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Abnormality of tibial epiphyses

MedGen UID:: 870581
•Concept ID:: C4025030
•: Anatomical Abnormality

Synonym:	Abnormality of end part of shinbone

HPO:	HP:0006508

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormality of tibial epiphyses

Abnormal skeletal morphology
- Abnormal appendicular skeleton morphology
  - Abnormal long bone morphology
    - Abnormal epiphysis morphology
      - Abnormal limb epiphysis morphology
        Abnormal lower limb epiphysis morphology
        Abnormality of tibial epiphyses
        Abnormality of the distal tibial epiphysis
        Enlarged distal tibial epiphysis
        Abnormality of the proximal tibial epiphysis
        Irregular proximal tibial epiphyses
        Small proximal tibial epiphyses
        Delayed tibial epiphyseal ossification

Professional guidelines

PubMed

N-acetylcysteine treatment ameliorates the skeletal phenotype of a mouse model of diastrophic dysplasia.

Monti L, Paganini C, Lecci S, De Leonardis F, Hay E, Cohen-Solal M, Villani S, Superti-Furga A, Tenni R, Forlino A, Rossi A
Hum Mol Genet 2015 Oct 1;24(19):5570-80. Epub 2015 Jul 23 doi: 10.1093/hmg/ddv289. PMID: 26206888

Dysplasia epiphysealis hemimelica: diagnosis and treatment.

Keret D, Spatz DK, Caro PA, Mason DE
J Pediatr Orthop 1992 May-Jun;12(3):365-72. doi: 10.1097/01241398-199205000-00016. PMID: 1573003

Origin and treatment of fractures in spina bifida.

Parsch K
Eur J Pediatr Surg 1991 Oct;1(5):298-305. doi: 10.1055/s-2008-1042509. PMID: 1747363

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Recent clinical studies

Etiology

Apophysitis and Osteochondrosis: Common Causes of Pain in Growing Bones.

Achar S, Yamanaka J
Am Fam Physician 2019 May 15;99(10):610-618. PMID: 31083875

A retrospective analysis of treatment and outcomes in patients with late onset tibia vara.

Rauh MA, Armstrong DG
Orthopedics 2008 Jan;31(1):71. doi: 10.3928/01477447-20080101-39. PMID: 19292167

Trevor's disease: the clinical manifestations and treatment of dysplasia epiphysealis hemimelica.

Smith EL, Raney EM, Matzkin EG, Fillman RR, Yandow SM
J Pediatr Orthop B 2007 Jul;16(4):297-302. doi: 10.1097/BPB.0b013e328092563f. PMID: 17527110

Percutaneous epiphysiodesis using transphyseal screws (PETS): prospective case study and review.

Nouth F, Kuo LA
J Pediatr Orthop 2004 Nov-Dec;24(6):721-5. PMID: 15502577

Dutch variant of Bellini metaphyseal dysplasia: report of two siblings.

Kozlowski K, Meradji M, Beemer FA
Australas Radiol 1995 Aug;39(3):282-6. doi: 10.1111/j.1440-1673.1995.tb00293.x. PMID: 7487766

See all (134)

Diagnosis

Trevor's disease of the distal radioulnar joint in two children with achondroplasia.

Kopriva JM, Miller KJ, Legare JM, Noonan KJ
Am J Med Genet A 2020 May;182(5):1249-1254. Epub 2020 Feb 29 doi: 10.1002/ajmg.a.61529. PMID: 32112622

Apophysitis and Osteochondrosis: Common Causes of Pain in Growing Bones.

Achar S, Yamanaka J
Am Fam Physician 2019 May 15;99(10):610-618. PMID: 31083875

A retrospective analysis of treatment and outcomes in patients with late onset tibia vara.

Rauh MA, Armstrong DG
Orthopedics 2008 Jan;31(1):71. doi: 10.3928/01477447-20080101-39. PMID: 19292167

Common lower extremity problems in children.

Wells L
Prim Care 1996 Jun;23(2):299-303. doi: 10.1016/s0095-4543(05)70277-3. PMID: 8784931

Dysplasia epiphysealis hemimelica: diagnosis and treatment.

Keret D, Spatz DK, Caro PA, Mason DE
J Pediatr Orthop 1992 May-Jun;12(3):365-72. doi: 10.1097/01241398-199205000-00016. PMID: 1573003

See all (109)

Therapy

Analysis of the effects of isotretinoin on the premature epiphyseal closure in pediatric populations: a literature review.

Alazawi S, Hendriksz T
J Osteopath Med 2021 Oct 11;122(1):45-53. doi: 10.1515/jom-2021-0108. PMID: 34626532

Failure of tension band plating: a case series.

Masquijo JJ, Firth GB, Sepúlveda D
J Pediatr Orthop B 2017 Sep;26(5):449-453. doi: 10.1097/BPB.0000000000000367. PMID: 27398644

Growth Abnormalities Following Anterior Cruciate Ligament Reconstruction in the Skeletally Immature Patient: A Systematic Review.

