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Chronic kidney disease mineral and bone disorder

MedGen UID:
885556
•Concept ID:
C4076240
•
Disease or Syndrome
Synonyms: Chronic Kidney Disease Mineral and Bone Disorder; Chronic Kidney Disease-Mineral and Bone Disorder; CKD-MBD
SNOMED CT: Chronic kidney disease mineral and bone disorder (713313000); CKD-MBD - chronic kidney disease mineral and bone disorder (713313000)

Definition

Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic kidney disease mineral and bone disorder

Professional guidelines

PubMed

Diagnosis and Management of Osteoporosis in Advanced Kidney Disease: A Review.
Ginsberg C, Ix JH
Am J Kidney Dis 2022 Mar;79(3):427-436. Epub 2021 Aug 20 doi: 10.1053/j.ajkd.2021.06.031. PMID: 34419519
KDOQI US Commentary on the 2017 KDIGO Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD).
Isakova T, Nickolas TL, Denburg M, Yarlagadda S, Weiner DE, Gutiérrez OM, Bansal V, Rosas SE, Nigwekar S, Yee J, Kramer H
Am J Kidney Dis 2017 Dec;70(6):737-751. Epub 2017 Sep 21 doi: 10.1053/j.ajkd.2017.07.019. PMID: 28941764
Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters.
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995

Recent clinical studies

Etiology

Bone and Chronic Kidney Disease.
Lafage-Proust MH
Semin Musculoskelet Radiol 2023 Aug;27(4):463-470. Epub 2023 Sep 25 doi: 10.1055/s-0043-1770353. PMID: 37748470
Osteoporosis and Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD): Back to Basics.
Pazianas M, Miller PD
Am J Kidney Dis 2021 Oct;78(4):582-589. Epub 2021 Mar 25 doi: 10.1053/j.ajkd.2020.12.024. PMID: 33774081
Osteoporosis in Patients with Chronic Kidney Diseases: A Systemic Review.
Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article
Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters.
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995
Renal osteodystrophy.
Tejwani NC, Schachter AK, Immerman I, Achan P
J Am Acad Orthop Surg 2006 May;14(5):303-11. doi: 10.5435/00124635-200605000-00006. PMID: 16675624

Diagnosis

Osteoporosis and Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD): Back to Basics.
Pazianas M, Miller PD
Am J Kidney Dis 2021 Oct;78(4):582-589. Epub 2021 Mar 25 doi: 10.1053/j.ajkd.2020.12.024. PMID: 33774081
Sagliker Syndrome.
Rubio-Manzanares Dorado M, Pino Díaz V, Fontillón Alberdi M, Padillo Ruíz J, Martos Martínez JM
Cir Esp (Engl Ed) 2020 Aug-Sep;98(7):414-416. Epub 2019 Dec 10 doi: 10.1016/j.ciresp.2019.11.002. PMID: 31836134
Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters.
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995
Renal osteodystrophy.
Tejwani NC, Schachter AK, Immerman I, Achan P
J Am Acad Orthop Surg 2006 May;14(5):303-11. doi: 10.5435/00124635-200605000-00006. PMID: 16675624
Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO).
Moe S, Drüeke T, Cunningham J, Goodman W, Martin K, Olgaard K, Ott S, Sprague S, Lameire N, Eknoyan G; Kidney Disease: Improving Global Outcomes (KDIGO)
Kidney Int 2006 Jun;69(11):1945-53. doi: 10.1038/sj.ki.5000414. PMID: 16641930

Therapy

Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD).
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article
Dietary interventions for mineral and bone disorder in people with chronic kidney disease.
Liu Z, Su G, Guo X, Wu Y, Liu X, Zou C, Zhang L, Yang Q, Xu Y, Ma W
Cochrane Database Syst Rev 2015 Sep 16;2015(9):CD010350. doi: 10.1002/14651858.CD010350.pub2. PMID: 26376110Free PMC Article
Renal osteodystrophy.
Tejwani NC, Schachter AK, Immerman I, Achan P
J Am Acad Orthop Surg 2006 May;14(5):303-11. doi: 10.5435/00124635-200605000-00006. PMID: 16675624
New Vitamin D analogues for osteodystrophy in chronic kidney disease.
Cunningham J
Pediatr Nephrol 2004 Jul;19(7):705-8. Epub 2004 May 13 doi: 10.1007/s00467-004-1478-0. PMID: 15141342
Review: Renal osteodystrophy--pathogenesis and treatment.
Cushner HM, Adams ND
Am J Med Sci 1986 Apr;291(4):264-75. doi: 10.1097/00000441-198604000-00008. PMID: 3518448

