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Hyperesthesia

MedGen UID:
9361
•Concept ID:
C0020453
•
Sign or Symptom
Synonyms: Hyperesthesias; Hyperesthetic Sensation; Hyperesthetic Sensations; Oxyesthesia; Oxyesthesias; Sensation, Hyperesthetic; Sensations, Hyperesthetic
SNOMED CT: Hyperesthesia (14151009); Hyperesthesia (increased sensitivity) (14151009); Heightened sensation (14151009); Increased sensitivity - sensation (14151009); Hypersensitivity - sensation (14151009); Heightened sensation of skin (14151009)
 
HPO: HP:0100963

Definition

Increased sensitivity to stimulation, excluding the special senses, which may refer to various modes of cutaneous sensibility including touch and thermal sensation without pain, as well as to pain. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperesthesia

Professional guidelines

PubMed

Approach to diagnosis, evaluation, and treatment of generalized and nonlocal dysesthesia: A review.
Labib A, Burke O, Nichols A, Maderal AD
J Am Acad Dermatol 2023 Dec;89(6):1192-1200. Epub 2023 Jul 28 doi: 10.1016/j.jaad.2023.06.063. PMID: 37517675
Current and Future Issues in the Development of Spinal Agents for the Management of Pain.
Yaksh TL, Fisher CJ, Hockman TM, Wiese AJ
Curr Neuropharmacol 2017;15(2):232-259. doi: 10.2174/1570159x14666160307145542. PMID: 26861470Free PMC Article
Diagnosis and treatment of pain in small-fiber neuropathy.
Hovaguimian A, Gibbons CH
Curr Pain Headache Rep 2011 Jun;15(3):193-200. doi: 10.1007/s11916-011-0181-7. PMID: 21286866Free PMC Article

Recent clinical studies

Etiology

Neuroinflammation and Oxidative Stress in the Pathogenesis of Autism Spectrum Disorder.
Usui N, Kobayashi H, Shimada S
Int J Mol Sci 2023 Mar 13;24(6) doi: 10.3390/ijms24065487. PMID: 36982559Free PMC Article
Pyomyositis: Are We Missing the Diagnosis?
Agarwal N, Aroor S, Saini P, Gupta A, Kaur N
Surg Infect (Larchmt) 2016 Oct;17(5):615-21. Epub 2016 Jul 27 doi: 10.1089/sur.2015.191. PMID: 27463090
Irritable bowel syndrome and visceral hypersensitivity : risk factors and pathophysiological mechanisms.
Deiteren A, de Wit A, van der Linden L, De Man JG, Pelckmans PA, De Winter BY
Acta Gastroenterol Belg 2016 Mar;79(1):29-38. PMID: 26852761
Vulvodynia interventions--systematic review and evidence grading.
Andrews JC
Obstet Gynecol Surv 2011 May;66(5):299-315. doi: 10.1097/OGX.0b013e3182277fb7. PMID: 21794194
Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values.
Rolke R, Baron R, Maier C, Tölle TR, Treede -DR, Beyer A, Binder A, Birbaumer N, Birklein F, Bötefür IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihöfner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B
Pain 2006 Aug;123(3):231-243. Epub 2006 May 11 doi: 10.1016/j.pain.2006.01.041. PMID: 16697110

Diagnosis

Approach to diagnosis, evaluation, and treatment of generalized and nonlocal dysesthesia: A review.
Labib A, Burke O, Nichols A, Maderal AD
J Am Acad Dermatol 2023 Dec;89(6):1192-1200. Epub 2023 Jul 28 doi: 10.1016/j.jaad.2023.06.063. PMID: 37517675
Gastroesophageal reflux disease and oral health: A narrative review.
Mahajan R, Kulkarni R, Stoopler ET
Spec Care Dentist 2022 Nov;42(6):555-564. Epub 2022 May 23 doi: 10.1111/scd.12726. PMID: 35605234
NOTALGIA PARESTHETICA.
Šitum M, Kolić M, Franceschi N, Pećina M
Acta Clin Croat 2018 Dec;57(4):721-725. doi: 10.20471/acc.2018.57.04.14. PMID: 31168209Free PMC Article
Quantitative Sensory Testing in Chronic Musculoskeletal Pain.
Uddin Z, MacDermid JC
Pain Med 2016 Sep;17(9):1694-703. Epub 2016 Feb 18 doi: 10.1093/pm/pnv105. PMID: 26893116
Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values.
Rolke R, Baron R, Maier C, Tölle TR, Treede -DR, Beyer A, Binder A, Birbaumer N, Birklein F, Bötefür IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihöfner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B
Pain 2006 Aug;123(3):231-243. Epub 2006 May 11 doi: 10.1016/j.pain.2006.01.041. PMID: 16697110

