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Abnormal intervertebral disk morphology

MedGen UID:
870792
•Concept ID:
C4025249
•
Anatomical Abnormality
Synonyms: Abnormality of the intervertebral disc; Abnormality of the intervertebral disk
 
HPO: HP:0005108

Definition

Any structural abnormality of the intervertebral disk. [from HPO]

Professional guidelines

PubMed

Management of chronic low back pain: rationales, principles, and targets of imaging-guided spinal injections.
Fritz J, Niemeyer T, Clasen S, Wiskirchen J, Tepe G, Kastler B, Nägele T, König CW, Claussen CD, Pereira PL
Radiographics 2007 Nov-Dec;27(6):1751-71. doi: 10.1148/rg.276065509. PMID: 18025516
Thoracic disk disease: diagnosis and treatment.
Vanichkachorn JS, Vaccaro AR
J Am Acad Orthop Surg 2000 May-Jun;8(3):159-69. doi: 10.5435/00124635-200005000-00003. PMID: 10874223
Childhood and adolescent lumbar pain: differential diagnosis and management.
Hoffman HJ
Clin Neurosurg 1980;27:553-76. doi: 10.1093/neurosurgery/27.cn_suppl_1.553. PMID: 6456106

Recent clinical studies

Etiology

Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration.
Wu J, Chen Y, Liao Z, Liu H, Zhang S, Zhong D, Qiu X, Chen T, Su D, Ke X, Wan Y, Zhou T, Su P
Mol Ther 2022 Oct 5;30(10):3241-3256. Epub 2022 May 26 doi: 10.1016/j.ymthe.2022.05.021. PMID: 35619555Free PMC Article
Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration.
Krut Z, Pelled G, Gazit D, Gazit Z
Cells 2021 Aug 29;10(9) doi: 10.3390/cells10092241. PMID: 34571890Free PMC Article
Lumbar Facet Tropism: A Comprehensive Review.
Alonso F, Kirkpatrick CM, Jeong W, Fisahn C, Usman S, Rustagi T, Loukas M, Chapman JR, Oskouian RJ, Tubbs RS
World Neurosurg 2017 Jun;102:91-96. Epub 2017 Mar 6 doi: 10.1016/j.wneu.2017.02.114. PMID: 28279769
Histology and pathology of the human intervertebral disc.
Roberts S, Evans H, Trivedi J, Menage J
J Bone Joint Surg Am 2006 Apr;88 Suppl 2:10-4. doi: 10.2106/JBJS.F.00019. PMID: 16595436
Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation.
Boden SD, Davis DO, Dina TS, Patronas NJ, Wiesel SW
J Bone Joint Surg Am 1990 Mar;72(3):403-8. PMID: 2312537

Diagnosis

The correlation between the lumbar disc MRI high-intensity zone and discogenic low back pain: a systematic review and meta-analysis.
Yang L, Li W, Yang Y, Zhao H, Yu X
J Orthop Surg Res 2023 Oct 7;18(1):758. doi: 10.1186/s13018-023-04187-5. PMID: 37805519Free PMC Article
Spinal pain.
Izzo R, Popolizio T, D'Aprile P, Muto M
Eur J Radiol 2015 May;84(5):746-56. Epub 2015 Feb 13 doi: 10.1016/j.ejrad.2015.01.018. PMID: 25824642
Post-therapeutic imaging findings.
Pollice S, Muto M, Scarabino T
Eur J Radiol 2015 May;84(5):799-806. Epub 2014 Jun 30 doi: 10.1016/j.ejrad.2014.06.010. PMID: 25017151
Lumbar disc nomenclature: version 2.0: Recommendations of the combined task forces of the North American Spine Society, the American Society of Spine Radiology and the American Society of Neuroradiology.
Fardon DF, Williams AL, Dohring EJ, Murtagh FR, Gabriel Rothman SL, Sze GK
Spine J 2014 Nov 1;14(11):2525-45. Epub 2014 Apr 24 doi: 10.1016/j.spinee.2014.04.022. PMID: 24768732
Magnetic resonance imaging of the lumbar spine in people without back pain.
Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS
N Engl J Med 1994 Jul 14;331(2):69-73. doi: 10.1056/NEJM199407143310201. PMID: 8208267

Therapy

Intraforaminal ozone therapy and particular side effects: preliminary results and early warning.
Vanni D, Galzio R, Kazakova A, Pantalone A, Sparvieri A, Salini V, Magliani V
Acta Neurochir (Wien) 2016 Mar;158(3):491-6. Epub 2015 Aug 21 doi: 10.1007/s00701-015-2545-y. PMID: 26293228
Computer-aided diagnosis of lumbar disc pathology from clinical lower spine MRI.
Alomari RS, Corso JJ, Chaudhary V, Dhillon G
Int J Comput Assist Radiol Surg 2010 May;5(3):287-93. Epub 2009 Sep 22 doi: 10.1007/s11548-009-0396-9. PMID: 20033498
Lumbar discography.
Guyer RD, Ohnmeiss DD; NASS
Spine J 2003 May-Jun;3(3 Suppl):11S-27S. doi: 10.1016/s1529-9430(02)00563-6. PMID: 14589214
Intraspinous postlaminectomy pseudomeningocele.
Paolini S, Ciappetta P, Piattella MC
Eur Spine J 2003 Jun;12(3):325-7. Epub 2002 Nov 28 doi: 10.1007/s00586-002-0482-y. PMID: 12800007Free PMC Article
Magnetic resonance imaging of the lumbar spine in people without back pain.
Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS
N Engl J Med 1994 Jul 14;331(2):69-73. doi: 10.1056/NEJM199407143310201. PMID: 8208267

