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Advanced sleep phase syndrome 3(FASPS3)

MedGen UID:
909447
•Concept ID:
C4225169
•
Disease or Syndrome
Synonym: Advanced sleep phase syndrome, familial, 3
 
Gene (location): PER3 (1p36.23)
 
Monarch Initiative: MONDO:0014814
OMIM®: 616882

Definition

Advanced sleep phase syndrome is characterized by early sleep time (sleep onset) and early morning awakening (sleep offset) (summary by Zhang et al., 2016). For a discussion of genetic heterogeneity of advanced sleep phase syndrome, see FASPS1 (604348). [from OMIM]

Clinical features

From HPO
Depression
MedGen UID:
4229
•Concept ID:
C0011581
•
Mental or Behavioral Dysfunction
Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover from these moods; having a pessimistic outlook on the future; feeling a pervasive sense of shame; having a low self-worth; experiencing thoughts of suicide and engaging in suicidal behavior.
See: Feature record | Search on this feature
Early chronotype
MedGen UID:
1646349
•Concept ID:
C4703587
•
Finding
A tendency towards rising very early in the morning and going to bed early in the evening.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Insomnia in neurological disorders: Prevalence, mechanisms, impact and treatment approaches.
de Bergeyck R, Geoffroy PA
Rev Neurol (Paris) 2023 Oct;179(7):767-781. Epub 2023 Aug 22 doi: 10.1016/j.neurol.2023.08.008. PMID: 37620177
British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update.
Wilson S, Anderson K, Baldwin D, Dijk DJ, Espie A, Espie C, Gringras P, Krystal A, Nutt D, Selsick H, Sharpley A
J Psychopharmacol 2019 Aug;33(8):923-947. Epub 2019 Jul 4 doi: 10.1177/0269881119855343. PMID: 31271339
Integrating Sleep and Alzheimer's Disease Pathophysiology: Hints for Sleep Disorders Management.
Proserpio P, Arnaldi D, Nobili F, Nobili L
J Alzheimers Dis 2018;63(3):871-886. doi: 10.3233/JAD-180041. PMID: 29710720

Recent clinical studies

Etiology

Evaluation of Sleep Habits and Disturbances Among US Adults, 2017-2020.
Di H, Guo Y, Daghlas I, Wang L, Liu G, Pan A, Liu L, Shan Z
JAMA Netw Open 2022 Nov 1;5(11):e2240788. doi: 10.1001/jamanetworkopen.2022.40788. PMID: 36346632Free PMC Article
High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults.
Duffy JF, Wang W, Ronda JM, Czeisler CA
J Pineal Res 2022 Aug;73(1):e12801. Epub 2022 May 13 doi: 10.1111/jpi.12801. PMID: 35436355Free PMC Article
Disturbance of the Circadian System in Shift Work and Its Health Impact.
Boivin DB, Boudreau P, Kosmadopoulos A
J Biol Rhythms 2022 Feb;37(1):3-28. Epub 2021 Dec 30 doi: 10.1177/07487304211064218. PMID: 34969316Free PMC Article
Association between circadian rhythm disruption and polycystic ovary syndrome.
Wang F, Xie N, Wu Y, Zhang Q, Zhu Y, Dai M, Zhou J, Pan J, Tang M, Cheng Q, Shi B, Guo Q, Li X, Xie L, Wang B, Yang D, Weng Q, Guo L, Ye J, Pan M, Zhang S, Zhou H, Zhen C, Liu P, Ning K, Brackenridge L, Hardiman PJ, Qu F
Fertil Steril 2021 Mar;115(3):771-781. Epub 2020 Dec 24 doi: 10.1016/j.fertnstert.2020.08.1425. PMID: 33358334
Association between circadian rhythms and neurodegenerative diseases.
Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K
Lancet Neurol 2019 Mar;18(3):307-318. Epub 2019 Feb 12 doi: 10.1016/S1474-4422(18)30461-7. PMID: 30784558Free PMC Article

