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Posterior fusion of lumbosacral vertebrae

MedGen UID:
870715
Concept ID:
C4025169
Finding
HPO: HP:0005626

Definition

Bony fusion of the posterior part of the L5 vertebral body with the sacrum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPosterior fusion of lumbosacral vertebrae

Conditions with this feature

Posterior fusion of lumbosacral vertebrae-blepharoptosis syndrome
MedGen UID:
348108
Concept ID:
C1860464
Disease or Syndrome
A rare syndrome characterized by congenital ptosis and posterior fusion of the lumbosacral vertebrae. It has been described in a mother and her two daughters.

Professional guidelines

PubMed

Chang CW, Fu TS, Chen WJ, Chen CW, Lai PL, Chen SH
World Neurosurg 2019 Jun;126:e330-e341. Epub 2019 Feb 26 doi: 10.1016/j.wneu.2019.02.050. PMID: 30822594
Ledbetter LN, Salzman KL, Sanders RK, Shah LM
Radiographics 2016 May-Jun;36(3):783-99. Epub 2016 Apr 8 doi: 10.1148/rg.2016150121. PMID: 27058729
Rubayi S
Orthop Clin North Am 1996 Jan;27(1):137-53. PMID: 8539044

Recent clinical studies

Etiology

Souslian FG, Patel PD
Br J Neurosurg 2024 Feb;38(1):61-67. Epub 2021 Jul 15 doi: 10.1080/02688697.2021.1881041. PMID: 34263676
Rathbone J, Rackham M, Nielsen D, Lee SM, Hing W, Riar S, Scott-Young M
Eur Spine J 2023 Jun;32(6):1911-1926. Epub 2023 Apr 18 doi: 10.1007/s00586-023-07567-x. PMID: 37071155
Preston G, Hoffmann J, Satin A, Derman PB, Khalil JG
J Am Acad Orthop Surg 2023 Apr 1;31(7):e356-e365. doi: 10.5435/JAAOS-D-22-00956. PMID: 36877764
Fenton-White HA
Spine J 2021 Sep;21(9):1528-1541. Epub 2021 Mar 20 doi: 10.1016/j.spinee.2021.03.016. PMID: 33757870
Li Y, Wang G, Jiang Z, Cui X, Li T, Liu X, Zhang W, Sun J
Medicine (Baltimore) 2017 Oct;96(43):e8393. doi: 10.1097/MD.0000000000008393. PMID: 29069034Free PMC Article

Diagnosis

Mehrotra A, Pandey SD, Singh S, Kanjilal S, Gajbhiye S, Dikshit P, Kumar A, Verma PK, Maurya VP, Bhaisora KS, Das KK, Srivastava AK, Jaiswal AK, Kumar R
Neurol India 2024 Jul 1;72(4):742-746. Epub 2024 Aug 31 doi: 10.4103/neurol-india.Neurol-India-D-23-00245. PMID: 39216027
Choi J, Kim JS, Hyun SJ, Kim KJ, Kim HJ, Deletis V, Park KS
Clin Neurophysiol 2022 Dec;144:59-66. Epub 2022 Oct 12 doi: 10.1016/j.clinph.2022.09.020. PMID: 36274572
Guan J, Liu T, Li W, Zhao H, Yang K, Li C, Feng N, Jiang G, Yang Y, Yu X
J Orthop Surg Res 2022 Feb 21;17(1):116. doi: 10.1186/s13018-022-03015-6. PMID: 35189915Free PMC Article
Cha EDK, Lynch CP, Patel MR, Jacob KC, Geoghegan CE, Jadczak CN, Mohan S, Singh K
Neurosurgery 2022 Feb 1;90(2):215-220. doi: 10.1227/NEU.0000000000001782. PMID: 34995271
Ledbetter LN, Salzman KL, Sanders RK, Shah LM
Radiographics 2016 May-Jun;36(3):783-99. Epub 2016 Apr 8 doi: 10.1148/rg.2016150121. PMID: 27058729

Therapy

Rathbone J, Rackham M, Nielsen D, Lee SM, Hing W, Riar S, Scott-Young M
Eur Spine J 2023 Jun;32(6):1911-1926. Epub 2023 Apr 18 doi: 10.1007/s00586-023-07567-x. PMID: 37071155
Gong K, Lin Y, Wang Z, Li F, Xiong W
BMC Musculoskelet Disord 2022 Oct 14;23(1):914. doi: 10.1186/s12891-022-05855-z. PMID: 36242007Free PMC Article
Shah DS, Fisher MWA, Hurley RK, Bharmal H
Clin Spine Surg 2022 Jul 1;35(6):229-232. Epub 2021 Jul 28 doi: 10.1097/BSD.0000000000001239. PMID: 34321391
de Kunder SL, van Kuijk SMJ, Rijkers K, Caelers IJMH, van Hemert WLW, de Bie RA, van Santbrink H
Spine J 2017 Nov;17(11):1712-1721. Epub 2017 Jun 21 doi: 10.1016/j.spinee.2017.06.018. PMID: 28647584
Galimberti F, Lubelski D, Healy AT, Wang T, Abdullah KG, Nowacki AS, Benzel EC, Mroz TE
Spine (Phila Pa 1976) 2015 Jul 15;40(14):1132-9. doi: 10.1097/BRS.0000000000000971. PMID: 25955186

