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Abnormality of the parathyroid gland

MedGen UID:
893009
•Concept ID:
C4025822
•
Anatomical Abnormality
Synonyms: disease of parathyroid gland; disease of parathyroid glands; disease or disorder of parathyroid gland; disorder of parathyroid gland; Parathyroid disease; parathyroid disease; parathyroid gland disease; parathyroid gland disease or disorder; parathyroid gland diseases; parathyroid gland disorder; parathyroid gland disorders
 
HPO: HP:0000828
Monarch Initiative: MONDO:0001223

Definition

An abnormality of the parathyroid gland. [from HPO]

Professional guidelines

PubMed

Parathyroidectomy for adults with primary hyperparathyroidism.
Pappachan JM, Lahart IM, Viswanath AK, Borumandi F, Sodi R, Metzendorf MI, Bongaerts B
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD013035. doi: 10.1002/14651858.CD013035.pub2. PMID: 36883976Free PMC Article
The medical and surgical treatment in secondary and tertiary hyperparathyroidism. Review.
Cocchiara G, Fazzotta S, Palumbo VD, Damiano G, Cajozzo M, Maione C, Buscemi S, Spinelli G, Ficarella S, Maffongelli A, Caternicchia F, Ignazio Lo Monte A, Buscemi G
Clin Ter 2017 Mar-Apr;168(2):e158-e167. doi: 10.7417/CT.2017.1999. PMID: 28383630
Management of skeletal health in patients with asymptomatic primary hyperparathyroidism.
Lewiecki EM
J Clin Densitom 2010 Oct-Dec;13(4):324-34. doi: 10.1016/j.jocd.2010.06.004. PMID: 21029971

Recent clinical studies

Etiology

LECT-2 amyloidosis: what do we know?
Mann BK, Bhandohal JS, Cobos E, Chitturi C, Eppanapally S
J Investig Med 2022 Feb;70(2):348-353. Epub 2021 Nov 30 doi: 10.1136/jim-2021-002149. PMID: 34848562
Genetic hypercalcemia.
Cormier C
Joint Bone Spine 2019 Jul;86(4):459-466. Epub 2018 Oct 6 doi: 10.1016/j.jbspin.2018.10.001. PMID: 30300686
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.
Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV
Nat Rev Endocrinol 2018 Dec;15(1):33-51. doi: 10.1038/s41574-018-0115-0. PMID: 30443043Free PMC Article
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article
Sonography of Normal and Abnormal Thyroid and Parathyroid Glands.
Andrioli M, Valcavi R
Front Horm Res 2016;45:1-15. Epub 2016 Mar 15 doi: 10.1159/000442273. PMID: 27002829

Diagnosis

Overview of the 2022 WHO Classification of Parathyroid Tumors.
Erickson LA, Mete O, Juhlin CC, Perren A, Gill AJ
Endocr Pathol 2022 Mar;33(1):64-89. Epub 2022 Feb 17 doi: 10.1007/s12022-022-09709-1. PMID: 35175514
DiGeorge syndrome: consider the diagnosis.
Altshuler E, Saidi A, Budd J
BMJ Case Rep 2022 Feb 2;15(2) doi: 10.1136/bcr-2021-245164. PMID: 35110278Free PMC Article
Parathyroid Imaging.
Itani M, Middleton WD
Radiol Clin North Am 2020 Nov;58(6):1071-1083. Epub 2020 Sep 17 doi: 10.1016/j.rcl.2020.07.006. PMID: 33040849
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article
Primary hyperparathyroidism.
Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F
Nat Rev Dis Primers 2016 May 19;2:16033. doi: 10.1038/nrdp.2016.33. PMID: 27194212Free PMC Article

