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Pleural fibroma

MedGen UID:
87255
•Concept ID:
C0334511
•
Neoplastic Process
Synonym: Fibrous mesothelioma, benign
SNOMED CT: Benign fibrous mesothelioma (15702005); Fibrous mesothelioma, benign (15702005); Pleural fibroma (1293083009); Solitary fibrous tumor of pleura (1293084003); Localized fibrous tumor of pleura (1293084003)

Definition

A localized neoplasm of probable fibroblastic derivation, that arises from the pleura. It is characterized by the presence of round to spindle-shaped cells, hylanized stroma formation, thin-walled branching blood vessels, and thin bands of collagen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleural fibroma

Professional guidelines

PubMed

Clinical and therapeutic management of a pleural fibrous tumor with ALK translocation.
Cruz-Castellanos P, Gutiérrez-Sainz L, Villamayor J, Esteban MI, Peláez A, Castro FJ
Cir Cir 2021;89(S1):102-105. doi: 10.24875/CIRU.20001346. PMID: 34762616
Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model.
Demicco EG, Park MS, Araujo DM, Fox PS, Bassett RL, Pollock RE, Lazar AJ, Wang WL
Mod Pathol 2012 Sep;25(9):1298-306. Epub 2012 May 11 doi: 10.1038/modpathol.2012.83. PMID: 22575866
Value of D2-40 in the differential diagnosis of pleural neoplasms with emphasis on its positivity in solitary fibrous tumor.
Hu Y, Yang Q, McMahon LA, Wang HL, Xu H
Appl Immunohistochem Mol Morphol 2010 Oct;18(5):411-3. doi: 10.1097/PAI.0b013e3181da8387. PMID: 20436345

Recent clinical studies

Therapy

Malignant localized fibrous tumor of the pleura occurring in a person environmentally exposed to tremolite asbestos.
Metintas M, Gibbs AR, Harmanci E, Ozdemir N, Paşaoğlu O, Işiksoy S, Arslan R, Erginel S, Adapinar B
Respiration 1997;64(3):236-9. doi: 10.1159/000196678. PMID: 9154678

Prognosis

Solitary fibrous tumor of the pleura: Can computed tomography features help predict malignancy? A series of 56 patients with histopathological correlates.
Hélage S, Revel MP, Chabi ML, Audureau É, Ferretti G, Laurent F, Alifano M, Mansuet-Lupo A, Buy JN, Vadrot D
Diagn Interv Imaging 2016 Mar;97(3):347-53. Epub 2015 Nov 2 doi: 10.1016/j.diii.2015.04.013. PMID: 26542536
Prognostic factors in solitary fibrous tumors of the pleura.
Schmid S, Csanadi A, Kaifi JT, Kübler M, Haager B, Kayser G, Passlick B, Wiesemann S
J Surg Res 2015 May 15;195(2):580-7. Epub 2015 Jan 30 doi: 10.1016/j.jss.2015.01.049. PMID: 25770743
Mesothelial and related neoplasms in children and adolescents: a clinicopathologic and immunohistochemical analysis of eight cases.
Coffin CM, Dehner LP
Pediatr Pathol 1992 May-Jun;12(3):333-47. doi: 10.3109/15513819209023314. PMID: 1384016

Clinical prediction guides

Solitary fibrous tumor of the pleura: Can computed tomography features help predict malignancy? A series of 56 patients with histopathological correlates.
Hélage S, Revel MP, Chabi ML, Audureau É, Ferretti G, Laurent F, Alifano M, Mansuet-Lupo A, Buy JN, Vadrot D
Diagn Interv Imaging 2016 Mar;97(3):347-53. Epub 2015 Nov 2 doi: 10.1016/j.diii.2015.04.013. PMID: 26542536
Prognostic factors in solitary fibrous tumors of the pleura.
Schmid S, Csanadi A, Kaifi JT, Kübler M, Haager B, Kayser G, Passlick B, Wiesemann S
J Surg Res 2015 May 15;195(2):580-7. Epub 2015 Jan 30 doi: 10.1016/j.jss.2015.01.049. PMID: 25770743
Study of serum big-insulin-like growth factor (IGF)-II and IGF binding proteins in two patients with extrapancreatic tumor hypoglycemia, using a combination of Western blotting methods.
Christofilis MA, Remacle-Bonnet M, Atlan-Gepner C, Garrouste F, Vialettes B, Fuentes P, Guidicelli R, Pommier G
Eur J Endocrinol 1998 Sep;139(3):317-22. doi: 10.1530/eje.0.1390317. PMID: 9758443
Multiple bilateral fibromas of the pleura.
Scattini CM, Orsi A
Thorax 1973 Nov;28(6):782-7. doi: 10.1136/thx.28.6.782. PMID: 4787991Free PMC Article

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