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Abnormal motor neuron morphology

MedGen UID:
871226
Concept ID:
C4025707
Anatomical Abnormality
Synonym: Abnormal shape of motor neuron
 
HPO: HP:0002450

Definition

Any structural anomaly that affects the motor neuron. [from HPO]

Professional guidelines

PubMed

McCray BA, Scherer SS
Neurotherapeutics 2021 Oct;18(4):2269-2285. Epub 2021 Oct 4 doi: 10.1007/s13311-021-01099-2. PMID: 34606075Free PMC Article
Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414Free PMC Article
Ross CA, Tabrizi SJ
Lancet Neurol 2011 Jan;10(1):83-98. doi: 10.1016/S1474-4422(10)70245-3. PMID: 21163446

Recent clinical studies

Etiology

McCray BA, Scherer SS
Neurotherapeutics 2021 Oct;18(4):2269-2285. Epub 2021 Oct 4 doi: 10.1007/s13311-021-01099-2. PMID: 34606075Free PMC Article
Israelyan N, Del Colle A, Li Z, Park Y, Xing A, Jacobsen JPR, Luna RA, Jensen DD, Madra M, Saurman V, Rahim R, Latorre R, Law K, Carson W, Bunnett NW, Caron MG, Margolis KG
Gastroenterology 2019 Aug;157(2):507-521.e4. Epub 2019 May 7 doi: 10.1053/j.gastro.2019.04.022. PMID: 31071306Free PMC Article
Mckee AC, Daneshvar DH
Handb Clin Neurol 2015;127:45-66. doi: 10.1016/B978-0-444-52892-6.00004-0. PMID: 25702209Free PMC Article
McKee AC, Daneshvar DH, Alvarez VE, Stein TD
Acta Neuropathol 2014 Jan;127(1):29-51. Epub 2013 Dec 24 doi: 10.1007/s00401-013-1230-6. PMID: 24366527Free PMC Article
Albin RL, Young AB, Penney JB
Trends Neurosci 1989 Oct;12(10):366-75. doi: 10.1016/0166-2236(89)90074-x. PMID: 2479133

Diagnosis

Tetter S, Arseni D, Murzin AG, Buhidma Y, Peak-Chew SY, Garringer HJ, Newell KL, Vidal R, Apostolova LG, Lashley T, Ghetti B, Ryskeldi-Falcon B
Nature 2024 Jan;625(7994):345-351. Epub 2023 Dec 6 doi: 10.1038/s41586-023-06801-2. PMID: 38057661Free PMC Article
Jaiser SR, Mitra D, Williams TL, Baker MR
J Neurol 2019 Mar;266(3):667-679. Epub 2019 Jan 10 doi: 10.1007/s00415-019-09186-3. PMID: 30631918Free PMC Article
Margolis SS, Sell GL, Zbinden MA, Bird LM
Neurotherapeutics 2015 Jul;12(3):641-50. doi: 10.1007/s13311-015-0361-y. PMID: 26040994Free PMC Article
Hentati F, Hentati E, Amouri R
Handb Clin Neurol 2013;115:933-8. doi: 10.1016/B978-0-444-52902-2.00052-7. PMID: 23931822
Bodensteiner JB
Semin Pediatr Neurol 2008 Mar;15(1):10-20. doi: 10.1016/j.spen.2008.01.003. PMID: 18342256

Therapy

Israelyan N, Del Colle A, Li Z, Park Y, Xing A, Jacobsen JPR, Luna RA, Jensen DD, Madra M, Saurman V, Rahim R, Latorre R, Law K, Carson W, Bunnett NW, Caron MG, Margolis KG
Gastroenterology 2019 Aug;157(2):507-521.e4. Epub 2019 May 7 doi: 10.1053/j.gastro.2019.04.022. PMID: 31071306Free PMC Article
Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R, Akiyama T, Hadano S, Aoki M, Saya H, Sobue G, Okano H
Nat Med 2018 Oct;24(10):1579-1589. Epub 2018 Aug 20 doi: 10.1038/s41591-018-0140-5. PMID: 30127392
Cacabelos R
Int J Mol Sci 2017 Mar 4;18(3) doi: 10.3390/ijms18030551. PMID: 28273839Free PMC Article
Margolis SS, Sell GL, Zbinden MA, Bird LM
Neurotherapeutics 2015 Jul;12(3):641-50. doi: 10.1007/s13311-015-0361-y. PMID: 26040994Free PMC Article
Obeso JA, Rodríguez-Oroz MC, Benitez-Temino B, Blesa FJ, Guridi J, Marin C, Rodriguez M
Mov Disord 2008;23 Suppl 3:S548-59. doi: 10.1002/mds.22062. PMID: 18781672