Collins MJ, Arns TA, Leroux T, Black A, Mascarenhas R, Bach BR Jr, Forsythe B
Arthroscopy 2016 Aug;32(8):1714-23. Epub 2016 May 7 doi: 10.1016/j.arthro.2016.02.025. PMID: 27161510

Hemiepiphysiodesis for posttraumatic tibial valgus.

Stevens PM, Pease F
J Pediatr Orthop 2006 May-Jun;26(3):385-92. doi: 10.1097/01.bpo.0000206515.84577.70. PMID: 16670554

Syphilis returns to the suburbs.

Hargrove A, Curtis N
Eur J Pediatr 2006 May;165(5):290-2. Epub 2006 Jan 13 doi: 10.1007/s00431-005-0050-7. PMID: 16411090

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Prognosis

The Immature Pediatric Appendicular Skeleton.

Nguyen JC, Caine D
Semin Musculoskelet Radiol 2024 Aug;28(4):361-374. Epub 2024 Jul 29 doi: 10.1055/s-0044-1786151. PMID: 39074720

Tall stature: a difficult diagnosis?

Meazza C, Gertosio C, Giacchero R, Pagani S, Bozzola M
Ital J Pediatr 2017 Aug 3;43(1):66. doi: 10.1186/s13052-017-0385-5. PMID: 28774346 Free PMC Article

Dysplasia epiphysealis hemimelica: a huge articular mass with unpredictable surgical results.

Luevitoonvechkij S, Khunsree S, Sirirungruangsarn Y, Settakorn J
BMJ Case Rep 2012 Nov 21;2012 doi: 10.1136/bcr-2012-007259. PMID: 23175015 Free PMC Article

Percutaneous epiphysiodesis using transphyseal screws (PETS): prospective case study and review.

Nouth F, Kuo LA
J Pediatr Orthop 2004 Nov-Dec;24(6):721-5. PMID: 15502577

'Epiphyseal dysgenesis' in Laurence-Moon-Biedl-Bardet syndrome.

Moses G, Howard C, Bar-Ziv J, Dekel S, Nyska M
J Pediatr Orthop B 1998 Jul;7(3):193-8. doi: 10.1097/01202412-199807000-00003. PMID: 9702668

See all (76)

Clinical prediction guides

Trevor's disease of the distal radioulnar joint in two children with achondroplasia.

Kopriva JM, Miller KJ, Legare JM, Noonan KJ
Am J Med Genet A 2020 May;182(5):1249-1254. Epub 2020 Feb 29 doi: 10.1002/ajmg.a.61529. PMID: 32112622

Tall stature: a difficult diagnosis?

Meazza C, Gertosio C, Giacchero R, Pagani S, Bozzola M
Ital J Pediatr 2017 Aug 3;43(1):66. doi: 10.1186/s13052-017-0385-5. PMID: 28774346 Free PMC Article

Physeal bar equivalent.

Peterson HA, Shaughnessy WJ, Stans AA
J Pediatr Orthop B 2017 Nov;26(6):507-514. doi: 10.1097/BPB.0000000000000384. PMID: 27748675

Growth plate forces in the adolescent human knee: a radiographic and mechanical study of epiphyseal staples.

Bylski-Austrow DI, Wall EJ, Rupert MP, Roy DR, Crawford AH
J Pediatr Orthop 2001 Nov-Dec;21(6):817-23. PMID: 11675562

Fibular shortening in poliomyelitis.

Sharma OP, Sharma N, Patond KR
Indian J Pediatr 1994 Jan-Feb;61(1):71-4. doi: 10.1007/BF02753561. PMID: 7927601

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Recent systematic reviews

A Chinese case of CHST3-related skeletal dysplasia and a systematic review.

Liang H, Qi W, Jin C, Pang Q, Cui L, Jiang Y, Wang O, Li M, Xing X, Liu W, Xia W
Endocrine 2023 Jun;80(3):658-668. Epub 2023 Feb 2 doi: 10.1007/s12020-023-03303-z. PMID: 36729370

Growth Abnormalities Following Anterior Cruciate Ligament Reconstruction in the Skeletally Immature Patient: A Systematic Review.

Collins MJ, Arns TA, Leroux T, Black A, Mascarenhas R, Bach BR Jr, Forsythe B
Arthroscopy 2016 Aug;32(8):1714-23. Epub 2016 May 7 doi: 10.1016/j.arthro.2016.02.025. PMID: 27161510

Treatment of dysplasia epiphysealis hemimelica: a systematic review of published reports and a report of seven patients.

Struijs PA, Kerkhoffs GM, Besselaar PP
J Foot Ankle Surg 2012 Sep-Oct;51(5):620-6. Epub 2012 Jul 21 doi: 10.1053/j.jfas.2012.05.008. PMID: 22819617

See all (3)

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Abnormality of tibial epiphyses

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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