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Abnormality of the autonomic nervous system

MedGen UID:: 871233
•Concept ID:: C4025714
•: Anatomical Abnormality

HPO:	HP:0002270

Definition

An abnormality of the autonomic nervous system. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormality of the autonomic nervous system

Phenotypic abnormality
- Abnormality of prenatal development or birth
  - Fetal anomaly
    - Congenital Systemic Disorder
      - Abnormality of the nervous system
        Abnormality of the peripheral nervous system
        Abnormality of the autonomic nervous system
        Abnormal autonomic nervous system morphology
        Abnormal enteric nervous system morphology
        Abnormal enteric ganglion morphology
        Abnormal enteric neuron morphology
        Abnormal autonomic nervous system physiology
        Abnormal sudomotor regulation
        Autonomic bladder dysfunction
        Familial dysautonomia
        Horner syndrome
        Congenital Horner syndrome
        Multiple system atrophy
        Multiple system atrophy, cerebellar type
        Multiple system atrophy, parkinsonian type
        Olivopontocerebellar atrophy
        Shy Drager Syndrome
        Striatonigral degeneration
        Neurocirculatory asthenia
        Chronic Orthostatic Intolerance
        Orthostatic hypotension
        Post-Exercise Hypotension
        Postural orthostatic tachycardia syndrome
        Vasovagal syncope
        Orthostatic tachycardia
        Pure autonomic failure
        Reduced sympathoneural responses to the cold pressor test

Conditions with this feature

Mungan syndrome

MedGen UID:: 369554
•Concept ID:: C1969653
•: Disease or Syndrome

Mungan syndrome (MGS) is characterized by chronic intestinal pseudoobstruction (CIPO), megaduodenum, long-segment Barrett esophagus, and cardiac abnormalities of variable severity (summary by Bonora et al., 2015).

See: Condition Record

Mungan syndrome

Professional guidelines

PubMed

Nonallergic Rhinitis: Treatment.

Lieberman PL, Smith P
Immunol Allergy Clin North Am 2016 May;36(2):305-19. Epub 2016 Feb 26 doi: 10.1016/j.iac.2015.12.007. PMID: 27083104

See all (1)

Recent clinical studies

Etiology

Cardiac response to water activities in children with Long QT syndrome type 1.

Lundström A, Wiklund U, Winbo A, Eliasson H, Karlsson M, Rydberg A
PLoS One 2023;18(12):e0295431. Epub 2023 Dec 7 doi: 10.1371/journal.pone.0295431. PMID: 38060596 Free PMC Article

Cardiac Vagal Regulation Is Impeded in Children With Cyclic Vomiting Syndrome.

Kolacz J, Kovacic K, Dang L, Li BUK, Lewis GF, Porges SW
Am J Gastroenterol 2023 Jul 1;118(7):1268-1275. Epub 2023 Jan 30 doi: 10.14309/ajg.0000000000002207. PMID: 36716443

In infants with congenital heart disease autonomic dysfunction is associated with pre-operative brain injury.

Schlatterer SD, Govindan RB, Murnick J, Barnett SD, Lopez C, Donofrio MT, Mulkey SB, Limperopoulos C, du Plessis AJ
Pediatr Res 2022 Jun;91(7):1723-1729. Epub 2021 Dec 28 doi: 10.1038/s41390-021-01931-7. PMID: 34963700 Free PMC Article

Facial Nerve Branching Patterns Vary With Vascular Anomalies.

Adidharma L, Bly RA, Theeuwen HA, Holdefer RN, Slimp J, Kinney GA, Martinez V, Whitlock KB, Perkins JA
Laryngoscope 2020 Nov;130(11):2708-2713. Epub 2020 Jan 11 doi: 10.1002/lary.28500. PMID: 31925962

Brain-heart interaction in perseverative cognition.

Ottaviani C
Psychophysiology 2018 Jul;55(7):e13082. Epub 2018 Apr 1 doi: 10.1111/psyp.13082. PMID: 29607505

See all (3208)

Diagnosis

Congenital Myenteric Hypoganglionosis.

Kapur RP, Bellizzi AM, Bond S, Chen H, Han JS, LeGallo RD, Midgen C, Poulin AA, Uddin N, Warren M, Velázquez Vega JE, Zuppan CW
Am J Surg Pathol 2021 Aug 1;45(8):1047-1060. doi: 10.1097/PAS.0000000000001670. PMID: 33492848

Autonomic dysreflexia in spinal cord injury.

Cowan H, Lakra C, Desai M
BMJ 2020 Oct 2;371:m3596. doi: 10.1136/bmj.m3596. PMID: 33008797

The extended autonomic system, dyshomeostasis, and COVID-19.

Goldstein DS
Clin Auton Res 2020 Aug;30(4):299-315. Epub 2020 Jul 22 doi: 10.1007/s10286-020-00714-0. PMID: 32700055 Free PMC Article

Imaging diagnosis.

Takegoshi H
Adv Otorhinolaryngol 2014;75:13-9. Epub 2013 Oct 11 doi: 10.1159/000350594. PMID: 24135343

The developmental etiology and pathogenesis of Hirschsprung disease.

Butler Tjaden NE, Trainor PA
Transl Res 2013 Jul;162(1):1-15. Epub 2013 Mar 22 doi: 10.1016/j.trsl.2013.03.001. PMID: 23528997 Free PMC Article

See all (3113)

Therapy

The role of the autonomic nervous system in polycystic ovary syndrome.

Yu Y, Chen T, Zheng Z, Jia F, Liao Y, Ren Y, Liu X, Liu Y
Front Endocrinol (Lausanne) 2023;14:1295061. Epub 2024 Jan 19 doi: 10.3389/fendo.2023.1295061. PMID: 38313837 Free PMC Article

Nonallergic Rhinitis: Treatment.

