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Herpes gestationis

MedGen UID:
9233
•Concept ID:
C0019343
•
Disease or Syndrome
Synonyms: Gestational pemphigoid; Pemphigoid gestationis
SNOMED CT: Pemphigoid gestationis (86081009); Herpes gestationis (86081009); Dermatitis herpetiformis of pregnancy (86081009)
 
Monarch Initiative: MONDO:0006558
Orphanet: ORPHA63275

Definition

A rare autoimmune bullous skin disease characterized by pruritus with or without polymorphic skin eruption, affecting pregnant women typically during the second and third trimester. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHerpes gestationis
Follow this link to review classifications for Herpes gestationis in Orphanet.

Professional guidelines

PubMed

Pruritus in pregnancy and childhood--do we really consider all relevant differential diagnoses?
Weisshaar E, Diepgen TL, Luger TA, Seeliger S, Witteler R, Ständer S
Eur J Dermatol 2005 Sep-Oct;15(5):320-31. PMID: 16172038
Focus on primary care: pruritic dermatological conditions in pregnancy.
Sherard GB 3rd, Atkinson SM Jr
Obstet Gynecol Surv 2001 Jul;56(7):427-32. doi: 10.1097/00006254-200107000-00022. PMID: 11435950
Pyridoxine in the treatment of herpes gestationis.
FOSNAUGH RP, BRYAN HG, ORDERS RL
Arch Dermatol 1961 Jul;84:90-5. doi: 10.1001/archderm.1961.01580130096014. PMID: 13700942

Recent clinical studies

Etiology

Nongenital herpes simplex virus.
Usatine RP, Tinitigan R
Am Fam Physician 2010 Nov 1;82(9):1075-82. PMID: 21121552
Herpes gestationis (Pemphigoid gestationis).
Al-Fouzan AW, Galadari I, Oumeish I, Oumeish OY
Clin Dermatol 2006 Mar-Apr;24(2):109-12. doi: 10.1016/j.clindermatol.2005.10.011. PMID: 16487884
Specific dermatoses of pregnancy: an evidence-based systematic review.
Kroumpouzos G, Cohen LM
Am J Obstet Gynecol 2003 Apr;188(4):1083-92. doi: 10.1067/mob.2003.129. PMID: 12712115
Herpes gestationis.
Jørgensen EH, Clemmensen O, Anagnostaki L
Acta Obstet Gynecol Scand 1987;66(2):175-7. doi: 10.3109/00016348709083043. PMID: 3303816
Herpes gestationis.
Quimby SR, Xenias SJ, Perry HO
Mayo Clin Proc 1982 Aug;57(8):520-6. PMID: 7047919

Diagnosis

Autoimmune bullous diseases during pregnancy: insight into pathogenetic mechanisms and clinical features.
Feliciani C, Genovese G, D'astolto R, Pontini P, Marzano AV
G Ital Dermatol Venereol 2019 Jun;154(3):256-262. Epub 2018 Oct 29 doi: 10.23736/S0392-0488.18.06153-9. PMID: 30375213
Specific dermatoses of pregnancy: an evidence-based systematic review.
Kroumpouzos G, Cohen LM
Am J Obstet Gynecol 2003 Apr;188(4):1083-92. doi: 10.1067/mob.2003.129. PMID: 12712115
Herpes gestationis.
Shornick JK
J Am Acad Dermatol 1987 Oct;17(4):539-56. doi: 10.1016/s0190-9622(87)70237-0. PMID: 3312312
Herpes gestationis.
Jørgensen EH, Clemmensen O, Anagnostaki L
Acta Obstet Gynecol Scand 1987;66(2):175-7. doi: 10.3109/00016348709083043. PMID: 3303816
Bullous pemphigoid.
Korman N
J Am Acad Dermatol 1987 May;16(5 Pt 1):907-24. doi: 10.1016/s0190-9622(87)70115-7. PMID: 3294944

Therapy

Complement in skin diseases.
Kotnik V
Acta Dermatovenerol Alp Pannonica Adriat 2011;20(1):3-11. PMID: 21879199
Herpes gestationis.
Tanzi P, Lojacono A, Tarantini M, Faden D
Int J Gynaecol Obstet 1994 Apr;45(1):47-9. doi: 10.1016/0020-7292(94)90765-x. PMID: 7913059
Pharmaceutical effect of contraceptive pills on the skin.
Foldes EG
Int J Clin Pharmacol Ther Toxicol 1988 Jul;26(7):356-9. PMID: 2974837
Herpes gestationis.
Quimby SR, Xenias SJ, Perry HO
Mayo Clin Proc 1982 Aug;57(8):520-6. PMID: 7047919
Unusal signs and symptoms associated with oral contraceptive medication.
Koide SS, Lyle KC
J Reprod Med 1975 Dec;15(6):214-24. PMID: 1104827

Prognosis

Interleukin-1 levels in blister fluids of some skin diseases with blister formation.
Imaizumi T, Nomura K, Hashimoto I, Sawada Y
Clin Physiol Biochem 1990;8(4):179-83. PMID: 2078919
Pemphigoid 'herpes' gestationis.
Mayou SC, Black MM, Holmes RC
Semin Dermatol 1988 Jun;7(2):104-10. PMID: 3153431
Bullous pemphigoid.
Korman N
J Am Acad Dermatol 1987 May;16(5 Pt 1):907-24. doi: 10.1016/s0190-9622(87)70115-7. PMID: 3294944
Bullous dermatoses of pregnancy.
Honeyman JF, Eguiguren G, Pinto A, Honeyman AR, de la Parra MA, Navarrete W
Arch Dermatol 1981 May;117(5):264-7. PMID: 7013716
Herpes gestationis.
Diamond WJ
S Afr Med J 1976 May 1;50(19):739-40. PMID: 775662

Clinical prediction guides

Pemphigoid gestationis: clinical and laboratory evaluation.
Cobo MF, Santi CG, Maruta CW, Aoki V
Clinics (Sao Paulo) 2009;64(11):1043-7. doi: 10.1590/S1807-59322009001100002. PMID: 19936176Free PMC Article
Pruritic urticarial papules and plaques of pregnancy.
Brzoza Z, Kasperska-Zajac A, Oleś E, Rogala B
J Midwifery Womens Health 2007 Jan-Feb;52(1):44-8. doi: 10.1016/j.jmwh.2006.09.007. PMID: 17207750
A comparative study of antibody titers of blister fluid and serum in patients with subepidermal immunobullous diseases.
Daneshpazhooh M, Shahdi M, Aghaeepoor M, Hasiri G, Chams C
Int J Dermatol 2004 May;43(5):348-51. doi: 10.1111/j.1365-4632.2004.01902.x. PMID: 15117364
The role of complement-derived mediators in inflammatory skin diseases.
Tagami H
Arch Dermatol Res 1992;284 Suppl 1:S2-9. doi: 10.1007/BF00638232. PMID: 1285651
Interleukin-1 levels in blister fluids of some skin diseases with blister formation.
Imaizumi T, Nomura K, Hashimoto I, Sawada Y
Clin Physiol Biochem 1990;8(4):179-83. PMID: 2078919

Recent systematic reviews

Specific dermatoses of pregnancy: an evidence-based systematic review.
Kroumpouzos G, Cohen LM
Am J Obstet Gynecol 2003 Apr;188(4):1083-92. doi: 10.1067/mob.2003.129. PMID: 12712115

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