Prognosis

Clinical and radiomics feature-based outcome analysis in lumbar disc herniation surgery.
Saravi B, Zink A, Ülkümen S, Couillard-Despres S, Wollborn J, Lang G, Hassel F
BMC Musculoskelet Disord 2023 Oct 6;24(1):791. doi: 10.1186/s12891-023-06911-y. PMID: 37803313Free PMC Article
The association between multiple sclerosis and spondylosis: When and why.
Xydis VG, Zikou AK, Kostadima V, Astrakas LG, Kosta P, Argyropoulou MI
Eur J Radiol 2017 Jun;91:47-51. Epub 2017 Mar 24 doi: 10.1016/j.ejrad.2017.03.017. PMID: 28629570
Histology and pathology of the human intervertebral disc.
Roberts S, Evans H, Trivedi J, Menage J
J Bone Joint Surg Am 2006 Apr;88 Suppl 2:10-4. doi: 10.2106/JBJS.F.00019. PMID: 16595436
Thoracic disk disease: diagnosis and treatment.
Vanichkachorn JS, Vaccaro AR
J Am Acad Orthop Surg 2000 May-Jun;8(3):159-69. doi: 10.5435/00124635-200005000-00003. PMID: 10874223
MR imaging of the spine: trauma and degenerative disease.
Wilmink JT
Eur Radiol 1999;9(7):1259-66. doi: 10.1007/s003300050832. PMID: 10460358

Clinical prediction guides

Clinical and radiomics feature-based outcome analysis in lumbar disc herniation surgery.
Saravi B, Zink A, Ülkümen S, Couillard-Despres S, Wollborn J, Lang G, Hassel F
BMC Musculoskelet Disord 2023 Oct 6;24(1):791. doi: 10.1186/s12891-023-06911-y. PMID: 37803313Free PMC Article
Imaging Assessment of the Postoperative Spine: An Updated Pictorial Review of Selected Complications.
Corona-Cedillo R, Saavedra-Navarrete MT, Espinoza-Garcia JJ, Mendoza-Aguilar AN, Ternovoy SK, Roldan-Valadez E
Biomed Res Int 2021;2021:9940001. Epub 2021 May 18 doi: 10.1155/2021/9940001. PMID: 34113681Free PMC Article
The association between multiple sclerosis and spondylosis: When and why.
Xydis VG, Zikou AK, Kostadima V, Astrakas LG, Kosta P, Argyropoulou MI
Eur J Radiol 2017 Jun;91:47-51. Epub 2017 Mar 24 doi: 10.1016/j.ejrad.2017.03.017. PMID: 28629570
Clinical and Radiographical Differences Between Thoracic Idiopathic Spinal Cord Herniation and Spinal Arachnoid Cyst.
Nakashima H, Imagama S, Yagi H, Kato F, Kanemura T, Sato K, Kawakami N, Kamiya M, Yoshihara H, Ito K, Matsuyama Y, Nishida Y, Ishiguro N
Spine (Phila Pa 1976) 2017 Aug 15;42(16):E963-E968. doi: 10.1097/BRS.0000000000002013. PMID: 27926670
Disc degeneration-related clinical phenotypes.
Battié MC, Lazáry A, Fairbank J, Eisenstein S, Heywood C, Brayda-Bruno M, Varga PP, McCall I
Eur Spine J 2014 Jun;23 Suppl 3:S305-14. Epub 2013 Jul 25 doi: 10.1007/s00586-013-2903-5. PMID: 23884550

Recent systematic reviews

The correlation between the lumbar disc MRI high-intensity zone and discogenic low back pain: a systematic review and meta-analysis.
Yang L, Li W, Yang Y, Zhao H, Yu X
J Orthop Surg Res 2023 Oct 7;18(1):758. doi: 10.1186/s13018-023-04187-5. PMID: 37805519Free PMC Article
Comparison of histological and morphometrical changes underlying subchondral bone abnormalities in inflammatory and degenerative musculoskeletal disorders: a systematic review.
Loef M, van Beest S, Kroon FPB, Bloem JL, Dekkers OM, Reijnierse M, Schoones JW, Kloppenburg M
Osteoarthritis Cartilage 2018 Aug;26(8):992-1002. Epub 2018 May 17 doi: 10.1016/j.joca.2018.05.007. PMID: 29777863
Variation of facet joint orientation and tropism in lumbar degenerative spondylolisthesis and disc herniation at L4-L5: A systematic review and meta-analysis.
Liu Z, Duan Y, Rong X, Wang B, Chen H, Liu H
Clin Neurol Neurosurg 2017 Oct;161:41-47. Epub 2017 Aug 18 doi: 10.1016/j.clineuro.2017.08.005. PMID: 28843706
The course of Modic vertebral body changes after posterolateral lumbar fusion on fused and adjacent levels: A systematic review of the literature.
Portella ST, Acioly MA
J Clin Neurosci 2017 Jul;41:6-10. Epub 2017 Apr 19 doi: 10.1016/j.jocn.2017.04.007. PMID: 28431955
Potential of magnetic resonance imaging findings to refine case definition for mechanical low back pain in epidemiological studies: a systematic review.
Endean A, Palmer KT, Coggon D
Spine (Phila Pa 1976) 2011 Jan 15;36(2):160-9. doi: 10.1097/BRS.0b013e3181cd9adb. PMID: 20739918Free PMC Article

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