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Early cutaneous photosensitivity

MedGen UID:
870443
•Concept ID:
C4024889
•
Finding
Synonym: Sun sensitivity occurring early in life
 
HPO: HP:0007396

Definition

Photosensitivity of the skin occurring early in life. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEarly cutaneous photosensitivity

Conditions with this feature

Cutaneous photosensitivity-lethal colitis syndrome
MedGen UID:
347455
•Concept ID:
C1857449
•
Disease or Syndrome
A rare inflammatory bowel disease characterized by early cutaneous photosensitivity manifesting by sun-induced facial erythematous and vesicular lesions and severe recurent colitis which lead to untreatable diarrhea. There have been no further descriptions in the literature since 1991.
See: Condition Record
Cutaneous photosensitivity-lethal colitis syndrome

Professional guidelines

PubMed

Evidence-based consensus guidelines for the diagnosis and management of erythropoietic protoporphyria and X-linked protoporphyria.
Dickey AK, Naik H, Keel SB, Levy C, Beaven SW, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Rudnick SR, Saberi B, Thapar M, Ungar J, Wang B, Balwani M; Porphyrias Consortium of the Rare Diseases Clinical Research Network
J Am Acad Dermatol 2023 Dec;89(6):1227-1237. Epub 2022 Aug 27 doi: 10.1016/j.jaad.2022.08.036. PMID: 36041558Free PMC Article
Treatment and Prevention of Pediatric Sunburn.
Dowd MD
Pediatr Ann 2019 Jun 1;48(6):e213-e214. doi: 10.3928/19382359-20190520-02. PMID: 31185109
Cutaneous Adverse Events of New Anti-melanoma Therapies: Classification and Management.
Hwang SJ, Anforth R, Carlos G, Fernandez-Peñas P
Actas Dermosifiliogr 2017 Jan-Feb;108(1):6-16. Epub 2016 Sep 15 doi: 10.1016/j.ad.2016.05.019. PMID: 27642030

Recent clinical studies

Etiology

Challenges in Sun Protection.
Surber C, Osterwalder U
Curr Probl Dermatol 2021;55:1-43. Epub 2021 Oct 25 doi: 10.1159/000517590. PMID: 34698021
Mild cutaneous reactions to drugs.
Crisafulli G, Franceschini F, Caimmi S, Bottau P, Liotti L, Saretta F, Bernardini R, Cardinale F, Mori F, Caffarelli C
Acta Biomed 2019 Jan 28;90(3-S):36-43. doi: 10.23750/abm.v90i3-S.8159. PMID: 30830060Free PMC Article
HLA-Cw6 and psoriasis.
Chen L, Tsai TF
Br J Dermatol 2018 Apr;178(4):854-862. Epub 2018 Mar 2 doi: 10.1111/bjd.16083. PMID: 29072309
Xeroderma pigmentosum.
Lehmann AR, McGibbon D, Stefanini M
Orphanet J Rare Dis 2011 Nov 1;6:70. doi: 10.1186/1750-1172-6-70. PMID: 22044607Free PMC Article
Porphyrias.
Puy H, Gouya L, Deybach JC
Lancet 2010 Mar 13;375(9718):924-37. doi: 10.1016/S0140-6736(09)61925-5. PMID: 20226990

Diagnosis

APE1-dependent base excision repair of DNA photodimers in human cells.
Gautam A, Fawcett H, Burdova K, Brazina J, Caldecott KW
Mol Cell 2023 Oct 19;83(20):3669-3678.e7. Epub 2023 Oct 9 doi: 10.1016/j.molcel.2023.09.013. PMID: 37816354
Evidence-based consensus guidelines for the diagnosis and management of erythropoietic protoporphyria and X-linked protoporphyria.
Dickey AK, Naik H, Keel SB, Levy C, Beaven SW, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Rudnick SR, Saberi B, Thapar M, Ungar J, Wang B, Balwani M; Porphyrias Consortium of the Rare Diseases Clinical Research Network
J Am Acad Dermatol 2023 Dec;89(6):1227-1237. Epub 2022 Aug 27 doi: 10.1016/j.jaad.2022.08.036. PMID: 36041558Free PMC Article
Lupus erythematosus revisited.
Kuhn A, Wenzel J, Bijl M
Semin Immunopathol 2016 Jan;38(1):97-112. Epub 2015 Dec 4 doi: 10.1007/s00281-015-0550-0. PMID: 26637330
Xeroderma pigmentosum.
Lehmann AR, McGibbon D, Stefanini M
Orphanet J Rare Dis 2011 Nov 1;6:70. doi: 10.1186/1750-1172-6-70. PMID: 22044607Free PMC Article
Porphyrias.
Puy H, Gouya L, Deybach JC
Lancet 2010 Mar 13;375(9718):924-37. doi: 10.1016/S0140-6736(09)61925-5. PMID: 20226990

