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Abnormal circulating gonadotropin concentration

MedGen UID:
892748
•Concept ID:
C4072886
•
Finding
Synonym: Abnormal circulating gonadotropin level
 
HPO: HP:0030338

Definition

An anomaly of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH). [from HPO]

Professional guidelines

PubMed

Circulating gonadotropin pattern in anorchia syndrome. Response to treatment.
Mendoza-Morfin F, Rodríguez-López M, Oliveros-Rodríguez A, Altamirano-Bustamante P, Navarrete-López R, Gutiérrez-Pérez H, Oseguera-Valladares R
Arch Invest Med (Mex) 1980;11(2):239-47. PMID: 6775612

Recent clinical studies

Etiology

Effects of chronic osteoarthritis pain on neuroendocrine function in men.
Khoromi S, Muniyappa R, Nackers L, Gray N, Baldwin H, Wong KA, Matheny LA, Moquin B, Rainer A, Hill S, Remaley A, Johnson LL, Max MB, Blackman MR
J Clin Endocrinol Metab 2006 Nov;91(11):4313-8. Epub 2006 Aug 15 doi: 10.1210/jc.2006-1122. PMID: 16912126
Advances in prenatal screening for Down syndrome: I. general principles and second trimester testing.
Benn PA
Clin Chim Acta 2002 Sep;323(1-2):1-16. doi: 10.1016/s0009-8981(02)00186-9. PMID: 12135803
Spontaneous and GnRH-provoked gonadotropin secretion and testosterone response to human chorionic gonadotropin in adolescent boys with thalassaemia major and delayed puberty.
Soliman AT, elZalabany MM, Ragab M, Abdel Fattah M, Hassab H, Rogol AD, Ansari BM
J Trop Pediatr 2000 Apr;46(2):79-85. doi: 10.1093/tropej/46.2.79. PMID: 10822933
Circulating maternal corticotropin-releasing hormone and gonadotropin-releasing hormone in normal and abnormal pregnancies.
Sorem KA, Smikle CB, Spencer DK, Yoder BA, Graveson MA, Siler-Khodr TM
Am J Obstet Gynecol 1996 Oct;175(4 Pt 1):912-6. doi: 10.1016/s0002-9378(96)80024-x. PMID: 8885747
Reproductive endocrinologic alterations in female asymptomatic obesity.
Azziz R
Fertil Steril 1989 Nov;52(5):703-25. doi: 10.1016/s0015-0282(16)61020-8. PMID: 2680625

Diagnosis

Insulin Resistance, Hyperinsulinemia, and LH: Relative Roles in Peripubertal Obesity-Associated Hyperandrogenemia.
Burt Solorzano CM, Knudsen KL, Anderson AD, Hutchens EG, Collins JS, Patrie JT, Marshall JC, McCartney CR
J Clin Endocrinol Metab 2018 Jul 1;103(7):2571-2582. doi: 10.1210/jc.2018-00131. PMID: 29897474Free PMC Article
Prenatal sonographic features of fetuses in trisomy 13 pregnancies. IV.
Chen CP
Taiwan J Obstet Gynecol 2010 Mar;49(1):3-12. doi: 10.1016/S1028-4559(10)60002-2. PMID: 20466286
Circulating maternal corticotropin-releasing hormone and gonadotropin-releasing hormone in normal and abnormal pregnancies.
Sorem KA, Smikle CB, Spencer DK, Yoder BA, Graveson MA, Siler-Khodr TM
Am J Obstet Gynecol 1996 Oct;175(4 Pt 1):912-6. doi: 10.1016/s0002-9378(96)80024-x. PMID: 8885747
The growth without growth hormone syndrome.
Geffner ME
Endocrinol Metab Clin North Am 1996 Sep;25(3):649-63. doi: 10.1016/s0889-8529(05)70345-5. PMID: 8879991
Steroidogenesis in human polycystic ovary.
Mahajan DK
Endocrinol Metab Clin North Am 1988 Dec;17(4):751-69. PMID: 3143567