Therapy

Parathyroid Disorders.
Sell J, Ramirez S, Partin M
Am Fam Physician 2022 Mar 1;105(3):289-298. PMID: 35289573
Thyroid and Parathyroid Conditions: Parathyroid Conditions.
Bragg S, Rhodes MA, Adams CS
FP Essent 2022 Mar;514:30-38. PMID: 35235284
Lithium-associated hyperparathyroidism.
Mifsud S, Cilia K, Mifsud EL, Gruppetta M
Br J Hosp Med (Lond) 2020 Nov 2;81(11):1-9. Epub 2020 Nov 17 doi: 10.12968/hmed.2020.0457. PMID: 33263481
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.
Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV
Nat Rev Endocrinol 2018 Dec;15(1):33-51. doi: 10.1038/s41574-018-0115-0. PMID: 30443043Free PMC Article
Parathyroid disorders.
Michels TC, Kelly KM
Am Fam Physician 2013 Aug 15;88(4):249-57. PMID: 23944728

Prognosis

Parathyroid Imaging.
Itani M, Middleton WD
Radiol Clin North Am 2020 Nov;58(6):1071-1083. Epub 2020 Sep 17 doi: 10.1016/j.rcl.2020.07.006. PMID: 33040849
Genetic hypercalcemia.
Cormier C
Joint Bone Spine 2019 Jul;86(4):459-466. Epub 2018 Oct 6 doi: 10.1016/j.jbspin.2018.10.001. PMID: 30300686
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.
Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV
Nat Rev Endocrinol 2018 Dec;15(1):33-51. doi: 10.1038/s41574-018-0115-0. PMID: 30443043Free PMC Article
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article
Primary hyperparathyroidism.
Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F
Nat Rev Dis Primers 2016 May 19;2:16033. doi: 10.1038/nrdp.2016.33. PMID: 27194212Free PMC Article

Clinical prediction guides

Calcium homeostasis and hyperparathyroidism: Nephrologic and endocrinologic points of view.
Lemoine S, Figueres L, Bacchetta J, Frey S, Dubourg L
Ann Endocrinol (Paris) 2022 Aug;83(4):237-243. Epub 2022 May 19 doi: 10.1016/j.ando.2022.05.003. PMID: 35598638
Primary hyperparathyroidism.
Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F
Nat Rev Dis Primers 2016 May 19;2:16033. doi: 10.1038/nrdp.2016.33. PMID: 27194212Free PMC Article
Sonography of Normal and Abnormal Thyroid and Parathyroid Glands.
Andrioli M, Valcavi R
Front Horm Res 2016;45:1-15. Epub 2016 Mar 15 doi: 10.1159/000442273. PMID: 27002829
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537
Sestamibi parathyroid imaging.
McBiles M, Lambert AT, Cote MG, Kim SY
Semin Nucl Med 1995 Jul;25(3):221-34. doi: 10.1016/s0001-2998(95)80012-3. PMID: 7570042

Recent systematic reviews

Parathyroidectomy for adults with primary hyperparathyroidism.
Pappachan JM, Lahart IM, Viswanath AK, Borumandi F, Sodi R, Metzendorf MI, Bongaerts B
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD013035. doi: 10.1002/14651858.CD013035.pub2. PMID: 36883976Free PMC Article
The otolaryngologic manifestations of Sotos syndrome 1: A systematic review.
Danis DO 3rd, Bodamer O, Levi JR
Int J Pediatr Otorhinolaryngol 2021 Apr;143:110649. Epub 2021 Feb 12 doi: 10.1016/j.ijporl.2021.110649. PMID: 33640723
Assessment and Comparison of (18)F-Fluorocholine PET and (99m)Tc-Sestamibi Scans in Identifying Parathyroid Adenomas: A Metaanalysis.
Whitman J, Allen IE, Bergsland EK, Suh I, Hope TA
J Nucl Med 2021 Sep 1;62(9):1285-1291. Epub 2021 Jan 15 doi: 10.2967/jnumed.120.257303. PMID: 33452040Free PMC Article
Systematic review of intravenous methylene blue in parathyroid surgery.
Patel HP, Chadwick DR, Harrison BJ, Balasubramanian SP
Br J Surg 2012 Oct;99(10):1345-51. doi: 10.1002/bjs.8814. PMID: 22961511
Parathyroid imaging: how good is it and how should it be done?
Kettle AG, O'Doherty MJ
Semin Nucl Med 2006 Jul;36(3):206-11. doi: 10.1053/j.semnuclmed.2006.03.003. PMID: 16762611

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