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Moderate generalized osteoporosis

MedGen UID:
870709
•Concept ID:
C4025163
•
Disease or Syndrome
Synonym: Moderate generalised osteoporosis
 
HPO: HP:0005653

Definition

Moderate osteoporosis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerate generalized osteoporosis

Professional guidelines

PubMed

Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.
Ayers C, Kansagara D, Lazur B, Fu R, Kwon A, Harrod C
Ann Intern Med 2023 Feb;176(2):182-195. Epub 2023 Jan 3 doi: 10.7326/M22-0684. PMID: 36592455
International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines.
Izquierdo M, Merchant RA, Morley JE, Anker SD, Aprahamian I, Arai H, Aubertin-Leheudre M, Bernabei R, Cadore EL, Cesari M, Chen LK, de Souto Barreto P, Duque G, Ferrucci L, Fielding RA, García-Hermoso A, Gutiérrez-Robledo LM, Harridge SDR, Kirk B, Kritchevsky S, Landi F, Lazarus N, Martin FC, Marzetti E, Pahor M, Ramírez-Vélez R, Rodriguez-Mañas L, Rolland Y, Ruiz JG, Theou O, Villareal DT, Waters DL, Won Won C, Woo J, Vellas B, Fiatarone Singh M
J Nutr Health Aging 2021;25(7):824-853. doi: 10.1007/s12603-021-1665-8. PMID: 34409961
Prevention and treatment of postmenopausal osteoporosis.
Tella SH, Gallagher JC
J Steroid Biochem Mol Biol 2014 Jul;142:155-70. Epub 2013 Oct 29 doi: 10.1016/j.jsbmb.2013.09.008. PMID: 24176761Free PMC Article

Recent clinical studies

Etiology

Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.
Ayers C, Kansagara D, Lazur B, Fu R, Kwon A, Harrod C
Ann Intern Med 2023 Feb;176(2):182-195. Epub 2023 Jan 3 doi: 10.7326/M22-0684. PMID: 36592455
Healthy Aging-Nutrition Matters: Start Early and Screen Often.
Roberts SB, Silver RE, Das SK, Fielding RA, Gilhooly CH, Jacques PF, Kelly JM, Mason JB, McKeown NM, Reardon MA, Rowan S, Saltzman E, Shukitt-Hale B, Smith CE, Taylor AA, Wu D, Zhang FF, Panetta K, Booth S
Adv Nutr 2021 Jul 30;12(4):1438-1448. doi: 10.1093/advances/nmab032. PMID: 33838032Free PMC Article
2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis.
Buckley L, Guyatt G, Fink HA, Cannon M, Grossman J, Hansen KE, Humphrey MB, Lane NE, Magrey M, Miller M, Morrison L, Rao M, Robinson AB, Saha S, Wolver S, Bannuru RR, Vaysbrot E, Osani M, Turgunbaev M, Miller AS, McAlindon T
Arthritis Rheumatol 2017 Aug;69(8):1521-1537. Epub 2017 Jun 6 doi: 10.1002/art.40137. PMID: 28585373
Long-term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J
Cochrane Database Syst Rev 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5. PMID: 28093732Free PMC Article
Prevention and treatment of postmenopausal osteoporosis.
Tella SH, Gallagher JC
J Steroid Biochem Mol Biol 2014 Jul;142:155-70. Epub 2013 Oct 29 doi: 10.1016/j.jsbmb.2013.09.008. PMID: 24176761Free PMC Article

