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Subretinal pigment epithelium hemorrhage

MedGen UID:
909943
•Concept ID:
C2037047
•
Pathologic Function
Synonym: Subretinal pigment epithelium haemorrhage
 
HPO: HP:0025244

Definition

An accumulation of blood located between the retinal pigment epithelium (RPE) and Bruch's membrane. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubretinal pigment epithelium hemorrhage

Professional guidelines

PubMed

Current Management of Subretinal Hemorrhage in Neovascular Age-Related Macular Degeneration.
Oncel D, Oncel D, Mishra K, Oncel M, Arevalo JF
Ophthalmologica 2023;246(5-6):295-305. Epub 2023 Oct 7 doi: 10.1159/000534440. PMID: 37806303
Chinese Guideline on the Management of Polypoidal Choroidal Vasculopathy (2022).
Chen YX, Zhang YQ, Chen CZ, Dai H, Li SY, Ma X, Sun XD, Tang SB, Wang YS, Wei WB, Wen F, Xu GZ, Yu WH, Zhang MX, Zhao MW, Zhang Y, Qi F, Xu X, Li XX
Chin Med Sci J 2023 Jun 30;38(2):77-93. doi: 10.24920/004213. PMID: 37263796
Polypoidal Choroidal Vasculopathy: Consensus Nomenclature and Non-Indocyanine Green Angiograph Diagnostic Criteria from the Asia-Pacific Ocular Imaging Society PCV Workgroup.
Cheung CMG, Lai TYY, Teo K, Ruamviboonsuk P, Chen SJ, Kim JE, Gomi F, Koh AH, Kokame G, Jordan-Yu JM, Corvi F, Invernizzi A, Ogura Y, Tan C, Mitchell P, Gupta V, Chhablani J, Chakravarthy U, Sadda SR, Wong TY, Staurenghi G, Lee WK
Ophthalmology 2021 Mar;128(3):443-452. Epub 2020 Aug 11 doi: 10.1016/j.ophtha.2020.08.006. PMID: 32795496

Recent clinical studies

Etiology

Current Management of Subretinal Hemorrhage in Neovascular Age-Related Macular Degeneration.
Oncel D, Oncel D, Mishra K, Oncel M, Arevalo JF
Ophthalmologica 2023;246(5-6):295-305. Epub 2023 Oct 7 doi: 10.1159/000534440. PMID: 37806303
Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents, and Age-Related Macular Degeneration Study: A Randomized Controlled Trial for Submacular Hemorrhage Secondary to Age-Related Macular Degeneration.
Gabrielle PH, Delyfer MN, Glacet-Bernard A, Conart JB, Uzzan J, Kodjikian L, Arndt C, Tadayoni R, Soudry-Faure A, Creuzot Garcher CP
Ophthalmology 2023 Sep;130(9):947-957. Epub 2023 Apr 22 doi: 10.1016/j.ophtha.2023.04.014. PMID: 37088447
Polypoidal Choroidal Vasculopathy: Consensus Nomenclature and Non-Indocyanine Green Angiograph Diagnostic Criteria from the Asia-Pacific Ocular Imaging Society PCV Workgroup.
Cheung CMG, Lai TYY, Teo K, Ruamviboonsuk P, Chen SJ, Kim JE, Gomi F, Koh AH, Kokame G, Jordan-Yu JM, Corvi F, Invernizzi A, Ogura Y, Tan C, Mitchell P, Gupta V, Chhablani J, Chakravarthy U, Sadda SR, Wong TY, Staurenghi G, Lee WK
Ophthalmology 2021 Mar;128(3):443-452. Epub 2020 Aug 11 doi: 10.1016/j.ophtha.2020.08.006. PMID: 32795496
INTRARETINAL HYPERREFLECTIVE LINES.
Amoroso F, Mrejen S, Pedinielli A, Tabary S, Souied EH, Gaudric A, Cohen SY
Retina 2021 Jan 1;41(1):82-92. doi: 10.1097/IAE.0000000000002806. PMID: 32251237
Exudative retinal detachment.
Amer R, Nalcı H, Yalçındağ N
Surv Ophthalmol 2017 Nov-Dec;62(6):723-769. Epub 2017 May 13 doi: 10.1016/j.survophthal.2017.05.001. PMID: 28506603

