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Abnormal nasolabial region morphology

MedGen UID:
870766
•Concept ID:
C4025223
•
Anatomical Abnormality
Synonyms: Abnormality of the nasolabial region; Anomaly of the nasolabial region; Deformity of the nasolabial region; Malformation of the nasolabial region
 
HPO: HP:0005289

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal nasolabial region morphology

Professional guidelines

PubMed

Single-Stage Posterior Vomerine Ostectomy and Primary Cheiloplasty in Patients with Bilateral Cleft Lip & Palate and Protuberant Premaxilla.
Hamdan US, Younan RA, Haddad M, Melhem AM, Najjar W, Hussein S, Kantar RS, Annan B, Johnson A, Liau J
Cleft Palate Craniofac J 2024 Oct;61(10):1670-1678. Epub 2023 May 30 doi: 10.1177/10556656231179609. PMID: 37253459
Nasal malformations associated with unilateral cleft lip. Accurate diagnosis and management.
Talmant JC
Scand J Plast Reconstr Surg Hand Surg 1993 Sep;27(3):183-91. doi: 10.3109/02844319309078110. PMID: 8272769

Recent clinical studies

Etiology

Prospective study of nasal growth in bilateral cleft lip and palate patients after naso-alveolar moulding and primary columella lengthening compared to controls at 5, 10 and 20 years.
Meazzini MC, Demonte LP, Parravicini F, Biglioli F, Autelitano L, Balbo N
Orthod Craniofac Res 2024 Jun;27 Suppl 1:70-79. Epub 2024 Jan 29 doi: 10.1111/ocr.12761. PMID: 38284309
Is the Nasolabial Region Symmetric in Individuals With Cleft Lip and Palate?
Dindaroglu F, Dogan E, Dogan S
Cleft Palate Craniofac J 2024 Jan;61(1):12-19. Epub 2022 Aug 1 doi: 10.1177/10556656221116535. PMID: 35912442
Interferon regulatory factor 6 variants affect nasolabial morphology in East Asian populations.
Tomita D, Yamaguchi T, Nakawaki T, Hikita Y, Adel M, Kim YI, Haga S, Takahashi M, Kawaguchi A, Isa M, Park SB, Ishida H, Maki K, Kimura R
Arch Oral Biol 2018 Jan;85:142-147. Epub 2017 Oct 9 doi: 10.1016/j.archoralbio.2017.10.005. PMID: 29065370
Nasal airway and septal variation in unilateral and bilateral cleft lip and palate.
Starbuck JM, Friel MT, Ghoneima A, Flores RL, Tholpady S, Kula K
Clin Anat 2014 Oct;27(7):999-1008. Epub 2014 Jun 26 doi: 10.1002/ca.22428. PMID: 24976342
3D facial morphometry in children with oral clefts.
Bugaighis I, Mattick CR, Tiddeman B, Hobson R
Cleft Palate Craniofac J 2014 Jul;51(4):452-61. Epub 2013 Apr 24 doi: 10.1597/12-217. PMID: 23614699

Diagnosis

Single-Stage Posterior Vomerine Ostectomy and Primary Cheiloplasty in Patients with Bilateral Cleft Lip & Palate and Protuberant Premaxilla.
Hamdan US, Younan RA, Haddad M, Melhem AM, Najjar W, Hussein S, Kantar RS, Annan B, Johnson A, Liau J
Cleft Palate Craniofac J 2024 Oct;61(10):1670-1678. Epub 2023 May 30 doi: 10.1177/10556656231179609. PMID: 37253459
Identification of a novel pathogenic mutation of the MYH3 gene in a family with distal arthrogryposis type 2B.
Wang WB, Kong LC, Zuo RT, Kang QL
Mol Med Rep 2020 Jan;21(1):438-444. Epub 2019 Nov 15 doi: 10.3892/mmr.2019.10820. PMID: 31746383
Assessment of regional asymmetry of the face before and after surgical correction of unilateral cleft lip.
Al-Rudainy D, Ju X, Stanton S, Mehendale FV, Ayoub A
J Craniomaxillofac Surg 2018 Jun;46(6):974-978. Epub 2018 Apr 6 doi: 10.1016/j.jcms.2018.03.023. PMID: 29752048
Nasal changes after orthognathic surgery for patients with prognathism and Class III malocclusion: analysis using three-dimensional photogrammetry.
Worasakwutiphong S, Chuang YF, Chang HW, Lin HH, Lin PJ, Lo LJ
J Formos Med Assoc 2015 Feb;114(2):112-23. Epub 2014 Dec 20 doi: 10.1016/j.jfma.2014.10.003. PMID: 25534453
Anthropometry for syndromology.
Lakshminarayana P, Janardhan K, David HS
Indian J Pediatr 1991 Mar-Apr;58(2):253-8. doi: 10.1007/BF02751131. PMID: 1879907

