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Dexamethasone-suppressible primary hyperaldosteronism

MedGen UID:
892448
•Concept ID:
C4023209
•
Disease or Syndrome
Synonym: Dexamethasone-suppresible primary hyperaldosteronism
 
HPO: HP:0011739

Definition

A form of primary hyperaldosteronism in which the overproduction of aldosterone can be suppressed by the administration of dexamethasone. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDexamethasone-suppressible primary hyperaldosteronism

Professional guidelines

PubMed

Long-term treatment of mineralocorticoid excess syndromes.
Mantero F, Opocher G, Rocco S, Carpenè G, Armanini D
Steroids 1995 Jan;60(1):81-6. doi: 10.1016/0039-128x(94)00018-8. PMID: 7792822
Differential diagnosis in primary aldosteronism.
Opocher G, Rocco S, Carpenè G, Mantero F
J Steroid Biochem Mol Biol 1993 Apr;45(1-3):49-55. doi: 10.1016/0960-0760(93)90121-c. PMID: 8481351

Recent clinical studies

Etiology

Primary aldosteronism: learning from the study of familial varieties.
Stowasser M, Gordon RD
J Hypertens 2000 Sep;18(9):1165-76. doi: 10.1097/00004872-200018090-00002. PMID: 10994747
Study on clinical and endocrine characteristics of dexamethasone-suppressible hyperaldosteronism compared with those in primary aldosteronism owing to aldosterone-producing adenoma.
Yamakita N, Yasuda K, Noritake N, Mercado-Asis LB, Murase H, Mune T, Morita H, Miura K
Acta Endocrinol (Copenh) 1989 Sep;121(3):334-44. doi: 10.1530/acta.0.1210334. PMID: 2552725
10. Hypertension. A comparison of the effects of angiotensin II infusion and variations in salt intake on plasma aldosterone levels in normal subjects, patients with essential hypertension and patients with hyperaldosteronism.
Zoccali C, Usherwood T, Brown JJ, Lever AF, Robertson JI, Fraser R
J Steroid Biochem 1983 Jul;19(1A):327-31. PMID: 6310234
Plasma immunoreactive proopiolipomelanocortin-derived peptides in patients with primary hyperaldosteronism, idiopathic hyperaldosteronism with bilateral adrenal hyperplasia, and dexamethasone-suppressible hyperaldosteronism.
Güllner HG, Nicholson WE, Gill JR Jr, Orth DN
J Clin Endocrinol Metab 1983 Apr;56(4):853-5. doi: 10.1210/jcem-56-4-853. PMID: 6300169
Dexamethasone-suppressible hyperaldosteronism.
New MI, Siegal EJ, Peterson RE
J Clin Endocrinol Metab 1973 Jul;37(1):93-100. doi: 10.1210/jcem-37-1-93. PMID: 4351777

Diagnosis

Primary aldosteronism: learning from the study of familial varieties.
Stowasser M, Gordon RD
J Hypertens 2000 Sep;18(9):1165-76. doi: 10.1097/00004872-200018090-00002. PMID: 10994747
Dexamethasone-suppressible hyperaldosteronism: clinical, biochemical and genetic relations.
Connell JM, Inglis GC, Fraser R, Jamieson A
J Hum Hypertens 1995 Jun;9(6):505-9. PMID: 7473536
Differential diagnosis in primary aldosteronism.
Opocher G, Rocco S, Carpenè G, Mantero F
J Steroid Biochem Mol Biol 1993 Apr;45(1-3):49-55. doi: 10.1016/0960-0760(93)90121-c. PMID: 8481351
17 alpha-hydroxylation deficiency.
Biglieri EG, Kater CE
Endocrinol Metab Clin North Am 1991 Jun;20(2):257-68. PMID: 1879398
Dexamethasone-suppressible hyperaldosteronism: pathophysiology, clinical aspects, and new insights into the pathogenesis.
Fallo F, Sonino N, Boscaro M, Armanini D, Mantero F, Dörr HG, Knorr D, Kuhnle U
Klin Wochenschr 1987 May 15;65(10):437-44. doi: 10.1007/BF01712834. PMID: 3037179

