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Benign Extrahepatic Bile Duct Neoplasm

MedGen UID:
96925
•Concept ID:
C0496871
•
Neoplastic Process
Synonyms: Benign Extrahepatic Bile Duct Tumor; Benign Neoplasm of Extrahepatic Bile Duct; Benign neoplasm of extrahepatic bile ducts; Benign Neoplasm of the Extrahepatic Bile Duct; Benign tumor of extrahepatic bile duct; Benign Tumor of Extrahepatic Bile Duct; Benign Tumor of the Extrahepatic Bile Duct
SNOMED CT: Benign tumor of extrahepatic bile duct (92096008); Benign neoplasm of extrahepatic bile ducts (92096008)

Definition

A neoplasm that arises from the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Endoscopic biliary stenting: indications, choice of stents, and results: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline - Updated October 2017.
Dumonceau JM, Tringali A, Papanikolaou IS, Blero D, Mangiavillano B, Schmidt A, Vanbiervliet G, Costamagna G, Devière J, García-Cano J, Gyökeres T, Hassan C, Prat F, Siersema PD, van Hooft JE
Endoscopy 2018 Sep;50(9):910-930. Epub 2018 Aug 7 doi: 10.1055/a-0659-9864. PMID: 30086596
Endoscopic management of primary sclerosing cholangitis.
Tabibian JH, Baron TH
Expert Rev Gastroenterol Hepatol 2018 Jul;12(7):693-703. Epub 2018 Jun 18 doi: 10.1080/17474124.2018.1483719. PMID: 29883229
The role of (18)F-fluorodeoxyglucose positron emission tomography in the diagnosis, staging, and follow-up of cholangiocarcinoma.
Moon CM, Bang S, Chung JB
Surg Oncol 2011 Mar;20(1):e10-7. Epub 2009 Oct 4 doi: 10.1016/j.suronc.2009.08.003. PMID: 19804967

Recent clinical studies

Etiology

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial.
Wang M, Li D, Chen R, Huang X, Li J, Liu Y, Liu J, Cheng W, Chen X, Zhao W, Li J, Tan Z, Huang H, Li D, Zhu F, Qin T, Ma J, Yu G, Zhou B, Zheng S, Tang Y, Han W, Meng L, Ke J, Feng F, Chen B, Yin X, Chen W, Ma H, Xu J, Liu Y, Lin R, Dong Y, Yu Y, Liu J, Zhang H, Qin R; Minimally Invasive Treatment Group in the Pancreatic Disease Branch of China's International Exchange and Promotion Association for Medicine and Healthcare (MITG-P-CPAM)
Lancet Gastroenterol Hepatol 2021 Jun;6(6):438-447. Epub 2021 Apr 27 doi: 10.1016/S2468-1253(21)00054-6. PMID: 33915091
Cholangiocarcinoma in patients with primary sclerosing cholangitis.
Fung BM, Tabibian JH
Curr Opin Gastroenterol 2020 Mar;36(2):77-84. doi: 10.1097/MOG.0000000000000616. PMID: 31850928
Endoscopic management of primary sclerosing cholangitis.
Tabibian JH, Baron TH
Expert Rev Gastroenterol Hepatol 2018 Jul;12(7):693-703. Epub 2018 Jun 18 doi: 10.1080/17474124.2018.1483719. PMID: 29883229
Differentiation of benign and malignant hilar bile duct stenosis.
Liu X, Yang Z, Tan H, Shao C, Liu L, Si S, Xu L, Sun Y
J Surg Res 2016 Jun 15;203(2):275-82. Epub 2016 Mar 25 doi: 10.1016/j.jss.2016.03.002. PMID: 27363632
Carcinoma gallbladder.
Biswas PK
Mymensingh Med J 2010 Jul;19(3):477-81. PMID: 20639849