Therapy

Recent Advances in Biomarkers and Regenerative Medicine for Diabetic Neuropathy.
Fujita Y, Murakami T, Nakamura A
Int J Mol Sci 2021 Feb 25;22(5) doi: 10.3390/ijms22052301. PMID: 33669048Free PMC Article
Current and Future Issues in the Development of Spinal Agents for the Management of Pain.
Yaksh TL, Fisher CJ, Hockman TM, Wiese AJ
Curr Neuropharmacol 2017;15(2):232-259. doi: 10.2174/1570159x14666160307145542. PMID: 26861470Free PMC Article
Nummular headache update.
Schwartz DP, Robbins MS, Grosberg BM
Curr Pain Headache Rep 2013 Jun;17(6):340. doi: 10.1007/s11916-013-0340-0. PMID: 23616207
Post-herpetic neuralgia: 208 cases.
Watson PNC, Evans RJ, Watt VR, Birkett N
Pain 1988 Dec;35(3):289-297. doi: 10.1016/0304-3959(88)90139-X. PMID: 2852344
Thallium poisoning: a review.
Saddique A, Peterson CD
Vet Hum Toxicol 1983 Feb;25(1):16-22. PMID: 6338655

Prognosis

Higher incidences of neuropathic pain and altered sensation following radial forearm free flap: A systematic review.
Bruin LL, Hundepool CA, Duraku LS, Mureau MAM, Zuidam JM
J Plast Reconstr Aesthet Surg 2022 Jan;75(1):1-9. Epub 2021 Oct 8 doi: 10.1016/j.bjps.2021.09.028. PMID: 34736849
Migraines and keloids: a 15-year Taiwan claim database analysis.
Lu YY, Qin H, Lu CC, Wu MK, Zhang CL, Wu CH
Postgrad Med J 2022 Jun;98(1160):450-455. Epub 2021 Feb 4 doi: 10.1136/postgradmedj-2020-139550. PMID: 33541932Free PMC Article
Clinical, electrophysiological findings and evaluation of prognosis of patients with Guillain-Barré syndrome.
Kılıç B, Güngör S, Özgör B
Turk J Pediatr 2019;61(2):200-208. doi: 10.24953/turkjped.2019.02.008. PMID: 32077646
Quantitative Sensory Testing in Chronic Musculoskeletal Pain.
Uddin Z, MacDermid JC
Pain Med 2016 Sep;17(9):1694-703. Epub 2016 Feb 18 doi: 10.1093/pm/pnv105. PMID: 26893116
Neuromuscular sequelae of critical illness.
Latronico N, Shehu I, Seghelini E
Curr Opin Crit Care 2005 Aug;11(4):381-90. doi: 10.1097/01.ccx.0000168530.30702.3e. PMID: 16015120

Clinical prediction guides

Replacement of the distal radio-ulnar joint with a semi-constrained Scheker DRUJ prosthesis.
Jawahier PA, Derksen BM, Jaquet JB, Schep NWL
Oper Orthop Traumatol 2023 Dec;35(6):341-351. Epub 2023 Aug 2 doi: 10.1007/s00064-023-00822-w. PMID: 37530813
Clinical, electrophysiological findings and evaluation of prognosis of patients with Guillain-Barré syndrome.
Kılıç B, Güngör S, Özgör B
Turk J Pediatr 2019;61(2):200-208. doi: 10.24953/turkjped.2019.02.008. PMID: 32077646
Pyomyositis: Are We Missing the Diagnosis?
Agarwal N, Aroor S, Saini P, Gupta A, Kaur N
Surg Infect (Larchmt) 2016 Oct;17(5):615-21. Epub 2016 Jul 27 doi: 10.1089/sur.2015.191. PMID: 27463090
Predictors of Persistent Neuropathic Pain--A Systematic Review.
Boogaard S, Heymans MW, de Vet HC, Peters ML, Loer SA, Zuurmond WW, Perez RS
Pain Physician 2015 Sep-Oct;18(5):433-57. PMID: 26431122
Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values.
Rolke R, Baron R, Maier C, Tölle TR, Treede -DR, Beyer A, Binder A, Birbaumer N, Birklein F, Bötefür IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihöfner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B
Pain 2006 Aug;123(3):231-243. Epub 2006 May 11 doi: 10.1016/j.pain.2006.01.041. PMID: 16697110

Recent systematic reviews

Higher incidences of neuropathic pain and altered sensation following radial forearm free flap: A systematic review.
Bruin LL, Hundepool CA, Duraku LS, Mureau MAM, Zuidam JM
J Plast Reconstr Aesthet Surg 2022 Jan;75(1):1-9. Epub 2021 Oct 8 doi: 10.1016/j.bjps.2021.09.028. PMID: 34736849
Tarsal coalition: Systematic review of arthroscopic management.
Addar A, Marwan Y, Algarni N, Algarni N, Berry GK, Benaroch T
Foot (Edinb) 2021 Dec;49:101864. Epub 2021 Sep 22 doi: 10.1016/j.foot.2021.101864. PMID: 34597922
Predictors of Persistent Neuropathic Pain--A Systematic Review.
Boogaard S, Heymans MW, de Vet HC, Peters ML, Loer SA, Zuurmond WW, Perez RS
Pain Physician 2015 Sep-Oct;18(5):433-57. PMID: 26431122
Acetyl-L-carnitine in the treatment of peripheral neuropathic pain: a systematic review and meta-analysis of randomized controlled trials.
Li S, Li Q, Li Y, Li L, Tian H, Sun X
PLoS One 2015;10(3):e0119479. Epub 2015 Mar 9 doi: 10.1371/journal.pone.0119479. PMID: 25751285Free PMC Article
Vulvodynia interventions--systematic review and evidence grading.
Andrews JC
Obstet Gynecol Surv 2011 May;66(5):299-315. doi: 10.1097/OGX.0b013e3182277fb7. PMID: 21794194

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