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Fibrillary astrocytoma

MedGen UID:
87270
•Concept ID:
C0334582
•
Neoplastic Process
Synonyms: Astrocytoma, Fibrillary; Fibrillary Astrocytoma; Fibrillary Astrocytomas
SNOMED CT: Fibrillary astrocytoma (71314006); Fibrous astrocytoma (71314006)
 
Monarch Initiative: MONDO:0016688
Orphanet: ORPHA251601

Definition

The most frequent histological variant of diffuse astrocytoma. It is predominantly composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic criterion but mitotic activity, necrosis and microvascular proliferation are absent. The occasional or regional occurrence of gemistocytic neoplastic cells is compatible with the diagnosis of fibrillary astrocytoma. (WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibrillary astrocytoma
Follow this link to review classifications for Fibrillary astrocytoma in Orphanet.

Professional guidelines

PubMed

Treatment and Outcome in 65 Children with Optic Pathway Gliomas.
El Beltagy MA, Reda M, Enayet A, Zaghloul MS, Awad M, Zekri W, Taha H, El-Khateeb N
World Neurosurg 2016 May;89:525-34. Epub 2016 Feb 18 doi: 10.1016/j.wneu.2016.02.042. PMID: 26898488
Initial management of children with hypothalamic and thalamic tumors and the modifying role of neurofibromatosis-1.
Allen JC
Pediatr Neurosurg 2000 Mar;32(3):154-62. doi: 10.1159/000028922. PMID: 10867564
Spinal cord astrocytoma: pathological and treatment considerations.
Minehan KJ, Shaw EG, Scheithauer BW, Davis DL, Onofrio BM
J Neurosurg 1995 Oct;83(4):590-5. doi: 10.3171/jns.1995.83.4.0590. PMID: 7674006

Recent clinical studies

Etiology

1p/19q co-deleted fibrillary astrocytomas: Not everything that is co-deleted is an oligodendroglioma.
Andrews C, Prayson RA
Ann Diagn Pathol 2020 Jun;46:151519. Epub 2020 Apr 8 doi: 10.1016/j.anndiagpath.2020.151519. PMID: 32305004
Treatment and Outcome in 65 Children with Optic Pathway Gliomas.
El Beltagy MA, Reda M, Enayet A, Zaghloul MS, Awad M, Zekri W, Taha H, El-Khateeb N
World Neurosurg 2016 May;89:525-34. Epub 2016 Feb 18 doi: 10.1016/j.wneu.2016.02.042. PMID: 26898488
Bilateral thalamic lesions.
Menon G, Nair S, Sudhir J, Rao BR, Krishnakumar K
Br J Neurosurg 2010 Oct;24(5):566-71. doi: 10.3109/02688691003777915. PMID: 20536292
Initial management of children with hypothalamic and thalamic tumors and the modifying role of neurofibromatosis-1.
Allen JC
Pediatr Neurosurg 2000 Mar;32(3):154-62. doi: 10.1159/000028922. PMID: 10867564
Stereotactic radiosurgery for recurrent gliomas.
Chamberlain MC, Barba D, Kormanik P, Shea WM
Cancer 1994 Aug 15;74(4):1342-7. doi: 10.1002/1097-0142(19940815)74:4<1342::aid-cncr2820740426>3.0.co;2-y. PMID: 8055458

Diagnosis

1p/19q co-deleted fibrillary astrocytomas: Not everything that is co-deleted is an oligodendroglioma.
Andrews C, Prayson RA
Ann Diagn Pathol 2020 Jun;46:151519. Epub 2020 Apr 8 doi: 10.1016/j.anndiagpath.2020.151519. PMID: 32305004
IDH-1 polymorphisms in pilocytic astrocytomas.
Prayson RA
Ann Diagn Pathol 2019 Dec;43:151411. Epub 2019 Oct 23 doi: 10.1016/j.anndiagpath.2019.151411. PMID: 31677487
Opticochiasmatic apoplexy in a five-year-old.
Ball BG, Wetmore C, Giannini C, Wetjen NM, Meyer FB
Pediatr Neurosurg 2011;47(4):279-83. Epub 2012 Mar 23 doi: 10.1159/000334309. PMID: 22456272
Incidental findings of mass lesions on neuroimages in children.
Perret C, Boltshauser E, Scheer I, Kellenberger CJ, Grotzer MA
Neurosurg Focus 2011 Dec;31(6):E20. doi: 10.3171/2011.9.FOCUS11121. PMID: 22133179
Bilateral thalamic astrocytoma.
Habek M, Brinar VV, Mubrin Z, Barun B, Zarković K
J Neurooncol 2007 Sep;84(2):175-7. Epub 2007 May 24 doi: 10.1007/s11060-007-9404-5. PMID: 17522784