Diagnosis

Light exposure during sleep impairs cardiometabolic function.
Mason IC, Grimaldi D, Reid KJ, Warlick CD, Malkani RG, Abbott SM, Zee PC
Proc Natl Acad Sci U S A 2022 Mar 22;119(12):e2113290119. Epub 2022 Mar 14 doi: 10.1073/pnas.2113290119. PMID: 35286195Free PMC Article
Sleep disorders in the elderly: a growing challenge.
Gulia KK, Kumar VM
Psychogeriatrics 2018 May;18(3):155-165. doi: 10.1111/psyg.12319. PMID: 29878472
Computing sleep deficiency.
Erren TC, Groß JV, Lewis P
J Sleep Res 2018 Jun;27(3):e12630. Epub 2017 Nov 20 doi: 10.1111/jsr.12630. PMID: 29159867
International classification of sleep disorders-third edition: highlights and modifications.
Sateia MJ
Chest 2014 Nov;146(5):1387-1394. doi: 10.1378/chest.14-0970. PMID: 25367475
Insomnia.
Sutton EL
Med Clin North Am 2014 May;98(3):565-81. doi: 10.1016/j.mcna.2014.01.008. PMID: 24758961

Therapy

Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study.
Ried K, Tamanna T, Matthews S, Sali A
J Sleep Res 2023 Jun;32(3):e13793. Epub 2022 Dec 20 doi: 10.1111/jsr.13793. PMID: 36539991
High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults.
Duffy JF, Wang W, Ronda JM, Czeisler CA
J Pineal Res 2022 Aug;73(1):e12801. Epub 2022 May 13 doi: 10.1111/jpi.12801. PMID: 35436355Free PMC Article
Disturbance of the Circadian System in Shift Work and Its Health Impact.
Boivin DB, Boudreau P, Kosmadopoulos A
J Biol Rhythms 2022 Feb;37(1):3-28. Epub 2021 Dec 30 doi: 10.1177/07487304211064218. PMID: 34969316Free PMC Article
Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder.
Lalanne S, Fougerou-Leurent C, Anderson GM, Schroder CM, Nir T, Chokron S, Delorme R, Claustrat B, Bellissant E, Kermarrec S, Franco P, Denis L, Tordjman S
Int J Mol Sci 2021 Feb 2;22(3) doi: 10.3390/ijms22031490. PMID: 33540815Free PMC Article
The Impact of Shift Work on Sleep, Alertness and Performance in Healthcare Workers.
Ganesan S, Magee M, Stone JE, Mulhall MD, Collins A, Howard ME, Lockley SW, Rajaratnam SMW, Sletten TL
Sci Rep 2019 Mar 15;9(1):4635. doi: 10.1038/s41598-019-40914-x. PMID: 30874565Free PMC Article

Prognosis

Association of ischemic stroke onset time with presenting severity, acute progression, and long-term outcome: A cohort study.
Ryu WS, Hong KS, Jeong SW, Park JE, Kim BJ, Kim JT, Lee KB, Park TH, Park SS, Park JM, Kang K, Cho YJ, Park HK, Lee BC, Yu KH, Oh MS, Lee SJ, Kim JG, Cha JK, Kim DH, Lee J, Han MK, Park MS, Choi KH, Lee J, Saver JL, Lo EH, Bae HJ, Kim DE
PLoS Med 2022 Feb;19(2):e1003910. Epub 2022 Feb 4 doi: 10.1371/journal.pmed.1003910. PMID: 35120123Free PMC Article
Sleep Irregularity and Risk of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis.
Huang T, Mariani S, Redline S
J Am Coll Cardiol 2020 Mar 10;75(9):991-999. doi: 10.1016/j.jacc.2019.12.054. PMID: 32138974Free PMC Article
Shift Work and Poor Mental Health: A Meta-Analysis of Longitudinal Studies.
Torquati L, Mielke GI, Brown WJ, Burton NW, Kolbe-Alexander TL
Am J Public Health 2019 Nov;109(11):e13-e20. Epub 2019 Sep 19 doi: 10.2105/AJPH.2019.305278. PMID: 31536404Free PMC Article
Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis.
Thaiss CA, Zeevi D, Levy M, Zilberman-Schapira G, Suez J, Tengeler AC, Abramson L, Katz MN, Korem T, Zmora N, Kuperman Y, Biton I, Gilad S, Harmelin A, Shapiro H, Halpern Z, Segal E, Elinav E
Cell 2014 Oct 23;159(3):514-29. Epub 2014 Oct 16 doi: 10.1016/j.cell.2014.09.048. PMID: 25417104
Adverse metabolic and cardiovascular consequences of circadian misalignment.
Scheer FA, Hilton MF, Mantzoros CS, Shea SA
Proc Natl Acad Sci U S A 2009 Mar 17;106(11):4453-8. Epub 2009 Mar 2 doi: 10.1073/pnas.0808180106. PMID: 19255424Free PMC Article