Lieberman PL, Smith P
Immunol Allergy Clin North Am 2016 May;36(2):305-19. Epub 2016 Feb 26 doi: 10.1016/j.iac.2015.12.007. PMID: 27083104

2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society.

January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, Conti JB, Ellinor PT, Ezekowitz MD, Field ME, Murray KT, Sacco RL, Stevenson WG, Tchou PJ, Tracy CM, Yancy CW; American College of Cardiology/American Heart Association Task Force on Practice Guidelines
J Am Coll Cardiol 2014 Dec 2;64(21):e1-76. Epub 2014 Mar 28 doi: 10.1016/j.jacc.2014.03.022. PMID: 24685669

Heart rate turbulence.

Cygankiewicz I
Prog Cardiovasc Dis 2013 Sep-Oct;56(2):160-71. Epub 2013 Aug 29 doi: 10.1016/j.pcad.2013.08.002. PMID: 24215748

Heart rate variability: a review.

Rajendra Acharya U, Paul Joseph K, Kannathal N, Lim CM, Suri JS
Med Biol Eng Comput 2006 Dec;44(12):1031-51. Epub 2006 Nov 17 doi: 10.1007/s11517-006-0119-0. PMID: 17111118

See all (1437)

Prognosis

Cardiovascular autonomic neuropathy in patients with schizophrenia.

Omar M, Wieben ES, Polcwiartek C, Fleischer J, Valentin JB, Aagaard J, Jensen SE, Nielsen RE
Nord J Psychiatry 2021 Oct;75(7):547-552. Epub 2021 Apr 7 doi: 10.1080/08039488.2021.1902566. PMID: 33825660

Autonomic involvement in Guillain-Barré syndrome: an update.

Zaeem Z, Siddiqi ZA, Zochodne DW
Clin Auton Res 2019 Jun;29(3):289-299. Epub 2018 Jul 17 doi: 10.1007/s10286-018-0542-y. PMID: 30019292

Cystic Fibrosis and the Nervous System.

Reznikov LR
Chest 2017 May;151(5):1147-1155. Epub 2016 Nov 19 doi: 10.1016/j.chest.2016.11.009. PMID: 27876591 Free PMC Article

Cardiac applications of 123I-mIBG imaging.

Chirumamilla A, Travin MI
Semin Nucl Med 2011 Sep;41(5):374-87. doi: 10.1053/j.semnuclmed.2011.04.001. PMID: 21803188

Hirschsprung's disease.

Kenny SE, Tam PK, Garcia-Barcelo M
Semin Pediatr Surg 2010 Aug;19(3):194-200. doi: 10.1053/j.sempedsurg.2010.03.004. PMID: 20610192

See all (1510)

Clinical prediction guides

Cardiac response to water activities in children with Long QT syndrome type 1.

Lundström A, Wiklund U, Winbo A, Eliasson H, Karlsson M, Rydberg A
PLoS One 2023;18(12):e0295431. Epub 2023 Dec 7 doi: 10.1371/journal.pone.0295431. PMID: 38060596 Free PMC Article

PTEN Immunohistochemistry.

Terra SA, de Arruda Lourenção PLT, Rodrigues MAM
Arch Pathol Lab Med 2022 May 1;147(5):577-583. doi: 10.5858/arpa.2021-0424-OA. PMID: 35943858

Cardiovascular autonomic neuropathy in patients with schizophrenia.

Chronotropic Incompetence and Reduced Heart Rate Recovery in Rheumatoid Arthritis.

Peçanha T, Rodrigues R, Pinto AJ, Sá-Pinto AL, Guedes L, Bonfiglioli K, Gualano B, Roschel H
J Clin Rheumatol 2018 Oct;24(7):375-380. doi: 10.1097/RHU.0000000000000745. PMID: 29742538

Cystic Fibrosis and the Nervous System.

Reznikov LR
Chest 2017 May;151(5):1147-1155. Epub 2016 Nov 19 doi: 10.1016/j.chest.2016.11.009. PMID: 27876591 Free PMC Article

See all (2132)

Recent systematic reviews

The role of central autonomic nervous system dysfunction in Takotsubo syndrome: a systematic review.

Brazdil V, Kala P, Hudec M, Poloczek M, Kanovsky J, Stipal R, Jerabek P, Bocek O, Pail M, Brazdil M
Clin Auton Res 2022 Feb;32(1):9-17. Epub 2022 Jan 8 doi: 10.1007/s10286-021-00844-z. PMID: 34997877 Free PMC Article

Autonomic nervous system dysfunction in Wilson's disease - A systematic literature review.

Kłysz B, Bembenek J, Skowrońska M, Członkowska A, Kurkowska-Jastrzębska I
Auton Neurosci 2021 Dec;236:102890. Epub 2021 Oct 5 doi: 10.1016/j.autneu.2021.102890. PMID: 34656966

Systemic Amyloidosis Recognition, Prognosis, and Therapy: A Systematic Review.

Gertz MA, Dispenzieri A
JAMA 2020 Jul 7;324(1):79-89. doi: 10.1001/jama.2020.5493. PMID: 32633805

The sympathetic nervous system and tendinopathy: a systematic review.

Jewson JL, Lambert GW, Storr M, Gaida JE
Sports Med 2015 May;45(5):727-43. doi: 10.1007/s40279-014-0300-9. PMID: 25655371

Stroke and ventricular arrhythmias.

Koppikar S, Baranchuk A, Guzmán JC, Morillo CA
Int J Cardiol 2013 Sep 30;168(2):653-9. Epub 2013 Apr 17 doi: 10.1016/j.ijcard.2013.03.058. PMID: 23602297

See all (35)

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Abnormality of the autonomic nervous system

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

Consumer resources

Reviews

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