Diagnosis

Cholangiocarcinoma in patients with primary sclerosing cholangitis.
Fung BM, Tabibian JH
Curr Opin Gastroenterol 2020 Mar;36(2):77-84. doi: 10.1097/MOG.0000000000000616. PMID: 31850928
Endoscopic management of primary sclerosing cholangitis.
Tabibian JH, Baron TH
Expert Rev Gastroenterol Hepatol 2018 Jul;12(7):693-703. Epub 2018 Jun 18 doi: 10.1080/17474124.2018.1483719. PMID: 29883229
Imaging features of benign and malignant ampullary and periampullary lesions.
Nikolaidis P, Hammond NA, Day K, Yaghmai V, Wood CG 3rd, Mosbach DS, Harmath CB, Taffel MT, Horowitz JM, Berggruen SM, Miller FH
Radiographics 2014 May-Jun;34(3):624-41. doi: 10.1148/rg.343125191. PMID: 24819785
Adult bile duct strictures: role of MR imaging and MR cholangiopancreatography in characterization.
Katabathina VS, Dasyam AK, Dasyam N, Hosseinzadeh K
Radiographics 2014 May-Jun;34(3):565-86. doi: 10.1148/rg.343125211. PMID: 24819781
Carcinoma gallbladder.
Biswas PK
Mymensingh Med J 2010 Jul;19(3):477-81. PMID: 20639849

Therapy

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial.
Wang M, Li D, Chen R, Huang X, Li J, Liu Y, Liu J, Cheng W, Chen X, Zhao W, Li J, Tan Z, Huang H, Li D, Zhu F, Qin T, Ma J, Yu G, Zhou B, Zheng S, Tang Y, Han W, Meng L, Ke J, Feng F, Chen B, Yin X, Chen W, Ma H, Xu J, Liu Y, Lin R, Dong Y, Yu Y, Liu J, Zhang H, Qin R; Minimally Invasive Treatment Group in the Pancreatic Disease Branch of China's International Exchange and Promotion Association for Medicine and Healthcare (MITG-P-CPAM)
Lancet Gastroenterol Hepatol 2021 Jun;6(6):438-447. Epub 2021 Apr 27 doi: 10.1016/S2468-1253(21)00054-6. PMID: 33915091
A rare case of eosinophilic cholangiopathy.
Li W, Jiang F, Li X, Li H, Zheng Z
Int J Immunopathol Pharmacol 2020 Jan-Dec;34:2058738420941752. doi: 10.1177/2058738420941752. PMID: 32684063Free PMC Article
Endoscopic management of primary sclerosing cholangitis.
Tabibian JH, Baron TH
Expert Rev Gastroenterol Hepatol 2018 Jul;12(7):693-703. Epub 2018 Jun 18 doi: 10.1080/17474124.2018.1483719. PMID: 29883229
Preoperative Stenting for Benign and Malignant Periampullary Diseases: Unnecessary if Not Harmful.
Gholami S, Brennan MF
Surg Clin North Am 2018 Feb;98(1):37-47. doi: 10.1016/j.suc.2017.09.005. PMID: 29191276Free PMC Article
Endoscopic papillectomy: indications, techniques, and results.
De Palma GD
World J Gastroenterol 2014 Feb 14;20(6):1537-43. doi: 10.3748/wjg.v20.i6.1537. PMID: 24587629Free PMC Article

Prognosis

Cholangiocarcinoma in patients with primary sclerosing cholangitis.
Fung BM, Tabibian JH
Curr Opin Gastroenterol 2020 Mar;36(2):77-84. doi: 10.1097/MOG.0000000000000616. PMID: 31850928
Endoscopic management of primary sclerosing cholangitis.
Tabibian JH, Baron TH
Expert Rev Gastroenterol Hepatol 2018 Jul;12(7):693-703. Epub 2018 Jun 18 doi: 10.1080/17474124.2018.1483719. PMID: 29883229
Carcinoma gallbladder.
Biswas PK
Mymensingh Med J 2010 Jul;19(3):477-81. PMID: 20639849
Ampullary tumors: radiologic-pathologic correlation.
Buck JL, Elsayed AM
Radiographics 1993 Jan;13(1):193-212. doi: 10.1148/radiographics.13.1.8426928. PMID: 8426928
Tumour markers in pancreatic cancer.
Haglund C, Kuusela P, Roberts PJ
Ann Chir Gynaecol 1989;78(1):41-53. PMID: 2667448

