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Mild oligozoospermia

MedGen UID:
896812
•Concept ID:
C4231238
•
Disease or Syndrome
Synonym: Oligozoospermia, mild
 
HPO: HP:0034816

Definition

A type of oligozoospermia characterized by a total number of more than 30 but less than 39 million sperm in the ejaculate or a concentration of more than 10 but less than 15 million sperm per milliliter. [from HPO]

Professional guidelines

PubMed

Genotype and phenotype in cystic fibrosis.
Zielenski J
Respiration 2000;67(2):117-33. doi: 10.1159/000029497. PMID: 10773783
Clinical review 100: Evaluation and treatment of the infertile couple.
Forti G, Krausz C
J Clin Endocrinol Metab 1998 Dec;83(12):4177-88. doi: 10.1210/jcem.83.12.5296. PMID: 9851748
Infertility-epidemiology, aetiology and effective management.
Templeton A
Health Bull (Edinb) 1995 Sep;53(5):294-8. PMID: 7490200

Recent clinical studies

Etiology

Y chromosome microdeletions in Chinese men with infertility: prevalence, phenotypes, and intracytoplasmic sperm injection outcomes.
Chen D, Fan G, Zhu X, Chen Q, Chen X, Gao F, Guo Z, Luo P, Gao Y
Reprod Biol Endocrinol 2023 Dec 5;21(1):116. doi: 10.1186/s12958-023-01168-5. PMID: 38053137Free PMC Article
Does Lepidium meyenii (Maca) improve seminal quality?
Alcalde AM, Rabasa J
Andrologia 2020 Nov;52(10):e13755. Epub 2020 Jul 12 doi: 10.1111/and.13755. PMID: 32654242
Sperm origins and concentration do not impact the clinical outcomes in intracytoplasmic sperm injection cycles.
Yang C, Zhou ZH, Zheng DN, Xu XF, Huang J, Lian Y, Qiao J
Asian J Androl 2018 Sep-Oct;20(5):454-458. doi: 10.4103/aja.aja_27_18. PMID: 29798938Free PMC Article
Natural course of idiopathic oligozoospermia: comparison of mild, moderate and severe forms.
Bak CW, Song SH, Yoon TK, Lim JJ, Shin TE, Sung S
Int J Urol 2010 Nov;17(11):937-43. Epub 2010 Sep 10 doi: 10.1111/j.1442-2042.2010.02628.x. PMID: 20831771
The effects of severity of oligozoospermia on Intracytoplasmic Sperm Injection (ICSI) cycle outcome.
Hashimoto H, Ishikawa T, Goto S, Kokeguchi S, Fujisawa M, Shiotani M
Syst Biol Reprod Med 2010 Feb;56(1):91-5. doi: 10.3109/19396360903509169. PMID: 20170289

Diagnosis

Does Lepidium meyenii (Maca) improve seminal quality?
Alcalde AM, Rabasa J
Andrologia 2020 Nov;52(10):e13755. Epub 2020 Jul 12 doi: 10.1111/and.13755. PMID: 32654242
Sperm origins and concentration do not impact the clinical outcomes in intracytoplasmic sperm injection cycles.
Yang C, Zhou ZH, Zheng DN, Xu XF, Huang J, Lian Y, Qiao J
Asian J Androl 2018 Sep-Oct;20(5):454-458. doi: 10.4103/aja.aja_27_18. PMID: 29798938Free PMC Article
Chromosomal abnormalities in patients with oligozoospermia and non-obstructive azoospermia.
Pylyp LY, Spinenko LO, Verhoglyad NV, Zukin VD
J Assist Reprod Genet 2013 Jun;30(5):729-32. Epub 2013 Apr 11 doi: 10.1007/s10815-013-9990-4. PMID: 23575767Free PMC Article
Natural course of idiopathic oligozoospermia: comparison of mild, moderate and severe forms.
Bak CW, Song SH, Yoon TK, Lim JJ, Shin TE, Sung S
Int J Urol 2010 Nov;17(11):937-43. Epub 2010 Sep 10 doi: 10.1111/j.1442-2042.2010.02628.x. PMID: 20831771
Y chromosome microdeletions in infertile men with varicocele.
Moro E, Marin P, Rossi A, Garolla A, Ferlin A
Mol Cell Endocrinol 2000 Mar 30;161(1-2):67-71. doi: 10.1016/s0303-7207(99)00226-9. PMID: 10773394