Diagnosis

RIDGE-SHAPED PERIPAPILLA.
Wakabayashi T, Yonekawa Y, Ohno-Matsui K, Cohen SY, Rowland C, Pulido JS
Retin Cases Brief Rep 2024 Jan 1;18(1):11-14. doi: 10.1097/ICB.0000000000001308. PMID: 36007179
Polypoidal Choroidal Vasculopathy: Consensus Nomenclature and Non-Indocyanine Green Angiograph Diagnostic Criteria from the Asia-Pacific Ocular Imaging Society PCV Workgroup.
Cheung CMG, Lai TYY, Teo K, Ruamviboonsuk P, Chen SJ, Kim JE, Gomi F, Koh AH, Kokame G, Jordan-Yu JM, Corvi F, Invernizzi A, Ogura Y, Tan C, Mitchell P, Gupta V, Chhablani J, Chakravarthy U, Sadda SR, Wong TY, Staurenghi G, Lee WK
Ophthalmology 2021 Mar;128(3):443-452. Epub 2020 Aug 11 doi: 10.1016/j.ophtha.2020.08.006. PMID: 32795496
INTRARETINAL HYPERREFLECTIVE LINES.
Amoroso F, Mrejen S, Pedinielli A, Tabary S, Souied EH, Gaudric A, Cohen SY
Retina 2021 Jan 1;41(1):82-92. doi: 10.1097/IAE.0000000000002806. PMID: 32251237
Exudative retinal detachment.
Amer R, Nalcı H, Yalçındağ N
Surv Ophthalmol 2017 Nov-Dec;62(6):723-769. Epub 2017 May 13 doi: 10.1016/j.survophthal.2017.05.001. PMID: 28506603
Best's vitelliform dystrophy.
Blodi CF, Stone EM
Ophthalmic Paediatr Genet 1990 Mar;11(1):49-59. PMID: 2190134

Therapy

Current Management of Subretinal Hemorrhage in Neovascular Age-Related Macular Degeneration.
Oncel D, Oncel D, Mishra K, Oncel M, Arevalo JF
Ophthalmologica 2023;246(5-6):295-305. Epub 2023 Oct 7 doi: 10.1159/000534440. PMID: 37806303
Chinese Guideline on the Management of Polypoidal Choroidal Vasculopathy (2022).
Chen YX, Zhang YQ, Chen CZ, Dai H, Li SY, Ma X, Sun XD, Tang SB, Wang YS, Wei WB, Wen F, Xu GZ, Yu WH, Zhang MX, Zhao MW, Zhang Y, Qi F, Xu X, Li XX
Chin Med Sci J 2023 Jun 30;38(2):77-93. doi: 10.24920/004213. PMID: 37263796
Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents, and Age-Related Macular Degeneration Study: A Randomized Controlled Trial for Submacular Hemorrhage Secondary to Age-Related Macular Degeneration.
Gabrielle PH, Delyfer MN, Glacet-Bernard A, Conart JB, Uzzan J, Kodjikian L, Arndt C, Tadayoni R, Soudry-Faure A, Creuzot Garcher CP
Ophthalmology 2023 Sep;130(9):947-957. Epub 2023 Apr 22 doi: 10.1016/j.ophtha.2023.04.014. PMID: 37088447
Polypoidal Choroidal Vasculopathy: Consensus Nomenclature and Non-Indocyanine Green Angiograph Diagnostic Criteria from the Asia-Pacific Ocular Imaging Society PCV Workgroup.
Cheung CMG, Lai TYY, Teo K, Ruamviboonsuk P, Chen SJ, Kim JE, Gomi F, Koh AH, Kokame G, Jordan-Yu JM, Corvi F, Invernizzi A, Ogura Y, Tan C, Mitchell P, Gupta V, Chhablani J, Chakravarthy U, Sadda SR, Wong TY, Staurenghi G, Lee WK
Ophthalmology 2021 Mar;128(3):443-452. Epub 2020 Aug 11 doi: 10.1016/j.ophtha.2020.08.006. PMID: 32795496
Exudative retinal detachment.
Amer R, Nalcı H, Yalçındağ N
Surv Ophthalmol 2017 Nov-Dec;62(6):723-769. Epub 2017 May 13 doi: 10.1016/j.survophthal.2017.05.001. PMID: 28506603