Prognosis

Jo DJ, Seo EM
PLoS One 2021;16(9):e0257316. Epub 2021 Sep 10 doi: 10.1371/journal.pone.0257316. PMID: 34506593Free PMC Article
Xue X, Zhao S, Miao F, Li K
Int Orthop 2020 May;44(5):979-986. Epub 2020 Mar 20 doi: 10.1007/s00264-020-04537-6. PMID: 32198669
Cui JJ, Gala RJ, Ondeck NT, McLynn RP, Bovonratwet P, Shultz B, Grauer JN
Spine J 2019 Apr;19(4):631-636. Epub 2018 Sep 13 doi: 10.1016/j.spinee.2018.09.004. PMID: 30219360
Aono H, Takenaka S, Nagamoto Y, Tobimatsu H, Yamashita T, Furuya M, Iwasaki M
World Neurosurg 2018 Apr;112:e473-e478. Epub 2018 Jan 31 doi: 10.1016/j.wneu.2018.01.062. PMID: 29355805
Li Y, Wang G, Jiang Z, Cui X, Li T, Liu X, Zhang W, Sun J
Medicine (Baltimore) 2017 Oct;96(43):e8393. doi: 10.1097/MD.0000000000008393. PMID: 29069034Free PMC Article

Clinical prediction guides

Rathbone J, Rackham M, Nielsen D, Lee SM, Hing W, Riar S, Scott-Young M
Eur Spine J 2023 Jun;32(6):1911-1926. Epub 2023 Apr 18 doi: 10.1007/s00586-023-07567-x. PMID: 37071155
Liu D, Shi B, Li Y, Liu Z, Sun X, Zhu Z, Qiu Y
Orthop Surg 2022 Jul;14(7):1413-1419. Epub 2022 Jun 9 doi: 10.1111/os.13317. PMID: 35678133Free PMC Article
Segawa T, Koga H, Oshina M, Ishibashi K, Takano Y, Iwai H, Inanami H
Medicina (Kaunas) 2021 Feb 3;57(2) doi: 10.3390/medicina57020135. PMID: 33546404Free PMC Article
Li Y, Wang G, Jiang Z, Cui X, Li T, Liu X, Zhang W, Sun J
Medicine (Baltimore) 2017 Oct;96(43):e8393. doi: 10.1097/MD.0000000000008393. PMID: 29069034Free PMC Article
de Kunder SL, van Kuijk SMJ, Rijkers K, Caelers IJMH, van Hemert WLW, de Bie RA, van Santbrink H
Spine J 2017 Nov;17(11):1712-1721. Epub 2017 Jun 21 doi: 10.1016/j.spinee.2017.06.018. PMID: 28647584

Recent systematic reviews

An B, Ren B, Han Z, Mao K, Liu J
J Orthop Surg Res 2023 Nov 10;18(1):856. doi: 10.1186/s13018-023-04312-4. PMID: 37950267Free PMC Article
Rathbone J, Rackham M, Nielsen D, Lee SM, Hing W, Riar S, Scott-Young M
Eur Spine J 2023 Jun;32(6):1911-1926. Epub 2023 Apr 18 doi: 10.1007/s00586-023-07567-x. PMID: 37071155
Formica M, Quarto E, Zanirato A, Mosconi L, Lontaro-Baracchini M, Alessio-Mazzola M, Felli L
Eur Spine J 2021 Jan;30(1):50-62. Epub 2020 Sep 15 doi: 10.1007/s00586-020-06598-y. PMID: 32930843
de Kunder SL, van Kuijk SMJ, Rijkers K, Caelers IJMH, van Hemert WLW, de Bie RA, van Santbrink H
Spine J 2017 Nov;17(11):1712-1721. Epub 2017 Jun 21 doi: 10.1016/j.spinee.2017.06.018. PMID: 28647584
Galimberti F, Lubelski D, Healy AT, Wang T, Abdullah KG, Nowacki AS, Benzel EC, Mroz TE
Spine (Phila Pa 1976) 2015 Jul 15;40(14):1132-9. doi: 10.1097/BRS.0000000000000971. PMID: 25955186

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