Therapy

Does Lepidium meyenii (Maca) improve seminal quality?
Alcalde AM, Rabasa J
Andrologia 2020 Nov;52(10):e13755. Epub 2020 Jul 12 doi: 10.1111/and.13755. PMID: 32654242
A prospective randomized study comparing gonadotropin-releasing hormone agonists or gonadotropin-releasing hormone antagonists in couples with unexplained infertility and/or mild oligozoospermia.
Zikopoulos K, Kaponis A, Adonakis G, Sotiriadis A, Kalantaridou S, Georgiou I, Paraskevaidis E
Fertil Steril 2005 May;83(5):1354-62. doi: 10.1016/j.fertnstert.2004.11.060. PMID: 15866569

Prognosis

Chromosomal abnormalities in patients with oligozoospermia and non-obstructive azoospermia.
Pylyp LY, Spinenko LO, Verhoglyad NV, Zukin VD
J Assist Reprod Genet 2013 Jun;30(5):729-32. Epub 2013 Apr 11 doi: 10.1007/s10815-013-9990-4. PMID: 23575767Free PMC Article
Natural course of idiopathic oligozoospermia: comparison of mild, moderate and severe forms.
Bak CW, Song SH, Yoon TK, Lim JJ, Shin TE, Sung S
Int J Urol 2010 Nov;17(11):937-43. Epub 2010 Sep 10 doi: 10.1111/j.1442-2042.2010.02628.x. PMID: 20831771
Incidental testicular cancers that subsequently developed in oligozoospermic and azoospermic patients: report of three cases.
Kanto S, Takahashi K, Maehara I, Fukuzaki A, Kyono K, Arai Y
Fertil Steril 2007 Nov;88(5):1374-6. Epub 2007 Apr 3 doi: 10.1016/j.fertnstert.2007.01.029. PMID: 17408623

Clinical prediction guides

Chromosomal abnormalities in patients with oligozoospermia and non-obstructive azoospermia.
Pylyp LY, Spinenko LO, Verhoglyad NV, Zukin VD
J Assist Reprod Genet 2013 Jun;30(5):729-32. Epub 2013 Apr 11 doi: 10.1007/s10815-013-9990-4. PMID: 23575767Free PMC Article
Natural course of idiopathic oligozoospermia: comparison of mild, moderate and severe forms.
Bak CW, Song SH, Yoon TK, Lim JJ, Shin TE, Sung S
Int J Urol 2010 Nov;17(11):937-43. Epub 2010 Sep 10 doi: 10.1111/j.1442-2042.2010.02628.x. PMID: 20831771
The effects of severity of oligozoospermia on Intracytoplasmic Sperm Injection (ICSI) cycle outcome.
Hashimoto H, Ishikawa T, Goto S, Kokeguchi S, Fujisawa M, Shiotani M
Syst Biol Reprod Med 2010 Feb;56(1):91-5. doi: 10.3109/19396360903509169. PMID: 20170289
Y chromosome microdeletions in infertile men with varicocele.
Moro E, Marin P, Rossi A, Garolla A, Ferlin A
Mol Cell Endocrinol 2000 Mar 30;161(1-2):67-71. doi: 10.1016/s0303-7207(99)00226-9. PMID: 10773394
Combined cytogenetic and Y chromosome microdeletion screening in males undergoing intracytoplasmic sperm injection.
van der Ven K, Montag M, Peschka B, Leygraaf J, Schwanitz G, Haidl G, Krebs D, van der Ven H
Mol Hum Reprod 1997 Aug;3(8):699-704. doi: 10.1093/molehr/3.8.699. PMID: 9294854

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