Therapy

Dexamethasone-suppressible hypertension.
Stewart PM
Lancet 2000 Aug 26;356(9231):697-9. doi: 10.1016/S0140-6736(00)02624-6. PMID: 11085685
Dexamethasone-suppressible hyperaldosteronism: clinical, biochemical and genetic relations.
Connell JM, Inglis GC, Fraser R, Jamieson A
J Hum Hypertens 1995 Jun;9(6):505-9. PMID: 7473536
Dexamethasone-suppressible hyperaldosteronism: pathophysiology, clinical aspects, and new insights into the pathogenesis.
Fallo F, Sonino N, Boscaro M, Armanini D, Mantero F, Dörr HG, Knorr D, Kuhnle U
Klin Wochenschr 1987 May 15;65(10):437-44. doi: 10.1007/BF01712834. PMID: 3037179
A new family with dexamethasone-suppressible hyperaldosteronism: aldosterone unresponsiveness to angiotensin II.
Fallo F, Sonino N, Armanini D, Luzzi T, Pedini F, Pasini C, Mantero F
Clin Endocrinol (Oxf) 1985 Jun;22(6):777-85. doi: 10.1111/j.1365-2265.1985.tb00168.x. PMID: 2990765
Dexamethasone-suppressible hyperaldosteronism.
New MI, Siegal EJ, Peterson RE
J Clin Endocrinol Metab 1973 Jul;37(1):93-100. doi: 10.1210/jcem-37-1-93. PMID: 4351777

Prognosis

Long-term treatment of mineralocorticoid excess syndromes.
Mantero F, Opocher G, Rocco S, Carpenè G, Armanini D
Steroids 1995 Jan;60(1):81-6. doi: 10.1016/0039-128x(94)00018-8. PMID: 7792822
Primary hyperaldosteronism in childhood due to unilateral macronodular hyperplasia. Case report.
Oberfield SE, Levine LS, Firpo A, Lawrence D Sr, Stoner E, Levy DJ, Sen S, New MI
Hypertension 1984 Jan-Feb;6(1):75-84. doi: 10.1161/01.hyp.6.1.75. PMID: 6319281
Dexamethasone-suppressible hyperaldosteronism.
New MI, Siegal EJ, Peterson RE
J Clin Endocrinol Metab 1973 Jul;37(1):93-100. doi: 10.1210/jcem-37-1-93. PMID: 4351777

Clinical prediction guides

Corticosteroids in essential hypertension: multiple candidate loci and phenotypic variation.
Connell JM, Kenyon CJ, Ingram M, Holloway C, Jamieson A, Panarelli M, Inglis G, Fraser R
Clin Exp Pharmacol Physiol 1996 May;23(5):369-74. doi: 10.1111/j.1440-1681.1996.tb02743.x. PMID: 8713673
Dexamethasone-suppressible hyperaldosteronism: studies on overproduction of 18-hydroxycortisol in three affected family members.
Davis JR, Burt D, Corrie JE, Edwards CR, Sheppard MC
Clin Endocrinol (Oxf) 1988 Sep;29(3):297-308. doi: 10.1111/j.1365-2265.1988.tb01228.x. PMID: 3251669
Effects of naloxone on the pituitary-adrenal axis in patients with dexamethasone-suppressible hyperaldosteronism.
Fallo F, Boscaro M, Sonino N, Mantero F
Clin Endocrinol (Oxf) 1987 Feb;26(2):163-8. doi: 10.1111/j.1365-2265.1987.tb00772.x. PMID: 2822294
A new family with dexamethasone-suppressible hyperaldosteronism: aldosterone unresponsiveness to angiotensin II.
Fallo F, Sonino N, Armanini D, Luzzi T, Pedini F, Pasini C, Mantero F
Clin Endocrinol (Oxf) 1985 Jun;22(6):777-85. doi: 10.1111/j.1365-2265.1985.tb00168.x. PMID: 2990765
Evidence for an unidentified ACTH-induced steroid hormone causing hypertension.
New MI, Peterson RE, Saenger P, Levine LS
J Clin Endocrinol Metab 1976 Dec;43(6):1283-93. doi: 10.1210/jcem-43-6-1283. PMID: 187612

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