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Herpes gestationis

MedGen UID:
9233
•Concept ID:
C0019343
•
Disease or Syndrome
Synonyms: Gestational pemphigoid; Pemphigoid gestationis
SNOMED CT: Pemphigoid gestationis (86081009); Herpes gestationis (86081009); Dermatitis herpetiformis of pregnancy (86081009)
 
Monarch Initiative: MONDO:0006558
Orphanet: ORPHA63275

Definition

A rare autoimmune bullous skin disease characterized by pruritus with or without polymorphic skin eruption, affecting pregnant women typically during the second and third trimester. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHerpes gestationis
Follow this link to review classifications for Herpes gestationis in Orphanet.

Professional guidelines

PubMed

Focus on primary care: pruritic dermatological conditions in pregnancy.
Sherard GB 3rd, Atkinson SM Jr
Obstet Gynecol Surv 2001 Jul;56(7):427-32. doi: 10.1097/00006254-200107000-00022. PMID: 11435950
Pyridoxine in the treatment of herpes gestationis.
FOSNAUGH RP, BRYAN HG, ORDERS RL
Arch Dermatol 1961 Jul;84:90-5. doi: 10.1001/archderm.1961.01580130096014. PMID: 13700942
Herpes gestationis; treatment with ACTH and cortisone.
ZAKON SJ, LEADER LO, SIEGEL I
Obstet Gynecol 1953 Jul;2(1):78-80. PMID: 13073084

Recent clinical studies

Etiology

Subepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.
Montagnon CM, Tolkachjov SN, Murrell DF, Camilleri MJ, Lehman JS
J Am Acad Dermatol 2021 Jul;85(1):1-14. Epub 2021 Mar 5 doi: 10.1016/j.jaad.2020.11.076. PMID: 33684496
Nongenital herpes simplex virus.
Usatine RP, Tinitigan R
Am Fam Physician 2010 Nov 1;82(9):1075-82. PMID: 21121552
Herpes gestationis (Pemphigoid gestationis).
Al-Fouzan AW, Galadari I, Oumeish I, Oumeish OY
Clin Dermatol 2006 Mar-Apr;24(2):109-12. doi: 10.1016/j.clindermatol.2005.10.011. PMID: 16487884
Herpes gestationis.
Shornick JK
Dermatol Clin 1993 Jul;11(3):527-33. PMID: 8365037
Herpes gestationis.
Quimby SR, Xenias SJ, Perry HO
Mayo Clin Proc 1982 Aug;57(8):520-6. PMID: 7047919

Diagnosis

Subepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.
Montagnon CM, Tolkachjov SN, Murrell DF, Camilleri MJ, Lehman JS
J Am Acad Dermatol 2021 Jul;85(1):1-14. Epub 2021 Mar 5 doi: 10.1016/j.jaad.2020.11.076. PMID: 33684496
Herpes gestationis.
Tanzi P, Lojacono A, Tarantini M, Faden D
Int J Gynaecol Obstet 1994 Apr;45(1):47-9. doi: 10.1016/0020-7292(94)90765-x. PMID: 7913059
Herpes gestationis.
Shornick JK
J Am Acad Dermatol 1987 Oct;17(4):539-56. doi: 10.1016/s0190-9622(87)70237-0. PMID: 3312312
Bullous pemphigoid.
Korman N
J Am Acad Dermatol 1987 May;16(5 Pt 1):907-24. doi: 10.1016/s0190-9622(87)70115-7. PMID: 3294944
Acrodermatitis enteropathica.
Bronson DM, Barsky R, Barsky S
J Am Acad Dermatol 1983 Jul;9(1):140-4. doi: 10.1016/s0190-9622(83)70120-9. PMID: 6886096

Therapy

Complement in skin diseases.
Kotnik V
Acta Dermatovenerol Alp Pannonica Adriat 2011;20(1):3-11. PMID: 21879199
Nongenital herpes simplex virus.
Usatine RP, Tinitigan R
Am Fam Physician 2010 Nov 1;82(9):1075-82. PMID: 21121552
Herpes gestationis.
Tanzi P, Lojacono A, Tarantini M, Faden D
Int J Gynaecol Obstet 1994 Apr;45(1):47-9. doi: 10.1016/0020-7292(94)90765-x. PMID: 7913059
Pemphigoid 'herpes' gestationis.
Mayou SC, Black MM, Holmes RC
Semin Dermatol 1988 Jun;7(2):104-10. PMID: 3153431
Herpes gestationis.
Quimby SR, Xenias SJ, Perry HO
Mayo Clin Proc 1982 Aug;57(8):520-6. PMID: 7047919

Prognosis

A subset of patients with pemphigoid (herpes) gestationis has serological evidence of celiac disease.
Saffari H, Zone JJ, Allen M, Leiferman KM
Int J Dermatol 2018 May;57(5):534-540. Epub 2018 Feb 23 doi: 10.1111/ijd.13925. PMID: 29473148
Fetal risks in herpes gestationis.
Shornick JK, Black MM
J Am Acad Dermatol 1992 Jan;26(1):63-8. doi: 10.1016/0190-9622(92)70008-4. PMID: 1732338
Pemphigoid 'herpes' gestationis.
Mayou SC, Black MM, Holmes RC
Semin Dermatol 1988 Jun;7(2):104-10. PMID: 3153431
Bullous pemphigoid.
Korman N
J Am Acad Dermatol 1987 May;16(5 Pt 1):907-24. doi: 10.1016/s0190-9622(87)70115-7. PMID: 3294944
The fetal prognosis in pemphigoid gestationis (herpes gestationis).
Holmes RC, Black MM
Br J Dermatol 1984 Jan;110(1):67-72. doi: 10.1111/j.1365-2133.1984.tb07314.x. PMID: 6362709

Clinical prediction guides

Pemphigoid gestationis: clinical and laboratory evaluation.
Cobo MF, Santi CG, Maruta CW, Aoki V
Clinics (Sao Paulo) 2009;64(11):1043-7. doi: 10.1590/S1807-59322009001100002. PMID: 19936176Free PMC Article
Pruritic urticarial papules and plaques of pregnancy.
Brzoza Z, Kasperska-Zajac A, Oleś E, Rogala B
J Midwifery Womens Health 2007 Jan-Feb;52(1):44-8. doi: 10.1016/j.jmwh.2006.09.007. PMID: 17207750
Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain.
Giudice GJ, Emery DJ, Zelickson BD, Anhalt GJ, Liu Z, Diaz LA
J Immunol 1993 Nov 15;151(10):5742-50. PMID: 8228259
The role of complement-derived mediators in inflammatory skin diseases.
Tagami H
Arch Dermatol Res 1992;284 Suppl 1:S2-9. doi: 10.1007/BF00638232. PMID: 1285651
Bullous pemphigoid, herpes gestationis and linear dermatitis herpetiformis: circulating anti-basement membrane zone antibodies; in vitro studies.
Pehamberger H, Gschnait F, Konrad K, Holubar K
J Invest Dermatol 1980 Feb;74(2):105-8. doi: 10.1111/1523-1747.ep12520017. PMID: 6985947

Recent systematic reviews

Specific dermatoses of pregnancy: an evidence-based systematic review.
Kroumpouzos G, Cohen LM
Am J Obstet Gynecol 2003 Apr;188(4):1083-92. doi: 10.1067/mob.2003.129. PMID: 12712115

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