAOCA: Associating Anatomical Details With Specific Surgical Strategies.
Jegatheeswaran A, DeCampli WM
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2023;26:63-74. Epub 2022 Dec 28 doi: 10.1053/j.pcsu.2022.12.007. PMID: 36842800
COVID-19 and pediatric fatty liver disease: Is there interplay?
Di Sessa A, Lanzaro F, Zarrilli S, Picone V, Guarino S, Miraglia Del Giudice E, Marzuillo P
World J Gastroenterol 2021 Jun 14;27(22):3064-3072. doi: 10.3748/wjg.v27.i22.3064. PMID: 34168408Free PMC Article
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma.
Peng J, Sun BF, Chen CY, Zhou JY, Chen YS, Chen H, Liu L, Huang D, Jiang J, Cui GS, Yang Y, Wang W, Guo D, Dai M, Guo J, Zhang T, Liao Q, Liu Y, Zhao YL, Han DL, Zhao Y, Yang YG, Wu W
Cell Res 2019 Sep;29(9):725-738. Epub 2019 Jul 4 doi: 10.1038/s41422-019-0195-y. PMID: 31273297Free PMC Article
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Intrinsic brain connectivity predicts impulse control disorders in patients with Parkinson's disease.
Tessitore A, De Micco R, Giordano A, di Nardo F, Caiazzo G, Siciliano M, De Stefano M, Russo A, Esposito F, Tedeschi G
Mov Disord 2017 Dec;32(12):1710-1719. Epub 2017 Sep 26 doi: 10.1002/mds.27139. PMID: 28949049

Clinical prediction guides

COVID-19 and pediatric fatty liver disease: Is there interplay?
Di Sessa A, Lanzaro F, Zarrilli S, Picone V, Guarino S, Miraglia Del Giudice E, Marzuillo P
World J Gastroenterol 2021 Jun 14;27(22):3064-3072. doi: 10.3748/wjg.v27.i22.3064. PMID: 34168408Free PMC Article
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma.
Peng J, Sun BF, Chen CY, Zhou JY, Chen YS, Chen H, Liu L, Huang D, Jiang J, Cui GS, Yang Y, Wang W, Guo D, Dai M, Guo J, Zhang T, Liao Q, Liu Y, Zhao YL, Han DL, Zhao Y, Yang YG, Wu W
Cell Res 2019 Sep;29(9):725-738. Epub 2019 Jul 4 doi: 10.1038/s41422-019-0195-y. PMID: 31273297Free PMC Article
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Altered intrinsic functional brain architecture in female patients with bulimia nervosa.
Wang L, Kong QM, Li K, Li XN, Zeng YW, Chen C, Qian Y, Feng SJ, Li JT, Su Y, Correll CU, Mitchell PB, Yan CG, Zhang DR, Si TM
J Psychiatry Neurosci 2017 Nov;42(6):414-423. doi: 10.1503/jpn.160183. PMID: 28949286Free PMC Article
Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.
EFSA GMO Panel Working Group on Animal Feeding Trials
Food Chem Toxicol 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13 doi: 10.1016/j.fct.2008.02.008. PMID: 18328408

Recent systematic reviews

Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review.
Menezes Júnior ADS, França-E-Silva ALG, Oliveira JM, Silva DMD
Int J Mol Sci 2023 Dec 30;25(1) doi: 10.3390/ijms25010535. PMID: 38203704Free PMC Article
Abnormal resting-state functional connectivity in patients with obsessive-compulsive disorder: A systematic review and meta-analysis.
Liu J, Cao L, Li H, Gao Y, Bu X, Liang K, Bao W, Zhang S, Qiu H, Li X, Hu X, Lu L, Zhang L, Hu X, Huang X, Gong Q
Neurosci Biobehav Rev 2022 Apr;135:104574. Epub 2022 Feb 10 doi: 10.1016/j.neubiorev.2022.104574. PMID: 35151769
Exploring Patterns of Disturbed Eating in Psychosis: A Scoping Review.
Stogios N, Smith E, Asgariroozbehani R, Hamel L, Gdanski A, Selby P, Sockalingam S, Graff-Guerrero A, Taylor VH, Agarwal SM, Hahn MK
Nutrients 2020 Dec 18;12(12) doi: 10.3390/nu12123883. PMID: 33353080Free PMC Article
The association between first-episode psychosis and abnormal glycaemic control: systematic review and meta-analysis.
Perry BI, McIntosh G, Weich S, Singh S, Rees K
Lancet Psychiatry 2016 Nov;3(11):1049-1058. Epub 2016 Oct 5 doi: 10.1016/S2215-0366(16)30262-0. PMID: 27720402
Cognition and resting-state functional connectivity in schizophrenia.
Sheffield JM, Barch DM
Neurosci Biobehav Rev 2016 Feb;61:108-20. Epub 2015 Dec 14 doi: 10.1016/j.neubiorev.2015.12.007. PMID: 26698018Free PMC Article

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