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Peritumoral Brain Edema

MedGen UID:
887794
•Concept ID:
C4054192
•
Finding
Synonym: PTBE

Definition

An intracranial edema that develops around a tumor in the meninges or brain. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeritumoral Brain Edema

Professional guidelines

PubMed

Peritumoral edema in meningiomas: pathophysiology, predictors, and principles for treatment.
Fiani B, Jarrah R, Bhandarkar AR, De Stefano F, Amare A, Aljameey UA, Reardon T
Clin Transl Oncol 2023 Apr;25(4):866-872. Epub 2022 Nov 24 doi: 10.1007/s12094-022-03009-0. PMID: 36427121
Glucocorticoids in the management of peritumoral brain edema: a review of molecular mechanisms.
Murayi R, Chittiboina P
Childs Nerv Syst 2016 Dec;32(12):2293-2302. Epub 2016 Sep 9 doi: 10.1007/s00381-016-3240-x. PMID: 27613642Free PMC Article
Secretory Meningiomas: Characteristic Features and Clinical Management of a Unique Subgroup.
Mohme M, Emami P, Matschke J, Regelsberger J, Westphal M, Eicker SO
Neurosurg Clin N Am 2016 Apr;27(2):181-7. Epub 2016 Feb 19 doi: 10.1016/j.nec.2015.11.001. PMID: 27012382

Recent clinical studies

Etiology

Bevacizumab reduces peritumoral brain edema in lung cancer brain metastases after radiotherapy.
Hua YC, Gao DZ, Wang KY, Ding XS, Xu WR, Li YB, Shi WW, Sun SB, Li XY
Thorac Cancer 2023 Nov;14(31):3133-3139. Epub 2023 Sep 17 doi: 10.1111/1759-7714.15106. PMID: 37718465Free PMC Article
Peritumoral edema in meningiomas: pathophysiology, predictors, and principles for treatment.
Fiani B, Jarrah R, Bhandarkar AR, De Stefano F, Amare A, Aljameey UA, Reardon T
Clin Transl Oncol 2023 Apr;25(4):866-872. Epub 2022 Nov 24 doi: 10.1007/s12094-022-03009-0. PMID: 36427121
Peritumoral Brain Edema and Surgical Outcome in Secretory Meningiomas: A Matched-Cohort Analysis.
Trivedi MM, Worley S, Raghavan A, Das P, Recinos PF, Barnett GH, Kshettry VR
World Neurosurg 2021 Jan;145:e170-e176. Epub 2020 Oct 3 doi: 10.1016/j.wneu.2020.09.151. PMID: 33022430
Vascularity of meningiomas.
Ansari SF, Shah KJ, Hassaneen W, Cohen-Gadol AA
Handb Clin Neurol 2020;169:153-165. doi: 10.1016/B978-0-12-804280-9.00010-X. PMID: 32553286
Evaluation of Epidemiologic Factors, Radiographic Features, and Pathologic Findings for Predicting Peritumoral Brain Edema in Meningiomas.
Sapkota MR, Yang Z, Zhu D, Zhang Y, Yuan T, Gao J, Si T, Wang J
J Magn Reson Imaging 2020 Jul;52(1):174-182. Epub 2020 Jan 10 doi: 10.1002/jmri.27046. PMID: 31922353