Prognosis

Illarioshkin SN, Klyushnikov SA, Vigont VA, Seliverstov YA, Kaznacheyeva EV
Biochemistry (Mosc) 2018 Sep;83(9):1030-1039. doi: 10.1134/S0006297918090043. PMID: 30472941
Mckee AC, Daneshvar DH
Handb Clin Neurol 2015;127:45-66. doi: 10.1016/B978-0-444-52892-6.00004-0. PMID: 25702209Free PMC Article
Hentati F, Hentati E, Amouri R
Handb Clin Neurol 2013;115:933-8. doi: 10.1016/B978-0-444-52902-2.00052-7. PMID: 23931822
McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC
Brain 2013 Jan;136(Pt 1):43-64. Epub 2012 Dec 2 doi: 10.1093/brain/aws307. PMID: 23208308Free PMC Article
Ross CA, Tabrizi SJ
Lancet Neurol 2011 Jan;10(1):83-98. doi: 10.1016/S1474-4422(10)70245-3. PMID: 21163446

Clinical prediction guides

Xie M, Pallegar PN, Parusel S, Nguyen AT, Wu LJ
Mol Neurodegener 2023 Oct 19;18(1):75. doi: 10.1186/s13024-023-00665-w. PMID: 37858176Free PMC Article
Beckers J, Tharkeshwar AK, Fumagalli L, Contardo M, Van Schoor E, Fazal R, Thal DR, Chandran S, Mancuso R, Van Den Bosch L, Van Damme P
Acta Neuropathol Commun 2023 Sep 18;11(1):151. doi: 10.1186/s40478-023-01648-0. PMID: 37723585Free PMC Article
Huin V, Coarelli G, Guemy C, Boluda S, Debs R, Mochel F, Stojkovic T, Grabli D, Maisonobe T, Gaymard B, Lenglet T, Tard C, Davion JB, Sablonnière B, Monin ML, Ewenczyk C, Viala K, Charles P, Le Ber I, Reilly MM, Houlden H, Cortese A, Seilhean D, Brice A, Durr A
Brain 2022 Jun 30;145(6):2121-2132. doi: 10.1093/brain/awab449. PMID: 34927205
Kalantari S, Carlston C, Alsaleh N, Abdel-Salam GMH, Alkuraya F, Kato M, Matsumoto N, Miyatake S, Yamamoto T, Fares-Taie L, Rozet JM, Chassaing N, Vincent-Delorme C, Kang-Bellin A, McWalter K, Bupp C, Palen E, Wagner MD, Niceta M, Cesario C, Milone R, Kaplan J, Wadman E, Dobyns WB, Filges I
Am J Med Genet A 2021 Dec;185(12):3728-3739. Epub 2021 Aug 3 doi: 10.1002/ajmg.a.62443. PMID: 34346154Free PMC Article
Dugger BN, Dickson DW
Cold Spring Harb Perspect Biol 2017 Jul 5;9(7) doi: 10.1101/cshperspect.a028035. PMID: 28062563Free PMC Article

Recent systematic reviews

Erro R, Schneider SA, Stamelou M, Quinn NP, Bhatia KP
J Neurol Neurosurg Psychiatry 2016 Mar;87(3):319-23. Epub 2015 May 19 doi: 10.1136/jnnp-2014-310256. PMID: 25991401
Annane D, Orlikowski D, Chevret S
Cochrane Database Syst Rev 2014 Dec 13;2014(12):CD001941. doi: 10.1002/14651858.CD001941.pub3. PMID: 25503955Free PMC Article
Annane D, Orlikowski D, Chevret S, Chevrolet JC, Raphaël JC
Cochrane Database Syst Rev 2007 Oct 17;(4):CD001941. doi: 10.1002/14651858.CD001941.pub2. PMID: 17943762

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