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Abnormal vitreous humor morphology

MedGen UID:
870895
•Concept ID:
C4025356
•
Anatomical Abnormality
Synonym: Abnormality of the vitreous humor
 
HPO: HP:0004327

Definition

Any structural anomaly of the vitreous body. [from HPO]

Conditions with this feature

Stickler syndrome type 2
MedGen UID:
347615
•Concept ID:
C1858084
•
Disease or Syndrome
Stickler syndrome is a connective tissue disorder that can include ocular findings of myopia, cataract, and retinal detachment; hearing loss that is both conductive and sensorineural; midfacial underdevelopment and cleft palate (either alone or as part of the Robin sequence); and mild spondyloepiphyseal dysplasia and/or precocious arthritis. Variable phenotypic expression of Stickler syndrome occurs both within and among families; interfamilial variability is in part explained by locus and allelic heterogeneity.
See: Condition Record
Stickler syndrome type 2

Professional guidelines

PubMed

Current concepts in the treatment of vitreous block, also known as aqueous misdirection.
Kaplowitz K, Yung E, Flynn R, Tsai JC
Surv Ophthalmol 2015 May-Jun;60(3):229-41. Epub 2014 Dec 27 doi: 10.1016/j.survophthal.2014.12.004. PMID: 25639795
The differential diagnosis of leukokoria.
Cheng KP, Hiles DA, Biglan AW
Pediatr Ann 1990 Jun;19(6):376-83, 386. doi: 10.3928/0090-4481-19900601-07. PMID: 2200999
Echography in the diagnosis and management of retinal detachment.
Sutherland GR, Forrester JV, Railton R
Br J Radiol 1975 Oct;48(574):796-800. doi: 10.1259/0007-1285-48-574-796. PMID: 1191899

Recent clinical studies

Etiology

Vitreous Structure and Visual Function in Myopic Vitreopathy Causing Vision-Degrading Myodesopsia.
Nguyen JH, Nguyen-Cuu J, Mamou J, Routledge B, Yee KMP, Sebag J
Am J Ophthalmol 2021 Apr;224:246-253. Epub 2020 Sep 17 doi: 10.1016/j.ajo.2020.09.017. PMID: 32950508
A clinicopathological study of persistent fetal vasculature.
Khurana S, Gupta PC, Vaiphei K, Singh R, Ram J
Indian J Ophthalmol 2019 Jun;67(6):785-787. doi: 10.4103/ijo.IJO_1375_18. PMID: 31124487Free PMC Article
Multimodal Imaging of Vitreoretinal Lymphoma.
Mapelli C, Invernizzi A, Barteselli G, Pellegrini M, Tabacchi E, Staurenghi G, Viola F
Ophthalmologica 2016;236(3):166-174. Epub 2016 Sep 15 doi: 10.1159/000447412. PMID: 27627063
Current concepts in the treatment of vitreous block, also known as aqueous misdirection.
Kaplowitz K, Yung E, Flynn R, Tsai JC
Surv Ophthalmol 2015 May-Jun;60(3):229-41. Epub 2014 Dec 27 doi: 10.1016/j.survophthal.2014.12.004. PMID: 25639795
Stickler syndrome and the vitreous phenotype: mutations in COL2A1 and COL11A1.
Richards AJ, McNinch A, Martin H, Oakhill K, Rai H, Waller S, Treacy B, Whittaker J, Meredith S, Poulson A, Snead MP
Hum Mutat 2010 Jun;31(6):E1461-71. doi: 10.1002/humu.21257. PMID: 20513134

Diagnosis

Inflammatory and angiogenic biomarkers in diabetic retinopathy.
Kaštelan S, Orešković I, Bišćan F, Kaštelan H, Gverović Antunica A
Biochem Med (Zagreb) 2020 Oct 15;30(3):030502. Epub 2020 Aug 5 doi: 10.11613/BM.2020.030502. PMID: 32774120Free PMC Article
Persistent Fetal Vasculature.
Chen C, Xiao H, Ding X
Asia Pac J Ophthalmol (Phila) 2019 Jan-Feb;8(1):86-95. Epub 2018 Oct 30 doi: 10.22608/APO.201854. PMID: 30375202
Autosomal dominant vitreoretinochoroidopathy.
Kaufman SJ, Goldberg MF, Orth DH, Fishman GA, Tessler H, Mizuno K
Arch Ophthalmol 1982 Feb;100(2):272-8. doi: 10.1001/archopht.1982.01030030274008. PMID: 7065944
Birdshot retinochoroidopathy.
Kaplan HJ, Aaberg TM
Am J Ophthalmol 1980 Dec;90(6):773-82. doi: 10.1016/s0002-9394(14)75192-x. PMID: 7446664
The lens and vitreous.
Freeman HM
Arch Ophthalmol 1969 Oct;82(4):551-66. doi: 10.1001/archopht.1969.00990020553022. PMID: 4902356

