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Increased adipose tissue

MedGen UID:
870151
•Concept ID:
C4024583
•
Finding
Synonyms: Increased Adipose Tissue; Increased fat tissue
 
HPO: HP:0009126

Definition

An increase in adipose tissue mass by hyperplastic growth (increase in the number of adipocytes) or by hypertrophic growth (increase in the size of adipocytes occurring primarily by lipid accumulation within the cell). [from HPO]

Conditions with this feature

Congenital muscular dystrophy with cataracts and intellectual disability
MedGen UID:
1382291
•Concept ID:
C4479410
•
Disease or Syndrome
MDCCAID is an autosomal recessive form of muscular dystrophy with onset of progressive muscle weakness in early childhood. Almost all patients also have early-onset cataracts, most have impaired intellectual development of varying severity, and some have seizures (summary by Wiessner et al., 2017 and Osborn et al., 2017).
See: Condition Record
Congenital muscular dystrophy with cataracts and intellectual disability

Professional guidelines

PubMed

Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis.
Lee KC, Wu PS, Lin HC
Clin Mol Hepatol 2023 Jan;29(1):77-98. Epub 2022 Oct 13 doi: 10.3350/cmh.2022.0237. PMID: 36226471Free PMC Article
Potential application of testosterone replacement therapy as treatment for obesity and type 2 diabetes in men.
Fink J, Matsumoto M, Tamura Y
Steroids 2018 Oct;138:161-166. Epub 2018 Aug 15 doi: 10.1016/j.steroids.2018.08.002. PMID: 30118780

Recent clinical studies

Etiology

Immunogenetic Aspects of Sarcopenic Obesity.
Mazurkiewicz Ł, Czernikiewicz K, Grygiel-Górniak B
Genes (Basel) 2024 Feb 5;15(2) doi: 10.3390/genes15020206. PMID: 38397196Free PMC Article
Sarcopenic obesity in older adults: a clinical overview.
Prado CM, Batsis JA, Donini LM, Gonzalez MC, Siervo M
Nat Rev Endocrinol 2024 May;20(5):261-277. Epub 2024 Feb 6 doi: 10.1038/s41574-023-00943-z. PMID: 38321142
Increased Adipose Tissue Fibrogenesis, Not Impaired Expandability, Is Associated With Nonalcoholic Fatty Liver Disease.
Beals JW, Smith GI, Shankaran M, Fuchs A, Schweitzer GG, Yoshino J, Field T, Matthews M, Nyangau E, Morozov D, Mittendorfer B, Hellerstein MK, Klein S
Hepatology 2021 Sep;74(3):1287-1299. Epub 2021 Jun 22 doi: 10.1002/hep.31822. PMID: 33743554Free PMC Article
Ceramide and sphingosine 1-phosphate in adipose dysfunction.
Fang Z, Pyne S, Pyne NJ
Prog Lipid Res 2019 Apr;74:145-159. Epub 2019 Apr 2 doi: 10.1016/j.plipres.2019.04.001. PMID: 30951736
Obesity and lung inflammation.
Mancuso P
J Appl Physiol (1985) 2010 Mar;108(3):722-8. Epub 2009 Oct 29 doi: 10.1152/japplphysiol.00781.2009. PMID: 19875709Free PMC Article

Diagnosis

Sarcopenic obesity in older adults: a clinical overview.
Prado CM, Batsis JA, Donini LM, Gonzalez MC, Siervo M
Nat Rev Endocrinol 2024 May;20(5):261-277. Epub 2024 Feb 6 doi: 10.1038/s41574-023-00943-z. PMID: 38321142
Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications.
Zorena K, Jachimowicz-Duda O, Ślęzak D, Robakowska M, Mrugacz M
Int J Mol Sci 2020 May 18;21(10) doi: 10.3390/ijms21103570. PMID: 32443588Free PMC Article
Ceramide and sphingosine 1-phosphate in adipose dysfunction.
Fang Z, Pyne S, Pyne NJ
Prog Lipid Res 2019 Apr;74:145-159. Epub 2019 Apr 2 doi: 10.1016/j.plipres.2019.04.001. PMID: 30951736
Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis.
Armstrong MJ, Hull D, Guo K, Barton D, Hazlehurst JM, Gathercole LL, Nasiri M, Yu J, Gough SC, Newsome PN, Tomlinson JW
J Hepatol 2016 Feb;64(2):399-408. Epub 2015 Sep 21 doi: 10.1016/j.jhep.2015.08.038. PMID: 26394161Free PMC Article
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.
Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB
Cell 2014 Oct 9;159(2):318-32. doi: 10.1016/j.cell.2014.09.035. PMID: 25303528Free PMC Article