Prognosis

Role of Chronic Kidney Disease (CKD)-Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD.
Yamada S, Nakano T
J Atheroscler Thromb 2023 Aug 1;30(8):835-850. Epub 2023 May 30 doi: 10.5551/jat.RV22006. PMID: 37258233Free PMC Article
Bone Disease in Chronic Kidney Disease and Kidney Transplant.
Bellorin-Font E, Rojas E, Martin KJ
Nutrients 2022 Dec 29;15(1) doi: 10.3390/nu15010167. PMID: 36615824Free PMC Article
Mineral Bone Disorders in Kidney Disease Patients: The Ever-Current Topic.
Hu L, Napoletano A, Provenzano M, Garofalo C, Bini C, Comai G, La Manna G
Int J Mol Sci 2022 Oct 13;23(20) doi: 10.3390/ijms232012223. PMID: 36293076Free PMC Article
Osteoporosis in Patients with Chronic Kidney Diseases: A Systemic Review.
Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article
Calciphylaxis: risk factors, diagnosis, and treatment.
Nigwekar SU, Kroshinsky D, Nazarian RM, Goverman J, Malhotra R, Jackson VA, Kamdar MM, Steele DJ, Thadhani RI
Am J Kidney Dis 2015 Jul;66(1):133-46. Epub 2015 May 7 doi: 10.1053/j.ajkd.2015.01.034. PMID: 25960299Free PMC Article

Clinical prediction guides

Inflammation and gut dysbiosis as drivers of CKD-MBD.
Evenepoel P, Stenvinkel P, Shanahan C, Pacifici R
Nat Rev Nephrol 2023 Oct;19(10):646-657. Epub 2023 Jul 24 doi: 10.1038/s41581-023-00736-7. PMID: 37488276
Progression of Vascular Calcification and Clinical Outcomes in Patients Receiving Maintenance Dialysis.
Zhang H, Li G, Yu X, Yang J, Jiang A, Cheng H, Fu J, Liang X, Liu J, Lou J, Wang M, Xing C, Zhang A, Zhang M, Xiao X, Yu C, Wang R, Wang L, Chen Y, Guan T, Peng A, Chen N, Hao C, Liu B, Wang S, Shen D, Jia Z, Liu Z; China Dialysis Calcification Study Group
JAMA Netw Open 2023 May 1;6(5):e2310909. doi: 10.1001/jamanetworkopen.2023.10909. PMID: 37126347Free PMC Article
Management of osteoporosis in patients with chronic kidney disease.
Abdalbary M, Sobh M, Elnagar S, Elhadedy MA, Elshabrawy N, Abdelsalam M, Asadipooya K, Sabry A, Halawa A, El-Husseini A
Osteoporos Int 2022 Nov;33(11):2259-2274. Epub 2022 Jun 24 doi: 10.1007/s00198-022-06462-3. PMID: 35748896
CKD-MBD post kidney transplantation.
Haffner D, Leifheit-Nestler M
Pediatr Nephrol 2021 Jan;36(1):41-50. Epub 2019 Dec 19 doi: 10.1007/s00467-019-04421-5. PMID: 31858226
Renal osteodystrophy.
Wong LY, Wu CJ, Lin JC
Zhonghua Yi Xue Za Zhi (Taipei) 1991 May;47(5):342-9. PMID: 1649677

Recent systematic reviews

Osteoporosis in Patients with Chronic Kidney Diseases: A Systemic Review.
Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article
Mineral bone disorders in chronic kidney disease.
Hou YC, Lu CL, Lu KC
Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94. doi: 10.1111/nep.13457. PMID: 30298663
Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD).
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article
Comparative Effectiveness of Phosphate Binders in Patients with Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis.
Sekercioglu N, Thabane L, Díaz Martínez JP, Nesrallah G, Longo CJ, Busse JW, Akhtar-Danesh N, Agarwal A, Al-Khalifah R, Iorio A, Guyatt GH
PLoS One 2016;11(6):e0156891. Epub 2016 Jun 8 doi: 10.1371/journal.pone.0156891. PMID: 27276077Free PMC Article
Dietary interventions for mineral and bone disorder in people with chronic kidney disease.
Liu Z, Su G, Guo X, Wu Y, Liu X, Zou C, Zhang L, Yang Q, Xu Y, Ma W
Cochrane Database Syst Rev 2015 Sep 16;2015(9):CD010350. doi: 10.1002/14651858.CD010350.pub2. PMID: 26376110Free PMC Article

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