Diagnosis

Calcium and vitamin D for increasing bone mineral density in premenopausal women.
Méndez-Sánchez L, Clark P, Winzenberg TM, Tugwell P, Correa-Burrows P, Costello R
Cochrane Database Syst Rev 2023 Jan 27;1(1):CD012664. doi: 10.1002/14651858.CD012664.pub2. PMID: 36705288Free PMC Article
Machine Learning Solutions for Osteoporosis-A Review.
Smets J, Shevroja E, Hügle T, Leslie WD, Hans D
J Bone Miner Res 2021 May;36(5):833-851. Epub 2021 Apr 4 doi: 10.1002/jbmr.4292. PMID: 33751686
Managing Menopausal Symptoms and Associated Clinical Issues in Breast Cancer Survivors.
Santen RJ, Stuenkel CA, Davis SR, Pinkerton JV, Gompel A, Lumsden MA
J Clin Endocrinol Metab 2017 Oct 1;102(10):3647-3661. doi: 10.1210/jc.2017-01138. PMID: 28934376
Osteoporosis: the emperor has no clothes.
Järvinen TL, Michaëlsson K, Aspenberg P, Sievänen H
J Intern Med 2015 Jun;277(6):662-73. doi: 10.1111/joim.12366. PMID: 25809279Free PMC Article
Prevention and treatment of postmenopausal osteoporosis.
Tella SH, Gallagher JC
J Steroid Biochem Mol Biol 2014 Jul;142:155-70. Epub 2013 Oct 29 doi: 10.1016/j.jsbmb.2013.09.008. PMID: 24176761Free PMC Article

Therapy

Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.
Ayers C, Kansagara D, Lazur B, Fu R, Kwon A, Harrod C
Ann Intern Med 2023 Feb;176(2):182-195. Epub 2023 Jan 3 doi: 10.7326/M22-0684. PMID: 36592455
International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines.
Izquierdo M, Merchant RA, Morley JE, Anker SD, Aprahamian I, Arai H, Aubertin-Leheudre M, Bernabei R, Cadore EL, Cesari M, Chen LK, de Souto Barreto P, Duque G, Ferrucci L, Fielding RA, García-Hermoso A, Gutiérrez-Robledo LM, Harridge SDR, Kirk B, Kritchevsky S, Landi F, Lazarus N, Martin FC, Marzetti E, Pahor M, Ramírez-Vélez R, Rodriguez-Mañas L, Rolland Y, Ruiz JG, Theou O, Villareal DT, Waters DL, Won Won C, Woo J, Vellas B, Fiatarone Singh M
J Nutr Health Aging 2021;25(7):824-853. doi: 10.1007/s12603-021-1665-8. PMID: 34409961
Healthy Aging-Nutrition Matters: Start Early and Screen Often.
Roberts SB, Silver RE, Das SK, Fielding RA, Gilhooly CH, Jacques PF, Kelly JM, Mason JB, McKeown NM, Reardon MA, Rowan S, Saltzman E, Shukitt-Hale B, Smith CE, Taylor AA, Wu D, Zhang FF, Panetta K, Booth S
Adv Nutr 2021 Jul 30;12(4):1438-1448. doi: 10.1093/advances/nmab032. PMID: 33838032Free PMC Article
A Nutraceutical Approach to Menopausal Complaints.
De Franciscis P, Colacurci N, Riemma G, Conte A, Pittana E, Guida M, Schiattarella A
Medicina (Kaunas) 2019 Aug 28;55(9) doi: 10.3390/medicina55090544. PMID: 31466381Free PMC Article
Prevention and treatment of postmenopausal osteoporosis.
Tella SH, Gallagher JC
J Steroid Biochem Mol Biol 2014 Jul;142:155-70. Epub 2013 Oct 29 doi: 10.1016/j.jsbmb.2013.09.008. PMID: 24176761Free PMC Article

Prognosis

Calcium and vitamin D for increasing bone mineral density in premenopausal women.
Méndez-Sánchez L, Clark P, Winzenberg TM, Tugwell P, Correa-Burrows P, Costello R
Cochrane Database Syst Rev 2023 Jan 27;1(1):CD012664. doi: 10.1002/14651858.CD012664.pub2. PMID: 36705288Free PMC Article
Machine Learning Solutions for Osteoporosis-A Review.
Smets J, Shevroja E, Hügle T, Leslie WD, Hans D
J Bone Miner Res 2021 May;36(5):833-851. Epub 2021 Apr 4 doi: 10.1002/jbmr.4292. PMID: 33751686
Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial.
Kendler DL, Marin F, Zerbini CAF, Russo LA, Greenspan SL, Zikan V, Bagur A, Malouf-Sierra J, Lakatos P, Fahrleitner-Pammer A, Lespessailles E, Minisola S, Body JJ, Geusens P, Möricke R, López-Romero P
Lancet 2018 Jan 20;391(10117):230-240. Epub 2017 Nov 9 doi: 10.1016/S0140-6736(17)32137-2. PMID: 29129436
Long-term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J
Cochrane Database Syst Rev 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5. PMID: 28093732Free PMC Article
Osteoporosis: the emperor has no clothes.
Järvinen TL, Michaëlsson K, Aspenberg P, Sievänen H
J Intern Med 2015 Jun;277(6):662-73. doi: 10.1111/joim.12366. PMID: 25809279Free PMC Article