Therapy

Childhood sunburn and risk of melanoma and non-melanoma skin cancer: a Mendelian randomization study.
Li Y, Wu J, Cao Z
Environ Sci Pollut Res Int 2023 Dec;30(58):122011-122023. Epub 2023 Nov 14 doi: 10.1007/s11356-023-30535-3. PMID: 37962759Free PMC Article
Challenges in Sun Protection.
Surber C, Osterwalder U
Curr Probl Dermatol 2021;55:1-43. Epub 2021 Oct 25 doi: 10.1159/000517590. PMID: 34698021
Lupus erythematosus revisited.
Kuhn A, Wenzel J, Bijl M
Semin Immunopathol 2016 Jan;38(1):97-112. Epub 2015 Dec 4 doi: 10.1007/s00281-015-0550-0. PMID: 26637330
Photodynamic therapy.
Davila ML
Gastrointest Endosc Clin N Am 2011 Jan;21(1):67-79. doi: 10.1016/j.giec.2010.09.002. PMID: 21112498
Erythropoietic protoporphyria.
Todd DJ
Br J Dermatol 1994 Dec;131(6):751-66. doi: 10.1111/j.1365-2133.1994.tb08577.x. PMID: 7857832

Prognosis

Challenges in Sun Protection.
Surber C, Osterwalder U
Curr Probl Dermatol 2021;55:1-43. Epub 2021 Oct 25 doi: 10.1159/000517590. PMID: 34698021
HLA-Cw6 and psoriasis.
Chen L, Tsai TF
Br J Dermatol 2018 Apr;178(4):854-862. Epub 2018 Mar 2 doi: 10.1111/bjd.16083. PMID: 29072309
Xeroderma Pigmentosum.
Black JO
Head Neck Pathol 2016 Jun;10(2):139-44. Epub 2016 Mar 14 doi: 10.1007/s12105-016-0707-8. PMID: 26975629Free PMC Article
Xeroderma pigmentosum.
Lehmann AR, McGibbon D, Stefanini M
Orphanet J Rare Dis 2011 Nov 1;6:70. doi: 10.1186/1750-1172-6-70. PMID: 22044607Free PMC Article
Erythropoietic protoporphyria.
Lecha M, Puy H, Deybach JC
Orphanet J Rare Dis 2009 Sep 10;4:19. doi: 10.1186/1750-1172-4-19. PMID: 19744342Free PMC Article

Clinical prediction guides

Childhood sunburn and risk of melanoma and non-melanoma skin cancer: a Mendelian randomization study.
Li Y, Wu J, Cao Z
Environ Sci Pollut Res Int 2023 Dec;30(58):122011-122023. Epub 2023 Nov 14 doi: 10.1007/s11356-023-30535-3. PMID: 37962759Free PMC Article
Xeroderma pigmentosum in Yemen.
Khatri ML
Int J Dermatol 2021 Mar;60(3):314-320. Epub 2021 Feb 4 doi: 10.1111/ijd.15395. PMID: 33538348
Photosensitivity and cancer immune-targeted therapies.
Lembo S, Raimondo A, Conti V, Venturini M
Photodermatol Photoimmunol Photomed 2020 May;36(3):172-178. Epub 2020 Feb 11 doi: 10.1111/phpp.12533. PMID: 31978248
HLA-Cw6 and psoriasis.
Chen L, Tsai TF
Br J Dermatol 2018 Apr;178(4):854-862. Epub 2018 Mar 2 doi: 10.1111/bjd.16083. PMID: 29072309
Lupus erythematosus revisited.
Kuhn A, Wenzel J, Bijl M
Semin Immunopathol 2016 Jan;38(1):97-112. Epub 2015 Dec 4 doi: 10.1007/s00281-015-0550-0. PMID: 26637330

Recent systematic reviews

Xeroderma Pigmentosum: A Genetic Condition Skin Cancer Correlated-A Systematic Review.
Brambullo T, Colonna MR, Vindigni V, Piaserico S, Masciopinto G, Galeano M, Costa AL, Bassetto F
Biomed Res Int 2022;2022:8549532. Epub 2022 Jul 18 doi: 10.1155/2022/8549532. PMID: 35898688Free PMC Article
Isolated solar angioedema: A systematic review of the literature.
Aronovich A, Snast I, Lapidoth M, Leshem YA, Enk CD, Tal Y, Mimouni D, Hodak E, Levi A
Photodermatol Photoimmunol Photomed 2021 Sep;37(5):431-438. Epub 2021 Mar 27 doi: 10.1111/phpp.12677. PMID: 33738834
Inherited genetic late-onset erythropoietic protoporphyria: A systematic review of the literature.
Noyman Y, Edel Y, Snast I, Sherman S, Kaftory R, Lapidoth M, Mimouni D, Hodak E, Levi A
Photodermatol Photoimmunol Photomed 2021 Sep;37(5):374-379. Epub 2021 Feb 21 doi: 10.1111/phpp.12667. PMID: 33556208
A systematic review and meta-analysis of cutaneous manifestations in late- versus early-onset systemic lupus erythematosus.
Medlin JL, Hansen KE, Fitz SR, Bartels CM
Semin Arthritis Rheum 2016 Jun;45(6):691-7. Epub 2016 Jan 21 doi: 10.1016/j.semarthrit.2016.01.004. PMID: 26972993Free PMC Article
Juvenile spring eruption: an outbreak report and systematic review of the literature.
Lava SA, Simonetti GD, Ragazzi M, Guarino Gubler S, Bianchetti MG
Br J Dermatol 2013 May;168(5):1066-72. doi: 10.1111/bjd.12197. PMID: 23374016

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