Therapy

Talc retinopathy.
Tse DT, Ober RR
Am J Ophthalmol 1980 Nov;90(5):624-40. doi: 10.1016/s0002-9394(14)75129-3. PMID: 6160767
The vitreous.
Tolentino FI
Arch Ophthalmol 1974 Oct;92(4):350-8. doi: 10.1001/archopht.1974.01010010360022. PMID: 4607273
The vitreous.
Jaffe NS
Arch Ophthalmol 1973 Jul;90(1):69-82. doi: 10.1001/archopht.1973.01000050071016. PMID: 4577008
Malignant glaucoma.
Simmons RJ
Br J Ophthalmol 1972 Mar;56(3):263-72. doi: 10.1136/bjo.56.3.263. PMID: 5032764Free PMC Article
The lens and vitreous.
Freeman HM
Arch Ophthalmol 1969 Oct;82(4):551-66. doi: 10.1001/archopht.1969.00990020553022. PMID: 4902356

Prognosis

Current concepts in the treatment of vitreous block, also known as aqueous misdirection.
Kaplowitz K, Yung E, Flynn R, Tsai JC
Surv Ophthalmol 2015 May-Jun;60(3):229-41. Epub 2014 Dec 27 doi: 10.1016/j.survophthal.2014.12.004. PMID: 25639795
Clinical features of the congenital vitreoretinopathies.
Edwards AO
Eye (Lond) 2008 Oct;22(10):1233-42. Epub 2008 Feb 29 doi: 10.1038/eye.2008.38. PMID: 18309337
Familial exudative vitreoretinopathy.
Benson WE
Trans Am Ophthalmol Soc 1995;93:473-521. PMID: 8719692Free PMC Article
The Wagner-Stickler syndrome complex.
Godel V, Nemet P, Lazar M
Doc Ophthalmol 1981 Dec 16;52(2):179-88. doi: 10.1007/BF01675204. PMID: 7035111
Birdshot retinochoroidopathy.
Kaplan HJ, Aaberg TM
Am J Ophthalmol 1980 Dec;90(6):773-82. doi: 10.1016/s0002-9394(14)75192-x. PMID: 7446664

Clinical prediction guides

Correlation of clinical and radiological predictors of retinoblastoma with high-risk histopathological features.
Yaqoob N, Zia N, Hamid A, Kaleem B, Jamal S, Amin S, Qaddoumi I, Jamal S
Pediatr Blood Cancer 2022 May;69(5):e29625. Epub 2022 Mar 6 doi: 10.1002/pbc.29625. PMID: 35253344
Human vitreous in proliferative diabetic retinopathy: Characterization and translational implications.
Nawaz IM, Rezzola S, Cancarini A, Russo A, Costagliola C, Semeraro F, Presta M
Prog Retin Eye Res 2019 Sep;72:100756. Epub 2019 Apr 2 doi: 10.1016/j.preteyeres.2019.03.002. PMID: 30951889
Magnetic resonance imaging of uveitis.
Li CQ, Cho AA, Edward NJ, Edward DP, Fajardo RG, Mafee MF
Neuroradiology 2015 Aug;57(8):825-32. Epub 2015 Apr 24 doi: 10.1007/s00234-015-1531-7. PMID: 25903430
Unilateral diplophthalmos.
Stefani FH, Hausmann N, Lund OE
Am J Ophthalmol 1991 Nov 15;112(5):581-6. doi: 10.1016/s0002-9394(14)76862-x. PMID: 1951597
Ocular complications.
Engerman R, Finkelstein D, Aguirre G, Diddie KR, Fox RR, Frank RN, Varma SD
Diabetes 1982;31(Suppl 1 Pt 2):82-8. doi: 10.2337/diab.31.1.s82. PMID: 6819171

Recent systematic reviews

Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta-analysis.
Møller-Lorentzen TB, Eckmann-Hansen C, Faber C, Larsen M, Subhi Y
Acta Ophthalmol 2020 Dec;98(8):755-762. Epub 2020 May 15 doi: 10.1111/aos.14465. PMID: 32410360
Tears and Eyewear in Forensic Investigation-A Review.
Aparna R, Shanti Iyer R
Forensic Sci Int 2020 Jan;306:110055. Epub 2019 Nov 15 doi: 10.1016/j.forsciint.2019.110055. PMID: 31785512

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