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Partial hyposmia

MedGen UID:
869339
•Concept ID:
C4023765
•
Finding
HPO: HP:0010635

Definition

Reduced ability to perceive certain odorants (implies that the sense of smell is maintained for other classes of odorants). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPartial hyposmia

Professional guidelines

PubMed

Screening performances of an 8-item UPSIT Italian version in the diagnosis of Parkinson's disease.
Landolfi A, Picillo M, Pellecchia MT, Troisi J, Amboni M, Barone P, Erro R
Neurol Sci 2023 Mar;44(3):889-895. Epub 2022 Nov 19 doi: 10.1007/s10072-022-06457-2. PMID: 36401656Free PMC Article
Differential diagnosis between constitutional delay of growth and puberty, idiopathic growth hormone deficiency and congenital hypogonadotropic hypogonadism: a clinical challenge for the pediatric endocrinologist.
Galazzi E, Persani LG
Minerva Endocrinol 2020 Dec;45(4):354-375. Epub 2020 Jul 23 doi: 10.23736/S0391-1977.20.03228-9. PMID: 32720501
Congenital hypogonadotropic hypogonadism in females: clinical spectrum, evaluation and genetics.
Bry-Gauillard H, Trabado S, Bouligand J, Sarfati J, Francou B, Salenave S, Chanson P, Brailly-Tabard S, Guiochon-Mantel A, Young J
Ann Endocrinol (Paris) 2010 May;71(3):158-62. Epub 2010 Apr 3 doi: 10.1016/j.ando.2010.02.024. PMID: 20363464

Recent clinical studies

Etiology

Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism.
Aung Y, Kokotsis V, Yin KN, Banerjee K, Butler G, Dattani MT, Dimitri P, Dunkel L, Hughes C, McGuigan M, Korbonits M, Paltoglou G, Sakka S, Shah P, Storr HL, Willemsen RH, Howard SR
Front Endocrinol (Lausanne) 2023;14:1226839. Epub 2023 Aug 28 doi: 10.3389/fendo.2023.1226839. PMID: 37701896Free PMC Article
Simultaneously complete but not partial taste and smell losses were associated with SARS-CoV-2 infection.
Trachootham D, Thongyen S, Lam-Ubol A, Chotechuang N, Pongpirul W, Prasithsirikul W
Int J Infect Dis 2021 May;106:329-337. Epub 2021 Apr 2 doi: 10.1016/j.ijid.2021.03.083. PMID: 33819604Free PMC Article
Epidemiology of smell and taste dysfunction.
Doty RL
Handb Clin Neurol 2019;164:3-13. doi: 10.1016/B978-0-444-63855-7.00001-0. PMID: 31604555
Transition in endocrinology: induction of puberty.
Dunkel L, Quinton R
Eur J Endocrinol 2014 Jun;170(6):R229-39. Epub 2014 May 17 doi: 10.1530/EJE-13-0894. PMID: 24836550
Posttraumatic olfactory loss.
Costanzo RM, Miwa T
Adv Otorhinolaryngol 2006;63:99-107. doi: 10.1159/000093753. PMID: 16733335

Diagnosis

Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism.
Aung Y, Kokotsis V, Yin KN, Banerjee K, Butler G, Dattani MT, Dimitri P, Dunkel L, Hughes C, McGuigan M, Korbonits M, Paltoglou G, Sakka S, Shah P, Storr HL, Willemsen RH, Howard SR
Front Endocrinol (Lausanne) 2023;14:1226839. Epub 2023 Aug 28 doi: 10.3389/fendo.2023.1226839. PMID: 37701896Free PMC Article
Transition in endocrinology: induction of puberty.
Dunkel L, Quinton R
Eur J Endocrinol 2014 Jun;170(6):R229-39. Epub 2014 May 17 doi: 10.1530/EJE-13-0894. PMID: 24836550
Chronic rhinosinusitis.
Ocampo CJ, Grammer LC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):205-11; quiz 212-3. Epub 2013 Feb 6 doi: 10.1016/j.jaip.2012.12.001. PMID: 24565477
Posttraumatic olfactory loss.
Costanzo RM, Miwa T
Adv Otorhinolaryngol 2006;63:99-107. doi: 10.1159/000093753. PMID: 16733335
Chemical senses.
Bartoshuk LM, Beauchamp GK
Annu Rev Psychol 1994;45:419-49. doi: 10.1146/annurev.ps.45.020194.002223. PMID: 8135507

Therapy

Anosmia or Ageusia Following COVID-19 Vaccination: A Systematic Review.
Arabzadeh Bahri R, Esmaeilpur Abianeh F, Peisepar M, Hadi R, Basti FA, Maleki S, Radkhah H
Ear Nose Throat J 2024 Jun;103(1_suppl):164S-170S. Epub 2024 Feb 27 doi: 10.1177/01455613241233098. PMID: 38411125
Comprehensive Assessment of the Functional Outcomes of Partial Turbinectomy: A Prospective Clinical Trial.
Çelik M, Altunal SK, Kocer U, Kucukguven A
Aesthetic Plast Surg 2024 Apr;48(8):1547-1556. Epub 2023 Jul 20 doi: 10.1007/s00266-023-03503-y. PMID: 37474819
The effectiveness of cerebrolysin, a multi-modal neurotrophic factor, for treatment of post-covid-19 persistent olfactory, gustatory and trigeminal chemosensory dysfunctions: a randomized clinical trial.
Hamed SA, Ahmed MAA
Expert Rev Clin Pharmacol 2023 Jul-Dec;16(12):1261-1276. Epub 2023 Dec 9 doi: 10.1080/17512433.2023.2282715. PMID: 37950370
Spectrum of Neurological Manifestations in Covid-19: A Review.
Garg RK
Neurol India 2020 May-Jun;68(3):560-572. doi: 10.4103/0028-3886.289000. PMID: 32643664
Chronic rhinosinusitis.
Ocampo CJ, Grammer LC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):205-11; quiz 212-3. Epub 2013 Feb 6 doi: 10.1016/j.jaip.2012.12.001. PMID: 24565477

