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Tunnel Clusters

MedGen UID:
925381
•Concept ID:
C4287849
•
Finding

Definition

A benign lesion characterized by the presence of rounded, lobular aggregates of endocervical glands in the cervical wall. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTunnel Clusters

Professional guidelines

PubMed

Immunohistochemical staining for Ki-67 antigen, carcinoembryonic antigen, and p53 in the differential diagnosis of glandular lesions of the cervix.
Cina SJ, Richardson MS, Austin RM, Kurman RJ
Mod Pathol 1997 Mar;10(3):176-80. PMID: 9071723

Recent clinical studies

Etiology

New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
Gastric mucin is expressed in a subset of endocervical tunnel clusters: type A tunnel clusters of gastric phenotype.
Kondo T, Hashi A, Murata SI, Fischer SE, Nara M, Nakazawa T, Yuminamochi T, Hoshi K, Katoh R
Histopathology 2007 Jun;50(7):843-50. doi: 10.1111/j.1365-2559.2007.02705.x. PMID: 17543073
The relationship of glands to thick-wall blood vessels as a marker of invasion in endocervical adenocarcinoma.
Wheeler DT, Kurman RJ
Int J Gynecol Pathol 2005 Apr;24(2):125-30. doi: 10.1097/01.pgp.0000152025.45106.6d. PMID: 15782068
Nonneoplastic findings in loop electrical excision procedure specimens from patients with persistent atypical squamous cells of uncertain significance in two consecutive pap smears.
Pinto AP, Tuon FF, Tizzot EL, Torres LF, Collaço LM
Diagn Cytopathol 2002 Aug;27(2):123-7. doi: 10.1002/dc.10133. PMID: 12203882

Diagnosis

New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
A pre-tailored panel of antibodies in the study of cervical mesonephric remnants.
Pavlakis K, Messini I, Yiannou P, Chrissanthakis D, Papaspyrou I, Panoskaltsis T, Stathopoulos EN
Gynecol Oncol 2010 Mar;116(3):468-72. Epub 2009 Nov 14 doi: 10.1016/j.ygyno.2009.10.055. PMID: 19913894
Symposium part III: tumor-like glandular lesions of the uterine cervix.
Nucci MR
Int J Gynecol Pathol 2002 Oct;21(4):347-59. doi: 10.1097/00004347-200210000-00004. PMID: 12352183
Mitotic activity and apoptosis in endocervical glandular lesions.
Moritani S, Ioffe OB, Sagae S, Dahmoush L, Silverberg SG, Hattori T
Int J Gynecol Pathol 2002 Apr;21(2):125-33. doi: 10.1097/00004347-200204000-00004. PMID: 11917221
Pseudoneoplastic glandular lesions of the uterine cervix.
Young RH, Clement PB
Semin Diagn Pathol 1991 Nov;8(4):234-49. PMID: 1759058

Prognosis

New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
Rabban JT, McAlhany S, Lerwill MF, Grenert JP, Zaloudek CJ
Am J Surg Pathol 2010 Feb;34(2):137-46. doi: 10.1097/PAS.0b013e3181c89c98. PMID: 20061933
The relationship of glands to thick-wall blood vessels as a marker of invasion in endocervical adenocarcinoma.
Wheeler DT, Kurman RJ
Int J Gynecol Pathol 2005 Apr;24(2):125-30. doi: 10.1097/01.pgp.0000152025.45106.6d. PMID: 15782068

Clinical prediction guides

PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
Rabban JT, McAlhany S, Lerwill MF, Grenert JP, Zaloudek CJ
Am J Surg Pathol 2010 Feb;34(2):137-46. doi: 10.1097/PAS.0b013e3181c89c98. PMID: 20061933
The relationship of glands to thick-wall blood vessels as a marker of invasion in endocervical adenocarcinoma.
Wheeler DT, Kurman RJ
Int J Gynecol Pathol 2005 Apr;24(2):125-30. doi: 10.1097/01.pgp.0000152025.45106.6d. PMID: 15782068

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