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Metastatic Malignant Neoplasm in the Epididymis

MedGen UID:
87568
•Concept ID:
C0347004
•
Neoplastic Process
Synonyms: Metastasis to epididymis; Metastatic malignant neoplasm of epididymis; Metastatic malignant neoplasm to epididymis; Metastatic Malignant Neoplasm to the Epididymis; Metastatic Neoplasm to the Epididymis; Metastatic tumor to epididymis; Metastatic Tumor to the Epididymis; Secondary malignant neoplasm of epididymis
SNOMED CT: Metastatic tumor to epididymis (94283001); Metastasis to epididymis (94283001); Secondary malignant neoplasm of epididymis (94283001); Metastatic malignant neoplasm to epididymis (94283001); Metastatic malignant neoplasm of epididymis (94283001)

Definition

A malignant neoplasm that has metastasized to the epididymis from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Epididymis

Professional guidelines

PubMed

Past, Present, and Future of Serum Tumor Markers in Management of Ovarian Cancer: A Guide for the Radiologist.
Rao S, Smith DA, Guler E, Kikano EG, Rajdev MA, Yoest JM, Ramaiya NH, Tirumani SH
Radiographics 2021 Oct;41(6):1839-1856. doi: 10.1148/rg.2021210005. PMID: 34597221
Clinical Use of Cancer Biomarkers in Epithelial Ovarian Cancer: Updated Guidelines From the European Group on Tumor Markers.
Sölétormos G, Duffy MJ, Othman Abu Hassan S, Verheijen RH, Tholander B, Bast RC Jr, Gaarenstroom KN, Sturgeon CM, Bonfrer JM, Petersen PH, Troonen H, CarloTorre G, Kanty Kulpa J, Tuxen MK, Molina R
Int J Gynecol Cancer 2016 Jan;26(1):43-51. doi: 10.1097/IGC.0000000000000586. PMID: 26588231Free PMC Article

Recent clinical studies

Etiology

Pathological predictors of metastatic disease in testicular non-seminomatous germ cell tumors: which tumor-node-metastasis staging system?
Scandura G, Wagner T, Beltran L, Alifrangis C, Shamash J, Berney DM
Mod Pathol 2021 Apr;34(4):834-841. Epub 2020 Dec 15 doi: 10.1038/s41379-020-00717-2. PMID: 33319858
Expression and clinical significance of annexin A2 and human epididymis protein 4 in endometrial carcinoma.
Deng L, Gao Y, Li X, Cai M, Wang H, Zhuang H, Tan M, Liu S, Hao Y, Lin B
J Exp Clin Cancer Res 2015 Sep 11;34(1):96. doi: 10.1186/s13046-015-0208-8. PMID: 26362938Free PMC Article
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.
Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390
Unusual scrotal pathology: an overview.
Rosevear HM, Mishail A, Sheynkin Y, Wald M
Nat Rev Urol 2009 Sep;6(9):491-500. Epub 2009 Aug 11 doi: 10.1038/nrurol.2009.149. PMID: 19668251
Male sterilization.
Davis JE
Curr Opin Obstet Gynecol 1992 Aug;4(4):522-6. PMID: 1324023

Diagnosis

von Hippel-Lindau disease-related neoplasia with an emphasis on renal manifestations.
Tekin B, Erickson LA, Gupta S
Semin Diagn Pathol 2024 Jan;41(1):20-27. Epub 2023 Nov 8 doi: 10.1053/j.semdp.2023.11.003. PMID: 37980175
Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis.
Anastasi E, Farina A, Granato T, Colaiacovo F, Pucci B, Tartaglione S, Angeloni A
Int J Mol Sci 2023 Jun 22;24(13) doi: 10.3390/ijms241310479. PMID: 37445657Free PMC Article
Identification of castration-dependent and -independent driver genes and pathways in castration-resistant prostate cancer (CRPC).
Li Y, Shi H, Zhao Z, Xu M
BMC Urol 2022 Oct 18;22(1):162. doi: 10.1186/s12894-022-01113-5. PMID: 36258196Free PMC Article
Unusual scrotal pathology: an overview.
Rosevear HM, Mishail A, Sheynkin Y, Wald M
Nat Rev Urol 2009 Sep;6(9):491-500. Epub 2009 Aug 11 doi: 10.1038/nrurol.2009.149. PMID: 19668251
Male sterilization.
Davis JE
Curr Opin Obstet Gynecol 1992 Aug;4(4):522-6. PMID: 1324023