Clinical prediction guides

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial.
Wang M, Li D, Chen R, Huang X, Li J, Liu Y, Liu J, Cheng W, Chen X, Zhao W, Li J, Tan Z, Huang H, Li D, Zhu F, Qin T, Ma J, Yu G, Zhou B, Zheng S, Tang Y, Han W, Meng L, Ke J, Feng F, Chen B, Yin X, Chen W, Ma H, Xu J, Liu Y, Lin R, Dong Y, Yu Y, Liu J, Zhang H, Qin R; Minimally Invasive Treatment Group in the Pancreatic Disease Branch of China's International Exchange and Promotion Association for Medicine and Healthcare (MITG-P-CPAM)
Lancet Gastroenterol Hepatol 2021 Jun;6(6):438-447. Epub 2021 Apr 27 doi: 10.1016/S2468-1253(21)00054-6. PMID: 33915091
Endoscopic management of primary sclerosing cholangitis.
Tabibian JH, Baron TH
Expert Rev Gastroenterol Hepatol 2018 Jul;12(7):693-703. Epub 2018 Jun 18 doi: 10.1080/17474124.2018.1483719. PMID: 29883229
Surgical strategy for mucin-producing bile duct tumor.
Ohtsuka M, Kimura F, Shimizu H, Yoshidome H, Kato A, Yoshitomi H, Furukawa K, Mitsuhashi N, Takeuchi D, Takayashiki T, Suda K, Miyazaki M
J Hepatobiliary Pancreat Sci 2010 May;17(3):236-40. Epub 2009 Aug 1 doi: 10.1007/s00534-009-0152-0. PMID: 19649559
Multiple tumors of the biliary tract.
Gertsch P, Thomas P, Baer H, Lerut J, Zimmermann A, Blumgart LH
Am J Surg 1990 Apr;159(4):386-8. doi: 10.1016/s0002-9610(05)81278-4. PMID: 2180336
Tumour markers in pancreatic cancer.
Haglund C, Kuusela P, Roberts PJ
Ann Chir Gynaecol 1989;78(1):41-53. PMID: 2667448

Recent systematic reviews

Long-term recurrence after endoscopic versus surgical ampullectomy of sporadic ampullary adenomas: a systematic review and meta-analysis.
Garg R, Thind K, Bhalla J, Simonson MT, Simons-Linares CR, Singh A, Joyce D, Chahal P
Surg Endosc 2023 Jul;37(7):5022-5044. Epub 2023 May 23 doi: 10.1007/s00464-023-10083-0. PMID: 37221416
Robotic-assisted versus open pancreaticoduodenectomy for patients with benign and malignant periampullary disease: a systematic review and meta-analysis of short-term outcomes.
Podda M, Gerardi C, Di Saverio S, Marino MV, Davies RJ, Pellino G, Pisanu A
Surg Endosc 2020 Jun;34(6):2390-2409. Epub 2020 Feb 18 doi: 10.1007/s00464-020-07460-4. PMID: 32072286
Parenchyma-Sparing, Limited Pancreatic Head Resection for Benign Tumors and Low-Risk Periampullary Cancer--a Systematic Review.
Beger HG, Mayer B, Rau BM
J Gastrointest Surg 2016 Jan;20(1):206-17. Epub 2015 Nov 2 doi: 10.1007/s11605-015-2981-2. PMID: 26525207
Duodenum-preserving total and partial pancreatic head resection for benign tumors--systematic review and meta-analysis.
Beger HG, Nakao A, Mayer B, Poch B
Pancreatology 2015 Mar-Apr;15(2):167-78. Epub 2015 Feb 7 doi: 10.1016/j.pan.2015.01.009. PMID: 25732271

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