Diagnosis

Predictive Factors of Postoperative Peritumoral Brain Edema after Meningioma Resection.
Li LM, Zheng WJ, Chen YZ, Hu ZH, Liao W, Lin QC, Zhu YH, Huang HT, Lin SH, Gong J
Neurol India 2021 Nov-Dec;69(6):1682-1687. doi: 10.4103/0028-3886.333500. PMID: 34979669
Association between tumor size and peritumoral brain edema in patients with convexity and parasagittal meningiomas.
Shin C, Kim JM, Cheong JH, Ryu JI, Won YD, Ko Y, Han MH
PLoS One 2021;16(6):e0252945. Epub 2021 Jun 10 doi: 10.1371/journal.pone.0252945. PMID: 34111188Free PMC Article
Effect of Piezo1 Overexpression on Peritumoral Brain Edema in Glioblastomas.
Qu S, Hu T, Qiu O, Su Y, Gu J, Xia Z
AJNR Am J Neuroradiol 2020 Aug;41(8):1423-1429. Epub 2020 Jul 16 doi: 10.3174/ajnr.A6638. PMID: 32675337Free PMC Article
Vascularity of meningiomas.
Ansari SF, Shah KJ, Hassaneen W, Cohen-Gadol AA
Handb Clin Neurol 2020;169:153-165. doi: 10.1016/B978-0-12-804280-9.00010-X. PMID: 32553286
Rapid and Accurate MRI Segmentation of Peritumoral Brain Edema in Meningiomas.
Latini F, Larsson EM, Ryttlefors M
Clin Neuroradiol 2017 Jun;27(2):145-152. Epub 2015 Nov 24 doi: 10.1007/s00062-015-0481-0. PMID: 26603998

Therapy

Bevacizumab reduces peritumoral brain edema in lung cancer brain metastases after radiotherapy.
Hua YC, Gao DZ, Wang KY, Ding XS, Xu WR, Li YB, Shi WW, Sun SB, Li XY
Thorac Cancer 2023 Nov;14(31):3133-3139. Epub 2023 Sep 17 doi: 10.1111/1759-7714.15106. PMID: 37718465Free PMC Article
Systemic therapy for relapsed/refractory meningioma: Is there potential for antiangiogenic agents?
Dasanu CA, Samara Y, Codreanu I, Limonadi FM, Hamid O, Alvarez-Argote J
J Oncol Pharm Pract 2019 Apr;25(3):638-647. Epub 2018 Sep 26 doi: 10.1177/1078155218799850. PMID: 30253729
Successful treatment using apatinib in intractable brain edema: A case report and literatures review.
Song Y MD, PhD, Liu B MD, PhD, Guan M Master of Medicine, Liu M
Cancer Biol Ther 2018;19(12):1093-1096. Epub 2018 Aug 6 doi: 10.1080/15384047.2018.1491502. PMID: 30081717Free PMC Article
Rapid and Accurate MRI Segmentation of Peritumoral Brain Edema in Meningiomas.
Latini F, Larsson EM, Ryttlefors M
Clin Neuroradiol 2017 Jun;27(2):145-152. Epub 2015 Nov 24 doi: 10.1007/s00062-015-0481-0. PMID: 26603998
Peritumoral brain edema in intracranial meningiomas: the emergence of vascular endothelial growth factor-directed therapy.
Hou J, Kshettry VR, Selman WR, Bambakidis NC
Neurosurg Focus 2013 Dec;35(6):E2. doi: 10.3171/2013.8.FOCUS13301. PMID: 24289127

Prognosis

Peritumoral edema in meningiomas: pathophysiology, predictors, and principles for treatment.
Fiani B, Jarrah R, Bhandarkar AR, De Stefano F, Amare A, Aljameey UA, Reardon T
Clin Transl Oncol 2023 Apr;25(4):866-872. Epub 2022 Nov 24 doi: 10.1007/s12094-022-03009-0. PMID: 36427121
Predictive Factors of Postoperative Peritumoral Brain Edema after Meningioma Resection.
Li LM, Zheng WJ, Chen YZ, Hu ZH, Liao W, Lin QC, Zhu YH, Huang HT, Lin SH, Gong J
Neurol India 2021 Nov-Dec;69(6):1682-1687. doi: 10.4103/0028-3886.333500. PMID: 34979669
Evaluation of Epidemiologic Factors, Radiographic Features, and Pathologic Findings for Predicting Peritumoral Brain Edema in Meningiomas.
Sapkota MR, Yang Z, Zhu D, Zhang Y, Yuan T, Gao J, Si T, Wang J
J Magn Reson Imaging 2020 Jul;52(1):174-182. Epub 2020 Jan 10 doi: 10.1002/jmri.27046. PMID: 31922353
Secretory Meningiomas: Characteristic Features and Clinical Management of a Unique Subgroup.
Mohme M, Emami P, Matschke J, Regelsberger J, Westphal M, Eicker SO
Neurosurg Clin N Am 2016 Apr;27(2):181-7. Epub 2016 Feb 19 doi: 10.1016/j.nec.2015.11.001. PMID: 27012382
Supportive care in neurooncology.
Pace A, Metro G, Fabi A
Curr Opin Oncol 2010 Nov;22(6):621-6. doi: 10.1097/CCO.0b013e32833e078c. PMID: 20706120

