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Elevated intestinal alkaline phosphatase

MedGen UID:
869318
•Concept ID:
C4023744
•
Finding
Synonym: Elevated intestinal ALP
 
HPO: HP:0010681

Definition

An abnormally increased level of alkaline phosphatase, intestinal type in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated intestinal alkaline phosphatase

Professional guidelines

PubMed

Teriparatide (rhPTH 1-34) treatment in the pediatric age: long-term efficacy and safety data in a cohort with genetic hypoparathyroidism.
Tuli G, Buganza R, Tessaris D, Einaudi S, Matarazzo P, de Sanctis L
Endocrine 2020 Feb;67(2):457-465. Epub 2019 Nov 8 doi: 10.1007/s12020-019-02128-z. PMID: 31705387
Hybrid classification of sphincter of Oddi dysfunction based on simplified Milwaukee criteria: effect of marginal serum liver and pancreas test elevations.
Silverman WB, Slivka A, Rabinovitz M, Wilson J
Dig Dis Sci 2001 Feb;46(2):278-81. doi: 10.1023/a:1005692530034. PMID: 11281175
Ursodeoxycholic acid in the treatment of primary sclerosing cholangitis.
Stiehl A
Ann Med 1994 Oct;26(5):345-9. doi: 10.3109/07853899409148349. PMID: 7826595

Recent clinical studies

Etiology

Alkaline Phosphatase Activity and Endotoxemia After Infant Cardiothoracic Surgery.
Davidson JA, Urban TT, Tong S, Maddux A, Hill G, Frank BS, Watson JD, Jaggers J, Simões EAF, Wischmeyer P
Shock 2019 Mar;51(3):328-336. doi: 10.1097/SHK.0000000000001162. PMID: 29664834Free PMC Article
Parenteral nutrition-associated liver complications in children.
Btaiche IF, Khalidi N
Pharmacotherapy 2002 Feb;22(2):188-211. doi: 10.1592/phco.22.3.188.33553. PMID: 11837558
Acute (ascending) cholangitis.
Hanau LH, Steigbigel NH
Infect Dis Clin North Am 2000 Sep;14(3):521-46. doi: 10.1016/s0891-5520(05)70119-7. PMID: 10987108
Metabolic effects of alcohol.
Mezey E
Fed Proc 1985 Jan;44(1 Pt 1):134-8. PMID: 3881285
Alkaline phosphatase isoenzymes.
Briere RO
CRC Crit Rev Clin Lab Sci 1978;10(1):1-30. PMID: 752443

Diagnosis

Alkaline phosphatase in clinical practice in childhood: Focus on rickets.
Cannalire G, Pilloni S, Esposito S, Biasucci G, Di Franco A, Street ME
Front Endocrinol (Lausanne) 2023;14:1111445. Epub 2023 Feb 2 doi: 10.3389/fendo.2023.1111445. PMID: 36817604Free PMC Article
Gastrointestinal manifestations of amyloidosis.
Ebert EC, Nagar M
Am J Gastroenterol 2008 Mar;103(3):776-87. Epub 2007 Dec 12 doi: 10.1111/j.1572-0241.2007.01669.x. PMID: 18076735
The osteomalacias.
Caniggia A
Ann Ital Med Int 1991 Oct-Dec;6(4 Pt 2):476-82. PMID: 1668641
Benign familial hyperphosphatasemia.
Siraganian PA, Mulvihill JJ, Mulivor RA, Miller RW
JAMA 1989 Mar 3;261(9):1310-2. PMID: 2915457
Clinical and biological significance of an isozyme tumor marker--PLAP.
Fishman WH
Clin Biochem 1987 Dec;20(6):387-92. doi: 10.1016/0009-9120(87)90003-8. PMID: 3325192

Therapy

Rifampicin induces the bone form of alkaline phosphatase in humans.
Nabil H, Kummu O, Lehenkari P, Rysä J, Risteli J, Hakkola J, Hukkanen J
Basic Clin Pharmacol Toxicol 2022 Jan;130 Suppl 1:81-94. Epub 2021 May 7 doi: 10.1111/bcpt.13586. PMID: 33851518
Alkaline Phosphatase Activity and Endotoxemia After Infant Cardiothoracic Surgery.
Davidson JA, Urban TT, Tong S, Maddux A, Hill G, Frank BS, Watson JD, Jaggers J, Simões EAF, Wischmeyer P
Shock 2019 Mar;51(3):328-336. doi: 10.1097/SHK.0000000000001162. PMID: 29664834Free PMC Article
Drug-, herb- and dietary supplement-induced liver injury.
Cavalieri ML, D'Agostino D
Arch Argent Pediatr 2017 Dec 1;115(6):e397-e403. doi: 10.5546/aap.2017.eng.e397. PMID: 29087122
Alkaline phosphatase predicts response in polycystic liver disease during somatostatin analogue therapy: a pooled analysis.
Gevers TJ, Nevens F, Torres VE, Hogan MC, Drenth JP
Liver Int 2016 Apr;36(4):595-602. Epub 2015 Nov 9 doi: 10.1111/liv.12986. PMID: 26481454Free PMC Article
Parenteral nutrition-associated liver complications in children.
Btaiche IF, Khalidi N
Pharmacotherapy 2002 Feb;22(2):188-211. doi: 10.1592/phco.22.3.188.33553. PMID: 11837558

