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Melanoma in Junctional Nevus

MedGen UID:
90782
•Concept ID:
C0334434
•
Neoplastic Process
Synonyms: Malignant melanoma in junctional nevus; Malignant Melanoma in Junctional Nevus; Malignant Melanoma of Skin in Junctional Nevus; Malignant Melanoma of the Skin in Junctional Nevus; Malignant Skin Melanoma in Junctional Nevus
SNOMED CT: Malignant melanoma in junctional nevus (915007)

Definition

A melanoma arising from a melanocytic nevus which involves the dermal-epidermal junction of the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMelanoma in Junctional Nevus

Professional guidelines

PubMed

Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin.
Massone C, Hofman-Wellenhof R, Chiodi S, Sola S
Genes (Basel) 2021 Aug 23;12(8) doi: 10.3390/genes12081288. PMID: 34440462Free PMC Article
Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach.
Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414
Lentigo maligna: review of salient characteristics and management.
Kallini JR, Jain SK, Khachemoune A
Am J Clin Dermatol 2013 Dec;14(6):473-80. doi: 10.1007/s40257-013-0044-6. PMID: 24019181

Recent clinical studies

Etiology

Melanoma on congenital melanocytic nevi.
Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Pitfalls of PRAME Immunohistochemistry in a Large Series of Melanocytic and Nonmelanocytic Lesions With Literature Review.
Turner N, Ko CJ, McNiff JM, Galan A
Am J Dermatopathol 2024 Jan 1;46(1):21-30. doi: 10.1097/DAD.0000000000002584. PMID: 37982498
Clinical and histological characteristics of melanocytic nevus in external auditory canals and auricles.
Lim HJ, Kim YT, Choo OS, Park K, Park HY, Choung YH
Eur Arch Otorhinolaryngol 2013 Nov;270(12):3035-42. Epub 2013 Jan 31 doi: 10.1007/s00405-013-2368-5. PMID: 23371542
Pigmented penile macules.
Mahto M, Woolley PD, Ashworth J
Int J STD AIDS 2004 Nov;15(11):717-9. doi: 10.1258/0956462042395276. PMID: 15537454
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Diagnosis

Pitfalls of PRAME Immunohistochemistry in a Large Series of Melanocytic and Nonmelanocytic Lesions With Literature Review.
Turner N, Ko CJ, McNiff JM, Galan A
Am J Dermatopathol 2024 Jan 1;46(1):21-30. doi: 10.1097/DAD.0000000000002584. PMID: 37982498
PRAME Expression in Melanocytic Tumors.
Lezcano C, Jungbluth AA, Nehal KS, Hollmann TJ, Busam KJ
Am J Surg Pathol 2018 Nov;42(11):1456-1465. doi: 10.1097/PAS.0000000000001134. PMID: 30045064Free PMC Article
Acral lentiginous melanoma.
Piliang MP
Clin Lab Med 2011 Jun;31(2):281-8. doi: 10.1016/j.cll.2011.03.005. PMID: 21549241
Pigmented penile macules.
Mahto M, Woolley PD, Ashworth J
Int J STD AIDS 2004 Nov;15(11):717-9. doi: 10.1258/0956462042395276. PMID: 15537454
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Therapy

Dermoscopic Image Classification of Pigmented Nevus under Deep Learning and the Correlation with Pathological Features.
Yang S, Shu C, Hu H, Ma G, Yang M
Comput Math Methods Med 2022;2022:9726181. Epub 2022 May 28 doi: 10.1155/2022/9726181. PMID: 35669372Free PMC Article
In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions.
Elagin V, Gubarkova E, Garanina O, Davydova D, Orlinskaya N, Matveev L, Klemenova I, Shlivko I, Shirmanova M, Zagaynova E
Sci Rep 2021 Jan 14;11(1):1405. doi: 10.1038/s41598-020-80744-w. PMID: 33446823Free PMC Article
Atypical histopathologic features in a melanocytic nevus after cryotherapy and pregnancy.
Wilford CE, Brantley JS, Diwan AH
J Cutan Pathol 2014 Oct;41(10):802-5. doi: 10.1111/j.1600-0560.2012.01824.x. PMID: 25351287
Diagnostic impact of nuclear DNA content and proliferative activity in benign and malignant melanocytic lesions.
Steinbeck ZR, Heselmeyer KM, Gerlach B, Björnhagen V, Auer GU
Melanoma Res 1996 Feb;6(1):37-43. doi: 10.1097/00008390-199602000-00006. PMID: 8640068
Epidermotropism in melanoma.
Warner TF, Gilbert EF, Ramirez G
J Cutan Pathol 1980 Feb;7(1):50-4. doi: 10.1111/j.1600-0560.1980.tb00977.x. PMID: 7358882

Prognosis

Melanoma on congenital melanocytic nevi.
Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Pitfalls of PRAME Immunohistochemistry in a Large Series of Melanocytic and Nonmelanocytic Lesions With Literature Review.
Turner N, Ko CJ, McNiff JM, Galan A
Am J Dermatopathol 2024 Jan 1;46(1):21-30. doi: 10.1097/DAD.0000000000002584. PMID: 37982498
Acral lentiginous melanoma.
Piliang MP
Clin Lab Med 2011 Jun;31(2):281-8. doi: 10.1016/j.cll.2011.03.005. PMID: 21549241
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671
Pigmented lesions of the vulva.
Rock B
Dermatol Clin 1992 Apr;10(2):361-70. PMID: 1606765

Clinical prediction guides

Pitfalls of PRAME Immunohistochemistry in a Large Series of Melanocytic and Nonmelanocytic Lesions With Literature Review.
Turner N, Ko CJ, McNiff JM, Galan A
Am J Dermatopathol 2024 Jan 1;46(1):21-30. doi: 10.1097/DAD.0000000000002584. PMID: 37982498
Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.
Bogdănici CM, Costea CF, Dumitrescu GF, Sava A, Ciobanu Apostol DG, Scripcariu DV, Nicoară SD, Tănase DM, Andriescu EC, Cărăuleanu A, Danciu M, Sălăvăstru SC, Schmitzer S, Cucu AI, Niagu IA
Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915. doi: 10.47162/RJME.62.4.03. PMID: 35673810Free PMC Article
Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin.
Massone C, Hofman-Wellenhof R, Chiodi S, Sola S
Genes (Basel) 2021 Aug 23;12(8) doi: 10.3390/genes12081288. PMID: 34440462Free PMC Article
In vivo dermoscopic and confocal microscopy multistep algorithm to detect in situ melanomas.
Borsari S, Pampena R, Benati E, Bombonato C, Kyrgidis A, Moscarella E, Lallas A, Argenziano G, Pellacani G, Longo C
Br J Dermatol 2018 Jul;179(1):163-172. Epub 2018 Apr 28 doi: 10.1111/bjd.16364. PMID: 29355898
Pointillist nevi.
Huynh PM, Glusac EJ, Bolognia JL
J Am Acad Dermatol 2001 Sep;45(3):397-400. doi: 10.1067/mjd.2001.116343. PMID: 11511837

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