Therapy

Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis.
Armstrong MJ, Hull D, Guo K, Barton D, Hazlehurst JM, Gathercole LL, Nasiri M, Yu J, Gough SC, Newsome PN, Tomlinson JW
J Hepatol 2016 Feb;64(2):399-408. Epub 2015 Sep 21 doi: 10.1016/j.jhep.2015.08.038. PMID: 26394161Free PMC Article
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.
Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB
Cell 2014 Oct 9;159(2):318-32. doi: 10.1016/j.cell.2014.09.035. PMID: 25303528Free PMC Article
Adipose tissue and ceramide biosynthesis in the pathogenesis of obesity.
Samad F, Badeanlou L, Shah C, Yang G
Adv Exp Med Biol 2011;721:67-86. doi: 10.1007/978-1-4614-0650-1_5. PMID: 21910083
Obesity and lung inflammation.
Mancuso P
J Appl Physiol (1985) 2010 Mar;108(3):722-8. Epub 2009 Oct 29 doi: 10.1152/japplphysiol.00781.2009. PMID: 19875709Free PMC Article
Adipokines, inflammation, and the endothelium in diabetes.
Aldhahi W, Hamdy O
Curr Diab Rep 2003 Aug;3(4):293-8. doi: 10.1007/s11892-003-0020-2. PMID: 12866991

Prognosis

Increased adipose tissue is associated with improved overall survival, independent of skeletal muscle mass in non-small cell lung cancer.
Tao J, Fang J, Chen L, Liang C, Chen B, Wang Z, Wu Y, Zhang J
J Cachexia Sarcopenia Muscle 2023 Dec;14(6):2591-2601. Epub 2023 Sep 19 doi: 10.1002/jcsm.13333. PMID: 37724690Free PMC Article
Increased Adipose Tissue Indices of Androgen Catabolism and Aromatization in Women With Metabolic Dysfunction.
Ostinelli G, Laforest S, Denham SG, Gauthier MF, Drolet-Labelle V, Scott E, Hould FS, Marceau S, Homer NZM, Bégin C, Andrew R, Tchernof A
J Clin Endocrinol Metab 2022 Jul 14;107(8):e3330-e3342. doi: 10.1210/clinem/dgac261. PMID: 35511873Free PMC Article
Human CD206+ macrophages associate with diabetes and adipose tissue lymphoid clusters.
Muir LA, Cho KW, Geletka LM, Baker NA, Flesher CG, Ehlers AP, Kaciroti N, Lindsly S, Ronquist S, Rajapakse I, O'Rourke RW, Lumeng CN
JCI Insight 2022 Feb 8;7(3) doi: 10.1172/jci.insight.146563. PMID: 34990410Free PMC Article
Review article: prognostic significance of body composition abnormalities in patients with cirrhosis.
Ebadi M, Bhanji RA, Tandon P, Mazurak V, Baracos VE, Montano-Loza AJ
Aliment Pharmacol Ther 2020 Aug;52(4):600-618. Epub 2020 Jul 3 doi: 10.1111/apt.15927. PMID: 32621329
Adipose tissue location and contribution to postinjury hypercoagulability.
Winfield RD, Mellnick VM, Chamieh J, Nohra E, Tan WH, Ramirez R, Raptis C, Turnbull IR, Bochicchio K, Reese S, Spinella PC, Bochicchio GV
J Trauma Acute Care Surg 2016 Jul;81(1):79-85. doi: 10.1097/TA.0000000000001096. PMID: 27120319

Clinical prediction guides

Increased adipose tissue is associated with improved overall survival, independent of skeletal muscle mass in non-small cell lung cancer.
Tao J, Fang J, Chen L, Liang C, Chen B, Wang Z, Wu Y, Zhang J
J Cachexia Sarcopenia Muscle 2023 Dec;14(6):2591-2601. Epub 2023 Sep 19 doi: 10.1002/jcsm.13333. PMID: 37724690Free PMC Article
The effect of obesity on adipose-derived stromal cells and adipose tissue and their impact on cancer.
Bunnell BA, Martin EC, Matossian MD, Brock CK, Nguyen K, Collins-Burow B, Burow ME
Cancer Metastasis Rev 2022 Sep;41(3):549-573. Epub 2022 Aug 24 doi: 10.1007/s10555-022-10063-1. PMID: 35999486
Exercise and GLUT4 in human subcutaneous adipose tissue.
Flores-Opazo M, Boland E, Garnham A, Murphy RM, McGee SL, Hargreaves M
Physiol Rep 2018 Nov;6(22):e13918. doi: 10.14814/phy2.13918. PMID: 30450826Free PMC Article
Adipose tissue location and contribution to postinjury hypercoagulability.
Winfield RD, Mellnick VM, Chamieh J, Nohra E, Tan WH, Ramirez R, Raptis C, Turnbull IR, Bochicchio K, Reese S, Spinella PC, Bochicchio GV
J Trauma Acute Care Surg 2016 Jul;81(1):79-85. doi: 10.1097/TA.0000000000001096. PMID: 27120319
Role of adipose tissue in haemostasis, coagulation and fibrinolysis.
Faber DR, de Groot PG, Visseren FL
Obes Rev 2009 Sep;10(5):554-63. Epub 2009 May 12 doi: 10.1111/j.1467-789X.2009.00593.x. PMID: 19460118

Recent systematic reviews

CHEMERIN AND FACTORS RELATED TO CARDIOVASCULAR RISK IN CHILDREN AND ADOLESCENTS: A SYSTEMATIC REVIEW.
Fontes VS, Neves FS, Cândido APC
Rev Paul Pediatr 2018 Apr-Jun;36(2):221-229. Epub 2018 Jan 15 doi: 10.1590/1984-0462/;2018;36;2;00003. PMID: 29412431Free PMC Article

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