Clinical prediction guides

Bevacizumab reduces peritumoral brain edema in lung cancer brain metastases after radiotherapy.
Hua YC, Gao DZ, Wang KY, Ding XS, Xu WR, Li YB, Shi WW, Sun SB, Li XY
Thorac Cancer 2023 Nov;14(31):3133-3139. Epub 2023 Sep 17 doi: 10.1111/1759-7714.15106. PMID: 37718465Free PMC Article
Peritumoral edema in meningiomas: pathophysiology, predictors, and principles for treatment.
Fiani B, Jarrah R, Bhandarkar AR, De Stefano F, Amare A, Aljameey UA, Reardon T
Clin Transl Oncol 2023 Apr;25(4):866-872. Epub 2022 Nov 24 doi: 10.1007/s12094-022-03009-0. PMID: 36427121
Predictive Factors of Postoperative Peritumoral Brain Edema after Meningioma Resection.
Li LM, Zheng WJ, Chen YZ, Hu ZH, Liao W, Lin QC, Zhu YH, Huang HT, Lin SH, Gong J
Neurol India 2021 Nov-Dec;69(6):1682-1687. doi: 10.4103/0028-3886.333500. PMID: 34979669
Association between tumor size and peritumoral brain edema in patients with convexity and parasagittal meningiomas.
Shin C, Kim JM, Cheong JH, Ryu JI, Won YD, Ko Y, Han MH
PLoS One 2021;16(6):e0252945. Epub 2021 Jun 10 doi: 10.1371/journal.pone.0252945. PMID: 34111188Free PMC Article
Evaluation of Epidemiologic Factors, Radiographic Features, and Pathologic Findings for Predicting Peritumoral Brain Edema in Meningiomas.
Sapkota MR, Yang Z, Zhu D, Zhang Y, Yuan T, Gao J, Si T, Wang J
J Magn Reson Imaging 2020 Jul;52(1):174-182. Epub 2020 Jan 10 doi: 10.1002/jmri.27046. PMID: 31922353

Recent systematic reviews

Peritumoral T2/FLAIR hyperintense MRI findings of meningiomas are not necessarily edema and may persist permanently: a systematic review.
Laajava J, Korja M
Neurosurg Rev 2023 Aug 5;46(1):193. doi: 10.1007/s10143-023-02094-1. PMID: 37541985Free PMC Article
Radiological Differentiation Between Intracranial Meningioma and Solitary Fibrous Tumor/Hemangiopericytoma: A Systematic Literature Review.
El-Abtah ME, Murayi R, Lee J, Recinos PF, Kshettry VR
World Neurosurg 2023 Feb;170:68-83. Epub 2022 Nov 18 doi: 10.1016/j.wneu.2022.11.062. PMID: 36403933
Peritumoral brain edema in intracranial meningiomas: the emergence of vascular endothelial growth factor-directed therapy.
Hou J, Kshettry VR, Selman WR, Bambakidis NC
Neurosurg Focus 2013 Dec;35(6):E2. doi: 10.3171/2013.8.FOCUS13301. PMID: 24289127

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