Prognosis

COVID-19 reinfection after pregnancy.
Gobin L, Vallée A, Zucman D, Carbonnel M, Laperrelle J, Brugière O, Martin A, Ayoubi JM, Farfour E
Infect Dis Now 2022 Mar;52(2):101-103. Epub 2022 Jan 20 doi: 10.1016/j.idnow.2022.01.002. PMID: 35065269Free PMC Article
Simultaneously complete but not partial taste and smell losses were associated with SARS-CoV-2 infection.
Trachootham D, Thongyen S, Lam-Ubol A, Chotechuang N, Pongpirul W, Prasithsirikul W
Int J Infect Dis 2021 May;106:329-337. Epub 2021 Apr 2 doi: 10.1016/j.ijid.2021.03.083. PMID: 33819604Free PMC Article
Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients.
Yachou Y, El Idrissi A, Belapasov V, Ait Benali S
Neurol Sci 2020 Oct;41(10):2657-2669. Epub 2020 Jul 28 doi: 10.1007/s10072-020-04575-3. PMID: 32725449Free PMC Article
Chronic rhinosinusitis.
Ocampo CJ, Grammer LC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):205-11; quiz 212-3. Epub 2013 Feb 6 doi: 10.1016/j.jaip.2012.12.001. PMID: 24565477
Posttraumatic olfactory loss.
Costanzo RM, Miwa T
Adv Otorhinolaryngol 2006;63:99-107. doi: 10.1159/000093753. PMID: 16733335

Clinical prediction guides

Anosmia or Ageusia Following COVID-19 Vaccination: A Systematic Review.
Arabzadeh Bahri R, Esmaeilpur Abianeh F, Peisepar M, Hadi R, Basti FA, Maleki S, Radkhah H
Ear Nose Throat J 2024 Jun;103(1_suppl):164S-170S. Epub 2024 Feb 27 doi: 10.1177/01455613241233098. PMID: 38411125
Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism.
Aung Y, Kokotsis V, Yin KN, Banerjee K, Butler G, Dattani MT, Dimitri P, Dunkel L, Hughes C, McGuigan M, Korbonits M, Paltoglou G, Sakka S, Shah P, Storr HL, Willemsen RH, Howard SR
Front Endocrinol (Lausanne) 2023;14:1226839. Epub 2023 Aug 28 doi: 10.3389/fendo.2023.1226839. PMID: 37701896Free PMC Article
Simultaneously complete but not partial taste and smell losses were associated with SARS-CoV-2 infection.
Trachootham D, Thongyen S, Lam-Ubol A, Chotechuang N, Pongpirul W, Prasithsirikul W
Int J Infect Dis 2021 May;106:329-337. Epub 2021 Apr 2 doi: 10.1016/j.ijid.2021.03.083. PMID: 33819604Free PMC Article
Spectrum of Neurological Manifestations in Covid-19: A Review.
Garg RK
Neurol India 2020 May-Jun;68(3):560-572. doi: 10.4103/0028-3886.289000. PMID: 32643664
Epidemiology of smell and taste dysfunction.
Doty RL
Handb Clin Neurol 2019;164:3-13. doi: 10.1016/B978-0-444-63855-7.00001-0. PMID: 31604555

Recent systematic reviews

Anosmia or Ageusia Following COVID-19 Vaccination: A Systematic Review.
Arabzadeh Bahri R, Esmaeilpur Abianeh F, Peisepar M, Hadi R, Basti FA, Maleki S, Radkhah H
Ear Nose Throat J 2024 Jun;103(1_suppl):164S-170S. Epub 2024 Feb 27 doi: 10.1177/01455613241233098. PMID: 38411125
A Systematic Review of Imaging Studies in Olfactory Dysfunction Secondary to COVID-19.
Keshavarz P, Haseli S, Yazdanpanah F, Bagheri F, Raygani N, Karimi-Galougahi M
Acad Radiol 2021 Nov;28(11):1530-1540. Epub 2021 Aug 30 doi: 10.1016/j.acra.2021.08.010. PMID: 34548231Free PMC Article
Objective Sensory Testing Methods Reveal a Higher Prevalence of Olfactory Loss in COVID-19-Positive Patients Compared to Subjective Methods: A Systematic Review and Meta-Analysis.
Hannum ME, Ramirez VA, Lipson SJ, Herriman RD, Toskala AK, Lin C, Joseph PV, Reed DR
Chem Senses 2020 Dec 5;45(9):865-874. doi: 10.1093/chemse/bjaa064. PMID: 33245136Free PMC Article

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