Prognosis

A systematic review of the cell death mechanisms in retinal pigment epithelium cells and photoreceptors after subretinal hemorrhage - Implications for treatment options.
Chhatwal S, Antony H, Lamei S, Kovács-Öller T, Klettner AK, Zille M
Biomed Pharmacother 2023 Nov;167:115572. Epub 2023 Sep 22 doi: 10.1016/j.biopha.2023.115572. PMID: 37742603
Visual Recovery and Prognosis in the Treatment of Submacular Hemorrhage due to Polypoidal Choroidal Vasculopathy and Retinal Arterial Macroaneurysm: A Retrospective Study.
Wu J, Yan T, Zhang R, Feng C, Xu C, Xu T, Li Y, Wang S, He J
Int J Clin Pract 2023;2023:3880297. Epub 2023 Jun 12 doi: 10.1155/2023/3880297. PMID: 37342617Free PMC Article
INTRARETINAL HYPERREFLECTIVE LINES.
Amoroso F, Mrejen S, Pedinielli A, Tabary S, Souied EH, Gaudric A, Cohen SY
Retina 2021 Jan 1;41(1):82-92. doi: 10.1097/IAE.0000000000002806. PMID: 32251237
Polypoidal choroidal vasculopathy.
Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA
Surv Ophthalmol 2004 Jan-Feb;49(1):25-37. doi: 10.1016/j.survophthal.2003.10.007. PMID: 14711438
Best's vitelliform dystrophy.
Blodi CF, Stone EM
Ophthalmic Paediatr Genet 1990 Mar;11(1):49-59. PMID: 2190134

Clinical prediction guides

Hyperreflective material in patients with non-neovascular pachychoroid disease.
Maruyama-Inoue M, Yanagi Y, Mohamed S, Inoue T, Kitajima Y, Ikeda S, Kadonosono K
BMC Ophthalmol 2023 Jun 6;23(1):255. doi: 10.1186/s12886-023-03011-2. PMID: 37280611Free PMC Article
Chinese Guideline on the Management of Polypoidal Choroidal Vasculopathy (2022).
Chen YX, Zhang YQ, Chen CZ, Dai H, Li SY, Ma X, Sun XD, Tang SB, Wang YS, Wei WB, Wen F, Xu GZ, Yu WH, Zhang MX, Zhao MW, Zhang Y, Qi F, Xu X, Li XX
Chin Med Sci J 2023 Jun 30;38(2):77-93. doi: 10.24920/004213. PMID: 37263796
Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents, and Age-Related Macular Degeneration Study: A Randomized Controlled Trial for Submacular Hemorrhage Secondary to Age-Related Macular Degeneration.
Gabrielle PH, Delyfer MN, Glacet-Bernard A, Conart JB, Uzzan J, Kodjikian L, Arndt C, Tadayoni R, Soudry-Faure A, Creuzot Garcher CP
Ophthalmology 2023 Sep;130(9):947-957. Epub 2023 Apr 22 doi: 10.1016/j.ophtha.2023.04.014. PMID: 37088447
Hypoxia Inhibits Subretinal Inflammation Resolution Thrombospondin-1 Dependently.
Touhami S, Béguier F, Yang T, Augustin S, Roubeix C, Blond F, Conart JB, Sahel JA, Bodaghi B, Delarasse C, Guillonneau X, Sennlaub F
Int J Mol Sci 2022 Jan 8;23(2) doi: 10.3390/ijms23020681. PMID: 35054863Free PMC Article
Pachychoroid pigment epitheliopathy.
Warrow DJ, Hoang QV, Freund KB
Retina 2013 Sep;33(8):1659-72. doi: 10.1097/IAE.0b013e3182953df4. PMID: 23751942

Recent systematic reviews

Differential diagnosis of myopic choroidal neovascularization (mCNV): insights from multimodal imaging and treatment implications.
Feo A, De Simone L, Cimino L, Angi M, Romano MR
Graefes Arch Clin Exp Ophthalmol 2024 Jul;262(7):2005-2026. Epub 2023 Dec 7 doi: 10.1007/s00417-023-06320-w. PMID: 38060000
A systematic review of the cell death mechanisms in retinal pigment epithelium cells and photoreceptors after subretinal hemorrhage - Implications for treatment options.
Chhatwal S, Antony H, Lamei S, Kovács-Öller T, Klettner AK, Zille M
Biomed Pharmacother 2023 Nov;167:115572. Epub 2023 Sep 22 doi: 10.1016/j.biopha.2023.115572. PMID: 37742603

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