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Elevated intestinal alkaline phosphatase

MedGen UID:
869318
•Concept ID:
C4023744
•
Finding
Synonym: Elevated intestinal ALP
 
HPO: HP:0010681

Definition

An abnormally increased level of alkaline phosphatase, intestinal type in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated intestinal alkaline phosphatase

Professional guidelines

PubMed

Teriparatide (rhPTH 1-34) treatment in the pediatric age: long-term efficacy and safety data in a cohort with genetic hypoparathyroidism.
Tuli G, Buganza R, Tessaris D, Einaudi S, Matarazzo P, de Sanctis L
Endocrine 2020 Feb;67(2):457-465. Epub 2019 Nov 8 doi: 10.1007/s12020-019-02128-z. PMID: 31705387
Prognostic factors in the operative and palliative treatment of pancreatic cancer.
Talar-Wojnarowska R, Gasiorowska A, Strzelczyk J, Janiak A, Malecka-Panas E
Neoplasma 2003;50(5):383-7. PMID: 14628094
Ursodeoxycholic acid in the treatment of primary sclerosing cholangitis.
Stiehl A
Ann Med 1994 Oct;26(5):345-9. doi: 10.3109/07853899409148349. PMID: 7826595

Recent clinical studies

Etiology

Parenteral nutrition-associated liver complications in children.
Btaiche IF, Khalidi N
Pharmacotherapy 2002 Feb;22(2):188-211. doi: 10.1592/phco.22.3.188.33553. PMID: 11837558
High serum alkaline phosphatase levels, a study in 181 Thai adult hospitalized patients.
Wiwanitkit V
BMC Fam Pract 2001;2:2. Epub 2001 Aug 24 doi: 10.1186/1471-2296-2-2. PMID: 11545676Free PMC Article
Cholesterol and bile acid metabolism in moderately advanced, stable cirrhosis of the liver.
von Bergmann K, Mok HY, Hardison WG, Grundy SM
Gastroenterology 1979 Dec;77(6):1183-92. PMID: 499706
Calcium absorption in Crohn's disease.
Krawitt EL, Beeken WL, Janney CD
Gastroenterology 1976 Aug;71(2):251-4. PMID: 939386
Chemical inhibition method for alkaline phosphatase isoenzymes in human serum.
O'Carroll D, Statland BE, Steele BW, Burke MD
Am J Clin Pathol 1975 Apr;63(4):564-72. doi: 10.1093/ajcp/63.4.564. PMID: 235209

Diagnosis

Alkaline phosphatase in clinical practice in childhood: Focus on rickets.
Cannalire G, Pilloni S, Esposito S, Biasucci G, Di Franco A, Street ME
Front Endocrinol (Lausanne) 2023;14:1111445. Epub 2023 Feb 2 doi: 10.3389/fendo.2023.1111445. PMID: 36817604Free PMC Article
Treatment of malabsorption vitamin D deficiency myopathy with intramuscular vitamin D.
Alyaarubi S, Rodd C
J Pediatr Endocrinol Metab 2005 Jul;18(7):719-22. doi: 10.1515/jpem.2005.18.7.719. PMID: 16128249
Amniotic fluid microvillar enzyme activity in fetal malformations.
Szabó M, Veress L, Teichmann F, Münnich A, Huszka M, Papp Z
Clin Genet 1990 Nov;38(5):340-5. doi: 10.1111/j.1399-0004.1990.tb03592.x. PMID: 1980862
Amebiasis. The ancient scourge is still with us.
Holtan N
Postgrad Med 1988 Jun;83(8):65-8, 72. doi: 10.1080/00325481.1988.11700302. PMID: 2897682
The clinical use of alkaline phosphatase enzymes.
Epstein E, Kiechle FL, Artiss JD, Zak B
Clin Lab Med 1986 Sep;6(3):491-505. PMID: 3527542