Therapy

Three-dimensional assessment of facial asymmetry in preschool patients with orofacial clefts after neonatal cheiloplasty.
Moslerová V, Dadáková M, Dupej J, Hoffmannova E, Borský J, Černý M, Bejda P, Kočandrlová K, Velemínská J
Int J Pediatr Otorhinolaryngol 2018 May;108:40-45. Epub 2018 Feb 16 doi: 10.1016/j.ijporl.2018.02.023. PMID: 29605363
Judgment of Nasolabial Esthetics in Cleft Lip and Palate Is Not Influenced by Overall Facial Attractiveness.
Kocher K, Kowalski P, Kolokitha OE, Katsaros C, Fudalej PS
Cleft Palate Craniofac J 2016 May;53(3):e45-52. Epub 2015 May 1 doi: 10.1597/14-019. PMID: 25932752
Nasal changes after orthognathic surgery for patients with prognathism and Class III malocclusion: analysis using three-dimensional photogrammetry.
Worasakwutiphong S, Chuang YF, Chang HW, Lin HH, Lin PJ, Lo LJ
J Formos Med Assoc 2015 Feb;114(2):112-23. Epub 2014 Dec 20 doi: 10.1016/j.jfma.2014.10.003. PMID: 25534453
Aesthetic evaluation of the nasolabial region in children with unilateral cleft lip and palate comparing expert versus nonexperience health professionals.
Paiva TS, Andre M, Paiva WS, Mattos BS
Biomed Res Int 2014;2014:460106. Epub 2014 Jul 13 doi: 10.1155/2014/460106. PMID: 25126560Free PMC Article
Nasolabial aesthetics.
Mitchell C, Oeltjen J, Panthaki Z, Thaller SR
J Craniofac Surg 2007 Jul;18(4):756-65. doi: 10.1097/scs.0b013e3180684360. PMID: 17667661

Prognosis

Dynamic Nasolabial Growth After Primary Surgery for Patients With Bilateral Cleft Lip: A Five-Year Follow-Up Study.
Wei Y, Zhong T, Yin X, Shi B, Zheng Q, Li J
J Oral Maxillofac Surg 2019 Oct;77(10):2125.e1-2125.e10. Epub 2019 May 30 doi: 10.1016/j.joms.2019.05.013. PMID: 31238020
Active Presurgical Infant Orthopedics for Unilateral Cleft Lip and Palate: Intercenter Outcome Comparison of Latham, Modified McNeil, and Nasoalveolar Molding.
Kornbluth M, Campbell RE, Daskalogiannakis J, Ross EJ, Glick PH, Russell KA, Doucet JC, Hathaway RR, Long RE Jr, Sitzman TJ
Cleft Palate Craniofac J 2018 May;55(5):639-648. Epub 2018 Feb 20 doi: 10.1177/1055665618757367. PMID: 29461877Free PMC Article
Outcome of In Situ Septoplasty and Extracorporeal Subtotal Septal Reconstruction in Crooked Noses: A Randomized Self-Controlled Study.
Gode S, Benzer M, Uslu M, Kaya I, Midilli R, Karci B
Aesthetic Plast Surg 2018 Feb;42(1):234-243. Epub 2017 Oct 12 doi: 10.1007/s00266-017-0973-1. PMID: 29026961
A retrospective evaluation of the aesthetics of the nasolabial complex after unilateral cleft lip repair using the Tennison-Randall technique: a study of 44 cases treated in a single cleft center.
Iliopoulos C, Mitsimponas K, Lazaridou D, Neukam FW, Stelzle F
J Craniomaxillofac Surg 2014 Dec;42(8):1679-83. Epub 2014 May 24 doi: 10.1016/j.jcms.2014.05.013. PMID: 24962045
The Eurocleft study: intercenter study of treatment outcome in patients with complete cleft lip and palate. Part 2: craniofacial form and nasolabial appearance.
Brattström V, Mølsted K, Prahl-Andersen B, Semb G, Shaw WC
Cleft Palate Craniofac J 2005 Jan;42(1):69-77. doi: 10.1597/02-119.2.1. PMID: 15643918

Clinical prediction guides

The Validation of an Innovative Method for 3D Capture and Analysis of the Nasolabial Region in Cleft Cases.
Ayoub A, Khan A, Aldhanhani A, Alnaser H, Naudi K, Ju X, Gillgrass T, Mossey P
Cleft Palate Craniofac J 2021 Jan;58(1):98-104. Epub 2020 Aug 12 doi: 10.1177/1055665620946987. PMID: 32783457Free PMC Article
Judgment of Nasolabial Esthetics in Cleft Lip and Palate Is Not Influenced by Overall Facial Attractiveness.
Kocher K, Kowalski P, Kolokitha OE, Katsaros C, Fudalej PS
Cleft Palate Craniofac J 2016 May;53(3):e45-52. Epub 2015 May 1 doi: 10.1597/14-019. PMID: 25932752
Aesthetic evaluation of the nasolabial region in children with unilateral cleft lip and palate comparing expert versus nonexperience health professionals.
Paiva TS, Andre M, Paiva WS, Mattos BS
Biomed Res Int 2014;2014:460106. Epub 2014 Jul 13 doi: 10.1155/2014/460106. PMID: 25126560Free PMC Article
3D facial morphometry in children with oral clefts.
Bugaighis I, Mattick CR, Tiddeman B, Hobson R
Cleft Palate Craniofac J 2014 Jul;51(4):452-61. Epub 2013 Apr 24 doi: 10.1597/12-217. PMID: 23614699
Methods of assessment of cleft-related facial deformity: a review.
Al-Omari I, Millett DT, Ayoub AF
Cleft Palate Craniofac J 2005 Mar;42(2):145-56. doi: 10.1597/02-149.1. PMID: 15748105

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