Therapy

Congenital hypogonadotropic hypogonadism and Kallmann syndrome as models for studying hormonal regulation of human testicular endocrine functions.
Trabado S, Lamothe S, Maione L, Bouvattier C, Sarfati J, Brailly-Tabard S, Young J
Ann Endocrinol (Paris) 2014 May;75(2):79-87. Epub 2014 May 9 doi: 10.1016/j.ando.2014.04.011. PMID: 24815726
Spontaneous and GnRH-provoked gonadotropin secretion and testosterone response to human chorionic gonadotropin in adolescent boys with thalassaemia major and delayed puberty.
Soliman AT, elZalabany MM, Ragab M, Abdel Fattah M, Hassab H, Rogol AD, Ansari BM
J Trop Pediatr 2000 Apr;46(2):79-85. doi: 10.1093/tropej/46.2.79. PMID: 10822933
Pituitary dysfunction in recently post-menopausal women. Nottingham EPIC Study Group.
Lyons A, Ng C, Fielding K, Hosking D, Selby C, Lawson N
Clin Endocrinol (Oxf) 1997 Oct;47(4):431-8. doi: 10.1046/j.1365-2265.1997.2761083.x. PMID: 9404441
Danazol. A synthetic steroid with diverse biologic effects.
Dmowski WP
J Reprod Med 1990 Jan;35(1 Suppl):69-74; discussion 74-5. PMID: 2404115
Disorders of prolactin and growth hormone secretion.
Ho KY, Evans WS, Thorner MO
Clin Endocrinol Metab 1985 Feb;14(1):1-32. doi: 10.1016/s0300-595x(85)80063-3. PMID: 3926353

Prognosis

The utility of circulating LHCGR as a predictor of Down's syndrome in early pregnancy.
Chambers AE, Mills WE, Mercadé I, Crovetto F, Crispi F, Bodi LR, Pugia M, Mira A, Lasalvia L, Banerjee S, Casals E, Gratacos E
BMC Pregnancy Childbirth 2014 Jun 6;14:197. doi: 10.1186/1471-2393-14-197. PMID: 24906955Free PMC Article
Follicular fluid soluble receptor for advanced glycation end-products (sRAGE): a potential indicator of ovarian reserve.
Merhi Z, Irani M, Doswell AD, Ambroggio J
J Clin Endocrinol Metab 2014 Feb;99(2):E226-33. Epub 2013 Nov 25 doi: 10.1210/jc.2013-3839. PMID: 24276462
Evidence for abnormal granulosa cell responsiveness to follicle-stimulating hormone in women with polycystic ovary syndrome.
Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch R, Chang RJ
J Clin Endocrinol Metab 2003 Apr;88(4):1742-7. doi: 10.1210/jc.2002-021280. PMID: 12679467
Diurnal variation of sex hormone binding globulin and insulin-like growth factor binding protein-1 in women with polycystic ovary syndrome.
Hamilton-Fairley D, White D, Griffiths M, Anyaoku V, Koistinen R, Seppälä M, Franks S
Clin Endocrinol (Oxf) 1995 Aug;43(2):159-65. doi: 10.1111/j.1365-2265.1995.tb01910.x. PMID: 7554310
Circulating gonadotropin pattern in anorchia syndrome. Response to treatment.
Mendoza-Morfin F, Rodríguez-López M, Oliveros-Rodríguez A, Altamirano-Bustamante P, Navarrete-López R, Gutiérrez-Pérez H, Oseguera-Valladares R
Arch Invest Med (Mex) 1980;11(2):239-47. PMID: 6775612

Clinical prediction guides

MKRN3 circulating levels in Prader-Willi syndrome: a pilot study.
Mariani M, Fintini D, Cirillo G, Palumbo S, Del Giudice EM, Bocchini S, Manco M, Cappa M, Grandone A
J Endocrinol Invest 2022 Nov;45(11):2165-2170. Epub 2022 Jul 19 doi: 10.1007/s40618-022-01860-0. PMID: 35854182
Follicular fluid soluble receptor for advanced glycation end-products (sRAGE): a potential indicator of ovarian reserve.
Merhi Z, Irani M, Doswell AD, Ambroggio J
J Clin Endocrinol Metab 2014 Feb;99(2):E226-33. Epub 2013 Nov 25 doi: 10.1210/jc.2013-3839. PMID: 24276462
Effects of chronic osteoarthritis pain on neuroendocrine function in men.
Khoromi S, Muniyappa R, Nackers L, Gray N, Baldwin H, Wong KA, Matheny LA, Moquin B, Rainer A, Hill S, Remaley A, Johnson LL, Max MB, Blackman MR
J Clin Endocrinol Metab 2006 Nov;91(11):4313-8. Epub 2006 Aug 15 doi: 10.1210/jc.2006-1122. PMID: 16912126
Characterization of human chorionic gonadotropin in normal and abnormal pregnancies.
Ho HH, O'Connor JF, Nakajima ST, Tieu J, Overstreet JW, Lasley BL
Early Pregnancy 1997 Sep;3(3):213-24. PMID: 10086072
Steroidogenesis in human polycystic ovary.
Mahajan DK
Endocrinol Metab Clin North Am 1988 Dec;17(4):751-69. PMID: 3143567

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