Clinical prediction guides

Social jetlag and obesity: A systematic review and meta-analysis.
Arab A, Karimi E, Garaulet M, Scheer FAJL
Obes Rev 2024 Mar;25(3):e13664. Epub 2023 Dec 10 doi: 10.1111/obr.13664. PMID: 38072635
Day-to-day deviations in sleep parameters and biological aging: Findings from the NHANES 2011-2014.
Wang X, Xu Y, Li X, Mansuri A, McCall WV, Liu Y, Su S
Sleep Health 2023 Dec;9(6):940-946. Epub 2023 Aug 28 doi: 10.1016/j.sleh.2023.07.018. PMID: 37648648Free PMC Article
Assessment of Circadian Rhythms.
Reid KJ
Neurol Clin 2019 Aug;37(3):505-526. doi: 10.1016/j.ncl.2019.05.001. PMID: 31256786Free PMC Article
Computing sleep deficiency.
Erren TC, Groß JV, Lewis P
J Sleep Res 2018 Jun;27(3):e12630. Epub 2017 Nov 20 doi: 10.1111/jsr.12630. PMID: 29159867
Adverse metabolic and cardiovascular consequences of circadian misalignment.
Scheer FA, Hilton MF, Mantzoros CS, Shea SA
Proc Natl Acad Sci U S A 2009 Mar 17;106(11):4453-8. Epub 2009 Mar 2 doi: 10.1073/pnas.0808180106. PMID: 19255424Free PMC Article

Recent systematic reviews

Social jetlag and obesity: A systematic review and meta-analysis.
Arab A, Karimi E, Garaulet M, Scheer FAJL
Obes Rev 2024 Mar;25(3):e13664. Epub 2023 Dec 10 doi: 10.1111/obr.13664. PMID: 38072635
Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review.
Hester L, Dang D, Barker CJ, Heath M, Mesiya S, Tienabeso T, Watson K
Chronobiol Int 2021 Oct;38(10):1375-1383. Epub 2021 May 24 doi: 10.1080/07420528.2021.1930029. PMID: 34030534
Sleep quality among shift-work nurses: A systematic review and meta-analysis.
Kang J, Noh W, Lee Y
Appl Nurs Res 2020 Apr;52:151227. Epub 2019 Dec 26 doi: 10.1016/j.apnr.2019.151227. PMID: 31902652
Shift Work and Poor Mental Health: A Meta-Analysis of Longitudinal Studies.
Torquati L, Mielke GI, Brown WJ, Burton NW, Kolbe-Alexander TL
Am J Public Health 2019 Nov;109(11):e13-e20. Epub 2019 Sep 19 doi: 10.2105/AJPH.2019.305278. PMID: 31536404Free PMC Article
The effect of blue-light blocking spectacle lenses on visual performance, macular health and the sleep-wake cycle: a systematic review of the literature.
Lawrenson JG, Hull CC, Downie LE
Ophthalmic Physiol Opt 2017 Nov;37(6):644-654. doi: 10.1111/opo.12406. PMID: 29044670

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