Therapy

Treatment and Outcome in 65 Children with Optic Pathway Gliomas.
El Beltagy MA, Reda M, Enayet A, Zaghloul MS, Awad M, Zekri W, Taha H, El-Khateeb N
World Neurosurg 2016 May;89:525-34. Epub 2016 Feb 18 doi: 10.1016/j.wneu.2016.02.042. PMID: 26898488
A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma.
Massimino M, Spreafico F, Riva D, Biassoni V, Poggi G, Solero C, Gandola L, Genitori L, Modena P, Simonetti F, Potepan P, Casanova M, Meazza C, Clerici CA, Catania S, Sardi I, Giangaspero F
J Neurooncol 2010 Oct;100(1):65-71. Epub 2010 Feb 12 doi: 10.1007/s11060-010-0136-6. PMID: 20151174
Prospective assessment of activities of daily living using modified Barthel's Index in children and young adults with low-grade gliomas treated with stereotactic conformal radiotherapy.
Jalali R, Dutta D, Kamble R, Gupta T, Munshi A, Sarin R, Dinshaw K
J Neurooncol 2008 Dec;90(3):321-8. Epub 2008 Aug 14 doi: 10.1007/s11060-008-9666-6. PMID: 18704269
Management of child optic pathway gliomas: new therapeutical option.
Suárez JC, Viano JC, Zunino S, Herrera EJ, Gomez J, Tramunt B, Marengo I, Hiramatzu E, Miras M, Pena M, Sonzini Astudillo B
Childs Nerv Syst 2006 Jul;22(7):679-84. Epub 2006 Jan 3 doi: 10.1007/s00381-005-0021-3. PMID: 16389565
Stereotactic radiosurgery for recurrent gliomas.
Chamberlain MC, Barba D, Kormanik P, Shea WM
Cancer 1994 Aug 15;74(4):1342-7. doi: 10.1002/1097-0142(19940815)74:4<1342::aid-cncr2820740426>3.0.co;2-y. PMID: 8055458

Prognosis

Treatment and Outcome in 65 Children with Optic Pathway Gliomas.
El Beltagy MA, Reda M, Enayet A, Zaghloul MS, Awad M, Zekri W, Taha H, El-Khateeb N
World Neurosurg 2016 May;89:525-34. Epub 2016 Feb 18 doi: 10.1016/j.wneu.2016.02.042. PMID: 26898488
Bilateral thalamic lesions.
Menon G, Nair S, Sudhir J, Rao BR, Krishnakumar K
Br J Neurosurg 2010 Oct;24(5):566-71. doi: 10.3109/02688691003777915. PMID: 20536292
Oligodendroglioma: pathology and molecular biology.
Engelhard HH, Stelea A, Cochran EJ
Surg Neurol 2002 Aug;58(2):111-7; discussion 117. doi: 10.1016/s0090-3019(02)00751-6. PMID: 12453646
Initial management of children with hypothalamic and thalamic tumors and the modifying role of neurofibromatosis-1.
Allen JC
Pediatr Neurosurg 2000 Mar;32(3):154-62. doi: 10.1159/000028922. PMID: 10867564
Stereotactic radiosurgery for recurrent gliomas.
Chamberlain MC, Barba D, Kormanik P, Shea WM
Cancer 1994 Aug 15;74(4):1342-7. doi: 10.1002/1097-0142(19940815)74:4<1342::aid-cncr2820740426>3.0.co;2-y. PMID: 8055458

Clinical prediction guides

Can permanent cell lines originate from low-grade astrocytomas: overgrowth of "glia-like" cells in pilocytic and fibrillary (diffuse) astrocytoma cultures.
Sivakova I, Mraz P, Kubikova E, El Falougy H, Perzelova A
Bratisl Lek Listy 2021;122(6):367-370. doi: 10.4149/10.4149/BLL_2021_061. PMID: 34002608
The expression level of cannabinoid receptors type 1 and 2 in the different types of astrocytomas.
Hashemi M, Bashi S, Zali A
Mol Biol Rep 2020 Jul;47(7):5461-5467. Epub 2020 Jul 4 doi: 10.1007/s11033-020-05636-8. PMID: 32623617
1p/19q co-deleted fibrillary astrocytomas: Not everything that is co-deleted is an oligodendroglioma.
Andrews C, Prayson RA
Ann Diagn Pathol 2020 Jun;46:151519. Epub 2020 Apr 8 doi: 10.1016/j.anndiagpath.2020.151519. PMID: 32305004
Opticochiasmatic apoplexy in a five-year-old.
Ball BG, Wetmore C, Giannini C, Wetjen NM, Meyer FB
Pediatr Neurosurg 2011;47(4):279-83. Epub 2012 Mar 23 doi: 10.1159/000334309. PMID: 22456272
Incidental findings of mass lesions on neuroimages in children.
Perret C, Boltshauser E, Scheer I, Kellenberger CJ, Grotzer MA
Neurosurg Focus 2011 Dec;31(6):E20. doi: 10.3171/2011.9.FOCUS11121. PMID: 22133179

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