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Stable angina

MedGen UID:
87401
•Concept ID:
C0340288
•
Disease or Syndrome
Synonyms: Angina Pectori, Stable; Angina Pectoris, Stable; Angina, Chronic Stable; Angina, Stable; Anginas, Chronic Stable; Anginas, Stable; Chronic Stable Angina; Chronic Stable Anginas; Pectori, Stable Angina; Pectoris, Stable Angina; Stable Angina; Stable Angina Pectori; Stable Angina Pectoris; Stable Angina, Chronic; Stable Anginas; Stable Anginas, Chronic
SNOMED CT: Stable angina (233819005)

Definition

Angina pectoris which has not recently changed in frequency, duration or intensity. Stable angina pectoris is relieved by rest or administration or oral, sublingual or transdermal antianginal medications. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStable angina

Professional guidelines

PubMed

Diagnosis and Management of Stable Angina: A Review.
Joshi PH, de Lemos JA
JAMA 2021 May 4;325(17):1765-1778. doi: 10.1001/jama.2021.1527. PMID: 33944871
Evaluation and Management of Patients With Stable Angina: Beyond the Ischemia Paradigm: JACC State-of-the-Art Review.
Ferraro R, Latina JM, Alfaddagh A, Michos ED, Blaha MJ, Jones SR, Sharma G, Trost JC, Boden WE, Weintraub WS, Lima JAC, Blumenthal RS, Fuster V, Arbab-Zadeh A
J Am Coll Cardiol 2020 Nov 10;76(19):2252-2266. doi: 10.1016/j.jacc.2020.08.078. PMID: 33153586
Treatment of Angina: Where Are We?
Balla C, Pavasini R, Ferrari R
Cardiology 2018;140(1):52-67. Epub 2018 Jun 6 doi: 10.1159/000487936. PMID: 29874661

Recent clinical studies

Etiology

Diagnosis and Management of Stable Angina: A Review.
Joshi PH, de Lemos JA
JAMA 2021 May 4;325(17):1765-1778. doi: 10.1001/jama.2021.1527. PMID: 33944871
Trimethylamine N-Oxide, Circulating Endothelial Progenitor Cells, and Endothelial Function in Patients with Stable Angina.
Chou RH, Chen CY, Chen IC, Huang HL, Lu YW, Kuo CS, Chang CC, Huang PH, Chen JW, Lin SJ
Sci Rep 2019 Mar 12;9(1):4249. doi: 10.1038/s41598-019-40638-y. PMID: 30862856Free PMC Article
Clinical characteristics, and in-hospital and long-term outcomes of stable angina treatment in patients below and over 40 years of age (from the PRESAGE registry).
Trzeciak P, Desperak P, Ciślak A, Hawranek M, Gąsior M
Kardiol Pol 2018;76(1):186-194. Epub 2017 Nov 23 doi: 10.5603/KP.a2017.0200. PMID: 29168551
WITHDRAWN: Trimetazidine for stable angina.
Ciapponi A, Pizarro R, Harrison J
Cochrane Database Syst Rev 2017 Mar 20;3(3):CD003614. doi: 10.1002/14651858.CD003614.pub3. PMID: 28319269Free PMC Article
Management of chronic stable angina: medical therapy, percutaneous transluminal coronary angioplasty, and coronary artery bypass graft surgery. Lessons from the randomized trials.
Solomon AJ, Gersh BJ
Ann Intern Med 1998 Feb 1;128(3):216-23. doi: 10.7326/0003-4819-128-3-199802010-00008. PMID: 9454530