Clinical prediction guides

Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.
Ayers C, Kansagara D, Lazur B, Fu R, Kwon A, Harrod C
Ann Intern Med 2023 Feb;176(2):182-195. Epub 2023 Jan 3 doi: 10.7326/M22-0684. PMID: 36592455
Ovarian suppression for adjuvant treatment of hormone receptor-positive early breast cancer.
Bui KT, Willson ML, Goel S, Beith J, Goodwin A
Cochrane Database Syst Rev 2020 Mar 6;3(3):CD013538. doi: 10.1002/14651858.CD013538. PMID: 32141074Free PMC Article
Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial.
Kendler DL, Marin F, Zerbini CAF, Russo LA, Greenspan SL, Zikan V, Bagur A, Malouf-Sierra J, Lakatos P, Fahrleitner-Pammer A, Lespessailles E, Minisola S, Body JJ, Geusens P, Möricke R, López-Romero P
Lancet 2018 Jan 20;391(10117):230-240. Epub 2017 Nov 9 doi: 10.1016/S0140-6736(17)32137-2. PMID: 29129436
Managing Menopausal Symptoms and Associated Clinical Issues in Breast Cancer Survivors.
Santen RJ, Stuenkel CA, Davis SR, Pinkerton JV, Gompel A, Lumsden MA
J Clin Endocrinol Metab 2017 Oct 1;102(10):3647-3661. doi: 10.1210/jc.2017-01138. PMID: 28934376
Black cohosh (Cimicifuga spp.) for menopausal symptoms.
Leach MJ, Moore V
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD007244. doi: 10.1002/14651858.CD007244.pub2. PMID: 22972105Free PMC Article

Recent systematic reviews

Calcium and vitamin D for increasing bone mineral density in premenopausal women.
Méndez-Sánchez L, Clark P, Winzenberg TM, Tugwell P, Correa-Burrows P, Costello R
Cochrane Database Syst Rev 2023 Jan 27;1(1):CD012664. doi: 10.1002/14651858.CD012664.pub2. PMID: 36705288Free PMC Article
Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.
Ayers C, Kansagara D, Lazur B, Fu R, Kwon A, Harrod C
Ann Intern Med 2023 Feb;176(2):182-195. Epub 2023 Jan 3 doi: 10.7326/M22-0684. PMID: 36592455
Effects of Different Types of Exercise on Bone Mineral Density in Postmenopausal Women: A Systematic Review and Meta-analysis.
Kemmler W, Shojaa M, Kohl M, von Stengel S
Calcif Tissue Int 2020 Nov;107(5):409-439. Epub 2020 Aug 12 doi: 10.1007/s00223-020-00744-w. PMID: 32785775Free PMC Article
2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis.
Buckley L, Guyatt G, Fink HA, Cannon M, Grossman J, Hansen KE, Humphrey MB, Lane NE, Magrey M, Miller M, Morrison L, Rao M, Robinson AB, Saha S, Wolver S, Bannuru RR, Vaysbrot E, Osani M, Turgunbaev M, Miller AS, McAlindon T
Arthritis Rheumatol 2017 Aug;69(8):1521-1537. Epub 2017 Jun 6 doi: 10.1002/art.40137. PMID: 28585373
Long-term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J
Cochrane Database Syst Rev 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5. PMID: 28093732Free PMC Article

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