Prognosis

Pancreaticoduodenectomy in a patient with intestinal malrotation and distal cholangiocarcinoma: a case report and review of the literature.
Arabi NA, Abdoun AA, Ali MO, Elhaj SK, Mohd SA
J Med Case Rep 2020 Sep 16;14(1):153. doi: 10.1186/s13256-020-02468-9. PMID: 32933586Free PMC Article
Alkaline phosphatase predicts response in polycystic liver disease during somatostatin analogue therapy: a pooled analysis.
Gevers TJ, Nevens F, Torres VE, Hogan MC, Drenth JP
Liver Int 2016 Apr;36(4):595-602. Epub 2015 Nov 9 doi: 10.1111/liv.12986. PMID: 26481454Free PMC Article
Gastrointestinal manifestations of amyloidosis.
Ebert EC, Nagar M
Am J Gastroenterol 2008 Mar;103(3):776-87. Epub 2007 Dec 12 doi: 10.1111/j.1572-0241.2007.01669.x. PMID: 18076735
Rotavirus causes hepatic transaminase elevation.
Teitelbaum JE, Daghistani R
Dig Dis Sci 2007 Dec;52(12):3396-8. Epub 2007 Apr 12 doi: 10.1007/s10620-007-9743-2. PMID: 17431773
Acute (ascending) cholangitis.
Hanau LH, Steigbigel NH
Infect Dis Clin North Am 2000 Sep;14(3):521-46. doi: 10.1016/s0891-5520(05)70119-7. PMID: 10987108

Clinical prediction guides

Systematic Evaluation of Clinical, Nutritional, and Fecal Microbial Factors for Their Association With Colorectal Polyps.
Schult D, Maurer HC, Frolova M, Ringelhan M, Mayr U, Ulrich J, Heilmaier M, Rasch S, Lahmer T, Reitmeier S, Hennig C, Gassner C, Thur N, Will T, Janssen KP, Steiger K, Jesinghaus M, Neuhaus K, Quante M, Haller D, Abdelhafez M, Schmid RM, Middelhoff M
Clin Transl Gastroenterol 2024 Feb 1;15(2):e00660. doi: 10.14309/ctg.0000000000000660. PMID: 38088370Free PMC Article
Modulation of pectin on intestinal barrier function via changes in microbial functional potential and bile acid metabolism.
Yin C, Wen X, Dang G, Zhong R, Meng Q, Feng X, Liu L, Wu S, He J, Chen L, Zhang H
J Nutr Biochem 2024 Feb;124:109491. Epub 2023 Oct 19 doi: 10.1016/j.jnutbio.2023.109491. PMID: 37865382
Rifampicin induces the bone form of alkaline phosphatase in humans.
Nabil H, Kummu O, Lehenkari P, Rysä J, Risteli J, Hakkola J, Hukkanen J
Basic Clin Pharmacol Toxicol 2022 Jan;130 Suppl 1:81-94. Epub 2021 May 7 doi: 10.1111/bcpt.13586. PMID: 33851518
Pancreaticoduodenectomy in a patient with intestinal malrotation and distal cholangiocarcinoma: a case report and review of the literature.
Arabi NA, Abdoun AA, Ali MO, Elhaj SK, Mohd SA
J Med Case Rep 2020 Sep 16;14(1):153. doi: 10.1186/s13256-020-02468-9. PMID: 32933586Free PMC Article
Elevated Alkaline Phosphatase in Infants With Parenteral Nutrition-Associated Liver Disease Reflects Bone Rather Than Liver Disease.
Nandivada P, Potemkin AK, Carlson SJ, Chang MI, Cowan E, O'Loughlin AA, Gura KM, Puder M
JPEN J Parenter Enteral Nutr 2015 Nov;39(8):973-6. Epub 2014 Aug 8 doi: 10.1177/0148607114545995. PMID: 25106918

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