Diagnosis

International Observational Analysis of Evolution and Outcomes of Chronic Stable Angina: The Multinational CLARIFY Study.
Mesnier J, Ducrocq G, Danchin N, Ferrari R, Ford I, Tardif JC, Tendera M, Fox KM, Steg PG; CLARIFY Investigators
Circulation 2021 Aug 17;144(7):512-523. Epub 2021 Jul 15 doi: 10.1161/CIRCULATIONAHA.121.054567. PMID: 34261331Free PMC Article
Diagnosis and Management of Stable Angina: A Review.
Joshi PH, de Lemos JA
JAMA 2021 May 4;325(17):1765-1778. doi: 10.1001/jama.2021.1527. PMID: 33944871
Trimethylamine N-Oxide, Circulating Endothelial Progenitor Cells, and Endothelial Function in Patients with Stable Angina.
Chou RH, Chen CY, Chen IC, Huang HL, Lu YW, Kuo CS, Chang CC, Huang PH, Chen JW, Lin SJ
Sci Rep 2019 Mar 12;9(1):4249. doi: 10.1038/s41598-019-40638-y. PMID: 30862856Free PMC Article
Ranolazine: A Contemporary Review.
Rayner-Hartley E, Sedlak T
J Am Heart Assoc 2016 Mar 15;5(3):e003196. doi: 10.1161/JAHA.116.003196. PMID: 26979079Free PMC Article
Stable angina pectoris.
Valgimigli M, Biscaglia S
Curr Atheroscler Rep 2014 Jul;16(7):422. doi: 10.1007/s11883-014-0422-4. PMID: 24838374

Therapy

Beneficial effect of ivabradine against cardiovascular diseases.
Gammone MA, Riccioni G, Massari F, D'Orazio N
Front Biosci (Schol Ed) 2020 Mar 1;12(1):161-172. doi: 10.2741/S545. PMID: 32114453
Post-truth era and cardiology: After ORBITA, before CABANA.
Ozeke O, Cay S, Ozcan F, Topaloglu S, Aras D
Indian Heart J 2018 May-Jun;70(3):439-442. Epub 2018 Apr 22 doi: 10.1016/j.ihj.2018.04.005. PMID: 29961465Free PMC Article
Ivabradine in chronic stable angina: Effects by and beyond heart rate reduction.
Camici PG, Gloekler S, Levy BI, Skalidis E, Tagliamonte E, Vardas P, Heusch G
Int J Cardiol 2016 Jul 15;215:1-6. Epub 2016 Apr 11 doi: 10.1016/j.ijcard.2016.04.001. PMID: 27104917
The COURAGE trial in perspective.
Prasad A, Rihal C, Holmes DR Jr
Catheter Cardiovasc Interv 2008 Jul 1;72(1):54-9. doi: 10.1002/ccd.21522. PMID: 18412271
Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients.
Antithrombotic Trialists' Collaboration
BMJ 2002 Jan 12;324(7329):71-86. doi: 10.1136/bmj.324.7329.71. PMID: 11786451Free PMC Article

Prognosis

Incidence of 12 common cardiovascular diseases and subsequent mortality risk in the general population.
Prugger C, Perier MC, Gonzalez-Izquierdo A, Hemingway H, Denaxas S, Empana JP
Eur J Prev Cardiol 2023 Oct 26;30(15):1715-1722. doi: 10.1093/eurjpc/zwad192. PMID: 37294923
Association of Cardiac Rehabilitation With All-Cause Mortality Among Patients With Cardiovascular Disease in the Netherlands.
Eijsvogels TMH, Maessen MFH, Bakker EA, Meindersma EP, van Gorp N, Pijnenburg N, Thompson PD, Hopman MTE
JAMA Netw Open 2020 Jul 1;3(7):e2011686. doi: 10.1001/jamanetworkopen.2020.11686. PMID: 32716516
Early Readmissions After Acute Myocardial Infarction.
Kwok CS, Wong CW, Shufflebotham H, Brindley L, Fatima T, Shufflebotham A, Barker D, Pawala A, Heatlie G, Mamas MA
Am J Cardiol 2017 Sep 1;120(5):723-728. Epub 2017 Jun 15 doi: 10.1016/j.amjcard.2017.05.049. PMID: 28728745
Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people.
Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, Deanfield J, Smeeth L, Timmis A, Hemingway H
Lancet Diabetes Endocrinol 2015 Feb;3(2):105-13. Epub 2014 Nov 11 doi: 10.1016/S2213-8587(14)70219-0. PMID: 25466521Free PMC Article
Angina (chronic stable).
O'Toole L
BMJ Clin Evid 2008 Oct 1;2008 PMID: 19445795Free PMC Article