Therapy

Parenteral nutrition-associated liver complications in children.
Btaiche IF, Khalidi N
Pharmacotherapy 2002 Feb;22(2):188-211. doi: 10.1592/phco.22.3.188.33553. PMID: 11837558
The effect of metronidazole on TPN-associated liver dysfunction in neonates.
Kubota A, Okada A, Imura K, Kawahara H, Nezu R, Kamata S, Takagi Y
J Pediatr Surg 1990 Jun;25(6):618-21. doi: 10.1016/0022-3468(90)90347-c. PMID: 2113577
Amebiasis. The ancient scourge is still with us.
Holtan N
Postgrad Med 1988 Jun;83(8):65-8, 72. doi: 10.1080/00325481.1988.11700302. PMID: 2897682
Cholesterol and bile acid metabolism in moderately advanced, stable cirrhosis of the liver.
von Bergmann K, Mok HY, Hardison WG, Grundy SM
Gastroenterology 1979 Dec;77(6):1183-92. PMID: 499706
Calcium absorption in Crohn's disease.
Krawitt EL, Beeken WL, Janney CD
Gastroenterology 1976 Aug;71(2):251-4. PMID: 939386

Prognosis

Pancreaticoduodenectomy in a patient with intestinal malrotation and distal cholangiocarcinoma: a case report and review of the literature.
Arabi NA, Abdoun AA, Ali MO, Elhaj SK, Mohd SA
J Med Case Rep 2020 Sep 16;14(1):153. doi: 10.1186/s13256-020-02468-9. PMID: 32933586Free PMC Article
Gastrointestinal manifestations of amyloidosis.
Ebert EC, Nagar M
Am J Gastroenterol 2008 Mar;103(3):776-87. Epub 2007 Dec 12 doi: 10.1111/j.1572-0241.2007.01669.x. PMID: 18076735
Rotavirus causes hepatic transaminase elevation.
Teitelbaum JE, Daghistani R
Dig Dis Sci 2007 Dec;52(12):3396-8. Epub 2007 Apr 12 doi: 10.1007/s10620-007-9743-2. PMID: 17431773
Acute (ascending) cholangitis.
Hanau LH, Steigbigel NH
Infect Dis Clin North Am 2000 Sep;14(3):521-46. doi: 10.1016/s0891-5520(05)70119-7. PMID: 10987108
Amebiasis. The ancient scourge is still with us.
Holtan N
Postgrad Med 1988 Jun;83(8):65-8, 72. doi: 10.1080/00325481.1988.11700302. PMID: 2897682

Clinical prediction guides

BIODEGRADABLE BILIARY STENTS: A NEW APPROACH FOR THE MANAGEMENT OF HEPATICOJEJUNOSTOMY STRICTURES FOLLOWING BILE DUCT INJURY. PROSPECTIVE STUDY.
Giménez ME, Palermo M, Houghton E, Acquafresca P, Finger C, Verde JM, Cúneo JC
Arq Bras Cir Dig 2016 Apr-Jun;29(2):112-6. doi: 10.1590/0102-6720201600020012. PMID: 27438039Free PMC Article
Growth phase and low pH affect the thermal regulation of the Yersinia enterocolitica inv gene.
Pepe JC, Badger JL, Miller VL
Mol Microbiol 1994 Jan;11(1):123-35. doi: 10.1111/j.1365-2958.1994.tb00295.x. PMID: 7511772
An alternate origin for the placental isoenzyme of alkaline phosphatase.
Griffiths J
Arch Pathol Lab Med 1992 Oct;116(10):1019-24. PMID: 1417440
The effect of the topical steroid clobetasone butyrate on coeliac mucosa maintained in organ culture.
Bramble MG, Watson AJ, Record CO
Digestion 1981;21(6):316-24. doi: 10.1159/000198584. PMID: 6788633
Calcium absorption in Crohn's disease.
Krawitt EL, Beeken WL, Janney CD
Gastroenterology 1976 Aug;71(2):251-4. PMID: 939386

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