Therapy

Primary intratesticular rhabdomyosarcoma, a rare entity: A case report with review of literature.
Lachi PK, Armugham N, Triveni B, Sheela B, Krishna MR
J Cancer Res Ther 2021 Apr-Jun;17(2):590-592. doi: 10.4103/jcrt.JCRT_585_15. PMID: 34121716
Efficacy of neoadjuvant chemotherapy combined with intraperitoneal hyperthermic chemotherapy in advanced ovarian cancer.
Xu Z, Ge X, Zhang T, Shi Y, Sun M
J BUON 2020 Mar-Apr;25(2):772-778. PMID: 32521866
Safety and Outcome Measures of First-in-Human Intraperitoneal α Radioimmunotherapy With 212Pb-TCMC-Trastuzumab.
Meredith RF, Torgue JJ, Rozgaja TA, Banaga EP, Bunch PW, Alvarez RD, Straughn JM Jr, Dobelbower MC, Lowy AM
Am J Clin Oncol 2018 Jul;41(7):716-721. doi: 10.1097/COC.0000000000000353. PMID: 27906723Free PMC Article
Gastrointestinal stromal tumour metastatic to the epididymis.
Ahmad A, Libbey NP, Somasundar P, Katz SC
BMJ Case Rep 2015 Sep 23;2015 doi: 10.1136/bcr-2015-211555. PMID: 26400593Free PMC Article
Male sterilization.
Davis JE
Curr Opin Obstet Gynecol 1992 Aug;4(4):522-6. PMID: 1324023

Prognosis

Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis.
Anastasi E, Farina A, Granato T, Colaiacovo F, Pucci B, Tartaglione S, Angeloni A
Int J Mol Sci 2023 Jun 22;24(13) doi: 10.3390/ijms241310479. PMID: 37445657Free PMC Article
Identification of castration-dependent and -independent driver genes and pathways in castration-resistant prostate cancer (CRPC).
Li Y, Shi H, Zhao Z, Xu M
BMC Urol 2022 Oct 18;22(1):162. doi: 10.1186/s12894-022-01113-5. PMID: 36258196Free PMC Article
Expression and clinical significance of annexin A2 and human epididymis protein 4 in endometrial carcinoma.
Deng L, Gao Y, Li X, Cai M, Wang H, Zhuang H, Tan M, Liu S, Hao Y, Lin B
J Exp Clin Cancer Res 2015 Sep 11;34(1):96. doi: 10.1186/s13046-015-0208-8. PMID: 26362938Free PMC Article
Papillary cystadenoma of the epididymis.
Odrzywolski KJ, Mukhopadhyay S
Arch Pathol Lab Med 2010 Apr;134(4):630-3. doi: 10.5858/134.4.630. PMID: 20367315
Miscellaneous rare paratesticular tumors.
Henley JD, Ferry J, Ulbright TM
Semin Diagn Pathol 2000 Nov;17(4):319-39. PMID: 11202548

Clinical prediction guides

Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis.
Anastasi E, Farina A, Granato T, Colaiacovo F, Pucci B, Tartaglione S, Angeloni A
Int J Mol Sci 2023 Jun 22;24(13) doi: 10.3390/ijms241310479. PMID: 37445657Free PMC Article
Pathological predictors of metastatic disease in testicular non-seminomatous germ cell tumors: which tumor-node-metastasis staging system?
Scandura G, Wagner T, Beltran L, Alifrangis C, Shamash J, Berney DM
Mod Pathol 2021 Apr;34(4):834-841. Epub 2020 Dec 15 doi: 10.1038/s41379-020-00717-2. PMID: 33319858
Pathological risk factors for higher clinical stage in testicular seminomas.
Trevino KE, Esmaeili-Shandiz A, Saeed O, Xu H, Ulbright TM, Idrees MT
Histopathology 2018 Nov;73(5):741-747. Epub 2018 Aug 14 doi: 10.1111/his.13667. PMID: 29858564
Testicular hilum and vascular invasion predict advanced clinical stage in nonseminomatous germ cell tumors.
Yilmaz A, Cheng T, Zhang J, Trpkov K
Mod Pathol 2013 Apr;26(4):579-86. Epub 2012 Dec 14 doi: 10.1038/modpathol.2012.189. PMID: 23238629
Unusual scrotal pathology: an overview.
Rosevear HM, Mishail A, Sheynkin Y, Wald M
Nat Rev Urol 2009 Sep;6(9):491-500. Epub 2009 Aug 11 doi: 10.1038/nrurol.2009.149. PMID: 19668251

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