Clinical prediction guides

Coronary angiography-derived contrast fractional flow reserve.
Gong Y, Zheng B, Yi T, Yang F, Hong T, Liu Z, Huo Y, Li J, Huo Y
Catheter Cardiovasc Interv 2022 Feb;99(3):763-771. Epub 2021 Feb 15 doi: 10.1002/ccd.29558. PMID: 33590679
Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART).
Williams MC, Kwiecinski J, Doris M, McElhinney P, D'Souza MS, Cadet S, Adamson PD, Moss AJ, Alam S, Hunter A, Shah ASV, Mills NL, Pawade T, Wang C, Weir McCall J, Bonnici-Mallia M, Murrills C, Roditi G, van Beek EJR, Shaw LJ, Nicol ED, Berman DS, Slomka PJ, Newby DE, Dweck MR, Dey D
Circulation 2020 May 5;141(18):1452-1462. Epub 2020 Mar 16 doi: 10.1161/CIRCULATIONAHA.119.044720. PMID: 32174130Free PMC Article
1-Year Outcomes of Angina Management Guided by Invasive Coronary Function Testing (CorMicA).
Ford TJ, Stanley B, Sidik N, Good R, Rocchiccioli P, McEntegart M, Watkins S, Eteiba H, Shaukat A, Lindsay M, Robertson K, Hood S, McGeoch R, McDade R, Yii E, McCartney P, Corcoran D, Collison D, Rush C, Sattar N, McConnachie A, Touyz RM, Oldroyd KG, Berry C
JACC Cardiovasc Interv 2020 Jan 13;13(1):33-45. Epub 2019 Nov 11 doi: 10.1016/j.jcin.2019.11.001. PMID: 31709984Free PMC Article
Vasospastic angina: A literature review of current evidence.
Picard F, Sayah N, Spagnoli V, Adjedj J, Varenne O
Arch Cardiovasc Dis 2019 Jan;112(1):44-55. Epub 2018 Sep 7 doi: 10.1016/j.acvd.2018.08.002. PMID: 30197243
Reconciling discordant myocardial perfusion imaging and coronary angiography.
Rollor J, Feldmeier R, Jerome S, Gupta A
J Nucl Cardiol 2018 Feb;25(1):86-93. Epub 2016 Jan 21 doi: 10.1007/s12350-016-0396-4. PMID: 26797922

Recent systematic reviews

Tongxinluo capsule in combination with conventional therapies for stable angina pectoris: A meta-analysis and systematic review.
Feng R, Lin Q, Wei D, Li Y, Zhang R, Jiang K, Li Y, Xie L, Xia J, Zheng P, Ji X, Wang W, Qu X, Gao Q, Pan Y, Liu J
Medicine (Baltimore) 2023 Oct 13;102(41):e35405. doi: 10.1097/MD.0000000000035405. PMID: 37832041Free PMC Article
Anti-anginal drugs-beliefs and evidence: systematic review covering 50 years of medical treatment.
Ferrari R, Pavasini R, Camici PG, Crea F, Danchin N, Pinto F, Manolis A, Marzilli M, Rosano GMC, Lopez-Sendon J, Fox K
Eur Heart J 2019 Jan 7;40(2):190-194. doi: 10.1093/eurheartj/ehy504. PMID: 30165445
The performance of non-invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: a meta-analysis focused on post-test disease probability.
Knuuti J, Ballo H, Juarez-Orozco LE, Saraste A, Kolh P, Rutjes AWS, Jüni P, Windecker S, Bax JJ, Wijns W
Eur Heart J 2018 Sep 14;39(35):3322-3330. doi: 10.1093/eurheartj/ehy267. PMID: 29850808
Exercise-based cardiac rehabilitation for coronary heart disease.
Anderson L, Thompson DR, Oldridge N, Zwisler AD, Rees K, Martin N, Taylor RS
Cochrane Database Syst Rev 2016 Jan 5;2016(1):CD001800. doi: 10.1002/14651858.CD001800.pub3. PMID: 26730878Free PMC Article
The diagnostic accuracy and outcomes after coronary computed tomography angiography vs. conventional functional testing in patients with stable angina pectoris: a systematic review and meta-analysis.
Nielsen LH, Ortner N, Nørgaard BL, Achenbach S, Leipsic J, Abdulla J
Eur Heart J Cardiovasc Imaging 2014 Sep;15(9):961-71. Epub 2014 Mar 11 doi: 10.1093/ehjci/jeu027. PMID: 24618659

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