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Breast Papillary Ductal Carcinoma In Situ

MedGen UID:
87227
•Concept ID:
C0334372
•
Neoplastic Process
Synonyms: Breast Intraductal Papillary Carcinoma; Breast Papillary DCIS; DCIS, papillary; Ductal carcinoma in situ, papillary; Intraductal papillary adenocarcinoma; Intraductal Papillary Adenocarcinoma; Intraductal Papillary Breast Adenocarcinoma; Intraductal Papillary Breast Carcinoma; Intraductal papillary carcinoma; Intraductal Papillary Carcinoma; Non-infiltrating intraductal papillary adenocarcinoma; Non-Infiltrating Intraductal Papillary Adenocarcinoma; Non-infiltrating intraductal papillary carcinoma; Non-Infiltrating Intraductal Papillary Carcinoma; Non-Infiltrating Papillary Breast Adenocarcinoma; Non-Infiltrating Papillary Breast Carcinoma; Non-Invasive Intraductal Papillary Adenocarcinoma; Non-Invasive Intraductal Papillary Carcinoma; Non-Invasive Papillary Breast Adenocarcinoma; Non-Invasive Papillary Breast Carcinoma; Noninfiltrating intraductal papillary adenocarcinoma; Noninfiltrating intraductal papillary carcinoma; Papillary DCIS; Papillary Ductal Carcinoma In Situ
SNOMED CT: Non-infiltrating intraductal papillary adenocarcinoma (30566004); Non-infiltrating intraductal papillary carcinoma (30566004); Ductal carcinoma in situ, papillary (30566004); DCIS, papillary (30566004); Noninfiltrating intraductal papillary adenocarcinoma (30566004); Noninfiltrating intraductal papillary carcinoma (30566004); Intraductal papillary adenocarcinoma (30566004); Intraductal papillary carcinoma (30566004)

Definition

Breast ductal carcinoma in situ characterized by the presence of filiform arborizing fibrovascular cores lined by neoplastic ductal epithelium. (WHO 2019) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Papillary Ductal Carcinoma In Situ

Professional guidelines

PubMed

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Pathological criteria and practical issues in papillary lesions of the breast - a review.
Ni YB, Tse GM
Histopathology 2016 Jan;68(1):22-32. doi: 10.1111/his.12866. PMID: 26768027

Recent clinical studies

Etiology

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Diagnosis

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Papillary neoplasms of the breast-reviewing the spectrum.
Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367
Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Rageth CJ, O'Flynn EAM, Pinker K, Kubik-Huch RA, Mundinger A, Decker T, Tausch C, Dammann F, Baltzer PA, Fallenberg EM, Foschini MP, Dellas S, Knauer M, Malhaire C, Sonnenschein M, Boos A, Morris E, Varga Z
Breast Cancer Res Treat 2019 Apr;174(2):279-296. Epub 2018 Nov 30 doi: 10.1007/s10549-018-05071-1. PMID: 30506111Free PMC Article

Therapy

Intraductal papillary carcinoma of breast with invasion: A nomogram and survival from the analysis of the SEER database.
Liu C, Liu S, Zhao L, Zheng W, Wang K, Tian Y, Gui Z, Zhang L
Cancer Med 2023 Jan;12(2):1305-1318. Epub 2022 Jul 15 doi: 10.1002/cam4.5007. PMID: 35837839Free PMC Article
Unilateral nipple discharge in a man without a palpable mass diagnosed as breast cancer.
Ramakrishna KN, Durland J, Ramos C, Dhamoon AS
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-236223. PMID: 33257364Free PMC Article
Male breast cancer: A 10 year retrospective case series in a tertiary care hospital.
Yetkin G, Celayir MF, Tanik C, Citgez B, Uludag M, Mihmanli M
J Pak Med Assoc 2019 Aug;69(8):1209-1212. PMID: 31431782
Neuroendocrine breast tumours: breast cancer or neuroendocrine cancer presenting in the breast?
Adams RW, Dyson P, Barthelmes L
Breast 2014 Apr;23(2):120-7. Epub 2013 Dec 15 doi: 10.1016/j.breast.2013.11.005. PMID: 24342375
Role of breast MR imaging for predicting malignancy of histologically borderline lesions diagnosed at core needle biopsy: prospective evaluation.
Pediconi F, Padula S, Dominelli V, Luciani M, Telesca M, Casali V, Kirchin MA, Passariello R, Catalano C
Radiology 2010 Dec;257(3):653-61. Epub 2010 Sep 30 doi: 10.1148/radiol.10100732. PMID: 20884914

Prognosis

Encapsulated papillary carcinoma of the breast: An institutional case series and literature review.
Tan HJ, Tan PH, Leong LCH, Tan VKM, Tan BKT, Lim SZ, Preetha M, Wong CY, Yong WS, Sim Y
Cancer Med 2023 May;12(10):11408-11416. Epub 2023 Mar 31 doi: 10.1002/cam4.5855. PMID: 36999966Free PMC Article
Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Intraductal Carcinomas of the Salivary Gland.
Todorovic E, Weinreb I
Surg Pathol Clin 2021 Mar;14(1):1-15. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.09.003. PMID: 33526215
Papillary neoplasms of the breast-reviewing the spectrum.
Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889

Clinical prediction guides

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Breast conservation therapy for ductal carcinoma in situ (DCIS): does presentation of disease affect long-term outcomes?
Bai HX, Motwani SB, Higgins SA, Haffty BG, Wilson LD, Lannin DR, Evans SB, Moran MS
Int J Clin Oncol 2014;19(3):460-6. Epub 2013 Jun 19 doi: 10.1007/s10147-013-0575-0. PMID: 23780727
Noninvasive papillary proliferations.
Oyama T, Koerner FC
Semin Diagn Pathol 2004 Feb;21(1):32-41. doi: 10.1053/j.semdp.2003.10.011. PMID: 15074557

Recent systematic reviews

Cytological study of 44 cases with solid papillary carcinoma and a systemic review of solid papillary carcinoma and neuroendocrine tumor of the breast.
Yamada M, Otsuki Y, Ikeya T, Shimizu SI, Tanioka F, Ogawa H, Kobayashi H
Diagn Cytopathol 2023 Jun;51(6):341-348. Epub 2023 Feb 7 doi: 10.1002/dc.25112. PMID: 36748676
The positive predictive value of vacuum assisted biopsy (VAB) in predicting final histological diagnosis for breast lesions of uncertain malignancy (B3 lesions): A systematic review & meta-analysis.
Cullinane C, Byrne J, Kelly L, O Sullivan M, Antony Corrigan M, Paul Redmond H
Eur J Surg Oncol 2022 Jul;48(7):1464-1474. Epub 2022 Apr 15 doi: 10.1016/j.ejso.2022.04.005. PMID: 35491362

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